ISMARA results: ID4_TCF4

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for ID4_TCF4_SNAI2

Z-value: 0.76

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Transcription factors associated with ID4_TCF4_SNAI2

Gene Symbol	Gene ID	Gene Info
ID4 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000172201.6	inhibitor of DNA binding 4, HLH protein
TCF4 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000196628.9	transcription factor 4
SNAI2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000019549.4	snail family transcriptional repressor 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
SNAI2	hg19_v2_chr8_-_49834299_49834446, hg19_v2_chr8_-_49833978_49833996	-0.54	9.4e-18	Click!
TCF4	hg19_v2_chr18_-_53303123_53303190	0.33	5.2e-07	Click!
ID4	hg19_v2_chr6_+_19837592_19837621	0.25	1.5e-04	Click!

Activity profile of ID4_TCF4_SNAI2 motif

Sorted Z-values of ID4_TCF4_SNAI2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr8_+_144816303 Show fit	117.64	ENST00000533004.1	FAM83H-AS1 Ensembl NCBI GeneCards UniProt NextProt Show fit	FAM83H antisense RNA 1 (head to head)
chr3_+_49507674 Show fit	97.79	ENST00000431960.1 ENST00000452317.1 ENST00000435508.2 ENST00000452060.1 ENST00000428779.1 ENST00000419218.1 ENST00000430636.1	DAG1 Ensembl NCBI GeneCards UniProt NextProt Show fit	dystroglycan 1 (dystrophin-associated glycoprotein 1)
chr19_+_18794470 Show fit	87.25	ENST00000321949.8 ENST00000338797.6	CRTC1 Ensembl NCBI GeneCards UniProt NextProt Show fit	CREB regulated transcription coactivator 1
chr10_+_92980517 Show fit	72.90	ENST00000336126.5	PCGF5 Ensembl NCBI GeneCards UniProt NextProt Show fit	polycomb group ring finger 5
chr19_+_38755042 Show fit	72.75	ENST00000301244.7	SPINT2 Ensembl NCBI GeneCards UniProt NextProt Show fit	serine peptidase inhibitor, Kunitz type, 2
chr19_+_38755203 Show fit	72.28	ENST00000587090.1 ENST00000454580.3	SPINT2 Ensembl NCBI GeneCards UniProt NextProt Show fit	serine peptidase inhibitor, Kunitz type, 2
chr7_-_22396533 Show fit	65.33	ENST00000344041.6	RAPGEF5 Ensembl NCBI GeneCards UniProt NextProt Show fit	Rap guanine nucleotide exchange factor (GEF) 5
chr5_+_156693091 Show fit	61.40	ENST00000318218.6 ENST00000442283.2 ENST00000522463.1 ENST00000521420.1	CYFIP2 Ensembl NCBI GeneCards UniProt NextProt Show fit	cytoplasmic FMR1 interacting protein 2
chr9_+_17579084 Show fit	56.77	ENST00000380607.4	SH3GL2 Ensembl NCBI GeneCards UniProt NextProt Show fit	SH3-domain GRB2-like 2
chr1_+_60280458 Show fit	56.02	ENST00000455990.1 ENST00000371208.3	HOOK1 Ensembl NCBI GeneCards UniProt NextProt Show fit	hook microtubule-tethering protein 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of ID4_TCF4_SNAI2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.9	245.6	GO:0006958	complement activation, classical pathway(GO:0006958)
0.4	217.9	GO:0043547	positive regulation of GTPase activity(GO:0043547)
10.8	172.7	GO:0090360	platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
27.6	165.3	GO:0052565	response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565)
2.0	159.5	GO:1902476	chloride transmembrane transport(GO:1902476)
39.7	158.9	GO:0060671	epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
3.3	144.6	GO:0015701	bicarbonate transport(GO:0015701)
4.6	134.2	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
1.0	132.6	GO:0050796	regulation of insulin secretion(GO:0050796)
21.8	109.1	GO:0016476	regulation of embryonic cell shape(GO:0016476)

Showing 1 to 10 of 1,168 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	1558.6	GO:0031224	intrinsic component of membrane(GO:0031224)
0.5	570.2	GO:0005615	extracellular space(GO:0005615)
3.4	272.2	GO:0030672	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
3.1	231.7	GO:0016328	lateral plasma membrane(GO:0016328)
7.8	195.8	GO:0008074	guanylate cyclase complex, soluble(GO:0008074)
1.3	137.6	GO:0008076	voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
1.2	131.3	GO:0043204	perikaryon(GO:0043204)
0.7	105.3	GO:0072562	blood microparticle(GO:0072562)
3.0	104.7	GO:0005859	muscle myosin complex(GO:0005859)
0.3	104.7	GO:0045202	synapse(GO:0045202)

Showing 1 to 10 of 308 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.5	406.6	GO:0004252	serine-type endopeptidase activity(GO:0004252)
3.2	343.7	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.3	284.8	GO:0003700	nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
7.8	195.8	GO:0004383	guanylate cyclase activity(GO:0004383)
0.6	164.6	GO:0005096	GTPase activator activity(GO:0005096)
1.4	128.5	GO:0003707	steroid hormone receptor activity(GO:0003707)
3.4	126.4	GO:0004683	calmodulin-dependent protein kinase activity(GO:0004683)
1.2	123.6	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
3.2	114.1	GO:0030552	cAMP binding(GO:0030552)
9.4	113.2	GO:0019911	structural constituent of myelin sheath(GO:0019911)

Showing 1 to 10 of 659 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.8	253.9	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
3.5	253.8	PID RHOA PATHWAY	RhoA signaling pathway
0.8	213.5	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.5	173.6	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.7	117.5	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
10.6	116.1	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
3.3	101.0	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
1.0	96.5	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
1.6	86.1	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
1.6	76.8	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly

Showing 1 to 10 of 105 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.7	259.0	REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE	Genes involved in Nitric oxide stimulates guanylate cyclase
4.5	169.7	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.8	164.6	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.6	161.1	REACTOME GENERIC TRANSCRIPTION PATHWAY	Genes involved in Generic Transcription Pathway
1.3	109.7	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
1.8	96.3	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
8.4	92.6	REACTOME CREATION OF C4 AND C2 ACTIVATORS	Genes involved in Creation of C4 and C2 activators
0.9	91.6	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
3.9	81.3	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
2.4	81.2	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins

Showing 1 to 10 of 171 entries

Results for ID4_TCF4_SNAI2

Z-value: 0.76

Motif logo

Transcription factors associated with ID4_TCF4_SNAI2

Activity-expression correlation:

Activity profile of ID4_TCF4_SNAI2 motif

Sorted Z-values of ID4_TCF4_SNAI2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of ID4_TCF4_SNAI2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: