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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for HOMEZ
Z-value: 1.13
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Transcription factors associated with HOMEZ
Network of associatons between targets according to the STRING database.
First level regulatory network of HOMEZ
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 89.1 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 24.8 | 74.5 | GO:0006428 | isoleucyl-tRNA aminoacylation(GO:0006428) |
| 0.7 | 61.4 | GO:0051436 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) |
| 0.4 | 61.4 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 2.1 | 49.9 | GO:0032201 | telomere maintenance via semi-conservative replication(GO:0032201) |
| 0.7 | 41.7 | GO:0006283 | transcription-coupled nucleotide-excision repair(GO:0006283) |
| 3.4 | 40.9 | GO:0001778 | plasma membrane repair(GO:0001778) |
| 0.2 | 37.3 | GO:0000910 | cytokinesis(GO:0000910) |
| 4.5 | 36.0 | GO:0006659 | phosphatidylserine biosynthetic process(GO:0006659) |
| 3.4 | 30.9 | GO:0000395 | mRNA 5'-splice site recognition(GO:0000395) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 67.5 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 2.8 | 59.1 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 1.4 | 43.3 | GO:0005838 | proteasome regulatory particle(GO:0005838) |
| 0.1 | 38.6 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.3 | 37.4 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.5 | 36.8 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 2.3 | 34.4 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.2 | 31.7 | GO:0030496 | midbody(GO:0030496) |
| 0.6 | 31.2 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 2.4 | 30.9 | GO:0000243 | commitment complex(GO:0000243) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 89.1 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.2 | 78.8 | GO:0045296 | cadherin binding(GO:0045296) |
| 24.8 | 74.5 | GO:0004822 | isoleucine-tRNA ligase activity(GO:0004822) |
| 0.8 | 64.6 | GO:0003684 | damaged DNA binding(GO:0003684) |
| 0.3 | 63.4 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 3.3 | 36.0 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 10.3 | 30.9 | GO:0030627 | pre-mRNA 5'-splice site binding(GO:0030627) |
| 6.0 | 29.8 | GO:0032139 | dinucleotide insertion or deletion binding(GO:0032139) |
| 3.5 | 28.3 | GO:0004176 | ATP-dependent peptidase activity(GO:0004176) |
| 1.2 | 25.5 | GO:0000339 | RNA cap binding(GO:0000339) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 104.8 | PID BARD1 PATHWAY | BARD1 signaling events |
| 1.4 | 63.6 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.9 | 57.2 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.3 | 38.2 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.5 | 30.2 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.2 | 29.4 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.5 | 25.9 | PID PI3KCI AKT PATHWAY | Class I PI3K signaling events mediated by Akt |
| 0.8 | 21.7 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.7 | 18.5 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.2 | 17.2 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 79.2 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 5.8 | 69.4 | REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
| 0.9 | 66.0 | REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 | Genes involved in CDK-mediated phosphorylation and removal of Cdc6 |
| 1.6 | 59.1 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.4 | 51.1 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 1.4 | 50.6 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.2 | 38.1 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 1.8 | 36.0 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.9 | 35.4 | REACTOME ELONGATION ARREST AND RECOVERY | Genes involved in Elongation arrest and recovery |
| 0.4 | 31.8 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |