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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for GMEB1
Z-value: 0.01
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Transcription factors associated with GMEB1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GMEB1 | hg19_v2_chr1_+_28995231_28995250 | 0.07 | 3.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_57831829 Show fit | 5.92 |
ENST00000321545.4
|
zinc finger protein 543 |
|
| chr1_+_202830876 Show fit | 4.21 |
ENST00000456105.2
|
RP11-480I12.7 |
|
| chr12_+_75784850 Show fit | 3.84 |
ENST00000550916.1
ENST00000435775.1 ENST00000378689.2 ENST00000378692.3 ENST00000320460.4 ENST00000547164.1 |
GLI pathogenesis-related 1 like 2 |
|
| chr3_+_122296465 Show fit | 3.82 |
ENST00000483793.1
|
poly (ADP-ribose) polymerase family, member 15 |
|
| chr3_+_62304648 Show fit | 3.79 |
ENST00000462069.1
ENST00000232519.5 ENST00000465142.1 |
chromosome 3 open reading frame 14 |
|
| chr4_-_83719884 Show fit | 3.51 |
ENST00000282709.4
ENST00000273908.4 |
stearoyl-CoA desaturase 5 |
|
| chr3_+_62304712 Show fit | 3.46 |
ENST00000494481.1
|
chromosome 3 open reading frame 14 |
|
| chr7_+_35840819 Show fit | 3.43 |
ENST00000399035.3
|
septin 7 |
|
| chr1_+_46668994 Show fit | 3.39 |
ENST00000371980.3
|
leucine rich adaptor protein 1 |
|
| chr6_-_24667180 Show fit | 3.37 |
ENST00000545995.1
|
tyrosyl-DNA phosphodiesterase 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of GMEB1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 9.0 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 1.3 | 7.8 | GO:0098535 | de novo centriole assembly(GO:0098535) |
| 1.9 | 7.6 | GO:0071894 | histone H2B conserved C-terminal lysine ubiquitination(GO:0071894) |
| 0.6 | 7.6 | GO:0071394 | cellular response to testosterone stimulus(GO:0071394) |
| 1.1 | 6.7 | GO:0090646 | mitochondrial tRNA processing(GO:0090646) |
| 1.3 | 6.4 | GO:0016476 | regulation of embryonic cell shape(GO:0016476) |
| 0.2 | 6.3 | GO:0061157 | mRNA destabilization(GO:0061157) |
| 0.1 | 5.8 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 0.1 | 5.7 | GO:2000300 | regulation of synaptic vesicle exocytosis(GO:2000300) |
| 0.7 | 5.6 | GO:0006933 | negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.5 | GO:0005814 | centriole(GO:0005814) |
| 0.0 | 8.3 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.1 | 7.8 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 0.1 | 7.4 | GO:0005844 | polysome(GO:0005844) |
| 1.3 | 6.7 | GO:0030678 | mitochondrial ribonuclease P complex(GO:0030678) |
| 0.5 | 6.4 | GO:0097227 | sperm annulus(GO:0097227) |
| 0.2 | 6.4 | GO:0005763 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 1.5 | 6.1 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
| 0.0 | 5.1 | GO:0005819 | spindle(GO:0005819) |
| 0.0 | 4.7 | GO:0042641 | actomyosin(GO:0042641) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 8.7 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.6 | 8.3 | GO:1990247 | N6-methyladenosine-containing RNA binding(GO:1990247) |
| 0.1 | 8.2 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.1 | 7.8 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
| 0.4 | 6.9 | GO:0004526 | ribonuclease P activity(GO:0004526) |
| 0.2 | 6.5 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 2.0 | 6.1 | GO:0036317 | tyrosyl-RNA phosphodiesterase activity(GO:0036317) 5'-tyrosyl-DNA phosphodiesterase activity(GO:0070260) |
| 0.2 | 5.3 | GO:0070008 | serine-type exopeptidase activity(GO:0070008) |
| 0.1 | 5.1 | GO:0003724 | RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186) |
| 0.1 | 5.1 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.9 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.1 | 5.2 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.1 | 5.1 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.1 | 4.8 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.0 | 4.8 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 4.7 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 4.6 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 4.3 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 3.1 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.1 | 3.1 | PID AURORA B PATHWAY | Aurora B signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.8 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 11.4 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.1 | 9.7 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 8.9 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.2 | 6.6 | REACTOME BOTULINUM NEUROTOXICITY | Genes involved in Botulinum neurotoxicity |
| 0.0 | 6.0 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.2 | 4.5 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 0.2 | 4.3 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.2 | 4.1 | REACTOME MITOCHONDRIAL TRNA AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.1 | 4.0 | REACTOME G ALPHA Z SIGNALLING EVENTS | Genes involved in G alpha (z) signalling events |