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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for GUCAGUU

Z-value: 0.76

Motif logo

logo of

miRNA associated with seed GUCAGUU

NamemiRBASE accession
hsa-miR-223-3p
MIMAT0000280

Activity profile of GUCAGUU motif

Sorted Z-values of GUCAGUU motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_172468472 4.56 ENST00000232458.5
ENST00000392692.3
ECT2
epithelial cell transforming sequence 2 oncogene
chr6_-_79787902 3.62 ENST00000275034.4
PHIP
pleckstrin homology domain interacting protein
chr2_+_223725652 3.53 ENST00000357430.3
ENST00000392066.3
ACSL3
acyl-CoA synthetase long-chain family member 3
chr15_-_52861394 3.28 ENST00000563277.1
ENST00000566423.1
ARPP19
cAMP-regulated phosphoprotein, 19kDa
chr4_-_187644930 3.27 ENST00000441802.2
FAT1
FAT atypical cadherin 1
chr1_-_70671216 3.23 ENST00000370952.3
LRRC40
leucine rich repeat containing 40
chrX_+_69509927 3.22 ENST00000374403.3
KIF4A
kinesin family member 4A
chr5_+_145826867 3.09 ENST00000296702.5
ENST00000394421.2
TCERG1
transcription elongation regulator 1
chr13_+_29233218 3.08 ENST00000380842.4
POMP
proteasome maturation protein
chr11_-_57103327 2.93 ENST00000529002.1
ENST00000278412.2
SSRP1
structure specific recognition protein 1
chr15_-_49447835 2.82 ENST00000388901.5
ENST00000299259.6
COPS2
COP9 signalosome subunit 2
chr3_+_152017181 2.74 ENST00000498502.1
ENST00000324196.5
ENST00000545754.1
ENST00000357472.3
MBNL1
muscleblind-like splicing regulator 1
chr6_+_116892530 2.70 ENST00000466444.2
ENST00000368590.5
ENST00000392526.1
RWDD1
RWD domain containing 1
chr15_+_77223960 2.57 ENST00000394885.3
RCN2
reticulocalbin 2, EF-hand calcium binding domain
chr5_+_86564739 2.48 ENST00000456692.2
ENST00000512763.1
ENST00000506290.1
RASA1
RAS p21 protein activator (GTPase activating protein) 1
chr16_+_22308717 2.46 ENST00000299853.5
ENST00000564209.1
ENST00000565358.1
ENST00000418581.2
ENST00000564883.1
ENST00000359210.4
ENST00000563024.1
POLR3E
polymerase (RNA) III (DNA directed) polypeptide E (80kD)
chr12_+_104324112 2.45 ENST00000299767.5
HSP90B1
heat shock protein 90kDa beta (Grp94), member 1
chr2_-_33824336 2.42 ENST00000431950.1
ENST00000403368.1
ENST00000441530.2
FAM98A
family with sequence similarity 98, member A
chr1_-_205719295 2.39 ENST00000367142.4
NUCKS1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr1_+_84543734 2.37 ENST00000370689.2
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr1_-_109968973 2.34 ENST00000271308.4
ENST00000538610.1
PSMA5
proteasome (prosome, macropain) subunit, alpha type, 5
chr8_-_67525473 2.34 ENST00000522677.3
MYBL1
v-myb avian myeloblastosis viral oncogene homolog-like 1
chr2_-_169104651 2.31 ENST00000355999.4
STK39
serine threonine kinase 39
chr3_-_113465065 2.30 ENST00000497255.1
ENST00000478020.1
ENST00000240922.3
ENST00000493900.1
NAA50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr2_+_99953816 2.27 ENST00000289371.6
EIF5B
eukaryotic translation initiation factor 5B
chr4_+_99916765 2.17 ENST00000296411.6
METAP1
methionyl aminopeptidase 1
chr1_-_78148324 2.17 ENST00000370801.3
ENST00000433749.1
ZZZ3
zinc finger, ZZ-type containing 3
chr5_+_151151471 2.16 ENST00000394123.3
ENST00000543466.1
G3BP1
GTPase activating protein (SH3 domain) binding protein 1
chr6_-_86352642 2.15 ENST00000355238.6
SYNCRIP
synaptotagmin binding, cytoplasmic RNA interacting protein
chr3_+_112709804 2.13 ENST00000383677.3
GTPBP8
GTP-binding protein 8 (putative)
chr5_+_65440032 2.13 ENST00000334121.6
SREK1
splicing regulatory glutamine/lysine-rich protein 1
chr2_-_174830430 2.07 ENST00000310015.6
ENST00000455789.2
SP3
Sp3 transcription factor
chr3_-_149688896 2.07 ENST00000239940.7
PFN2
profilin 2
chr6_+_155054459 2.04 ENST00000367178.3
ENST00000417268.1
ENST00000367186.4
SCAF8
SR-related CTD-associated factor 8
chrX_-_13956737 2.02 ENST00000454189.2
GPM6B
glycoprotein M6B
chr17_+_16318850 1.98 ENST00000338560.7
TRPV2
transient receptor potential cation channel, subfamily V, member 2
chr8_-_104427313 1.97 ENST00000297578.4
SLC25A32
solute carrier family 25 (mitochondrial folate carrier), member 32
chr4_-_74124502 1.92 ENST00000358602.4
ENST00000330838.6
ENST00000561029.1
ANKRD17
ankyrin repeat domain 17
chr12_-_118797475 1.91 ENST00000541786.1
ENST00000419821.2
ENST00000541878.1
TAOK3
TAO kinase 3
chr2_+_29117509 1.89 ENST00000407426.3
WDR43
WD repeat domain 43
chr13_-_50367057 1.89 ENST00000261667.3
KPNA3
karyopherin alpha 3 (importin alpha 4)
chr13_+_50656307 1.74 ENST00000378180.4
DLEU1
deleted in lymphocytic leukemia 1 (non-protein coding)
chr8_-_66546439 1.73 ENST00000276569.3
ARMC1
armadillo repeat containing 1
chr15_-_68498376 1.64 ENST00000540479.1
ENST00000395465.3
CALML4
calmodulin-like 4
chr12_+_70636765 1.58 ENST00000552231.1
ENST00000229195.3
ENST00000547780.1
ENST00000418359.3
CNOT2
CCR4-NOT transcription complex, subunit 2
chr2_+_159313452 1.51 ENST00000389757.3
ENST00000389759.3
PKP4
plakophilin 4
chr1_+_93913713 1.45 ENST00000604705.1
ENST00000370253.2
FNBP1L
formin binding protein 1-like
chr11_-_95657231 1.40 ENST00000409459.1
ENST00000352297.7
ENST00000393223.3
ENST00000346299.5
MTMR2
myotubularin related protein 2
chr3_+_150321068 1.40 ENST00000471696.1
ENST00000477889.1
ENST00000485923.1
SELT
Selenoprotein T
chr17_-_30669138 1.36 ENST00000225805.4
ENST00000577809.1
C17orf75
chromosome 17 open reading frame 75
chr12_+_121837844 1.36 ENST00000361234.5
RNF34
ring finger protein 34, E3 ubiquitin protein ligase
chrX_-_134049262 1.35 ENST00000370783.3
MOSPD1
motile sperm domain containing 1
chr21_+_30396950 1.29 ENST00000399975.3
ENST00000399976.2
ENST00000334352.4
ENST00000399973.1
ENST00000535828.1
USP16
ubiquitin specific peptidase 16
chr5_+_71403061 1.26 ENST00000512974.1
ENST00000296755.7
MAP1B
microtubule-associated protein 1B
chr3_+_142720366 1.25 ENST00000493782.1
ENST00000397933.2
ENST00000473835.2
ENST00000493598.2
U2SURP
U2 snRNP-associated SURP domain containing
chr12_-_90049828 1.23 ENST00000261173.2
ENST00000348959.3
ATP2B1
ATPase, Ca++ transporting, plasma membrane 1
chr17_-_8534067 1.19 ENST00000360416.3
ENST00000269243.4
MYH10
myosin, heavy chain 10, non-muscle
chr10_-_101989315 1.18 ENST00000370397.7
CHUK
conserved helix-loop-helix ubiquitous kinase
chr12_+_67663056 1.17 ENST00000545606.1
CAND1
cullin-associated and neddylation-dissociated 1
chr4_+_166248775 1.16 ENST00000261507.6
ENST00000507013.1
ENST00000393766.2
ENST00000504317.1
MSMO1
methylsterol monooxygenase 1
chr13_-_76056250 1.14 ENST00000377636.3
ENST00000431480.2
ENST00000377625.2
ENST00000425511.1
TBC1D4
TBC1 domain family, member 4
chr16_-_20911641 1.06 ENST00000564349.1
ENST00000324344.4
ERI2
DCUN1D3
ERI1 exoribonuclease family member 2
DCN1, defective in cullin neddylation 1, domain containing 3
chr1_+_244214577 1.04 ENST00000358704.4
ZBTB18
zinc finger and BTB domain containing 18
chr5_-_132113036 1.00 ENST00000378706.1
SEPT8
septin 8
chr3_+_147127142 0.96 ENST00000282928.4
ZIC1
Zic family member 1
chr19_+_10982189 0.95 ENST00000327064.4
ENST00000588947.1
CARM1
coactivator-associated arginine methyltransferase 1
chr9_+_127624387 0.92 ENST00000353214.2
ARPC5L
actin related protein 2/3 complex, subunit 5-like
chr4_-_140098339 0.91 ENST00000394235.2
ELF2
E74-like factor 2 (ets domain transcription factor)
chr1_-_41131326 0.90 ENST00000372684.3
RIMS3
regulating synaptic membrane exocytosis 3
chr2_-_69614373 0.88 ENST00000361060.5
ENST00000357308.4
GFPT1
glutamine--fructose-6-phosphate transaminase 1
chr16_-_87525651 0.88 ENST00000268616.4
ZCCHC14
zinc finger, CCHC domain containing 14
chr12_+_111843749 0.85 ENST00000341259.2
SH2B3
SH2B adaptor protein 3
chr4_-_90758227 0.85 ENST00000506691.1
ENST00000394986.1
ENST00000506244.1
ENST00000394989.2
ENST00000394991.3
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chrX_+_118708493 0.84 ENST00000371558.2
UBE2A
ubiquitin-conjugating enzyme E2A
chr5_+_112196919 0.83 ENST00000505459.1
ENST00000282999.3
ENST00000515463.1
SRP19
signal recognition particle 19kDa
chr16_+_67880574 0.83 ENST00000219169.4
NUTF2
nuclear transport factor 2
chr10_-_121356007 0.82 ENST00000369093.2
ENST00000436547.2
TIAL1
TIA1 cytotoxic granule-associated RNA binding protein-like 1
chr9_+_37422663 0.81 ENST00000318158.6
ENST00000607784.1
GRHPR
glyoxylate reductase/hydroxypyruvate reductase
chr17_+_57784826 0.79 ENST00000262291.4
VMP1
vacuole membrane protein 1
chr8_-_102217796 0.79 ENST00000519744.1
ENST00000311212.4
ENST00000521272.1
ENST00000519882.1
ZNF706
zinc finger protein 706
chr3_-_72496035 0.77 ENST00000477973.2
RYBP
RING1 and YY1 binding protein
chr6_+_69345166 0.77 ENST00000370598.1
BAI3
brain-specific angiogenesis inhibitor 3
chr5_-_43313574 0.76 ENST00000325110.6
ENST00000433297.2
HMGCS1
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
chr1_-_39339777 0.75 ENST00000397572.2
MYCBP
MYC binding protein
chr13_+_98086445 0.71 ENST00000245304.4
RAP2A
RAP2A, member of RAS oncogene family
chr17_+_55162453 0.71 ENST00000575322.1
ENST00000337714.3
ENST00000314126.3
AKAP1
A kinase (PRKA) anchor protein 1
chr14_-_78083112 0.70 ENST00000216484.2
SPTLC2
serine palmitoyltransferase, long chain base subunit 2
chr10_+_31608054 0.66 ENST00000320985.10
ENST00000361642.5
ENST00000560721.2
ENST00000558440.1
ENST00000424869.1
ENST00000542815.3
ZEB1
zinc finger E-box binding homeobox 1
chr6_-_34360413 0.65 ENST00000607016.1
NUDT3
nudix (nucleoside diphosphate linked moiety X)-type motif 3
chr6_+_4890226 0.65 ENST00000343762.5
CDYL
chromodomain protein, Y-like
chr1_+_27022485 0.59 ENST00000324856.7
ARID1A
AT rich interactive domain 1A (SWI-like)
chr20_-_32274179 0.59 ENST00000343380.5
E2F1
E2F transcription factor 1
chr2_-_166060571 0.57 ENST00000360093.3
SCN3A
sodium channel, voltage-gated, type III, alpha subunit
chr1_-_190446759 0.46 ENST00000367462.3
BRINP3
bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr2_+_36582857 0.44 ENST00000280527.2
CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr18_+_60382672 0.44 ENST00000400316.4
ENST00000262719.5
PHLPP1
PH domain and leucine rich repeat protein phosphatase 1
chr6_+_43484760 0.43 ENST00000372389.3
ENST00000372344.2
ENST00000304004.3
ENST00000423780.1
POLR1C
polymerase (RNA) I polypeptide C, 30kDa
chr11_-_62446527 0.40 ENST00000294119.2
ENST00000529640.1
ENST00000534176.1
ENST00000301935.5
UBXN1
UBX domain protein 1
chr12_+_75874460 0.40 ENST00000266659.3
GLIPR1
GLI pathogenesis-related 1
chr1_-_108507631 0.39 ENST00000527011.1
ENST00000370056.4
VAV3
vav 3 guanine nucleotide exchange factor
chr1_+_65730385 0.38 ENST00000263441.7
ENST00000395325.3
DNAJC6
DnaJ (Hsp40) homolog, subfamily C, member 6
chr17_+_30677136 0.35 ENST00000394670.4
ENST00000321233.6
ENST00000394673.2
ENST00000341711.6
ENST00000579634.1
ENST00000580759.1
ENST00000342555.6
ENST00000577908.1
ENST00000394679.5
ENST00000582165.1
ZNF207
zinc finger protein 207
chr22_+_40573921 0.35 ENST00000454349.2
ENST00000335727.9
TNRC6B
trinucleotide repeat containing 6B
chr2_-_166930131 0.34 ENST00000303395.4
ENST00000409050.1
ENST00000423058.2
ENST00000375405.3
SCN1A
sodium channel, voltage-gated, type I, alpha subunit
chr11_+_119019722 0.34 ENST00000307417.3
ABCG4
ATP-binding cassette, sub-family G (WHITE), member 4
chr13_+_33160553 0.33 ENST00000315596.10
PDS5B
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr1_+_97187318 0.31 ENST00000609116.1
ENST00000370198.1
ENST00000370197.1
ENST00000426398.2
ENST00000394184.3
PTBP2
polypyrimidine tract binding protein 2
chr3_-_9291063 0.30 ENST00000383836.3
SRGAP3
SLIT-ROBO Rho GTPase activating protein 3
chr20_-_33999766 0.30 ENST00000349714.5
ENST00000438533.1
ENST00000359226.2
ENST00000374384.2
ENST00000374377.5
ENST00000407996.2
ENST00000424405.1
ENST00000542501.1
ENST00000397554.1
ENST00000540457.1
ENST00000374380.2
ENST00000374385.5
UQCC1
ubiquinol-cytochrome c reductase complex assembly factor 1
chr1_+_36396677 0.29 ENST00000373191.4
ENST00000397828.2
AGO3
argonaute RISC catalytic component 3
chrX_-_43832711 0.28 ENST00000378062.5
NDP
Norrie disease (pseudoglioma)
chr18_+_54318616 0.28 ENST00000254442.3
WDR7
WD repeat domain 7
chr19_+_49375649 0.28 ENST00000200453.5
PPP1R15A
protein phosphatase 1, regulatory subunit 15A
chr11_-_31839488 0.27 ENST00000419022.1
ENST00000379132.3
ENST00000379129.2
PAX6
paired box 6
chr15_-_49338748 0.25 ENST00000559471.1
SECISBP2L
SECIS binding protein 2-like
chr8_-_105601134 0.22 ENST00000276654.5
ENST00000424843.2
LRP12
low density lipoprotein receptor-related protein 12
chr6_-_99395787 0.22 ENST00000369244.2
ENST00000229971.1
FBXL4
F-box and leucine-rich repeat protein 4
chr14_+_79745746 0.20 ENST00000281127.7
NRXN3
neurexin 3
chr2_-_40679186 0.20 ENST00000406785.2
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr12_-_125348448 0.17 ENST00000339570.5
SCARB1
scavenger receptor class B, member 1
chr2_+_79740118 0.16 ENST00000496558.1
ENST00000451966.1
CTNNA2
catenin (cadherin-associated protein), alpha 2
chr16_-_73082274 0.16 ENST00000268489.5
ZFHX3
zinc finger homeobox 3
chr3_-_197476560 0.14 ENST00000273582.5
KIAA0226
KIAA0226
chr3_-_48130707 0.14 ENST00000360240.6
ENST00000383737.4
MAP4
microtubule-associated protein 4
chr9_-_99801592 0.14 ENST00000259470.5
CTSV
cathepsin V
chr4_-_39979576 0.12 ENST00000303538.8
ENST00000503396.1
PDS5A
PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
chr10_-_121632266 0.10 ENST00000360003.3
ENST00000369077.3
MCMBP
minichromosome maintenance complex binding protein
chr17_+_57970469 0.09 ENST00000443572.2
ENST00000406116.3
ENST00000225577.4
ENST00000393021.3
RPS6KB1
ribosomal protein S6 kinase, 70kDa, polypeptide 1
chr12_-_54673871 0.08 ENST00000209875.4
CBX5
chromobox homolog 5
chr2_+_5832799 0.08 ENST00000322002.3
SOX11
SRY (sex determining region Y)-box 11
chr9_-_14314066 0.08 ENST00000397575.3
NFIB
nuclear factor I/B
chr7_-_15601595 0.07 ENST00000342526.3
AGMO
alkylglycerol monooxygenase
chr5_+_139493665 0.07 ENST00000331327.3
PURA
purine-rich element binding protein A
chr1_-_24306798 0.06 ENST00000374452.5
ENST00000492112.2
ENST00000343255.5
ENST00000344989.6
SRSF10
serine/arginine-rich splicing factor 10
chr15_-_68521996 0.05 ENST00000418702.2
ENST00000565471.1
ENST00000564752.1
ENST00000566347.1
ENST00000249806.5
ENST00000562767.1
CLN6
RP11-315D16.2
ceroid-lipofuscinosis, neuronal 6, late infantile, variant
Uncharacterized protein
chr9_-_27005686 0.05 ENST00000380055.5
LRRC19
leucine rich repeat containing 19
chr1_+_247579451 0.03 ENST00000391828.3
ENST00000366497.2
NLRP3
NLR family, pyrin domain containing 3
chr8_-_28243934 0.03 ENST00000521185.1
ENST00000520290.1
ENST00000344423.5
ZNF395
zinc finger protein 395
chr5_-_114961858 0.02 ENST00000282382.4
ENST00000456936.3
ENST00000408996.4
TMED7-TICAM2
TMED7
TICAM2
TMED7-TICAM2 readthrough
transmembrane emp24 protein transport domain containing 7
toll-like receptor adaptor molecule 2
chrX_+_100805496 0.02 ENST00000372829.3
ARMCX1
armadillo repeat containing, X-linked 1
chr4_+_2470664 0.02 ENST00000314289.8
ENST00000541204.1
ENST00000502316.1
ENST00000507247.1
ENST00000509258.1
ENST00000511859.1
RNF4
ring finger protein 4

Network of associatons between targets according to the STRING database.

First level regulatory network of GUCAGUU

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.5 GO:2001245 regulation of phosphatidylcholine biosynthetic process(GO:2001245)
0.8 2.3 GO:0023016 signal transduction by trans-phosphorylation(GO:0023016) negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687)
0.7 2.0 GO:0015883 FAD transport(GO:0015883) FAD transmembrane transport(GO:0035350)
0.6 1.9 GO:0090070 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
0.6 2.4 GO:0019046 release from viral latency(GO:0019046)
0.5 1.9 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.5 2.4 GO:0097338 response to clozapine(GO:0097338)
0.5 1.4 GO:2000374 regulation of oxygen metabolic process(GO:2000374)
0.4 1.3 GO:0035522 monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.4 0.4 GO:1903093 regulation of protein K48-linked deubiquitination(GO:1903093) negative regulation of protein K48-linked deubiquitination(GO:1903094) negative regulation of ubiquitin-specific protease activity(GO:2000157)
0.4 1.2 GO:0021592 fourth ventricle development(GO:0021592) third ventricle development(GO:0021678)
0.4 1.4 GO:2000645 negative regulation of receptor catabolic process(GO:2000645)
0.3 2.1 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.3 2.7 GO:2000825 positive regulation of androgen receptor activity(GO:2000825)
0.3 2.2 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.3 2.3 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.3 2.9 GO:0051610 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.3 1.1 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.3 0.8 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
0.3 4.1 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.2 1.2 GO:1990034 calcium ion export from cell(GO:1990034)
0.2 1.2 GO:1902741 interferon-alpha secretion(GO:0072642) regulation of interferon-alpha secretion(GO:1902739) positive regulation of interferon-alpha secretion(GO:1902741)
0.2 3.2 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.2 1.5 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.2 0.8 GO:1904046 negative regulation of vascular endothelial growth factor production(GO:1904046)
0.2 3.1 GO:0043248 proteasome assembly(GO:0043248)
0.2 0.9 GO:0034971 regulation of growth plate cartilage chondrocyte proliferation(GO:0003420) histone H3-R17 methylation(GO:0034971)
0.2 2.2 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.2 2.8 GO:0000338 protein deneddylation(GO:0000338)
0.2 0.7 GO:1904504 regulation of lipophagy(GO:1904502) positive regulation of lipophagy(GO:1904504)
0.2 2.4 GO:0036500 ATF6-mediated unfolded protein response(GO:0036500)
0.2 2.1 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.2 3.6 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.1 0.7 GO:1901906 diadenosine polyphosphate catabolic process(GO:0015961) diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.1 2.0 GO:0061339 establishment of monopolar cell polarity(GO:0061162) establishment or maintenance of monopolar cell polarity(GO:0061339)
0.1 0.6 GO:0003408 optic cup formation involved in camera-type eye development(GO:0003408)
0.1 1.2 GO:0010265 SCF complex assembly(GO:0010265)
0.1 0.3 GO:0060734 regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:0060734) positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.1 0.8 GO:1902455 negative regulation of stem cell population maintenance(GO:1902455)
0.1 1.9 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.1 0.7 GO:0045602 negative regulation of endothelial cell differentiation(GO:0045602)
0.1 1.1 GO:0045116 protein neddylation(GO:0045116)
0.1 0.8 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.1 0.9 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.1 0.7 GO:0045722 positive regulation of gluconeogenesis(GO:0045722)
0.1 0.3 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.1 0.6 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.1 0.2 GO:0015920 lipopolysaccharide transport(GO:0015920)
0.1 0.3 GO:0098795 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing by siRNA(GO:0090625) mRNA cleavage involved in gene silencing(GO:0098795)
0.1 1.6 GO:0033522 histone H2A ubiquitination(GO:0033522)
0.1 0.3 GO:0003322 pancreatic A cell development(GO:0003322)
0.1 1.6 GO:0019054 modulation by virus of host process(GO:0019054)
0.0 0.4 GO:0002870 lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911)
0.0 2.5 GO:0000281 mitotic cytokinesis(GO:0000281)
0.0 2.9 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.0 0.1 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
0.0 0.4 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.0 1.3 GO:0007628 adult walking behavior(GO:0007628)
0.0 0.2 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.0 0.3 GO:0035278 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.0 2.1 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 2.0 GO:0045773 positive regulation of axon extension(GO:0045773)
0.0 2.7 GO:0045445 myoblast differentiation(GO:0045445)
0.0 0.4 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.2 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.0 2.3 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.0 0.1 GO:1990834 response to odorant(GO:1990834)
0.0 0.2 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
0.0 2.2 GO:0032508 DNA duplex unwinding(GO:0032508)
0.0 0.1 GO:0061386 closure of optic fissure(GO:0061386)
0.0 0.7 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.1 GO:0051012 microtubule sliding(GO:0051012)
0.0 0.2 GO:0006451 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0 2.3 GO:0006446 regulation of translational initiation(GO:0006446)
0.0 0.9 GO:2000300 regulation of synaptic vesicle exocytosis(GO:2000300)
0.0 0.8 GO:0017145 stem cell division(GO:0017145)
0.0 0.7 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.0 0.3 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.0 0.4 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.0 0.4 GO:0048009 insulin-like growth factor receptor signaling pathway(GO:0048009)
0.0 0.8 GO:0007566 embryo implantation(GO:0007566)
0.0 0.2 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.0 0.4 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.0 2.7 GO:1901796 regulation of signal transduction by p53 class mediator(GO:1901796)
0.0 0.4 GO:0033119 negative regulation of RNA splicing(GO:0033119)
0.0 3.1 GO:0007163 establishment or maintenance of cell polarity(GO:0007163)
0.0 1.5 GO:0010324 membrane invagination(GO:0010324)
0.0 0.3 GO:0050855 regulation of B cell receptor signaling pathway(GO:0050855)
0.0 2.0 GO:0008213 protein methylation(GO:0006479) protein alkylation(GO:0008213)
0.0 0.1 GO:2000795 trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 4.6 GO:0097149 centralspindlin complex(GO:0097149)
0.3 2.4 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.3 2.3 GO:0031415 NatA complex(GO:0031415)
0.3 2.2 GO:0097452 GAIT complex(GO:0097452)
0.3 2.0 GO:0032584 growth cone membrane(GO:0032584)
0.2 1.2 GO:0097513 myosin II filament(GO:0097513)
0.2 0.6 GO:0035189 Rb-E2F complex(GO:0035189)
0.2 2.3 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.2 0.7 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.2 0.8 GO:0033503 HULC complex(GO:0033503)
0.2 1.5 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 2.5 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 2.4 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 2.2 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 2.4 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 2.9 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.1 1.2 GO:0008385 IkappaB kinase complex(GO:0008385)
0.1 0.8 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.1 5.7 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 4.3 GO:0045171 intercellular bridge(GO:0045171)
0.1 2.8 GO:0008180 COP9 signalosome(GO:0008180)
0.1 1.2 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 2.7 GO:0005844 polysome(GO:0005844)
0.0 1.7 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 1.5 GO:0051233 spindle midzone(GO:0051233)
0.0 0.9 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 3.5 GO:0005811 lipid particle(GO:0005811)
0.0 0.3 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.0 0.4 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 0.6 GO:0071564 npBAF complex(GO:0071564)
0.0 0.4 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.8 GO:0000421 autophagosome membrane(GO:0000421)
0.0 1.7 GO:0043195 terminal bouton(GO:0043195)
0.0 0.9 GO:0048786 presynaptic active zone(GO:0048786)
0.0 1.8 GO:0018995 host(GO:0018995) host cell(GO:0043657)
0.0 0.3 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 2.9 GO:0043197 dendritic spine(GO:0043197)
0.0 2.3 GO:0030175 filopodium(GO:0030175)
0.0 4.0 GO:0005681 spliceosomal complex(GO:0005681)
0.0 2.0 GO:0016605 PML body(GO:0016605)
0.0 5.3 GO:0016607 nuclear speck(GO:0016607)
0.0 0.8 GO:0031519 PcG protein complex(GO:0031519)
0.0 0.7 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.2 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.1 GO:0044300 cerebellar mossy fiber(GO:0044300)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.7 GO:0001069 regulatory region RNA binding(GO:0001069)
0.7 2.0 GO:0015230 FAD transmembrane transporter activity(GO:0015230)
0.4 0.4 GO:0036435 K48-linked polyubiquitin binding(GO:0036435)
0.3 1.2 GO:0008384 IkappaB kinase activity(GO:0008384)
0.2 0.7 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.2 2.4 GO:0046790 virion binding(GO:0046790)
0.2 2.3 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.2 3.5 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.2 2.5 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.2 2.3 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.2 0.9 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.2 0.8 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 2.4 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 1.6 GO:0001224 RNA polymerase II transcription cofactor binding(GO:0001224)
0.1 0.7 GO:0052846 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432) inositol diphosphate tetrakisphosphate diphosphatase activity(GO:0052840) inositol bisdiphosphate tetrakisphosphate diphosphatase activity(GO:0052841) inositol diphosphate pentakisphosphate diphosphatase activity(GO:0052842) inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity(GO:0052843) inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity(GO:0052844) inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity(GO:0052845) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity(GO:0052846) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052847) inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052848)
0.1 2.9 GO:0001056 RNA polymerase III activity(GO:0001056)
0.1 4.6 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 0.8 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.1 0.3 GO:0034041 sterol-transporting ATPase activity(GO:0034041)
0.1 1.4 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.1 3.2 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 0.8 GO:0008312 7S RNA binding(GO:0008312)
0.1 3.1 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 2.3 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 3.3 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.1 2.2 GO:0008143 poly(A) binding(GO:0008143)
0.1 0.2 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.1 1.9 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 1.1 GO:0097602 cullin family protein binding(GO:0097602)
0.1 2.2 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 1.2 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.1 2.0 GO:0043175 RNA polymerase core enzyme binding(GO:0043175)
0.0 0.2 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)
0.0 1.9 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.1 GO:0030984 kininogen binding(GO:0030984)
0.0 0.2 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.0 1.2 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.9 GO:0008483 transaminase activity(GO:0008483)
0.0 0.3 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.0 3.8 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.7 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 1.2 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 2.3 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.1 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 2.1 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 0.8 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 0.5 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 2.0 GO:0008276 protein methyltransferase activity(GO:0008276)
0.0 2.1 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 1.2 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0 0.1 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.0 1.4 GO:0002039 p53 binding(GO:0002039)
0.0 0.8 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 4.6 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 1.3 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 0.4 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.3 GO:0035198 miRNA binding(GO:0035198)
0.0 0.2 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 0.4 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 1.4 GO:0005262 calcium channel activity(GO:0005262)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.6 PID PLK1 PATHWAY PLK1 signaling events
0.0 2.5 PID AURORA A PATHWAY Aurora A signaling
0.0 2.4 PID IL3 PATHWAY IL3-mediated signaling events
0.0 3.7 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.6 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 1.3 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 2.4 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 0.6 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.9 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.9 PID EPO PATHWAY EPO signaling pathway
0.0 0.7 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 0.4 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 2.1 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.0 2.1 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.7 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.9 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 0.7 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 0.8 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.8 PID CMYB PATHWAY C-MYB transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.4 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.2 3.5 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 1.4 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.1 2.9 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.1 3.2 REACTOME KINESINS Genes involved in Kinesins
0.1 1.2 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.1 4.9 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.1 2.4 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 1.7 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.1 2.4 REACTOME ELONGATION ARREST AND RECOVERY Genes involved in Elongation arrest and recovery
0.1 1.9 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 2.4 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.6 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 0.4 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 1.6 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 2.3 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.3 REACTOME REGULATORY RNA PATHWAYS Genes involved in Regulatory RNA pathways
0.0 0.9 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.7 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 1.8 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 0.3 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 1.2 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.3 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 3.1 REACTOME TRANSLATION Genes involved in Translation
0.0 0.1 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling