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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for GZF1
Z-value: 0.47
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Transcription factors associated with GZF1
Network of associatons between targets according to the STRING database.
First level regulatory network of GZF1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 20.6 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.7 | 19.2 | GO:0009235 | cobalamin metabolic process(GO:0009235) |
| 0.2 | 14.4 | GO:0030834 | regulation of actin filament depolymerization(GO:0030834) |
| 1.4 | 11.2 | GO:0060699 | regulation of endoribonuclease activity(GO:0060699) |
| 3.2 | 9.7 | GO:0002661 | B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663) |
| 1.2 | 6.0 | GO:0061198 | fungiform papilla formation(GO:0061198) |
| 1.9 | 5.8 | GO:0061188 | negative regulation of chromatin silencing at rDNA(GO:0061188) |
| 1.8 | 5.5 | GO:0021836 | cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836) regulation of negative chemotaxis(GO:0050923) |
| 0.5 | 5.3 | GO:0070836 | caveola assembly(GO:0070836) |
| 1.2 | 4.6 | GO:0006382 | adenosine to inosine editing(GO:0006382) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 21.3 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.1 | 20.6 | GO:0048770 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.0 | 14.4 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.7 | 11.2 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 1.1 | 9.7 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
| 0.1 | 6.7 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.3 | 6.0 | GO:0016580 | Sin3 complex(GO:0016580) |
| 0.1 | 5.8 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 0.3 | 4.8 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
| 0.0 | 4.7 | GO:0030424 | axon(GO:0030424) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 14.4 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 2.2 | 11.2 | GO:0043023 | ribosomal large subunit binding(GO:0043023) |
| 2.4 | 9.7 | GO:0005026 | transforming growth factor beta receptor activity, type II(GO:0005026) |
| 0.4 | 6.0 | GO:0032041 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
| 0.3 | 5.8 | GO:0032454 | histone demethylase activity (H3-K9 specific)(GO:0032454) |
| 0.0 | 5.8 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.9 | 5.5 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
| 0.2 | 5.3 | GO:0070300 | phosphatidic acid binding(GO:0070300) |
| 1.5 | 4.6 | GO:0016422 | mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422) |
| 0.1 | 4.3 | GO:0001671 | ATPase activator activity(GO:0001671) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 11.2 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.2 | 9.7 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.4 | 6.0 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.1 | 5.5 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 2.3 | SA TRKA RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.0 | 1.8 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 1.7 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 1.4 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 1.3 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 11.2 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.4 | 9.7 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.2 | 6.0 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.2 | 5.5 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.1 | 4.8 | REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |
| 0.0 | 4.6 | REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA | Genes involved in Processing of Capped Intron-Containing Pre-mRNA |
| 0.1 | 2.3 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 0.1 | 2.2 | REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM | Genes involved in Transport of Mature Transcript to Cytoplasm |
| 0.0 | 1.9 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 1.4 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |