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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for GUCAGUU
Z-value: 0.76
Motif logo
miRNA associated with seed GUCAGUU
| Name | miRBASE accession |
|---|---|
|
hsa-miR-223-3p
|
MIMAT0000280 |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_+_172468472 Show fit | 4.56 |
ENST00000232458.5
ENST00000392692.3 |
epithelial cell transforming sequence 2 oncogene |
|
| chr6_-_79787902 Show fit | 3.62 |
ENST00000275034.4
|
pleckstrin homology domain interacting protein |
|
| chr2_+_223725652 Show fit | 3.53 |
ENST00000357430.3
ENST00000392066.3 |
acyl-CoA synthetase long-chain family member 3 |
|
| chr15_-_52861394 Show fit | 3.28 |
ENST00000563277.1
ENST00000566423.1 |
cAMP-regulated phosphoprotein, 19kDa |
|
| chr4_-_187644930 Show fit | 3.27 |
ENST00000441802.2
|
FAT atypical cadherin 1 |
|
| chr1_-_70671216 Show fit | 3.23 |
ENST00000370952.3
|
leucine rich repeat containing 40 |
|
| chrX_+_69509927 Show fit | 3.22 |
ENST00000374403.3
|
kinesin family member 4A |
|
| chr5_+_145826867 Show fit | 3.09 |
ENST00000296702.5
ENST00000394421.2 |
transcription elongation regulator 1 |
|
| chr13_+_29233218 Show fit | 3.08 |
ENST00000380842.4
|
proteasome maturation protein |
|
| chr11_-_57103327 Show fit | 2.93 |
ENST00000529002.1
ENST00000278412.2 |
structure specific recognition protein 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of GUCAGUU
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.1 | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore(GO:0051988) |
| 0.2 | 3.6 | GO:0043568 | positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568) |
| 1.2 | 3.5 | GO:2001245 | regulation of phosphatidylcholine biosynthetic process(GO:2001245) |
| 0.2 | 3.2 | GO:0051256 | mitotic spindle midzone assembly(GO:0051256) |
| 0.2 | 3.1 | GO:0043248 | proteasome assembly(GO:0043248) |
| 0.0 | 3.1 | GO:0007163 | establishment or maintenance of cell polarity(GO:0007163) |
| 0.3 | 2.9 | GO:0051610 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.0 | 2.9 | GO:0006383 | transcription from RNA polymerase III promoter(GO:0006383) |
| 0.2 | 2.8 | GO:0000338 | protein deneddylation(GO:0000338) |
| 0.3 | 2.7 | GO:2000825 | positive regulation of androgen receptor activity(GO:2000825) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.7 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 5.3 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.9 | 4.6 | GO:0097149 | centralspindlin complex(GO:0097149) |
| 0.1 | 4.3 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.0 | 4.0 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 0.0 | 3.5 | GO:0005811 | lipid particle(GO:0005811) |
| 0.1 | 2.9 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
| 0.0 | 2.9 | GO:0043197 | dendritic spine(GO:0043197) |
| 0.1 | 2.8 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.1 | 2.7 | GO:0005844 | polysome(GO:0005844) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.6 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.0 | 4.6 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 3.8 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.2 | 3.5 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
| 0.1 | 3.3 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.1 | 3.2 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.1 | 3.1 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.1 | 2.9 | GO:0001056 | RNA polymerase III activity(GO:0001056) |
| 0.9 | 2.7 | GO:0001069 | regulatory region RNA binding(GO:0001069) |
| 0.2 | 2.5 | GO:0019870 | potassium channel inhibitor activity(GO:0019870) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.6 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 3.7 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 2.5 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.0 | 2.4 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.0 | 2.4 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.0 | 2.1 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
| 0.0 | 2.1 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 1.6 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 1.3 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 0.9 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.9 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.2 | 3.5 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.1 | 3.2 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 3.1 | REACTOME TRANSLATION | Genes involved in Translation |
| 0.1 | 2.9 | REACTOME RNA POL III CHAIN ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |
| 0.2 | 2.4 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.1 | 2.4 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 2.4 | REACTOME ELONGATION ARREST AND RECOVERY | Genes involved in Elongation arrest and recovery |
| 0.1 | 2.4 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.0 | 2.3 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |