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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for HOMEZ

Z-value: 1.13

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Transcription factors associated with HOMEZ

Gene Symbol Gene ID Gene Info
HOMEZ
ENSG00000215271.6 homeobox and leucine zipper encoding

Activity profile of HOMEZ motif

Sorted Z-values of HOMEZ motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr9_-_95055956 35.43 ENST00000375629.3
ENST00000447699.2
ENST00000375643.3
ENST00000395554.3
IARS
isoleucyl-tRNA synthetase
chr7_-_7679633 31.08 ENST00000401447.1
RPA3
replication protein A3, 14kDa
chr3_+_33155525 28.37 ENST00000449224.1
CRTAP
cartilage associated protein
chr10_-_27443294 28.33 ENST00000396296.3
ENST00000375972.3
ENST00000376016.3
ENST00000491542.2
YME1L1
YME1-like 1 ATPase
chr9_-_95056010 24.84 ENST00000443024.2
IARS
isoleucyl-tRNA synthetase
chr3_-_64009658 24.23 ENST00000394431.2
PSMD6
proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
chrX_-_135962876 22.83 ENST00000431446.3
ENST00000570135.1
ENST00000320676.7
ENST00000562646.1
RBMX
RNA binding motif protein, X-linked
chr11_+_102217936 21.71 ENST00000532832.1
ENST00000530675.1
ENST00000533742.1
ENST00000227758.2
ENST00000532672.1
ENST00000531259.1
ENST00000527465.1
BIRC2
baculoviral IAP repeat containing 2
chr2_+_187371440 21.54 ENST00000445547.1
ZC3H15
zinc finger CCCH-type containing 15
chr8_-_54935001 21.02 ENST00000396401.3
ENST00000521604.2
TCEA1
transcription elongation factor A (SII), 1
chr20_-_5107180 20.42 ENST00000379160.3
PCNA
proliferating cell nuclear antigen
chr11_-_62607036 20.18 ENST00000311713.7
ENST00000278856.4
WDR74
WD repeat domain 74
chr5_+_72143988 19.27 ENST00000506351.2
TNPO1
transportin 1
chr4_-_103747011 19.11 ENST00000350435.7
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr1_+_113161778 18.96 ENST00000263168.3
CAPZA1
capping protein (actin filament) muscle Z-line, alpha 1
chrX_+_119737806 18.71 ENST00000371317.5
MCTS1
malignant T cell amplified sequence 1
chr13_-_31038370 18.47 ENST00000399489.1
ENST00000339872.4
HMGB1
high mobility group box 1
chr1_+_24018269 17.79 ENST00000374550.3
RPL11
ribosomal protein L11
chr4_-_103746683 17.70 ENST00000504211.1
ENST00000508476.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr4_-_174254823 17.57 ENST00000438704.2
HMGB2
high mobility group box 2
chr6_+_34725263 17.10 ENST00000374018.1
ENST00000374017.3
SNRPC
small nuclear ribonucleoprotein polypeptide C
chr14_+_58711539 17.00 ENST00000216455.4
ENST00000412908.2
ENST00000557508.1
PSMA3
proteasome (prosome, macropain) subunit, alpha type, 3
chr20_+_30327063 16.99 ENST00000300403.6
ENST00000340513.4
TPX2
TPX2, microtubule-associated
chr8_-_101962777 16.85 ENST00000395951.3
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr4_-_103746924 16.51 ENST00000505207.1
ENST00000502404.1
ENST00000507845.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr2_+_242289502 16.39 ENST00000451310.1
SEPT2
septin 2
chr1_-_165738072 15.44 ENST00000481278.1
TMCO1
transmembrane and coiled-coil domains 1
chr3_-_146262488 15.41 ENST00000487389.1
PLSCR1
phospholipid scramblase 1
chr7_+_98923505 15.29 ENST00000432884.2
ENST00000262942.5
ARPC1A
actin related protein 2/3 complex, subunit 1A, 41kDa
chr10_-_72648541 14.91 ENST00000299299.3
PCBD1
pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
chr2_-_150444116 14.90 ENST00000428879.1
ENST00000422782.2
MMADHC
methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria
chr10_-_121296045 14.72 ENST00000392865.1
RGS10
regulator of G-protein signaling 10
chr14_-_105420241 14.34 ENST00000557457.1
AHNAK2
AHNAK nucleoprotein 2
chr4_+_140222609 14.30 ENST00000296543.5
ENST00000398947.1
NAA15
N(alpha)-acetyltransferase 15, NatA auxiliary subunit
chr2_+_233415363 14.23 ENST00000409514.1
ENST00000409098.1
ENST00000409495.1
ENST00000409167.3
ENST00000409322.1
ENST00000409394.1
EIF4E2
eukaryotic translation initiation factor 4E family member 2
chr1_+_220267429 14.19 ENST00000366922.1
ENST00000302637.5
IARS2
isoleucyl-tRNA synthetase 2, mitochondrial
chr2_-_225362533 13.87 ENST00000451538.1
CUL3
cullin 3
chr1_-_54405773 13.79 ENST00000371376.1
HSPB11
heat shock protein family B (small), member 11
chr1_-_19426149 13.77 ENST00000429347.2
UBR4
ubiquitin protein ligase E3 component n-recognin 4
chr6_+_34725181 13.77 ENST00000244520.5
SNRPC
small nuclear ribonucleoprotein polypeptide C
chr10_-_95242044 13.68 ENST00000371501.4
ENST00000371502.4
ENST00000371489.1
MYOF
myoferlin
chr16_-_23607598 13.63 ENST00000562133.1
ENST00000570319.1
ENST00000007516.3
NDUFAB1
NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa
chr20_+_44441626 13.37 ENST00000372568.4
UBE2C
ubiquitin-conjugating enzyme E2C
chrX_+_12993336 13.32 ENST00000380635.1
TMSB4X
thymosin beta 4, X-linked
chr2_+_109237717 13.29 ENST00000409441.1
LIMS1
LIM and senescent cell antigen-like domains 1
chrX_-_119709637 13.28 ENST00000404115.3
CUL4B
cullin 4B
chr1_-_193075180 13.22 ENST00000367440.3
GLRX2
glutaredoxin 2
chr4_-_104119528 13.20 ENST00000380026.3
ENST00000503705.1
ENST00000265148.3
CENPE
centromere protein E, 312kDa
chr3_-_107941230 13.14 ENST00000264538.3
IFT57
intraflagellar transport 57 homolog (Chlamydomonas)
chr10_-_95241951 12.91 ENST00000358334.5
ENST00000359263.4
ENST00000371488.3
MYOF
myoferlin
chr2_+_216974020 12.89 ENST00000392132.2
ENST00000417391.1
XRCC5
X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
chr20_-_48330377 12.76 ENST00000371711.4
B4GALT5
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
chr3_-_146262637 12.24 ENST00000472349.1
ENST00000342435.4
PLSCR1
phospholipid scramblase 1
chr1_-_245027833 12.20 ENST00000444376.2
HNRNPU
heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
chr17_-_80017856 12.13 ENST00000577574.1
DUS1L
dihydrouridine synthase 1-like (S. cerevisiae)
chr11_+_101983176 12.08 ENST00000524575.1
YAP1
Yes-associated protein 1
chr17_-_8113542 12.08 ENST00000578549.1
ENST00000535053.1
ENST00000582368.1
AURKB
aurora kinase B
chr12_-_50419177 12.01 ENST00000454520.2
ENST00000546595.1
ENST00000548824.1
ENST00000549777.1
ENST00000546723.1
ENST00000427314.2
ENST00000552157.1
ENST00000552310.1
ENST00000548644.1
ENST00000312377.5
ENST00000546786.1
ENST00000550149.1
ENST00000546764.1
ENST00000552004.1
ENST00000548320.1
ENST00000547905.1
ENST00000550651.1
ENST00000551145.1
ENST00000434422.1
ENST00000552921.1
RACGAP1
Rac GTPase activating protein 1
chr19_-_49121054 11.86 ENST00000546623.1
ENST00000084795.5
RPL18
ribosomal protein L18
chr4_+_83956237 11.86 ENST00000264389.2
COPS4
COP9 signalosome subunit 4
chr5_+_177019159 11.85 ENST00000332598.6
TMED9
transmembrane emp24 protein transport domain containing 9
chrX_+_118708493 11.83 ENST00000371558.2
UBE2A
ubiquitin-conjugating enzyme E2A
chr1_+_29063119 11.75 ENST00000474884.1
ENST00000542507.1
YTHDF2
YTH domain family, member 2
chr7_-_7680601 11.71 ENST00000396682.2
RPA3
replication protein A3, 14kDa
chr4_+_83956312 11.66 ENST00000509317.1
ENST00000503682.1
ENST00000511653.1
COPS4
COP9 signalosome subunit 4
chr5_+_96038476 11.64 ENST00000511049.1
ENST00000309190.5
ENST00000510156.1
ENST00000509903.1
ENST00000511782.1
ENST00000504465.1
CAST
calpastatin
chr2_+_118572226 11.61 ENST00000263239.2
DDX18
DEAD (Asp-Glu-Ala-Asp) box polypeptide 18
chr22_-_36924944 11.27 ENST00000405442.1
ENST00000402116.1
EIF3D
eukaryotic translation initiation factor 3, subunit D
chr7_-_102985288 11.19 ENST00000379263.3
DNAJC2
DnaJ (Hsp40) homolog, subfamily C, member 2
chr18_-_54305658 11.16 ENST00000586262.1
ENST00000217515.6
TXNL1
thioredoxin-like 1
chr1_+_144220127 11.06 ENST00000369373.5
NBPF8
neuroblastoma breakpoint family, member 8
chr4_-_170679024 10.86 ENST00000393381.2
C4orf27
chromosome 4 open reading frame 27
chrX_-_109590174 10.85 ENST00000372054.1
GNG5P2
guanine nucleotide binding protein (G protein), gamma 5 pseudogene 2
chrX_-_114953669 10.78 ENST00000449327.1
RP1-241P17.4
Uncharacterized protein
chrX_-_77225135 10.74 ENST00000458128.1
PGAM4
phosphoglycerate mutase family member 4
chr9_-_127952032 10.71 ENST00000456642.1
ENST00000373546.3
ENST00000373547.4
PPP6C
protein phosphatase 6, catalytic subunit
chr15_+_65843130 10.64 ENST00000569894.1
PTPLAD1
protein tyrosine phosphatase-like A domain containing 1
chr1_-_245027766 10.55 ENST00000283179.9
HNRNPU
heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
chrX_+_118708517 10.54 ENST00000346330.3
UBE2A
ubiquitin-conjugating enzyme E2A
chr16_-_58585513 10.47 ENST00000245138.4
ENST00000567285.1
CNOT1
CCR4-NOT transcription complex, subunit 1
chr11_-_47664072 10.32 ENST00000542981.1
ENST00000530428.1
ENST00000302503.3
MTCH2
mitochondrial carrier 2
chr12_+_72148614 10.12 ENST00000261263.3
RAB21
RAB21, member RAS oncogene family
chr10_+_85899196 10.06 ENST00000372134.3
GHITM
growth hormone inducible transmembrane protein
chr17_+_66521936 10.03 ENST00000592800.1
PRKAR1A
protein kinase, cAMP-dependent, regulatory, type I, alpha
chrX_-_151999269 9.94 ENST00000370277.3
CETN2
centrin, EF-hand protein, 2
chr6_+_44214824 9.78 ENST00000371646.5
ENST00000353801.3
HSP90AB1
heat shock protein 90kDa alpha (cytosolic), class B member 1
chr4_+_113568207 9.61 ENST00000511529.1
LARP7
La ribonucleoprotein domain family, member 7
chr3_-_64009102 9.56 ENST00000478185.1
ENST00000482510.1
ENST00000497323.1
ENST00000492933.1
ENST00000295901.4
PSMD6
proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
chr2_+_85843252 9.52 ENST00000409025.1
ENST00000409470.1
ENST00000323701.6
ENST00000409766.3
USP39
ubiquitin specific peptidase 39
chr16_+_74330673 9.48 ENST00000219313.4
ENST00000540379.1
ENST00000567958.1
ENST00000568615.2
PSMD7
proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
chr5_+_112196919 9.46 ENST00000505459.1
ENST00000282999.3
ENST00000515463.1
SRP19
signal recognition particle 19kDa
chr18_-_47018897 9.45 ENST00000418495.1
RPL17
ribosomal protein L17
chr2_+_47630108 9.40 ENST00000233146.2
ENST00000454849.1
ENST00000543555.1
MSH2
mutS homolog 2
chr18_+_3247413 9.37 ENST00000579226.1
ENST00000217652.3
MYL12A
myosin, light chain 12A, regulatory, non-sarcomeric
chr10_-_123734683 9.25 ENST00000369017.5
ENST00000369023.3
NSMCE4A
non-SMC element 4 homolog A (S. cerevisiae)
chr18_+_20513278 9.23 ENST00000327155.5
RBBP8
retinoblastoma binding protein 8
chr8_+_91013577 9.17 ENST00000220764.2
DECR1
2,4-dienoyl CoA reductase 1, mitochondrial
chr9_-_128412696 9.08 ENST00000420643.1
MAPKAP1
mitogen-activated protein kinase associated protein 1
chr1_-_68962782 9.08 ENST00000456315.2
DEPDC1
DEP domain containing 1
chr2_-_55237484 8.93 ENST00000394609.2
RTN4
reticulon 4
chr22_+_42017987 8.91 ENST00000405506.1
XRCC6
X-ray repair complementing defective repair in Chinese hamster cells 6
chr3_-_10362725 8.89 ENST00000397109.3
ENST00000428626.1
ENST00000445064.1
ENST00000431352.1
ENST00000397117.1
ENST00000337354.4
ENST00000383801.2
ENST00000432213.1
ENST00000350697.3
SEC13
SEC13 homolog (S. cerevisiae)
chr18_-_47017956 8.78 ENST00000584895.1
ENST00000332968.6
ENST00000580210.1
ENST00000579408.1
RPL17-C18orf32
RPL17
RPL17-C18orf32 readthrough
ribosomal protein L17
chr7_-_102985035 8.71 ENST00000426036.2
ENST00000249270.7
ENST00000454277.1
ENST00000412522.1
DNAJC2
DnaJ (Hsp40) homolog, subfamily C, member 2
chr1_-_153958805 8.53 ENST00000368575.3
RAB13
RAB13, member RAS oncogene family
chr5_+_95066823 8.46 ENST00000506817.1
ENST00000379982.3
RHOBTB3
Rho-related BTB domain containing 3
chr6_+_138725343 8.43 ENST00000607197.1
ENST00000367697.3
HEBP2
heme binding protein 2
chr5_-_96518907 8.43 ENST00000508447.1
ENST00000283109.3
RIOK2
RIO kinase 2
chr5_-_52405564 8.39 ENST00000510818.2
ENST00000396954.3
ENST00000508922.1
ENST00000361377.4
ENST00000582677.1
ENST00000584946.1
ENST00000450852.3
MOCS2
molybdenum cofactor synthesis 2
chr3_-_146262352 8.36 ENST00000462666.1
PLSCR1
phospholipid scramblase 1
chr16_-_69373396 8.24 ENST00000562595.1
ENST00000562081.1
ENST00000306875.4
COG8
component of oligomeric golgi complex 8
chr4_+_57845024 8.21 ENST00000431623.2
ENST00000441246.2
POLR2B
polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
chr1_-_153950164 8.13 ENST00000271843.4
JTB
jumping translocation breakpoint
chr1_-_153518270 8.10 ENST00000354332.4
ENST00000368716.4
S100A4
S100 calcium binding protein A4
chr4_-_106629796 8.05 ENST00000416543.1
ENST00000515819.1
ENST00000420368.2
ENST00000503746.1
ENST00000340139.5
ENST00000433009.1
INTS12
integrator complex subunit 12
chr9_+_106856831 8.01 ENST00000303219.8
ENST00000374787.3
SMC2
structural maintenance of chromosomes 2
chr2_-_178129853 7.97 ENST00000397062.3
NFE2L2
nuclear factor, erythroid 2-like 2
chr15_+_77223960 7.93 ENST00000394885.3
RCN2
reticulocalbin 2, EF-hand calcium binding domain
chr1_-_153949751 7.84 ENST00000428469.1
JTB
jumping translocation breakpoint
chr1_-_153950098 7.77 ENST00000356648.1
JTB
jumping translocation breakpoint
chr1_-_40349106 7.75 ENST00000545233.1
ENST00000537440.1
ENST00000537223.1
ENST00000541099.1
ENST00000441669.2
ENST00000544981.1
ENST00000316891.5
ENST00000372818.1
TRIT1
tRNA isopentenyltransferase 1
chr1_+_212208919 7.74 ENST00000366991.4
ENST00000542077.1
DTL
denticleless E3 ubiquitin protein ligase homolog (Drosophila)
chr7_+_100303676 7.68 ENST00000303151.4
POP7
processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae)
chr9_-_128003606 7.64 ENST00000324460.6
HSPA5
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
chr6_+_64281906 7.63 ENST00000370651.3
PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr1_-_153950116 7.56 ENST00000368589.1
JTB
jumping translocation breakpoint
chr22_-_32058166 7.49 ENST00000435900.1
ENST00000336566.4
PISD
phosphatidylserine decarboxylase
chr6_-_33282163 7.49 ENST00000434618.2
ENST00000456592.2
TAPBP
TAP binding protein (tapasin)
chr22_-_32808194 7.43 ENST00000451746.2
ENST00000216038.5
RTCB
RNA 2',3'-cyclic phosphate and 5'-OH ligase
chr15_+_89787180 7.41 ENST00000300027.8
ENST00000310775.7
ENST00000567891.1
ENST00000564920.1
ENST00000565255.1
ENST00000567996.1
ENST00000451393.2
ENST00000563250.1
FANCI
Fanconi anemia, complementation group I
chr8_+_132916318 7.39 ENST00000254624.5
ENST00000522709.1
EFR3A
EFR3 homolog A (S. cerevisiae)
chr8_-_13134045 7.33 ENST00000512044.2
DLC1
deleted in liver cancer 1
chr6_-_43027105 7.23 ENST00000230413.5
ENST00000487429.1
ENST00000489623.1
ENST00000468957.1
MRPL2
mitochondrial ribosomal protein L2
chr12_+_19282643 7.20 ENST00000317589.4
ENST00000355397.3
ENST00000359180.3
ENST00000309364.4
ENST00000540972.1
ENST00000429027.2
PLEKHA5
pleckstrin homology domain containing, family A member 5
chr17_+_30469473 7.18 ENST00000333942.6
ENST00000358365.3
ENST00000583994.1
ENST00000545287.2
RHOT1
ras homolog family member T1
chr1_-_6420737 7.15 ENST00000541130.1
ENST00000377845.3
ACOT7
acyl-CoA thioesterase 7
chr12_-_65153175 7.07 ENST00000543646.1
ENST00000542058.1
ENST00000258145.3
GNS
glucosamine (N-acetyl)-6-sulfatase
chr1_-_86174065 7.00 ENST00000370574.3
ENST00000431532.2
ZNHIT6
zinc finger, HIT-type containing 6
chr6_-_109702885 6.99 ENST00000504373.1
CD164
CD164 molecule, sialomucin
chr2_+_11674213 6.97 ENST00000381486.2
GREB1
growth regulation by estrogen in breast cancer 1
chr10_-_126849068 6.97 ENST00000494626.2
ENST00000337195.5
CTBP2
C-terminal binding protein 2
chr22_-_22901477 6.95 ENST00000420709.1
ENST00000398741.1
ENST00000405655.3
PRAME
preferentially expressed antigen in melanoma
chr12_-_92539614 6.92 ENST00000256015.3
BTG1
B-cell translocation gene 1, anti-proliferative
chr2_-_37068530 6.89 ENST00000593798.1
AC007382.1
Uncharacterized protein
chr14_-_74959978 6.89 ENST00000541064.1
NPC2
Niemann-Pick disease, type C2
chr5_-_140700322 6.83 ENST00000313368.5
TAF7
TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa
chr14_-_74960030 6.83 ENST00000553490.1
ENST00000557510.1
NPC2
Niemann-Pick disease, type C2
chr10_+_51572339 6.78 ENST00000344348.6
NCOA4
nuclear receptor coactivator 4
chr7_+_89783689 6.73 ENST00000297205.2
STEAP1
six transmembrane epithelial antigen of the prostate 1
chr14_-_74959994 6.68 ENST00000238633.2
ENST00000434013.2
NPC2
Niemann-Pick disease, type C2
chr1_+_44401479 6.66 ENST00000438616.3
ARTN
artemin
chr20_+_61299155 6.55 ENST00000451793.1
SLCO4A1
solute carrier organic anion transporter family, member 4A1
chr22_-_22901636 6.50 ENST00000406503.1
ENST00000439106.1
ENST00000402697.1
ENST00000543184.1
ENST00000398743.2
PRAME
preferentially expressed antigen in melanoma
chrX_+_49160148 6.45 ENST00000407599.3
GAGE10
G antigen 10
chr3_-_98312548 6.35 ENST00000264193.2
CPOX
coproporphyrinogen oxidase
chr14_-_45603657 6.34 ENST00000396062.3
FKBP3
FK506 binding protein 3, 25kDa
chr1_+_40204538 6.25 ENST00000324379.5
ENST00000356511.2
ENST00000497370.1
ENST00000470213.1
ENST00000372835.5
ENST00000372830.1
PPIE
peptidylprolyl isomerase E (cyclophilin E)
chr16_+_30075463 6.24 ENST00000562168.1
ENST00000569545.1
ALDOA
aldolase A, fructose-bisphosphate
chr11_+_74303575 6.23 ENST00000263681.2
POLD3
polymerase (DNA-directed), delta 3, accessory subunit
chr6_-_75960024 6.19 ENST00000370081.2
COX7A2
cytochrome c oxidase subunit VIIa polypeptide 2 (liver)
chr4_+_57845043 6.18 ENST00000433463.1
ENST00000314595.5
POLR2B
polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
chr11_+_58910295 6.16 ENST00000420244.1
FAM111A
family with sequence similarity 111, member A
chr8_-_62602327 6.13 ENST00000445642.3
ENST00000517847.2
ENST00000389204.4
ENST00000517661.1
ENST00000517903.1
ENST00000522603.1
ENST00000522349.1
ENST00000522835.1
ENST00000541428.1
ENST00000518306.1
ASPH
aspartate beta-hydroxylase
chr12_-_71551652 6.12 ENST00000546561.1
TSPAN8
tetraspanin 8
chr7_+_117824210 6.11 ENST00000422760.1
ENST00000411938.1
NAA38
N(alpha)-acetyltransferase 38, NatC auxiliary subunit
chr1_+_74701062 6.02 ENST00000326637.3
TNNI3K
TNNI3 interacting kinase
chr1_+_89246647 6.01 ENST00000544045.1
PKN2
protein kinase N2
chr7_+_101460882 6.00 ENST00000292535.7
ENST00000549414.2
ENST00000550008.2
ENST00000546411.2
ENST00000556210.1
CUX1
cut-like homeobox 1
chr3_-_133969437 5.96 ENST00000460933.1
ENST00000296084.4
RYK
receptor-like tyrosine kinase
chr7_+_128379346 5.94 ENST00000535011.2
ENST00000542996.2
ENST00000535623.1
ENST00000538546.1
ENST00000249364.4
ENST00000449187.2
CALU
calumenin
chr12_-_10978957 5.93 ENST00000240619.2
TAS2R10
taste receptor, type 2, member 10
chr1_-_6259641 5.92 ENST00000234875.4
RPL22
ribosomal protein L22
chr12_+_112451120 5.91 ENST00000261735.3
ENST00000455836.1
ERP29
endoplasmic reticulum protein 29
chr12_-_8803128 5.91 ENST00000543467.1
MFAP5
microfibrillar associated protein 5
chr6_+_31633011 5.87 ENST00000375885.4
CSNK2B
casein kinase 2, beta polypeptide
chr16_-_18801643 5.84 ENST00000322989.4
ENST00000563390.1
RPS15A
ribosomal protein S15a
chr11_+_8008867 5.77 ENST00000309828.4
ENST00000449102.2
EIF3F
eukaryotic translation initiation factor 3, subunit F
chr17_+_41150290 5.77 ENST00000589037.1
ENST00000253788.5
RPL27
ribosomal protein L27
chr20_+_1099233 5.77 ENST00000246015.4
ENST00000335877.6
ENST00000438768.2
PSMF1
proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
chr1_-_143767881 5.77 ENST00000419275.1
PPIAL4G
peptidylprolyl isomerase A (cyclophilin A)-like 4G
chr2_-_3523507 5.66 ENST00000327435.6
ADI1
acireductone dioxygenase 1
chr15_+_52155001 5.63 ENST00000544199.1
TMOD3
tropomodulin 3 (ubiquitous)
chr10_-_27149904 5.57 ENST00000376166.1
ENST00000376138.3
ENST00000355394.4
ENST00000346832.5
ENST00000376134.3
ENST00000376137.4
ENST00000536334.1
ENST00000490841.2
ABI1
abl-interactor 1
chr5_+_141488070 5.54 ENST00000253814.4
NDFIP1
Nedd4 family interacting protein 1
chr10_-_126849588 5.49 ENST00000411419.2
CTBP2
C-terminal binding protein 2
chr10_+_5488564 5.47 ENST00000449083.1
ENST00000380359.3
NET1
neuroepithelial cell transforming 1
chr18_-_47018869 5.46 ENST00000583036.1
ENST00000580261.1
RPL17
ribosomal protein L17
chr20_-_31989307 5.43 ENST00000473997.1
ENST00000544843.1
ENST00000346416.2
ENST00000357886.4
ENST00000339269.5
CDK5RAP1
CDK5 regulatory subunit associated protein 1
chr16_+_88869621 5.41 ENST00000301019.4
CDT1
chromatin licensing and DNA replication factor 1
chr10_+_51572408 5.39 ENST00000374082.1
NCOA4
nuclear receptor coactivator 4
chr12_-_52911718 5.38 ENST00000548409.1
KRT5
keratin 5
chr5_+_85913721 5.32 ENST00000247655.3
ENST00000509578.1
ENST00000515763.1
COX7C
cytochrome c oxidase subunit VIIc
chr22_-_31364187 5.32 ENST00000215862.4
ENST00000397641.3
MORC2
MORC family CW-type zinc finger 2
chr1_-_165738085 5.31 ENST00000464650.1
ENST00000392129.6
TMCO1
transmembrane and coiled-coil domains 1
chr20_-_5093713 5.21 ENST00000342308.5
ENST00000202834.7
TMEM230
transmembrane protein 230
chr4_+_169753156 5.07 ENST00000393726.3
ENST00000507735.1
PALLD
palladin, cytoskeletal associated protein
chr5_+_147774275 5.03 ENST00000513826.1
FBXO38
F-box protein 38
chr12_+_100594557 5.00 ENST00000546902.1
ENST00000552376.1
ENST00000551617.1
ACTR6
ARP6 actin-related protein 6 homolog (yeast)
chr19_-_39330818 4.99 ENST00000594769.1
ENST00000602021.1
AC104534.3
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial
chr14_+_23235886 4.99 ENST00000604262.1
ENST00000431881.2
ENST00000412791.1
ENST00000358043.5
OXA1L
oxidase (cytochrome c) assembly 1-like

Network of associatons between targets according to the STRING database.

First level regulatory network of HOMEZ

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
24.8 74.5 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
10.0 30.1 GO:1901873 regulation of post-translational protein modification(GO:1901873)
7.2 21.7 GO:1902523 positive regulation of protein K63-linked ubiquitination(GO:1902523)
6.6 19.9 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
6.4 12.9 GO:1904430 negative regulation of t-circle formation(GO:1904430)
6.2 18.7 GO:0002188 translation reinitiation(GO:0002188)
5.6 11.3 GO:0001732 formation of cytoplasmic translation initiation complex(GO:0001732)
5.1 20.4 GO:1902990 leading strand elongation(GO:0006272) mitotic telomere maintenance via semi-conservative replication(GO:1902990)
5.1 20.4 GO:0019747 regulation of isoprenoid metabolic process(GO:0019747)
4.7 28.3 GO:0035694 mitochondrial protein catabolic process(GO:0035694)
4.6 18.5 GO:0002840 plasmacytoid dendritic cell activation(GO:0002270) T cell mediated immune response to tumor cell(GO:0002424) regulation of T cell mediated immune response to tumor cell(GO:0002840) regulation of restriction endodeoxyribonuclease activity(GO:0032072) negative regulation of apoptotic cell clearance(GO:2000426)
4.5 36.0 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
4.4 17.8 GO:2000435 regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435)
4.0 12.1 GO:0044878 mitotic cytokinesis checkpoint(GO:0044878)
3.5 13.9 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831)
3.4 30.9 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
3.4 40.9 GO:0001778 plasma membrane repair(GO:0001778)
3.3 13.2 GO:0048200 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
3.2 22.7 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
3.2 9.5 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
3.1 9.4 GO:0010520 regulation of reciprocal meiotic recombination(GO:0010520)
3.0 12.0 GO:0044837 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
2.9 17.1 GO:2000483 negative regulation of interleukin-8 secretion(GO:2000483)
2.8 8.5 GO:1902463 protein localization to cell leading edge(GO:1902463)
2.8 8.4 GO:2000234 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
2.7 10.7 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
2.6 2.6 GO:0006293 nucleotide-excision repair, preincision complex stabilization(GO:0006293) nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
2.6 28.4 GO:0006983 ER overload response(GO:0006983)
2.4 9.8 GO:1903660 negative regulation of complement-dependent cytotoxicity(GO:1903660)
2.4 14.3 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
2.4 9.5 GO:0061643 chemorepulsion of dopaminergic neuron axon(GO:0036518) chemorepulsion of axon(GO:0061643)
2.3 4.6 GO:0035720 intraciliary anterograde transport(GO:0035720)
2.2 13.2 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
2.1 49.9 GO:0032201 telomere maintenance via semi-conservative replication(GO:0032201)
2.0 6.1 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
2.0 12.1 GO:0002943 tRNA dihydrouridine synthesis(GO:0002943)
2.0 8.0 GO:1901377 mycotoxin catabolic process(GO:0043387) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound catabolic process(GO:1901377) regulation of glutathione biosynthetic process(GO:1903786) positive regulation of glutathione biosynthetic process(GO:1903788)
2.0 5.9 GO:0044278 cell wall disruption in other organism(GO:0044278)
1.9 89.1 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
1.8 5.5 GO:0048294 negative regulation of isotype switching to IgE isotypes(GO:0048294)
1.8 18.1 GO:0042262 DNA protection(GO:0042262)
1.8 5.4 GO:1902595 regulation of DNA replication origin binding(GO:1902595)
1.8 7.1 GO:1900533 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
1.8 17.6 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
1.7 8.6 GO:0097461 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
1.7 23.9 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
1.7 8.5 GO:0030047 actin modification(GO:0030047)
1.7 11.7 GO:1904688 regulation of cap-independent translational initiation(GO:1903677) positive regulation of cap-independent translational initiation(GO:1903679) regulation of cytoplasmic translational initiation(GO:1904688) positive regulation of cytoplasmic translational initiation(GO:1904690)
1.7 5.0 GO:0070272 proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
1.7 14.9 GO:0006729 tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146)
1.6 19.3 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
1.6 12.5 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
1.5 9.1 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
1.5 5.9 GO:0043335 protein unfolding(GO:0043335)
1.5 23.5 GO:0000338 protein deneddylation(GO:0000338)
1.4 4.3 GO:0060447 bud outgrowth involved in lung branching(GO:0060447)
1.4 13.6 GO:0009249 protein lipoylation(GO:0009249)
1.3 12.1 GO:1902459 positive regulation of stem cell population maintenance(GO:1902459)
1.3 8.0 GO:0010940 positive regulation of necrotic cell death(GO:0010940)
1.3 6.7 GO:0097021 Peyer's patch morphogenesis(GO:0061146) lymphocyte migration into lymphoid organs(GO:0097021)
1.3 9.2 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
1.3 13.2 GO:0070900 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
1.2 5.0 GO:0031179 peptide amidation(GO:0001519) protein amidation(GO:0018032) peptide modification(GO:0031179)
1.2 3.7 GO:0060279 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
1.2 7.2 GO:1902513 regulation of organelle transport along microtubule(GO:1902513)
1.2 2.4 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
1.2 26.9 GO:0060972 left/right pattern formation(GO:0060972)
1.2 7.0 GO:0048254 snoRNA localization(GO:0048254)
1.1 16.8 GO:0090168 Golgi reassembly(GO:0090168)
1.1 8.9 GO:0097680 double-strand break repair via classical nonhomologous end joining(GO:0097680)
1.1 3.3 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
1.0 4.2 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
1.0 22.8 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
1.0 23.2 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
1.0 8.0 GO:0010032 meiotic chromosome condensation(GO:0010032)
1.0 8.9 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
1.0 6.7 GO:0061635 regulation of protein complex stability(GO:0061635)
0.9 5.6 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.9 3.4 GO:0048496 maintenance of organ identity(GO:0048496)
0.8 4.2 GO:0030200 heparan sulfate proteoglycan catabolic process(GO:0030200)
0.8 14.7 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.8 3.2 GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990)
0.8 6.9 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.7 4.5 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.7 5.9 GO:0033211 positive regulation of activin receptor signaling pathway(GO:0032927) adiponectin-activated signaling pathway(GO:0033211)
0.7 41.7 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.7 10.0 GO:0045835 negative regulation of meiotic nuclear division(GO:0045835)
0.7 4.8 GO:0051026 chiasma assembly(GO:0051026)
0.7 6.8 GO:0015846 polyamine transport(GO:0015846)
0.7 61.4 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436)
0.7 2.7 GO:0034334 adherens junction maintenance(GO:0034334)
0.7 2.6 GO:0045332 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.6 6.3 GO:0051597 response to methylmercury(GO:0051597)
0.6 19.0 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.6 3.8 GO:0018343 protein farnesylation(GO:0018343)
0.6 5.7 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.6 7.4 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.6 8.2 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.6 10.4 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.6 14.9 GO:0009235 cobalamin metabolic process(GO:0009235)
0.5 2.2 GO:0036289 peptidyl-serine autophosphorylation(GO:0036289)
0.5 3.7 GO:1902474 positive regulation of protein localization to synapse(GO:1902474)
0.5 2.6 GO:0050906 detection of stimulus involved in sensory perception(GO:0050906) detection of chemical stimulus involved in sensory perception(GO:0050907) detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.5 7.2 GO:0061458 reproductive system development(GO:0061458)
0.5 6.2 GO:0045071 regulation of viral genome replication(GO:0045069) negative regulation of viral genome replication(GO:0045071)
0.5 7.7 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.5 6.5 GO:0070327 thyroid hormone transport(GO:0070327)
0.5 2.5 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
0.5 5.8 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.5 4.1 GO:2000643 positive regulation of early endosome to late endosome transport(GO:2000643)
0.4 11.6 GO:0097341 inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341)
0.4 8.9 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.4 7.1 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.4 2.2 GO:0002725 negative regulation of T cell cytokine production(GO:0002725)
0.4 23.6 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.4 2.5 GO:0010751 negative regulation of nitric oxide mediated signal transduction(GO:0010751)
0.4 8.9 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.4 61.4 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.4 3.3 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
0.4 7.5 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.4 5.0 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.4 3.7 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.4 4.5 GO:0010815 bradykinin catabolic process(GO:0010815)
0.4 12.2 GO:0006622 protein targeting to lysosome(GO:0006622)
0.4 8.1 GO:0016180 snRNA processing(GO:0016180)
0.4 1.2 GO:0042427 serotonin biosynthetic process(GO:0042427)
0.4 17.0 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.4 18.9 GO:0042339 keratan sulfate metabolic process(GO:0042339)
0.4 3.0 GO:0006777 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720)
0.4 2.6 GO:0070294 renal sodium ion absorption(GO:0070294)
0.4 7.4 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.4 13.3 GO:0051894 positive regulation of focal adhesion assembly(GO:0051894) positive regulation of adherens junction organization(GO:1903393)
0.3 2.7 GO:0035986 senescence-associated heterochromatin focus assembly(GO:0035986)
0.3 0.9 GO:0002184 cytoplasmic translational termination(GO:0002184)
0.3 1.7 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.3 3.1 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.3 12.1 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.3 6.0 GO:0086069 bundle of His cell to Purkinje myocyte communication(GO:0086069)
0.3 3.9 GO:0006012 galactose metabolic process(GO:0006012)
0.3 3.1 GO:0045838 positive regulation of membrane potential(GO:0045838)
0.3 3.0 GO:0040033 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974) regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
0.2 6.5 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.2 7.2 GO:0002181 cytoplasmic translation(GO:0002181)
0.2 37.3 GO:0000910 cytokinesis(GO:0000910)
0.2 1.1 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.2 7.0 GO:0021522 spinal cord motor neuron differentiation(GO:0021522)
0.2 0.9 GO:0044240 multicellular organism lipid catabolic process(GO:0044240)
0.2 4.5 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.2 24.7 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.2 5.4 GO:0031581 hemidesmosome assembly(GO:0031581)
0.2 0.5 GO:0042727 flavin-containing compound biosynthetic process(GO:0042727)
0.2 3.6 GO:0035855 megakaryocyte development(GO:0035855)
0.2 5.9 GO:0060216 definitive hemopoiesis(GO:0060216)
0.2 6.0 GO:0050775 positive regulation of dendrite morphogenesis(GO:0050775)
0.2 0.5 GO:1903371 regulation of endoplasmic reticulum tubular network organization(GO:1903371)
0.2 3.4 GO:0003334 keratinocyte development(GO:0003334)
0.2 0.8 GO:0032071 regulation of endodeoxyribonuclease activity(GO:0032071)
0.2 5.5 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.2 12.1 GO:0045454 cell redox homeostasis(GO:0045454)
0.1 1.0 GO:0015760 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.1 9.5 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.1 1.0 GO:0009597 detection of virus(GO:0009597)
0.1 3.9 GO:0032463 negative regulation of protein homooligomerization(GO:0032463)
0.1 0.8 GO:1901843 positive regulation of high voltage-gated calcium channel activity(GO:1901843)
0.1 14.2 GO:0006413 translational initiation(GO:0006413)
0.1 1.9 GO:0051260 protein homooligomerization(GO:0051260)
0.1 4.5 GO:0000209 protein polyubiquitination(GO:0000209)
0.1 9.2 GO:2001022 positive regulation of response to DNA damage stimulus(GO:2001022)
0.1 2.0 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.1 4.8 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.1 1.0 GO:1901475 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.1 9.0 GO:0006901 vesicle coating(GO:0006901)
0.1 1.4 GO:0098719 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.1 3.6 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 3.5 GO:0051607 defense response to virus(GO:0051607)
0.1 9.8 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.1 1.2 GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
0.1 5.7 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.1 6.5 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.1 2.9 GO:0061641 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.1 0.5 GO:0060356 leucine import(GO:0060356)
0.1 1.4 GO:0052695 cellular glucuronidation(GO:0052695)
0.1 0.7 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.1 1.7 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.1 3.1 GO:0014003 oligodendrocyte development(GO:0014003)
0.1 3.1 GO:0048814 regulation of dendrite morphogenesis(GO:0048814)
0.1 1.2 GO:0007413 axonal fasciculation(GO:0007413)
0.1 2.4 GO:0042573 retinoic acid metabolic process(GO:0042573)
0.1 2.7 GO:0060334 regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.1 1.6 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 0.7 GO:0006451 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.1 8.2 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.1 9.8 GO:0006338 chromatin remodeling(GO:0006338)
0.1 4.7 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.1 4.3 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.1 0.3 GO:0060011 Sertoli cell proliferation(GO:0060011)
0.1 6.1 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1 6.3 GO:0046330 positive regulation of JNK cascade(GO:0046330)
0.0 7.4 GO:0090002 establishment of protein localization to plasma membrane(GO:0090002)
0.0 0.6 GO:0034453 microtubule anchoring(GO:0034453)
0.0 0.4 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.0 0.1 GO:1900063 regulation of peroxisome organization(GO:1900063)
0.0 0.4 GO:0097503 sialylation(GO:0097503)
0.0 0.1 GO:0009183 purine deoxyribonucleoside diphosphate biosynthetic process(GO:0009183) dGDP metabolic process(GO:0046066)
0.0 1.9 GO:0009301 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 3.0 GO:1902600 hydrogen ion transmembrane transport(GO:1902600)
0.0 1.2 GO:0045652 regulation of megakaryocyte differentiation(GO:0045652)
0.0 0.9 GO:0007224 smoothened signaling pathway(GO:0007224)
0.0 1.5 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079)
0.0 3.5 GO:0007605 sensory perception of sound(GO:0007605)
0.0 0.4 GO:0009812 flavonoid metabolic process(GO:0009812)
0.0 2.8 GO:0010389 regulation of G2/M transition of mitotic cell cycle(GO:0010389)
0.0 1.0 GO:1900047 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.0 0.8 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 0.1 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 0.6 GO:0046326 positive regulation of glucose import(GO:0046326)
0.0 3.9 GO:0008654 phospholipid biosynthetic process(GO:0008654)
0.0 2.1 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.0 0.2 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.0 0.7 GO:0007346 regulation of mitotic cell cycle(GO:0007346)
0.0 0.4 GO:0006378 mRNA polyadenylation(GO:0006378)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
6.8 20.4 GO:0070557 PCNA-p21 complex(GO:0070557)
4.6 22.8 GO:0044530 supraspliceosomal complex(GO:0044530)
4.5 22.4 GO:0033503 HULC complex(GO:0033503)
4.4 21.8 GO:0043564 Ku70:Ku80 complex(GO:0043564)
3.1 9.4 GO:0032302 MutSbeta complex(GO:0032302)
2.8 59.1 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
2.7 19.0 GO:0071203 WASH complex(GO:0071203)
2.7 10.8 GO:0031417 NatC complex(GO:0031417)
2.6 21.0 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
2.4 9.8 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
2.4 12.1 GO:0071148 TEAD-1-YAP complex(GO:0071148)
2.4 12.0 GO:0097149 centralspindlin complex(GO:0097149)
2.4 30.9 GO:0000243 commitment complex(GO:0000243)
2.3 9.3 GO:0030915 Smc5-Smc6 complex(GO:0030915)
2.3 34.4 GO:0005662 DNA replication factor A complex(GO:0005662)
2.3 22.7 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
2.0 14.3 GO:0031415 N-terminal protein acetyltransferase complex(GO:0031414) NatA complex(GO:0031415)
2.0 21.7 GO:0001741 XY body(GO:0001741)
1.9 25.3 GO:1990023 mitotic spindle midzone(GO:1990023)
1.9 17.0 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
1.6 3.1 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
1.6 6.2 GO:0043625 delta DNA polymerase complex(GO:0043625)
1.5 13.9 GO:0005827 polar microtubule(GO:0005827)
1.4 17.3 GO:0044292 dendrite terminus(GO:0044292)
1.4 17.0 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
1.4 17.0 GO:0043203 axon hillock(GO:0043203)
1.4 43.3 GO:0005838 proteasome regulatory particle(GO:0005838)
1.3 8.9 GO:0061700 GATOR2 complex(GO:0061700)
1.3 10.1 GO:0098559 cytoplasmic side of early endosome membrane(GO:0098559)
1.3 3.8 GO:0005953 CAAX-protein geranylgeranyltransferase complex(GO:0005953)
1.2 3.7 GO:0043511 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
1.2 9.5 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
1.2 16.4 GO:0097227 sperm annulus(GO:0097227)
1.1 6.7 GO:0042825 TAP complex(GO:0042825)
1.1 4.5 GO:0030891 VCB complex(GO:0030891)
1.1 7.7 GO:0000172 ribonuclease MRP complex(GO:0000172)
1.1 7.4 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
1.0 10.5 GO:0030015 CCR4-NOT core complex(GO:0030015)
1.0 6.1 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
1.0 3.0 GO:0019008 molybdopterin synthase complex(GO:0019008)
1.0 13.8 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
1.0 12.5 GO:0097470 ribbon synapse(GO:0097470)
0.9 14.2 GO:0034518 mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.9 8.1 GO:0032039 integrator complex(GO:0032039)
0.9 7.0 GO:0070761 pre-snoRNP complex(GO:0070761)
0.8 5.9 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.8 6.7 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.8 23.6 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.8 12.2 GO:0044754 autolysosome(GO:0044754)
0.8 8.0 GO:0000796 condensin complex(GO:0000796)
0.7 6.8 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.7 9.9 GO:0000109 nucleotide-excision repair complex(GO:0000109)
0.6 8.9 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.6 31.2 GO:0008180 COP9 signalosome(GO:0008180)
0.6 11.1 GO:0030992 intraciliary transport particle B(GO:0030992)
0.6 67.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.6 9.1 GO:0031932 TORC2 complex(GO:0031932)
0.6 22.9 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.5 5.9 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.5 10.0 GO:0031588 cAMP-dependent protein kinase complex(GO:0005952) nucleotide-activated protein kinase complex(GO:0031588)
0.5 36.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.5 14.4 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.4 5.6 GO:0031209 SCAR complex(GO:0031209)
0.4 4.3 GO:0005614 interstitial matrix(GO:0005614)
0.3 37.4 GO:0035578 azurophil granule lumen(GO:0035578)
0.3 2.4 GO:0000813 ESCRT I complex(GO:0000813)
0.3 11.8 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.3 0.9 GO:0018444 translation release factor complex(GO:0018444)
0.3 26.3 GO:0005746 mitochondrial respiratory chain(GO:0005746)
0.3 8.8 GO:0005680 anaphase-promoting complex(GO:0005680)
0.3 28.2 GO:0017053 transcriptional repressor complex(GO:0017053)
0.3 5.8 GO:0005839 proteasome core complex(GO:0005839)
0.3 5.9 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.3 7.2 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.3 4.7 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.2 1.2 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.2 12.4 GO:0043034 costamere(GO:0043034)
0.2 2.7 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.2 26.2 GO:0005901 caveola(GO:0005901)
0.2 10.4 GO:0031430 M band(GO:0031430)
0.2 7.8 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.2 9.3 GO:0005865 striated muscle thin filament(GO:0005865)
0.2 31.7 GO:0030496 midbody(GO:0030496)
0.2 12.4 GO:0016328 lateral plasma membrane(GO:0016328)
0.2 5.7 GO:0000502 proteasome complex(GO:0000502)
0.2 4.9 GO:0090544 BAF-type complex(GO:0090544)
0.2 23.2 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.2 4.8 GO:0000795 synaptonemal complex(GO:0000795)
0.2 2.6 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.2 0.9 GO:0030894 replisome(GO:0030894) nuclear replisome(GO:0043601)
0.1 3.4 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.1 12.8 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 14.8 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 17.2 GO:0005769 early endosome(GO:0005769)
0.1 15.0 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 38.6 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 2.5 GO:0097228 sperm principal piece(GO:0097228)
0.1 20.4 GO:0000793 condensed chromosome(GO:0000793)
0.1 9.4 GO:0016459 myosin complex(GO:0016459)
0.1 5.4 GO:0045095 keratin filament(GO:0045095)
0.1 4.5 GO:0001772 immunological synapse(GO:0001772)
0.1 1.2 GO:0044666 MLL3/4 complex(GO:0044666)
0.1 1.2 GO:0097542 ciliary tip(GO:0097542)
0.1 12.3 GO:0035579 specific granule membrane(GO:0035579)
0.1 14.7 GO:0043197 dendritic spine(GO:0043197)
0.1 9.0 GO:0101002 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.1 3.5 GO:0002102 podosome(GO:0002102)
0.1 2.7 GO:0045171 intercellular bridge(GO:0045171)
0.1 5.9 GO:0005802 trans-Golgi network(GO:0005802)
0.1 17.0 GO:0010008 endosome membrane(GO:0010008)
0.1 18.0 GO:0031965 nuclear membrane(GO:0031965)
0.1 21.0 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 2.7 GO:0035580 specific granule lumen(GO:0035580)
0.1 17.9 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 1.4 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 5.7 GO:0001650 fibrillar center(GO:0001650)
0.0 1.6 GO:0005643 nuclear pore(GO:0005643)
0.0 0.8 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 1.4 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 2.2 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 3.4 GO:0005741 mitochondrial outer membrane(GO:0005741) organelle outer membrane(GO:0031968)
0.0 4.7 GO:0005681 spliceosomal complex(GO:0005681)
0.0 3.2 GO:0005635 nuclear envelope(GO:0005635)
0.0 1.4 GO:0000922 spindle pole(GO:0000922)
0.0 0.4 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 12.3 GO:0000139 Golgi membrane(GO:0000139)
0.0 0.6 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 0.9 GO:0008021 synaptic vesicle(GO:0008021)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
24.8 74.5 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
10.3 30.9 GO:0030627 pre-mRNA 5'-splice site binding(GO:0030627)
7.2 21.7 GO:0098770 FBXO family protein binding(GO:0098770)
6.0 29.8 GO:0032139 dinucleotide insertion or deletion binding(GO:0032139)
4.5 13.6 GO:0000035 acyl binding(GO:0000035) phosphopantetheine binding(GO:0031177)
4.4 17.6 GO:0044378 non-sequence-specific DNA binding, bending(GO:0044378)
3.7 14.9 GO:0004505 phenylalanine 4-monooxygenase activity(GO:0004505)
3.5 28.3 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
3.5 13.9 GO:0031208 POZ domain binding(GO:0031208)
3.4 6.8 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
3.4 17.0 GO:0061676 importin-alpha family protein binding(GO:0061676)
3.3 19.9 GO:0061649 ubiquitinated histone binding(GO:0061649)
3.3 13.2 GO:0043515 kinetochore binding(GO:0043515)
3.3 36.0 GO:0017128 phospholipid scramblase activity(GO:0017128)
3.3 9.8 GO:0001884 pyrimidine nucleoside binding(GO:0001884) UTP binding(GO:0002134) sulfonylurea receptor binding(GO:0017098) pyrimidine ribonucleoside binding(GO:0032551)
3.1 18.5 GO:0010858 calcium-dependent protein kinase regulator activity(GO:0010858)
2.8 8.4 GO:0030366 molybdopterin synthase activity(GO:0030366)
2.7 10.7 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
2.6 13.2 GO:0030613 oxidoreductase activity, acting on phosphorus or arsenic in donors(GO:0030613) oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor(GO:0030614)
2.5 7.5 GO:0004609 phosphatidylserine decarboxylase activity(GO:0004609)
2.4 23.5 GO:0019784 NEDD8-specific protease activity(GO:0019784)
2.3 9.2 GO:0008670 2,4-dienoyl-CoA reductase (NADPH) activity(GO:0008670)
2.2 21.8 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
2.1 8.6 GO:0052851 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
2.0 12.1 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
2.0 9.9 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
1.9 11.6 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
1.9 89.1 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
1.8 12.5 GO:0030267 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
1.8 17.8 GO:1990948 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
1.8 7.1 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
1.7 6.7 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433)
1.6 11.2 GO:0047134 protein-disulfide reductase activity(GO:0047134)
1.6 9.5 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
1.3 12.1 GO:0035174 histone serine kinase activity(GO:0035174)
1.3 3.9 GO:0033858 N-acetylgalactosamine kinase activity(GO:0033858)
1.3 3.8 GO:0004662 CAAX-protein geranylgeranyltransferase activity(GO:0004662)
1.2 5.0 GO:0004504 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
1.2 3.7 GO:0070699 type II activin receptor binding(GO:0070699)
1.2 12.8 GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
1.2 25.5 GO:0000339 RNA cap binding(GO:0000339)
1.1 3.3 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
1.1 14.3 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
1.1 9.5 GO:0008312 7S RNA binding(GO:0008312)
1.0 4.2 GO:0030305 beta-glucuronidase activity(GO:0004566) heparanase activity(GO:0030305)
1.0 4.8 GO:0032552 deoxyribonucleotide binding(GO:0032552)
0.9 10.4 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.9 11.7 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.9 25.2 GO:0070034 telomerase RNA binding(GO:0070034)
0.9 3.5 GO:0004920 interleukin-10 receptor activity(GO:0004920)
0.8 5.8 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.8 6.5 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.8 7.2 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.8 7.0 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.8 64.6 GO:0003684 damaged DNA binding(GO:0003684)
0.7 18.6 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.7 7.1 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.7 5.0 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.7 14.4 GO:0001055 RNA polymerase II activity(GO:0001055)
0.6 8.1 GO:0050786 RAGE receptor binding(GO:0050786)
0.6 3.1 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.6 5.9 GO:0070492 oligosaccharide binding(GO:0070492)
0.6 7.4 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.6 1.7 GO:0002113 interleukin-33 binding(GO:0002113)
0.6 17.0 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.6 23.9 GO:0042974 retinoic acid receptor binding(GO:0042974)
0.5 20.9 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.5 9.9 GO:0017049 GTP-Rho binding(GO:0017049)
0.5 6.0 GO:0031013 troponin I binding(GO:0031013)
0.5 10.3 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.5 5.9 GO:0033038 bitter taste receptor activity(GO:0033038)
0.5 4.3 GO:0045545 syndecan binding(GO:0045545)
0.5 2.7 GO:0004906 interferon-gamma receptor activity(GO:0004906)
0.5 15.1 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.5 7.7 GO:0004526 ribonuclease P activity(GO:0004526)
0.5 12.1 GO:0070064 proline-rich region binding(GO:0070064)
0.5 21.1 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.4 6.3 GO:0016018 cyclosporin A binding(GO:0016018)
0.4 9.3 GO:0005523 tropomyosin binding(GO:0005523)
0.4 19.0 GO:0003785 actin monomer binding(GO:0003785)
0.4 1.2 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.4 24.5 GO:0003743 translation initiation factor activity(GO:0003743)
0.4 7.6 GO:0051787 misfolded protein binding(GO:0051787)
0.4 4.4 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.4 7.0 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.4 7.4 GO:0070182 DNA polymerase binding(GO:0070182)
0.3 1.0 GO:0015315 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.3 3.6 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.3 5.8 GO:0070628 proteasome binding(GO:0070628)
0.3 12.1 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.3 16.5 GO:0015485 cholesterol binding(GO:0015485)
0.3 63.4 GO:0003735 structural constituent of ribosome(GO:0003735)
0.3 0.9 GO:0047223 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity(GO:0047223)
0.3 6.0 GO:0004697 protein kinase C activity(GO:0004697)
0.3 4.1 GO:0005132 type I interferon receptor binding(GO:0005132)
0.3 1.2 GO:0030760 nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760)
0.3 0.8 GO:0036487 nitric-oxide synthase inhibitor activity(GO:0036487)
0.3 2.1 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.3 4.5 GO:0017160 Ral GTPase binding(GO:0017160)
0.3 4.8 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.3 2.8 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.3 1.0 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.2 12.2 GO:0050681 androgen receptor binding(GO:0050681)
0.2 5.6 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.2 5.7 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.2 8.8 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.2 3.2 GO:0035497 cAMP response element binding(GO:0035497)
0.2 78.8 GO:0045296 cadherin binding(GO:0045296)
0.2 0.9 GO:0004771 sterol esterase activity(GO:0004771)
0.2 7.6 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.2 10.1 GO:0019003 GDP binding(GO:0019003)
0.2 8.2 GO:0042169 SH2 domain binding(GO:0042169)
0.2 3.7 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.2 0.9 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.2 5.0 GO:0043022 ribosome binding(GO:0043022)
0.2 2.4 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.1 4.3 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 2.7 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 3.4 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 4.0 GO:0008143 poly(A) binding(GO:0008143)
0.1 2.6 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.1 0.4 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.1 10.1 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 1.4 GO:0015385 sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.1 5.5 GO:0050699 WW domain binding(GO:0050699)
0.1 9.1 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.1 4.5 GO:0042287 MHC protein binding(GO:0042287)
0.1 2.6 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 2.9 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 3.4 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.1 4.3 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 13.7 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 1.0 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.1 10.1 GO:0005262 calcium channel activity(GO:0005262)
0.1 3.0 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 4.8 GO:0008026 ATP-dependent helicase activity(GO:0008026) purine NTP-dependent helicase activity(GO:0070035)
0.1 1.0 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.1 1.2 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.1 13.0 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.1 1.8 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 1.2 GO:0030515 snoRNA binding(GO:0030515)
0.1 2.9 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 10.4 GO:0005516 calmodulin binding(GO:0005516)
0.0 6.9 GO:0051015 actin filament binding(GO:0051015)
0.0 9.6 GO:0008083 growth factor activity(GO:0008083)
0.0 0.8 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 5.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.4 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 2.4 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 2.4 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.2 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 15.6 GO:0019901 protein kinase binding(GO:0019901)
0.0 0.1 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 7.3 GO:0016887 ATPase activity(GO:0016887)
0.0 0.1 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.0 0.5 GO:0070566 adenylyltransferase activity(GO:0070566)
0.0 1.6 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 3.9 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.0 0.7 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 1.4 GO:0044325 ion channel binding(GO:0044325)
0.0 1.1 GO:0019900 kinase binding(GO:0019900)
0.0 0.1 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.0 GO:0035276 ethanol binding(GO:0035276)
0.0 0.0 GO:0004967 glucagon receptor activity(GO:0004967)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 104.8 PID BARD1 PATHWAY BARD1 signaling events
1.4 63.6 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.9 57.2 PID AURORA B PATHWAY Aurora B signaling
0.8 21.7 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.7 18.5 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.5 30.2 PID PLK1 PATHWAY PLK1 signaling events
0.5 25.9 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.3 7.6 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.3 15.6 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.3 38.2 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.3 9.5 PID WNT SIGNALING PATHWAY Wnt signaling network
0.3 5.9 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.3 2.7 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.2 29.4 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.2 13.3 PID ILK PATHWAY Integrin-linked kinase signaling
0.2 17.2 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.2 6.0 PID RHOA PATHWAY RhoA signaling pathway
0.2 6.7 PID FANCONI PATHWAY Fanconi anemia pathway
0.2 4.3 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.2 12.5 PID CDC42 PATHWAY CDC42 signaling events
0.2 2.7 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 8.7 PID RHOA REG PATHWAY Regulation of RhoA activity
0.1 3.7 PID ALK1 PATHWAY ALK1 signaling events
0.1 8.9 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.1 7.5 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 7.7 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 3.2 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 1.3 PID ARF 3PATHWAY Arf1 pathway
0.1 3.5 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 3.9 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 2.2 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 2.8 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 0.8 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 0.5 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
5.8 69.4 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
1.8 36.0 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
1.6 59.1 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
1.4 50.6 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
1.2 21.8 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
1.0 19.3 REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
1.0 16.5 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.9 66.0 REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.9 35.4 REACTOME ELONGATION ARREST AND RECOVERY Genes involved in Elongation arrest and recovery
0.8 17.0 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.8 25.4 REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.8 14.2 REACTOME TRNA AMINOACYLATION Genes involved in tRNA Aminoacylation
0.8 10.9 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.7 19.0 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.7 12.1 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.7 9.8 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.5 12.8 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.5 21.7 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.5 79.2 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.5 13.3 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.5 12.1 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.5 12.0 REACTOME KINESINS Genes involved in Kinesins
0.5 29.4 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.4 5.4 REACTOME CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX Genes involved in CDT1 association with the CDC6:ORC:origin complex
0.4 2.4 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.4 51.1 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.4 31.8 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.3 6.2 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.3 6.5 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.3 8.9 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.3 4.0 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.3 9.5 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.3 3.0 REACTOME REGULATORY RNA PATHWAYS Genes involved in Regulatory RNA pathways
0.3 2.2 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.2 38.1 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2 6.3 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.2 9.1 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.2 5.7 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.2 3.3 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.2 6.0 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.2 30.1 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.2 14.2 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.2 8.7 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.2 4.2 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.2 13.4 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.2 6.7 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.2 2.7 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.1 3.1 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.1 3.5 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 1.3 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.1 0.9 REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND Genes involved in Processive synthesis on the lagging strand
0.1 2.5 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.1 4.1 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 2.8 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.1 5.9 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.1 3.9 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.1 3.2 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 6.3 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 9.7 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 4.4 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 2.7 REACTOME G1 PHASE Genes involved in G1 Phase
0.1 1.9 REACTOME RNA POL II PRE TRANSCRIPTION EVENTS Genes involved in RNA Polymerase II Pre-transcription Events
0.1 3.8 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 4.3 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 3.4 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.9 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.0 1.1 REACTOME EXTRACELLULAR MATRIX ORGANIZATION Genes involved in Extracellular matrix organization
0.0 2.2 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 1.8 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 2.5 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 0.2 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis