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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for HNF4A
Z-value: 0.88
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Transcription factors associated with HNF4A
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HNF4A | hg19_v2_chr20_+_42984330_42984445 | 0.62 | 4.1e-24 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_-_42811986 Show fit | 33.87 |
ENST00000511224.1
ENST00000507920.1 ENST00000510965.1 |
selenoprotein P, plasma, 1 |
|
| chr5_-_42812143 Show fit | 33.56 |
ENST00000514985.1
|
selenoprotein P, plasma, 1 |
|
| chr6_+_31949801 Show fit | 25.88 |
ENST00000428956.2
ENST00000498271.1 |
complement component 4A (Rodgers blood group) |
|
| chr6_+_31982539 Show fit | 25.55 |
ENST00000435363.2
ENST00000425700.2 |
complement component 4B (Chido blood group) |
|
| chr20_+_56136136 Show fit | 17.36 |
ENST00000319441.4
ENST00000543666.1 |
phosphoenolpyruvate carboxykinase 1 (soluble) |
|
| chr16_+_8768422 Show fit | 16.40 |
ENST00000268251.8
ENST00000564714.1 |
4-aminobutyrate aminotransferase |
|
| chr9_+_139839711 Show fit | 15.67 |
ENST00000224181.3
|
complement component 8, gamma polypeptide |
|
| chr9_+_139839686 Show fit | 15.17 |
ENST00000371634.2
|
complement component 8, gamma polypeptide |
|
| chr19_+_35629702 Show fit | 13.81 |
ENST00000351325.4
|
FXYD domain containing ion transport regulator 1 |
|
| chr17_+_41857793 Show fit | 13.62 |
ENST00000449302.3
|
chromosome 17 open reading frame 105 |
Network of associatons between targets according to the STRING database.
First level regulatory network of HNF4A
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.0 | 51.4 | GO:2000427 | positive regulation of apoptotic cell clearance(GO:2000427) |
| 2.0 | 39.8 | GO:0019373 | epoxygenase P450 pathway(GO:0019373) |
| 11.7 | 35.2 | GO:0010902 | positive regulation of very-low-density lipoprotein particle remodeling(GO:0010902) |
| 1.4 | 30.8 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 4.0 | 27.9 | GO:0016098 | monoterpenoid metabolic process(GO:0016098) |
| 4.5 | 26.9 | GO:0010731 | protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734) |
| 5.2 | 20.7 | GO:0010961 | cellular magnesium ion homeostasis(GO:0010961) |
| 0.2 | 20.1 | GO:0030521 | androgen receptor signaling pathway(GO:0030521) |
| 4.3 | 17.4 | GO:0006114 | glycerol biosynthetic process(GO:0006114) response to methionine(GO:1904640) |
| 4.1 | 16.4 | GO:1904450 | negative regulation of gamma-aminobutyric acid secretion(GO:0014053) aspartate secretion(GO:0061528) regulation of aspartate secretion(GO:1904448) positive regulation of aspartate secretion(GO:1904450) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 93.0 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.3 | 62.0 | GO:0072562 | blood microparticle(GO:0072562) |
| 5.6 | 44.4 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
| 0.0 | 31.4 | GO:0005615 | extracellular space(GO:0005615) |
| 3.4 | 30.8 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.1 | 29.3 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 1.3 | 26.9 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.1 | 25.9 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.0 | 25.2 | GO:0031226 | intrinsic component of plasma membrane(GO:0031226) |
| 0.0 | 18.6 | GO:0005759 | mitochondrial matrix(GO:0005759) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 56.4 | GO:0001848 | complement binding(GO:0001848) |
| 2.9 | 40.9 | GO:0070330 | aromatase activity(GO:0070330) |
| 7.0 | 35.2 | GO:0060230 | lipoprotein lipase activator activity(GO:0060230) |
| 0.5 | 26.9 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 3.2 | 25.9 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 4.1 | 24.6 | GO:0004882 | androgen receptor activity(GO:0004882) |
| 4.1 | 20.7 | GO:0031708 | endothelin B receptor binding(GO:0031708) |
| 3.5 | 17.6 | GO:0033695 | oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875) |
| 5.8 | 17.4 | GO:0004613 | phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613) |
| 4.1 | 16.4 | GO:0003867 | 4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 47.6 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.4 | 33.1 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.3 | 20.7 | PID ENDOTHELIN PATHWAY | Endothelins |
| 0.2 | 20.1 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.2 | 11.4 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.2 | 10.9 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.4 | 10.3 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.0 | 10.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 8.0 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.3 | 7.9 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.4 | 61.3 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 2.4 | 51.9 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.4 | 33.8 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 1.1 | 30.8 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 1.3 | 27.1 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.1 | 22.7 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 19.0 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 1.3 | 17.4 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |
| 0.5 | 16.4 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.5 | 14.1 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |