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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for HNF4A
Z-value: 0.88
Motif logo
Transcription factors associated with HNF4A
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
HNF4A
|
ENSG00000101076.12 | hepatocyte nuclear factor 4 alpha |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HNF4A | hg19_v2_chr20_+_42984330_42984445 | 0.62 | 4.1e-24 | Click! |
Activity profile of HNF4A motif
Sorted Z-values of HNF4A motif
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_-_42811986 | 33.87 |
ENST00000511224.1
ENST00000507920.1 ENST00000510965.1 |
SEPP1
|
selenoprotein P, plasma, 1 |
| chr5_-_42812143 | 33.56 |
ENST00000514985.1
|
SEPP1
|
selenoprotein P, plasma, 1 |
| chr6_+_31949801 | 25.88 |
ENST00000428956.2
ENST00000498271.1 |
C4A
|
complement component 4A (Rodgers blood group) |
| chr6_+_31982539 | 25.55 |
ENST00000435363.2
ENST00000425700.2 |
C4B
|
complement component 4B (Chido blood group) |
| chr20_+_56136136 | 17.36 |
ENST00000319441.4
ENST00000543666.1 |
PCK1
|
phosphoenolpyruvate carboxykinase 1 (soluble) |
| chr16_+_8768422 | 16.40 |
ENST00000268251.8
ENST00000564714.1 |
ABAT
|
4-aminobutyrate aminotransferase |
| chr9_+_139839711 | 15.67 |
ENST00000224181.3
|
C8G
|
complement component 8, gamma polypeptide |
| chr9_+_139839686 | 15.17 |
ENST00000371634.2
|
C8G
|
complement component 8, gamma polypeptide |
| chr19_+_35629702 | 13.81 |
ENST00000351325.4
|
FXYD1
|
FXYD domain containing ion transport regulator 1 |
| chr17_+_41857793 | 13.62 |
ENST00000449302.3
|
C17orf105
|
chromosome 17 open reading frame 105 |
| chr19_+_35630022 | 13.08 |
ENST00000589209.1
|
FXYD1
|
FXYD domain containing ion transport regulator 1 |
| chr19_+_45449228 | 12.03 |
ENST00000252490.4
|
APOC2
|
apolipoprotein C-II |
| chr10_-_17171817 | 11.97 |
ENST00000377833.4
|
CUBN
|
cubilin (intrinsic factor-cobalamin receptor) |
| chr19_+_45449301 | 11.69 |
ENST00000591597.1
|
APOC2
|
apolipoprotein C-II |
| chr17_+_41052808 | 11.52 |
ENST00000592383.1
ENST00000253801.2 ENST00000585489.1 |
G6PC
|
glucose-6-phosphatase, catalytic subunit |
| chr19_+_45449266 | 11.48 |
ENST00000592257.1
|
APOC2
|
apolipoprotein C-II |
| chr20_+_57875457 | 11.29 |
ENST00000337938.2
ENST00000311585.7 ENST00000371028.2 |
EDN3
|
endothelin 3 |
| chr10_+_96698406 | 11.06 |
ENST00000260682.6
|
CYP2C9
|
cytochrome P450, family 2, subfamily C, polypeptide 9 |
| chr19_+_39616410 | 10.87 |
ENST00000602004.1
ENST00000599470.1 ENST00000321944.4 ENST00000593480.1 ENST00000358301.3 ENST00000593690.1 ENST00000599386.1 |
PAK4
|
p21 protein (Cdc42/Rac)-activated kinase 4 |
| chr3_+_37284824 | 10.64 |
ENST00000431105.1
|
GOLGA4
|
golgin A4 |
| chr2_-_28113217 | 10.07 |
ENST00000444339.2
|
RBKS
|
ribokinase |
| chr10_+_96443378 | 9.67 |
ENST00000285979.6
|
CYP2C18
|
cytochrome P450, family 2, subfamily C, polypeptide 18 |
| chr10_+_96443204 | 9.66 |
ENST00000339022.5
|
CYP2C18
|
cytochrome P450, family 2, subfamily C, polypeptide 18 |
| chr6_+_43265992 | 9.56 |
ENST00000449231.1
ENST00000372589.3 ENST00000372585.5 |
SLC22A7
|
solute carrier family 22 (organic anion transporter), member 7 |
| chr3_-_194072019 | 9.50 |
ENST00000429275.1
ENST00000323830.3 |
CPN2
|
carboxypeptidase N, polypeptide 2 |
| chr10_+_96522361 | 9.25 |
ENST00000371321.3
|
CYP2C19
|
cytochrome P450, family 2, subfamily C, polypeptide 19 |
| chr2_-_21266935 | 9.21 |
ENST00000233242.1
|
APOB
|
apolipoprotein B |
| chr17_+_4675175 | 9.02 |
ENST00000270560.3
|
TM4SF5
|
transmembrane 4 L six family member 5 |
| chr4_+_159593271 | 8.89 |
ENST00000512251.1
ENST00000511912.1 |
ETFDH
|
electron-transferring-flavoprotein dehydrogenase |
| chr19_-_36304201 | 8.78 |
ENST00000301175.3
|
PRODH2
|
proline dehydrogenase (oxidase) 2 |
| chr12_+_109273806 | 8.57 |
ENST00000228476.3
ENST00000547768.1 |
DAO
|
D-amino-acid oxidase |
| chr19_-_15235906 | 8.36 |
ENST00000600984.1
|
ILVBL
|
ilvB (bacterial acetolactate synthase)-like |
| chr13_+_52586517 | 8.11 |
ENST00000523764.1
ENST00000521508.1 |
ALG11
|
ALG11, alpha-1,2-mannosyltransferase |
| chr16_-_16317321 | 8.10 |
ENST00000205557.7
ENST00000575728.1 |
ABCC6
|
ATP-binding cassette, sub-family C (CFTR/MRP), member 6 |
| chr18_+_29769978 | 8.00 |
ENST00000269202.6
ENST00000581447.1 |
MEP1B
|
meprin A, beta |
| chr14_-_76447494 | 7.79 |
ENST00000238682.3
|
TGFB3
|
transforming growth factor, beta 3 |
| chr2_+_44502597 | 7.63 |
ENST00000260649.6
ENST00000409387.1 |
SLC3A1
|
solute carrier family 3 (amino acid transporter heavy chain), member 1 |
| chr7_+_45927956 | 7.62 |
ENST00000275525.3
ENST00000457280.1 |
IGFBP1
|
insulin-like growth factor binding protein 1 |
| chr22_-_42526802 | 7.62 |
ENST00000359033.4
ENST00000389970.3 ENST00000360608.5 |
CYP2D6
|
cytochrome P450, family 2, subfamily D, polypeptide 6 |
| chr19_+_41594377 | 7.53 |
ENST00000330436.3
|
CYP2A13
|
cytochrome P450, family 2, subfamily A, polypeptide 13 |
| chr1_+_180601139 | 7.52 |
ENST00000367590.4
ENST00000367589.3 |
XPR1
|
xenotropic and polytropic retrovirus receptor 1 |
| chr1_-_161193349 | 7.45 |
ENST00000469730.2
ENST00000463273.1 ENST00000464492.1 ENST00000367990.3 ENST00000470459.2 ENST00000468465.1 ENST00000463812.1 |
APOA2
|
apolipoprotein A-II |
| chr6_+_30594619 | 7.39 |
ENST00000318999.7
ENST00000376485.4 ENST00000376478.2 ENST00000319027.5 ENST00000376483.4 ENST00000329992.8 ENST00000330083.5 |
ATAT1
|
alpha tubulin acetyltransferase 1 |
| chr17_+_27369918 | 7.17 |
ENST00000323372.4
|
PIPOX
|
pipecolic acid oxidase |
| chr19_-_12886327 | 7.07 |
ENST00000397668.3
ENST00000587178.1 ENST00000264827.5 |
HOOK2
|
hook microtubule-tethering protein 2 |
| chr13_+_113777105 | 7.07 |
ENST00000409306.1
ENST00000375551.3 ENST00000375559.3 |
F10
|
coagulation factor X |
| chr17_-_38256973 | 7.07 |
ENST00000246672.3
|
NR1D1
|
nuclear receptor subfamily 1, group D, member 1 |
| chr2_-_222436988 | 7.04 |
ENST00000409854.1
ENST00000281821.2 ENST00000392071.4 ENST00000443796.1 |
EPHA4
|
EPH receptor A4 |
| chr15_+_101142722 | 6.61 |
ENST00000332783.7
ENST00000558747.1 ENST00000343276.4 |
ASB7
|
ankyrin repeat and SOCS box containing 7 |
| chr1_+_94884023 | 6.56 |
ENST00000315713.5
|
ABCD3
|
ATP-binding cassette, sub-family D (ALD), member 3 |
| chr8_-_98290087 | 6.54 |
ENST00000322128.3
|
TSPYL5
|
TSPY-like 5 |
| chr11_-_73720276 | 6.53 |
ENST00000348534.4
|
UCP3
|
uncoupling protein 3 (mitochondrial, proton carrier) |
| chr10_-_96829246 | 6.50 |
ENST00000371270.3
ENST00000535898.1 ENST00000539050.1 |
CYP2C8
|
cytochrome P450, family 2, subfamily C, polypeptide 8 |
| chr7_+_45928079 | 6.48 |
ENST00000468955.1
|
IGFBP1
|
insulin-like growth factor binding protein 1 |
| chr1_-_60392452 | 6.47 |
ENST00000371204.3
|
CYP2J2
|
cytochrome P450, family 2, subfamily J, polypeptide 2 |
| chr1_+_78511586 | 6.41 |
ENST00000370759.3
|
GIPC2
|
GIPC PDZ domain containing family, member 2 |
| chr3_-_124653579 | 6.37 |
ENST00000478191.1
ENST00000311075.3 |
MUC13
|
mucin 13, cell surface associated |
| chr17_+_1646130 | 6.18 |
ENST00000453066.1
ENST00000324015.3 ENST00000450523.2 ENST00000453723.1 ENST00000382061.4 |
SERPINF2
|
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 |
| chrX_+_38211777 | 6.12 |
ENST00000039007.4
|
OTC
|
ornithine carbamoyltransferase |
| chr1_-_161207875 | 6.06 |
ENST00000512372.1
ENST00000437437.2 ENST00000442691.2 ENST00000412844.2 ENST00000428574.2 ENST00000505005.1 ENST00000508740.1 ENST00000508387.1 ENST00000504010.1 ENST00000511676.1 ENST00000502985.1 ENST00000367981.3 ENST00000515621.1 ENST00000511944.1 ENST00000511748.1 ENST00000367984.4 ENST00000367985.3 |
NR1I3
|
nuclear receptor subfamily 1, group I, member 3 |
| chr2_-_228244013 | 6.06 |
ENST00000304568.3
|
TM4SF20
|
transmembrane 4 L six family member 20 |
| chr17_+_44039704 | 5.94 |
ENST00000420682.2
ENST00000415613.2 ENST00000571987.1 ENST00000574436.1 ENST00000431008.3 |
MAPT
|
microtubule-associated protein tau |
| chr12_-_54121212 | 5.85 |
ENST00000548263.1
ENST00000430117.2 ENST00000550804.1 ENST00000549173.1 ENST00000551900.1 ENST00000546619.1 ENST00000548177.1 ENST00000549349.1 |
CALCOCO1
|
calcium binding and coiled-coil domain 1 |
| chr15_-_41120896 | 5.84 |
ENST00000299174.5
ENST00000427255.2 |
PPP1R14D
|
protein phosphatase 1, regulatory (inhibitor) subunit 14D |
| chrX_+_118108601 | 5.73 |
ENST00000371628.3
|
LONRF3
|
LON peptidase N-terminal domain and ring finger 3 |
| chr12_-_54121261 | 5.58 |
ENST00000549784.1
ENST00000262059.4 |
CALCOCO1
|
calcium binding and coiled-coil domain 1 |
| chr20_+_57875658 | 5.58 |
ENST00000371025.3
|
EDN3
|
endothelin 3 |
| chr12_+_121163538 | 5.43 |
ENST00000242592.4
|
ACADS
|
acyl-CoA dehydrogenase, C-2 to C-3 short chain |
| chr11_+_27076764 | 5.42 |
ENST00000525090.1
|
BBOX1
|
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 |
| chr17_-_2614927 | 5.41 |
ENST00000435359.1
|
CLUH
|
clustered mitochondria (cluA/CLU1) homolog |
| chr3_+_46919235 | 5.40 |
ENST00000449590.1
|
PTH1R
|
parathyroid hormone 1 receptor |
| chr12_+_56114151 | 5.26 |
ENST00000547072.1
ENST00000552930.1 ENST00000257895.5 |
RDH5
|
retinol dehydrogenase 5 (11-cis/9-cis) |
| chr1_+_196857144 | 5.25 |
ENST00000367416.2
ENST00000251424.4 ENST00000367418.2 |
CFHR4
|
complement factor H-related 4 |
| chr1_-_161207953 | 5.25 |
ENST00000367982.4
|
NR1I3
|
nuclear receptor subfamily 1, group I, member 3 |
| chr9_+_27109133 | 5.20 |
ENST00000519097.1
ENST00000380036.4 |
TEK
|
TEK tyrosine kinase, endothelial |
| chr7_-_37956409 | 5.14 |
ENST00000436072.2
|
SFRP4
|
secreted frizzled-related protein 4 |
| chrX_+_118108571 | 5.14 |
ENST00000304778.7
|
LONRF3
|
LON peptidase N-terminal domain and ring finger 3 |
| chr4_+_113152881 | 5.04 |
ENST00000274000.5
|
AP1AR
|
adaptor-related protein complex 1 associated regulatory protein |
| chr12_+_56114189 | 5.01 |
ENST00000548082.1
|
RDH5
|
retinol dehydrogenase 5 (11-cis/9-cis) |
| chr1_-_161208013 | 4.99 |
ENST00000515452.1
ENST00000367983.4 |
NR1I3
|
nuclear receptor subfamily 1, group I, member 3 |
| chr17_-_44896047 | 4.95 |
ENST00000225512.5
|
WNT3
|
wingless-type MMTV integration site family, member 3 |
| chr17_-_7082668 | 4.89 |
ENST00000573083.1
ENST00000574388.1 |
ASGR1
|
asialoglycoprotein receptor 1 |
| chr2_-_43019698 | 4.78 |
ENST00000431905.1
ENST00000294973.6 |
HAAO
|
3-hydroxyanthranilate 3,4-dioxygenase |
| chr1_+_43855560 | 4.78 |
ENST00000562955.1
|
SZT2
|
seizure threshold 2 homolog (mouse) |
| chr19_+_4639514 | 4.64 |
ENST00000327473.4
|
TNFAIP8L1
|
tumor necrosis factor, alpha-induced protein 8-like 1 |
| chr18_+_54318566 | 4.61 |
ENST00000589935.1
ENST00000357574.3 |
WDR7
|
WD repeat domain 7 |
| chr11_+_74870818 | 4.58 |
ENST00000525845.1
ENST00000534186.1 ENST00000428359.2 |
SLCO2B1
|
solute carrier organic anion transporter family, member 2B1 |
| chrX_+_66764375 | 4.57 |
ENST00000374690.3
|
AR
|
androgen receptor |
| chr9_-_136605042 | 4.49 |
ENST00000371872.4
ENST00000298628.5 ENST00000422262.2 |
SARDH
|
sarcosine dehydrogenase |
| chr4_-_10023095 | 4.35 |
ENST00000264784.3
|
SLC2A9
|
solute carrier family 2 (facilitated glucose transporter), member 9 |
| chr20_-_44485835 | 4.16 |
ENST00000457981.1
ENST00000426915.1 ENST00000217455.4 |
ACOT8
|
acyl-CoA thioesterase 8 |
| chr11_+_63137251 | 4.09 |
ENST00000310969.4
ENST00000279178.3 |
SLC22A9
|
solute carrier family 22 (organic anion transporter), member 9 |
| chr16_+_19429018 | 4.03 |
ENST00000542583.2
|
TMC5
|
transmembrane channel-like 5 |
| chr19_-_10687983 | 4.00 |
ENST00000587069.1
|
AP1M2
|
adaptor-related protein complex 1, mu 2 subunit |
| chr20_+_57875758 | 3.81 |
ENST00000395654.3
|
EDN3
|
endothelin 3 |
| chr1_-_161207986 | 3.77 |
ENST00000506209.1
ENST00000367980.2 |
NR1I3
|
nuclear receptor subfamily 1, group I, member 3 |
| chr2_+_219433281 | 3.65 |
ENST00000273064.6
ENST00000509807.2 ENST00000542068.1 |
RQCD1
|
RCD1 required for cell differentiation1 homolog (S. pombe) |
| chr11_-_32456891 | 3.53 |
ENST00000452863.3
|
WT1
|
Wilms tumor 1 |
| chr18_+_54318616 | 3.51 |
ENST00000254442.3
|
WDR7
|
WD repeat domain 7 |
| chr4_+_113152978 | 3.46 |
ENST00000309703.6
|
AP1AR
|
adaptor-related protein complex 1 associated regulatory protein |
| chr19_-_49339080 | 3.45 |
ENST00000595764.1
|
HSD17B14
|
hydroxysteroid (17-beta) dehydrogenase 14 |
| chr1_+_241695424 | 3.43 |
ENST00000366558.3
ENST00000366559.4 |
KMO
|
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) |
| chr16_-_87970122 | 3.39 |
ENST00000309893.2
|
CA5A
|
carbonic anhydrase VA, mitochondrial |
| chr17_+_61554413 | 3.37 |
ENST00000538928.1
ENST00000290866.4 ENST00000428043.1 |
ACE
|
angiotensin I converting enzyme |
| chr19_-_10687948 | 3.35 |
ENST00000592285.1
|
AP1M2
|
adaptor-related protein complex 1, mu 2 subunit |
| chr2_-_62733476 | 3.35 |
ENST00000335390.5
|
TMEM17
|
transmembrane protein 17 |
| chr17_-_7082861 | 3.26 |
ENST00000269299.3
|
ASGR1
|
asialoglycoprotein receptor 1 |
| chr11_-_45939565 | 3.22 |
ENST00000525192.1
ENST00000378750.5 |
PEX16
|
peroxisomal biogenesis factor 16 |
| chr10_+_102106829 | 3.19 |
ENST00000370355.2
|
SCD
|
stearoyl-CoA desaturase (delta-9-desaturase) |
| chr19_+_1205740 | 3.11 |
ENST00000326873.7
|
STK11
|
serine/threonine kinase 11 |
| chr11_-_45939374 | 3.10 |
ENST00000533151.1
ENST00000241041.3 |
PEX16
|
peroxisomal biogenesis factor 16 |
| chr3_+_123813509 | 3.07 |
ENST00000460856.1
ENST00000240874.3 |
KALRN
|
kalirin, RhoGEF kinase |
| chr10_-_103815874 | 2.91 |
ENST00000370033.4
ENST00000311122.5 |
C10orf76
|
chromosome 10 open reading frame 76 |
| chr19_+_49055332 | 2.86 |
ENST00000201586.2
|
SULT2B1
|
sulfotransferase family, cytosolic, 2B, member 1 |
| chr6_-_32145861 | 2.78 |
ENST00000336984.6
|
AGPAT1
|
1-acylglycerol-3-phosphate O-acyltransferase 1 |
| chr3_+_124303539 | 2.73 |
ENST00000428018.2
|
KALRN
|
kalirin, RhoGEF kinase |
| chr12_+_121416489 | 2.71 |
ENST00000541395.1
ENST00000544413.1 |
HNF1A
|
HNF1 homeobox A |
| chr11_-_73720122 | 2.69 |
ENST00000426995.2
|
UCP3
|
uncoupling protein 3 (mitochondrial, proton carrier) |
| chr19_+_39881951 | 2.65 |
ENST00000315588.5
ENST00000594368.1 ENST00000599213.2 ENST00000596297.1 |
MED29
|
mediator complex subunit 29 |
| chr6_+_43739697 | 2.60 |
ENST00000230480.6
|
VEGFA
|
vascular endothelial growth factor A |
| chr20_+_62694461 | 2.55 |
ENST00000343484.5
ENST00000395053.3 |
TCEA2
|
transcription elongation factor A (SII), 2 |
| chr19_-_41256207 | 2.53 |
ENST00000598485.2
ENST00000470681.1 ENST00000339153.3 ENST00000598729.1 |
C19orf54
|
chromosome 19 open reading frame 54 |
| chr1_+_241695670 | 2.52 |
ENST00000366557.4
|
KMO
|
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) |
| chr1_-_11863171 | 2.51 |
ENST00000376592.1
|
MTHFR
|
methylenetetrahydrofolate reductase (NAD(P)H) |
| chr1_-_41131326 | 2.50 |
ENST00000372684.3
|
RIMS3
|
regulating synaptic membrane exocytosis 3 |
| chr7_+_33765593 | 2.48 |
ENST00000311067.3
|
RP11-89N17.1
|
HCG1643653; Uncharacterized protein |
| chr6_-_29343068 | 2.45 |
ENST00000396806.3
|
OR12D3
|
olfactory receptor, family 12, subfamily D, member 3 |
| chr6_-_31864977 | 2.35 |
ENST00000395728.3
ENST00000375528.4 |
EHMT2
|
euchromatic histone-lysine N-methyltransferase 2 |
| chr2_+_73441350 | 2.32 |
ENST00000389501.4
|
SMYD5
|
SMYD family member 5 |
| chr1_+_145727681 | 2.29 |
ENST00000417171.1
ENST00000451928.2 |
PDZK1
|
PDZ domain containing 1 |
| chr12_+_53497263 | 2.26 |
ENST00000551896.1
ENST00000301466.3 |
SOAT2
|
sterol O-acyltransferase 2 |
| chr2_+_48796120 | 2.16 |
ENST00000394754.1
|
STON1-GTF2A1L
|
STON1-GTF2A1L readthrough |
| chr1_-_15911510 | 2.16 |
ENST00000375826.3
|
AGMAT
|
agmatine ureohydrolase (agmatinase) |
| chr5_-_32444828 | 2.08 |
ENST00000265069.8
|
ZFR
|
zinc finger RNA binding protein |
| chr3_+_123813543 | 2.07 |
ENST00000360013.3
|
KALRN
|
kalirin, RhoGEF kinase |
| chr15_+_63340775 | 2.05 |
ENST00000559281.1
ENST00000317516.7 |
TPM1
|
tropomyosin 1 (alpha) |
| chr1_-_155271213 | 2.04 |
ENST00000342741.4
|
PKLR
|
pyruvate kinase, liver and RBC |
| chr3_+_108541545 | 2.02 |
ENST00000295756.6
|
TRAT1
|
T cell receptor associated transmembrane adaptor 1 |
| chr1_+_199996702 | 2.01 |
ENST00000367362.3
|
NR5A2
|
nuclear receptor subfamily 5, group A, member 2 |
| chr14_-_101295407 | 1.96 |
ENST00000596284.1
|
AL117190.2
|
AL117190.2 |
| chr12_-_7125770 | 1.91 |
ENST00000261407.4
|
LPCAT3
|
lysophosphatidylcholine acyltransferase 3 |
| chr22_+_25003626 | 1.90 |
ENST00000451366.1
ENST00000406383.2 ENST00000428855.1 |
GGT1
|
gamma-glutamyltransferase 1 |
| chr6_+_43266063 | 1.79 |
ENST00000372574.3
|
SLC22A7
|
solute carrier family 22 (organic anion transporter), member 7 |
| chr20_-_3644046 | 1.76 |
ENST00000290417.2
ENST00000319242.3 |
GFRA4
|
GDNF family receptor alpha 4 |
| chr1_-_155270770 | 1.73 |
ENST00000392414.3
|
PKLR
|
pyruvate kinase, liver and RBC |
| chr14_+_100485712 | 1.70 |
ENST00000544450.2
|
EVL
|
Enah/Vasp-like |
| chr17_-_17494972 | 1.69 |
ENST00000435340.2
ENST00000255389.5 ENST00000395781.2 |
PEMT
|
phosphatidylethanolamine N-methyltransferase |
| chr19_+_751122 | 1.59 |
ENST00000215582.6
|
MISP
|
mitotic spindle positioning |
| chr2_-_208994548 | 1.59 |
ENST00000282141.3
|
CRYGC
|
crystallin, gamma C |
| chr12_-_21757774 | 1.53 |
ENST00000261195.2
|
GYS2
|
glycogen synthase 2 (liver) |
| chr11_-_61659006 | 1.51 |
ENST00000278829.2
|
FADS3
|
fatty acid desaturase 3 |
| chr2_-_31637560 | 1.48 |
ENST00000379416.3
|
XDH
|
xanthine dehydrogenase |
| chr3_+_108541608 | 1.45 |
ENST00000426646.1
|
TRAT1
|
T cell receptor associated transmembrane adaptor 1 |
| chr17_-_28618867 | 1.37 |
ENST00000394819.3
ENST00000577623.1 |
BLMH
|
bleomycin hydrolase |
| chr12_+_121416340 | 1.32 |
ENST00000257555.6
ENST00000400024.2 |
HNF1A
|
HNF1 homeobox A |
| chr2_-_11810284 | 1.22 |
ENST00000306928.5
|
NTSR2
|
neurotensin receptor 2 |
| chr7_-_15601595 | 1.15 |
ENST00000342526.3
|
AGMO
|
alkylglycerol monooxygenase |
| chr15_+_63340858 | 1.12 |
ENST00000560615.1
|
TPM1
|
tropomyosin 1 (alpha) |
| chr11_-_116694009 | 1.10 |
ENST00000357780.3
|
APOA4
|
apolipoprotein A-IV |
| chr3_-_187009646 | 1.09 |
ENST00000296280.6
ENST00000392470.2 ENST00000169293.6 ENST00000439271.1 ENST00000392472.2 ENST00000392475.2 |
MASP1
|
mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) |
| chr19_+_35862192 | 1.08 |
ENST00000597214.1
|
GPR42
|
G protein-coupled receptor 42 (gene/pseudogene) |
| chr7_-_75452673 | 1.08 |
ENST00000416943.1
|
CCL24
|
chemokine (C-C motif) ligand 24 |
| chr20_-_36661826 | 1.01 |
ENST00000373448.2
ENST00000373447.3 |
TTI1
|
TELO2 interacting protein 1 |
| chr6_+_31926857 | 1.01 |
ENST00000375394.2
ENST00000544581.1 |
SKIV2L
|
superkiller viralicidic activity 2-like (S. cerevisiae) |
| chr4_-_120243545 | 0.99 |
ENST00000274024.3
|
FABP2
|
fatty acid binding protein 2, intestinal |
| chr1_-_29508321 | 0.98 |
ENST00000546138.1
|
SRSF4
|
serine/arginine-rich splicing factor 4 |
| chr11_-_63536113 | 0.95 |
ENST00000433688.1
ENST00000546282.2 |
C11orf95
RP11-466C23.4
|
chromosome 11 open reading frame 95 RP11-466C23.4 |
| chr5_+_79950463 | 0.90 |
ENST00000265081.6
|
MSH3
|
mutS homolog 3 |
| chr10_+_52152766 | 0.84 |
ENST00000596442.1
|
AC069547.2
|
Uncharacterized protein |
| chrX_+_65382433 | 0.82 |
ENST00000374727.3
|
HEPH
|
hephaestin |
| chr1_+_199996733 | 0.69 |
ENST00000236914.3
|
NR5A2
|
nuclear receptor subfamily 5, group A, member 2 |
| chr5_-_102455801 | 0.67 |
ENST00000508629.1
ENST00000399004.2 |
GIN1
|
gypsy retrotransposon integrase 1 |
| chr11_+_119056178 | 0.64 |
ENST00000525131.1
ENST00000531114.1 ENST00000355547.5 ENST00000322712.4 |
PDZD3
|
PDZ domain containing 3 |
| chr6_+_31691121 | 0.56 |
ENST00000480039.1
ENST00000375810.4 ENST00000375805.2 ENST00000375809.3 ENST00000375804.2 ENST00000375814.3 ENST00000375806.2 |
C6orf25
|
chromosome 6 open reading frame 25 |
| chrX_+_65382381 | 0.56 |
ENST00000519389.1
|
HEPH
|
hephaestin |
| chrX_-_77041685 | 0.52 |
ENST00000373344.5
ENST00000395603.3 |
ATRX
|
alpha thalassemia/mental retardation syndrome X-linked |
| chr1_-_43855479 | 0.52 |
ENST00000290663.6
ENST00000372457.4 |
MED8
|
mediator complex subunit 8 |
| chr14_+_38677123 | 0.51 |
ENST00000267377.2
|
SSTR1
|
somatostatin receptor 1 |
| chr4_+_95376396 | 0.47 |
ENST00000508216.1
ENST00000514743.1 |
PDLIM5
|
PDZ and LIM domain 5 |
| chr15_+_63340734 | 0.44 |
ENST00000560959.1
|
TPM1
|
tropomyosin 1 (alpha) |
| chr5_-_16509101 | 0.44 |
ENST00000399793.2
|
FAM134B
|
family with sequence similarity 134, member B |
| chr22_+_19950060 | 0.33 |
ENST00000449653.1
|
COMT
|
catechol-O-methyltransferase |
| chr19_+_10196981 | 0.32 |
ENST00000591813.1
|
C19orf66
|
chromosome 19 open reading frame 66 |
| chr4_-_76928641 | 0.31 |
ENST00000264888.5
|
CXCL9
|
chemokine (C-X-C motif) ligand 9 |
| chr10_+_104404218 | 0.31 |
ENST00000302424.7
|
TRIM8
|
tripartite motif containing 8 |
| chr3_-_187009798 | 0.18 |
ENST00000337774.5
|
MASP1
|
mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) |
| chr19_+_35861831 | 0.18 |
ENST00000454971.1
|
GPR42
|
G protein-coupled receptor 42 (gene/pseudogene) |
Network of associatons between targets according to the STRING database.
First level regulatory network of HNF4A
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 11.7 | 35.2 | GO:0010902 | positive regulation of very-low-density lipoprotein particle remodeling(GO:0010902) |
| 5.2 | 20.7 | GO:0010961 | cellular magnesium ion homeostasis(GO:0010961) |
| 4.5 | 26.9 | GO:0010731 | protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734) |
| 4.3 | 17.4 | GO:0006114 | glycerol biosynthetic process(GO:0006114) response to methionine(GO:1904640) |
| 4.1 | 16.4 | GO:1904450 | negative regulation of gamma-aminobutyric acid secretion(GO:0014053) aspartate secretion(GO:0061528) regulation of aspartate secretion(GO:1904448) positive regulation of aspartate secretion(GO:1904450) |
| 4.0 | 27.9 | GO:0016098 | monoterpenoid metabolic process(GO:0016098) |
| 4.0 | 51.4 | GO:2000427 | positive regulation of apoptotic cell clearance(GO:2000427) |
| 3.4 | 10.1 | GO:0006014 | D-ribose metabolic process(GO:0006014) |
| 2.9 | 8.6 | GO:0006522 | alanine metabolic process(GO:0006522) alanine catabolic process(GO:0006524) pyruvate family amino acid metabolic process(GO:0009078) pyruvate family amino acid catabolic process(GO:0009080) |
| 2.8 | 8.5 | GO:0048203 | vesicle targeting, trans-Golgi to endosome(GO:0048203) |
| 2.5 | 7.5 | GO:0060621 | regulation of cholesterol import(GO:0060620) negative regulation of cholesterol import(GO:0060621) regulation of sterol import(GO:2000909) negative regulation of sterol import(GO:2000910) |
| 2.4 | 7.2 | GO:0019477 | L-lysine catabolic process to acetyl-CoA(GO:0019474) L-lysine catabolic process(GO:0019477) L-lysine metabolic process(GO:0046440) |
| 2.4 | 7.1 | GO:0060086 | circadian temperature homeostasis(GO:0060086) |
| 2.3 | 7.0 | GO:0097156 | fasciculation of motor neuron axon(GO:0097156) |
| 2.1 | 10.7 | GO:0019805 | quinolinate biosynthetic process(GO:0019805) |
| 2.1 | 6.3 | GO:0032581 | ER-dependent peroxisome organization(GO:0032581) |
| 2.1 | 10.3 | GO:0034371 | chylomicron remodeling(GO:0034371) |
| 2.0 | 6.1 | GO:0070781 | arginine biosynthetic process via ornithine(GO:0042450) response to biotin(GO:0070781) |
| 2.0 | 39.8 | GO:0019373 | epoxygenase P450 pathway(GO:0019373) |
| 1.9 | 7.8 | GO:1905071 | ossification involved in bone remodeling(GO:0043932) frontal suture morphogenesis(GO:0060364) occluding junction disassembly(GO:1905071) regulation of occluding junction disassembly(GO:1905073) positive regulation of occluding junction disassembly(GO:1905075) |
| 1.7 | 5.0 | GO:0044339 | canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339) Spemann organizer formation(GO:0060061) |
| 1.6 | 11.5 | GO:0015760 | hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760) |
| 1.6 | 7.9 | GO:0060125 | negative regulation of growth hormone secretion(GO:0060125) |
| 1.5 | 4.6 | GO:0060599 | lateral sprouting involved in mammary gland duct morphogenesis(GO:0060599) |
| 1.5 | 4.5 | GO:1901053 | sarcosine metabolic process(GO:1901052) sarcosine catabolic process(GO:1901053) |
| 1.5 | 5.9 | GO:0090258 | negative regulation of mitochondrial fission(GO:0090258) |
| 1.5 | 8.8 | GO:0006562 | proline catabolic process(GO:0006562) |
| 1.4 | 30.8 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 1.3 | 7.6 | GO:1990822 | L-cystine transport(GO:0015811) basic amino acid transmembrane transport(GO:1990822) |
| 1.3 | 7.5 | GO:0030643 | cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502) |
| 1.2 | 12.0 | GO:0015889 | cobalamin transport(GO:0015889) |
| 1.1 | 3.4 | GO:2000118 | regulation of sodium-dependent phosphate transport(GO:2000118) |
| 1.0 | 7.9 | GO:1904262 | negative regulation of TORC1 signaling(GO:1904262) |
| 0.9 | 5.4 | GO:0048312 | intracellular distribution of mitochondria(GO:0048312) |
| 0.9 | 7.1 | GO:0007598 | blood coagulation, extrinsic pathway(GO:0007598) |
| 0.9 | 6.2 | GO:0010757 | negative regulation of plasminogen activation(GO:0010757) |
| 0.9 | 3.5 | GO:0072166 | posterior mesonephric tubule development(GO:0072166) negative regulation of metanephric glomerulus development(GO:0072299) negative regulation of metanephric glomerular mesangial cell proliferation(GO:0072302) |
| 0.9 | 2.6 | GO:1903570 | regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572) |
| 0.8 | 3.4 | GO:1903597 | negative regulation of gap junction assembly(GO:1903597) |
| 0.8 | 3.8 | GO:0042866 | pyruvate biosynthetic process(GO:0042866) |
| 0.7 | 5.2 | GO:0048014 | Tie signaling pathway(GO:0048014) |
| 0.7 | 7.4 | GO:1900227 | positive regulation of NLRP3 inflammasome complex assembly(GO:1900227) |
| 0.7 | 2.9 | GO:0000103 | sulfate assimilation(GO:0000103) |
| 0.6 | 5.4 | GO:0045329 | carnitine biosynthetic process(GO:0045329) |
| 0.6 | 8.9 | GO:0033539 | fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539) |
| 0.6 | 3.5 | GO:0001920 | negative regulation of receptor recycling(GO:0001920) |
| 0.5 | 2.7 | GO:0061113 | pancreas morphogenesis(GO:0061113) |
| 0.5 | 2.2 | GO:1901162 | primary amino compound biosynthetic process(GO:1901162) |
| 0.5 | 9.2 | GO:1990845 | adaptive thermogenesis(GO:1990845) |
| 0.5 | 4.1 | GO:0015747 | urate transport(GO:0015747) |
| 0.5 | 2.5 | GO:0033274 | response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829) |
| 0.5 | 1.5 | GO:0006145 | purine nucleobase catabolic process(GO:0006145) |
| 0.5 | 4.3 | GO:0046415 | urate metabolic process(GO:0046415) |
| 0.5 | 1.4 | GO:0043418 | homocysteine catabolic process(GO:0043418) |
| 0.5 | 15.9 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 0.5 | 3.6 | GO:0003065 | positive regulation of heart rate by epinephrine(GO:0003065) |
| 0.5 | 8.1 | GO:0006490 | oligosaccharide-lipid intermediate biosynthetic process(GO:0006490) |
| 0.4 | 14.1 | GO:0036499 | PERK-mediated unfolded protein response(GO:0036499) |
| 0.4 | 4.2 | GO:0016559 | peroxisome fission(GO:0016559) |
| 0.4 | 6.4 | GO:0030277 | maintenance of gastrointestinal epithelium(GO:0030277) |
| 0.3 | 10.3 | GO:0042572 | retinol metabolic process(GO:0042572) |
| 0.3 | 7.2 | GO:0000042 | protein targeting to Golgi(GO:0000042) |
| 0.3 | 0.8 | GO:0035565 | regulation of pronephros size(GO:0035565) renal glucose absorption(GO:0035623) |
| 0.3 | 1.9 | GO:0019344 | cysteine biosynthetic process(GO:0019344) |
| 0.3 | 3.4 | GO:0006703 | estrogen biosynthetic process(GO:0006703) |
| 0.2 | 2.3 | GO:0098856 | intestinal cholesterol absorption(GO:0030299) intestinal lipid absorption(GO:0098856) |
| 0.2 | 1.7 | GO:0006686 | sphingomyelin biosynthetic process(GO:0006686) |
| 0.2 | 5.4 | GO:0060732 | positive regulation of inositol phosphate biosynthetic process(GO:0060732) |
| 0.2 | 7.1 | GO:0045022 | early endosome to late endosome transport(GO:0045022) |
| 0.2 | 2.8 | GO:0016024 | CDP-diacylglycerol biosynthetic process(GO:0016024) |
| 0.2 | 20.1 | GO:0030521 | androgen receptor signaling pathway(GO:0030521) |
| 0.2 | 1.1 | GO:2000418 | positive regulation of eosinophil migration(GO:2000418) |
| 0.2 | 8.0 | GO:1901998 | toxin transport(GO:1901998) |
| 0.2 | 1.2 | GO:0046485 | ether lipid metabolic process(GO:0046485) |
| 0.2 | 4.6 | GO:0032007 | negative regulation of TOR signaling(GO:0032007) |
| 0.1 | 1.7 | GO:1900028 | negative regulation of ruffle assembly(GO:1900028) |
| 0.1 | 2.3 | GO:0018027 | peptidyl-lysine dimethylation(GO:0018027) |
| 0.1 | 8.1 | GO:0018279 | protein N-linked glycosylation via asparagine(GO:0018279) |
| 0.1 | 1.5 | GO:0035860 | glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860) |
| 0.1 | 0.5 | GO:0045875 | negative regulation of sister chromatid cohesion(GO:0045875) |
| 0.1 | 14.8 | GO:0030449 | regulation of complement activation(GO:0030449) |
| 0.1 | 1.3 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
| 0.1 | 1.0 | GO:0032006 | regulation of TOR signaling(GO:0032006) |
| 0.1 | 6.5 | GO:0071480 | cellular response to gamma radiation(GO:0071480) |
| 0.1 | 1.0 | GO:0034427 | nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'(GO:0034427) |
| 0.1 | 10.9 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) |
| 0.1 | 5.6 | GO:0050690 | regulation of defense response to virus by virus(GO:0050690) |
| 0.1 | 2.3 | GO:0015879 | carnitine transport(GO:0015879) |
| 0.1 | 11.4 | GO:0030518 | intracellular steroid hormone receptor signaling pathway(GO:0030518) |
| 0.1 | 0.5 | GO:0038170 | somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170) |
| 0.1 | 11.3 | GO:0060996 | dendritic spine development(GO:0060996) |
| 0.1 | 0.9 | GO:0043570 | maintenance of DNA repeat elements(GO:0043570) |
| 0.1 | 3.2 | GO:0046949 | fatty-acyl-CoA biosynthetic process(GO:0046949) |
| 0.1 | 1.9 | GO:0036150 | phosphatidylserine acyl-chain remodeling(GO:0036150) |
| 0.1 | 0.7 | GO:0015074 | DNA integration(GO:0015074) |
| 0.1 | 0.3 | GO:0016036 | cellular response to phosphate starvation(GO:0016036) positive regulation of sulfur amino acid metabolic process(GO:0031337) negative regulation of catecholamine metabolic process(GO:0045914) negative regulation of dopamine metabolic process(GO:0045963) positive regulation of homocysteine metabolic process(GO:0050668) |
| 0.1 | 3.4 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.0 | 2.4 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.0 | 0.6 | GO:0031282 | regulation of guanylate cyclase activity(GO:0031282) |
| 0.0 | 0.3 | GO:0043950 | positive regulation of cAMP-mediated signaling(GO:0043950) |
| 0.0 | 0.9 | GO:0006825 | copper ion transport(GO:0006825) |
| 0.0 | 1.0 | GO:0019433 | triglyceride catabolic process(GO:0019433) |
| 0.0 | 2.3 | GO:0032259 | methylation(GO:0032259) |
| 0.0 | 3.3 | GO:0007224 | smoothened signaling pathway(GO:0007224) |
| 0.0 | 1.5 | GO:0009250 | glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250) |
| 0.0 | 5.4 | GO:0002244 | hematopoietic progenitor cell differentiation(GO:0002244) |
| 0.0 | 1.1 | GO:0006636 | unsaturated fatty acid biosynthetic process(GO:0006636) |
| 0.0 | 5.6 | GO:0045861 | negative regulation of proteolysis(GO:0045861) |
| 0.0 | 1.2 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.6 | 44.4 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
| 4.1 | 16.4 | GO:0032144 | 4-aminobutyrate transaminase complex(GO:0032144) |
| 3.4 | 30.8 | GO:0005579 | membrane attack complex(GO:0005579) |
| 2.0 | 12.0 | GO:0031232 | extrinsic component of external side of plasma membrane(GO:0031232) |
| 1.8 | 7.1 | GO:0070695 | FHF complex(GO:0070695) |
| 1.3 | 26.9 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 1.2 | 5.9 | GO:0045298 | tubulin complex(GO:0045298) |
| 0.8 | 4.8 | GO:1990130 | Iml1 complex(GO:1990130) |
| 0.7 | 7.4 | GO:0097427 | microtubule bundle(GO:0097427) |
| 0.7 | 7.5 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 0.6 | 3.1 | GO:0036398 | TCR signalosome(GO:0036398) |
| 0.5 | 1.0 | GO:0031931 | TORC1 complex(GO:0031931) |
| 0.5 | 6.2 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.4 | 5.0 | GO:1990909 | Wnt signalosome(GO:1990909) |
| 0.3 | 7.0 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.3 | 8.9 | GO:0031304 | intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305) |
| 0.3 | 7.1 | GO:0031233 | intrinsic component of external side of plasma membrane(GO:0031233) |
| 0.3 | 0.9 | GO:0032302 | MutSbeta complex(GO:0032302) |
| 0.3 | 62.0 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.3 | 1.0 | GO:0055087 | Ski complex(GO:0055087) |
| 0.2 | 6.3 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.2 | 3.3 | GO:0036038 | MKS complex(GO:0036038) |
| 0.2 | 14.9 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.2 | 3.6 | GO:0032059 | bleb(GO:0032059) |
| 0.1 | 7.5 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.1 | 5.6 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.1 | 5.2 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.1 | 11.3 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.1 | 1.5 | GO:0016529 | sarcoplasmic reticulum(GO:0016529) |
| 0.1 | 3.5 | GO:0042101 | T cell receptor complex(GO:0042101) |
| 0.1 | 10.4 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.1 | 29.3 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.1 | 93.0 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.1 | 1.6 | GO:0005938 | cell cortex(GO:0005938) |
| 0.1 | 6.4 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.1 | 25.9 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.1 | 16.6 | GO:0030133 | transport vesicle(GO:0030133) |
| 0.0 | 6.9 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 6.0 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.0 | 8.8 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 18.6 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 31.4 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 1.5 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.0 | 1.7 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.0 | 25.2 | GO:0031226 | intrinsic component of plasma membrane(GO:0031226) |
| 0.0 | 1.5 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 0.6 | GO:0005903 | brush border(GO:0005903) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.0 | 35.2 | GO:0060230 | lipoprotein lipase activator activity(GO:0060230) |
| 5.8 | 17.4 | GO:0004613 | phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613) |
| 4.1 | 20.7 | GO:0031708 | endothelin B receptor binding(GO:0031708) |
| 4.1 | 24.6 | GO:0004882 | androgen receptor activity(GO:0004882) |
| 4.1 | 16.4 | GO:0003867 | 4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298) |
| 3.5 | 17.6 | GO:0033695 | oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875) |
| 3.2 | 25.9 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 2.9 | 40.9 | GO:0070330 | aromatase activity(GO:0070330) |
| 2.9 | 11.5 | GO:0004346 | glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309) |
| 2.7 | 8.1 | GO:0000026 | alpha-1,2-mannosyltransferase activity(GO:0000026) |
| 2.6 | 7.8 | GO:0034714 | type III transforming growth factor beta receptor binding(GO:0034714) |
| 2.3 | 9.2 | GO:0035473 | lipase binding(GO:0035473) |
| 2.2 | 8.8 | GO:0004657 | proline dehydrogenase activity(GO:0004657) |
| 2.1 | 8.5 | GO:0035650 | AP-1 adaptor complex binding(GO:0035650) |
| 2.1 | 56.4 | GO:0001848 | complement binding(GO:0001848) |
| 1.9 | 7.5 | GO:0000822 | inositol hexakisphosphate binding(GO:0000822) |
| 1.9 | 7.5 | GO:0070653 | high-density lipoprotein particle receptor binding(GO:0070653) |
| 1.5 | 4.5 | GO:0046997 | sarcosine dehydrogenase activity(GO:0008480) oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor(GO:0046997) |
| 1.5 | 5.9 | GO:0099609 | microtubule lateral binding(GO:0099609) |
| 1.5 | 8.9 | GO:0048039 | ubiquinone binding(GO:0048039) |
| 1.5 | 7.4 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
| 1.4 | 5.4 | GO:0008336 | gamma-butyrobetaine dioxygenase activity(GO:0008336) |
| 1.3 | 9.2 | GO:0017077 | oxidative phosphorylation uncoupler activity(GO:0017077) |
| 1.3 | 14.1 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 1.3 | 7.6 | GO:0015184 | L-cystine transmembrane transporter activity(GO:0015184) |
| 1.2 | 7.2 | GO:0016647 | oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647) |
| 1.1 | 12.0 | GO:0031419 | cobalamin binding(GO:0031419) |
| 1.1 | 5.4 | GO:0004991 | parathyroid hormone receptor activity(GO:0004991) |
| 1.1 | 3.2 | GO:0016215 | stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215) |
| 1.0 | 8.1 | GO:0004873 | asialoglycoprotein receptor activity(GO:0004873) |
| 0.9 | 3.8 | GO:0004743 | pyruvate kinase activity(GO:0004743) |
| 0.9 | 8.4 | GO:0030976 | thiamine pyrophosphate binding(GO:0030976) |
| 0.8 | 8.4 | GO:1901702 | urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702) |
| 0.8 | 9.2 | GO:0008391 | arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392) |
| 0.7 | 3.5 | GO:0044729 | hemi-methylated DNA-binding(GO:0044729) |
| 0.7 | 7.0 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) PH domain binding(GO:0042731) |
| 0.7 | 8.1 | GO:0043225 | anion transmembrane-transporting ATPase activity(GO:0043225) |
| 0.6 | 14.5 | GO:0071949 | FAD binding(GO:0071949) |
| 0.6 | 10.3 | GO:0004745 | retinol dehydrogenase activity(GO:0004745) |
| 0.6 | 3.4 | GO:0047045 | testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045) |
| 0.6 | 2.3 | GO:0005124 | scavenger receptor binding(GO:0005124) |
| 0.6 | 11.4 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.6 | 1.7 | GO:0004608 | phosphatidyl-N-methylethanolamine N-methyltransferase activity(GO:0000773) phosphatidylethanolamine N-methyltransferase activity(GO:0004608) phosphatidyl-N-dimethylethanolamine N-methyltransferase activity(GO:0080101) |
| 0.6 | 3.4 | GO:0008240 | tripeptidyl-peptidase activity(GO:0008240) peptidyl-dipeptidase activity(GO:0008241) |
| 0.6 | 6.1 | GO:0042301 | phosphate ion binding(GO:0042301) |
| 0.5 | 15.9 | GO:0015347 | sodium-independent organic anion transmembrane transporter activity(GO:0015347) |
| 0.5 | 2.5 | GO:0004489 | methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489) |
| 0.5 | 26.9 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.5 | 2.3 | GO:0046974 | histone methyltransferase activity (H3-K9 specific)(GO:0046974) |
| 0.4 | 7.1 | GO:0001222 | transcription corepressor binding(GO:0001222) |
| 0.4 | 2.6 | GO:0043183 | vascular endothelial growth factor receptor 1 binding(GO:0043183) |
| 0.4 | 11.3 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.4 | 5.4 | GO:0003995 | acyl-CoA dehydrogenase activity(GO:0003995) |
| 0.4 | 2.9 | GO:0050294 | steroid sulfotransferase activity(GO:0050294) |
| 0.4 | 1.9 | GO:0047184 | 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184) |
| 0.4 | 6.0 | GO:0048018 | receptor agonist activity(GO:0048018) |
| 0.3 | 9.5 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.3 | 7.9 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.3 | 10.9 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.3 | 0.9 | GO:0000404 | heteroduplex DNA loop binding(GO:0000404) double-strand/single-strand DNA junction binding(GO:0000406) dinucleotide repeat insertion binding(GO:0032181) |
| 0.3 | 1.5 | GO:0016725 | oxidoreductase activity, acting on CH or CH2 groups(GO:0016725) |
| 0.3 | 10.1 | GO:0019200 | carbohydrate kinase activity(GO:0019200) |
| 0.3 | 7.1 | GO:0051959 | dynein light intermediate chain binding(GO:0051959) |
| 0.3 | 1.8 | GO:0016167 | glial cell-derived neurotrophic factor receptor activity(GO:0016167) |
| 0.2 | 5.1 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.2 | 3.4 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.2 | 1.2 | GO:0016714 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714) |
| 0.2 | 6.2 | GO:0008198 | ferrous iron binding(GO:0008198) |
| 0.2 | 1.1 | GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
| 0.2 | 3.5 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.2 | 0.5 | GO:0015616 | DNA translocase activity(GO:0015616) |
| 0.2 | 2.8 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
| 0.2 | 2.2 | GO:0016813 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813) |
| 0.1 | 1.9 | GO:0036374 | glutathione hydrolase activity(GO:0036374) |
| 0.1 | 1.5 | GO:0035251 | UDP-glucosyltransferase activity(GO:0035251) |
| 0.1 | 3.1 | GO:0030275 | LRR domain binding(GO:0030275) |
| 0.1 | 0.5 | GO:0004994 | somatostatin receptor activity(GO:0004994) |
| 0.1 | 1.7 | GO:0005522 | profilin binding(GO:0005522) |
| 0.1 | 0.6 | GO:0030249 | guanylate cyclase regulator activity(GO:0030249) |
| 0.1 | 2.3 | GO:0008374 | O-acyltransferase activity(GO:0008374) |
| 0.1 | 0.3 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 0.1 | 1.9 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.1 | 3.4 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.1 | 1.4 | GO:0004180 | carboxypeptidase activity(GO:0004180) |
| 0.1 | 5.3 | GO:0005319 | lipid transporter activity(GO:0005319) |
| 0.1 | 5.2 | GO:0004714 | transmembrane receptor protein tyrosine kinase activity(GO:0004714) |
| 0.1 | 6.2 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 6.2 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.1 | 1.6 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.0 | 2.4 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.0 | 0.3 | GO:0016206 | catechol O-methyltransferase activity(GO:0016206) |
| 0.0 | 1.2 | GO:0008188 | neuropeptide receptor activity(GO:0008188) |
| 0.0 | 8.3 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 3.1 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.0 | 1.0 | GO:0005504 | fatty acid binding(GO:0005504) |
| 0.0 | 2.1 | GO:0098531 | RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531) |
| 0.0 | 6.3 | GO:0008022 | protein C-terminus binding(GO:0008022) |
| 0.0 | 1.0 | GO:0004004 | RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) |
| 0.0 | 2.3 | GO:0008168 | methyltransferase activity(GO:0008168) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 47.6 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.4 | 33.1 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.4 | 10.3 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.3 | 5.9 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.3 | 7.1 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.3 | 7.9 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.3 | 20.7 | PID ENDOTHELIN PATHWAY | Endothelins |
| 0.2 | 10.9 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.2 | 7.8 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.2 | 20.1 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.2 | 7.0 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.2 | 11.4 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.2 | 5.0 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.2 | 7.1 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.2 | 2.6 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.1 | 8.0 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 3.4 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.1 | 5.2 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.1 | 5.1 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 3.5 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 2.3 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 10.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 6.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.4 | 61.3 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 2.4 | 51.9 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 1.3 | 17.4 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |
| 1.3 | 27.1 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 1.1 | 30.8 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.8 | 10.7 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.7 | 11.4 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.7 | 12.0 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.5 | 7.1 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.5 | 14.1 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.5 | 16.4 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.4 | 5.6 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.4 | 33.8 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.3 | 8.2 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.3 | 6.4 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.3 | 8.1 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.3 | 5.4 | REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.3 | 4.3 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.2 | 4.6 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |
| 0.2 | 3.4 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.2 | 4.2 | REACTOME ALPHA LINOLENIC ACID ALA METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 0.2 | 11.5 | REACTOME GLUCOSE TRANSPORT | Genes involved in Glucose transport |
| 0.2 | 7.6 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.2 | 4.6 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.2 | 5.9 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.2 | 5.2 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.2 | 2.8 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |
| 0.1 | 1.5 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |
| 0.1 | 7.9 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 6.5 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.1 | 2.6 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.1 | 3.1 | REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 | Genes involved in Regulation of AMPK activity via LKB1 |
| 0.1 | 1.9 | REACTOME ACYL CHAIN REMODELLING OF PS | Genes involved in Acyl chain remodelling of PS |
| 0.1 | 22.7 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 14.0 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 3.6 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.1 | 2.9 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.1 | 10.4 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.1 | 2.2 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.1 | 2.7 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 19.0 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.1 | 1.7 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.1 | 3.5 | REACTOME DOWNSTREAM TCR SIGNALING | Genes involved in Downstream TCR signaling |
| 0.1 | 1.9 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.1 | 1.7 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.1 | 1.4 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.1 | 3.1 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 2.3 | REACTOME RNA POL I TRANSCRIPTION INITIATION | Genes involved in RNA Polymerase I Transcription Initiation |
| 0.0 | 3.9 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.0 | 5.3 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.0 | 1.5 | REACTOME GLUCOSE METABOLISM | Genes involved in Glucose metabolism |