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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for HOXD9
Z-value: 0.31
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Transcription factors associated with HOXD9
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXD9 | hg19_v2_chr2_+_176987088_176987088 | 0.06 | 3.4e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXD9
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 11.0 | GO:0040015 | negative regulation of multicellular organism growth(GO:0040015) |
| 2.2 | 8.9 | GO:0071461 | cellular response to redox state(GO:0071461) |
| 0.1 | 8.3 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.5 | 8.0 | GO:0015671 | oxygen transport(GO:0015671) |
| 0.8 | 7.6 | GO:0031666 | positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666) |
| 1.9 | 7.5 | GO:0050717 | positive regulation of interleukin-1 alpha secretion(GO:0050717) |
| 0.1 | 6.5 | GO:2000257 | regulation of complement activation(GO:0030449) regulation of protein activation cascade(GO:2000257) |
| 1.3 | 6.4 | GO:0048539 | immunoglobulin biosynthetic process(GO:0002378) bone marrow development(GO:0048539) |
| 0.1 | 6.4 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.2 | 5.6 | GO:0007597 | blood coagulation, intrinsic pathway(GO:0007597) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 26.2 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 17.3 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.1 | 14.2 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.0 | 12.6 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.1 | 11.5 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.6 | 8.0 | GO:0005833 | hemoglobin complex(GO:0005833) |
| 1.5 | 7.5 | GO:0097179 | protease inhibitor complex(GO:0097179) |
| 0.2 | 5.1 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.0 | 4.6 | GO:0034705 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
| 1.0 | 4.2 | GO:0097224 | sperm connecting piece(GO:0097224) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.1 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.0 | 9.8 | GO:0003823 | antigen binding(GO:0003823) |
| 0.9 | 8.9 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 0.6 | 8.0 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 0.5 | 7.4 | GO:0050700 | CARD domain binding(GO:0050700) |
| 0.2 | 6.4 | GO:0019198 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.4 | 5.1 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 1.2 | 5.0 | GO:0015254 | glycerol channel activity(GO:0015254) urea channel activity(GO:0015265) |
| 0.0 | 4.4 | GO:0004866 | endopeptidase inhibitor activity(GO:0004866) |
| 0.9 | 4.3 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.9 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.3 | 8.8 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.1 | 7.2 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.0 | 6.7 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 6.0 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 5.1 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.1 | 4.7 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.1 | 4.3 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.0 | 3.3 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 3.2 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.6 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.4 | 7.5 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.0 | 6.6 | REACTOME TOLL RECEPTOR CASCADES | Genes involved in Toll Receptor Cascades |
| 0.2 | 6.4 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 0.0 | 6.4 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.3 | 5.6 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.3 | 4.7 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.1 | 4.3 | REACTOME INWARDLY RECTIFYING K CHANNELS | Genes involved in Inwardly rectifying K+ channels |
| 0.2 | 3.5 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.1 | 3.5 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |