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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for IRX3
Z-value: 1.22
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Transcription factors associated with IRX3
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_91574142 Show fit | 51.27 |
ENST00000547937.1
|
decorin |
|
| chr12_-_91573132 Show fit | 47.06 |
ENST00000550563.1
ENST00000546370.1 |
decorin |
|
| chr8_+_84824920 Show fit | 46.35 |
ENST00000523678.1
|
RP11-120I21.2 |
|
| chr13_-_88323218 Show fit | 44.48 |
ENST00000436290.2
ENST00000453832.2 ENST00000606590.1 |
MIR4500 host gene (non-protein coding) |
|
| chr12_-_91573316 Show fit | 37.64 |
ENST00000393155.1
|
decorin |
|
| chr12_-_91546926 Show fit | 34.07 |
ENST00000550758.1
|
decorin |
|
| chr16_-_30032610 Show fit | 33.47 |
ENST00000574405.1
|
double C2-like domains, alpha |
|
| chr12_-_91573249 Show fit | 33.44 |
ENST00000550099.1
ENST00000546391.1 ENST00000551354.1 |
decorin |
|
| chr5_+_54320078 Show fit | 32.22 |
ENST00000231009.2
|
granzyme K (granzyme 3; tryptase II) |
|
| chr7_+_20686946 Show fit | 25.37 |
ENST00000443026.2
ENST00000406935.1 |
ATP-binding cassette, sub-family B (MDR/TAP), member 5 |
Network of associatons between targets according to the STRING database.
First level regulatory network of IRX3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 17.7 | 212.3 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 1.0 | 93.5 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 1.0 | 71.4 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.9 | 44.5 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 3.4 | 44.4 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
| 0.3 | 41.0 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.8 | 32.5 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 3.6 | 32.1 | GO:2000501 | regulation of natural killer cell chemotaxis(GO:2000501) |
| 1.7 | 31.3 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 2.2 | 29.0 | GO:0045059 | positive thymic T cell selection(GO:0045059) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 227.4 | GO:0005615 | extracellular space(GO:0005615) |
| 14.5 | 203.5 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.5 | 92.4 | GO:0072562 | blood microparticle(GO:0072562) |
| 1.1 | 57.3 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 52.9 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 2.5 | 35.7 | GO:0005833 | hemoglobin complex(GO:0005833) |
| 0.6 | 31.4 | GO:0001533 | cornified envelope(GO:0001533) |
| 2.0 | 31.3 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.2 | 29.5 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 2.6 | 29.0 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 196.8 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.7 | 125.1 | GO:0003823 | antigen binding(GO:0003823) |
| 1.0 | 57.3 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.3 | 56.9 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.5 | 54.4 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.9 | 44.5 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.7 | 36.4 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.2 | 31.4 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 1.0 | 31.3 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.0 | 28.7 | GO:0005509 | calcium ion binding(GO:0005509) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.7 | 207.1 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.5 | 133.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.4 | 63.9 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.5 | 26.7 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.6 | 21.7 | PID S1P S1P3 PATHWAY | S1P3 pathway |
| 0.4 | 21.2 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.3 | 18.0 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.2 | 17.0 | ST INTEGRIN SIGNALING PATHWAY | Integrin Signaling Pathway |
| 0.1 | 16.6 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 15.0 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.5 | 203.5 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.9 | 44.5 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 2.2 | 44.4 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.1 | 29.3 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 1.3 | 29.0 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.3 | 26.0 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.4 | 24.2 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.4 | 23.7 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.6 | 23.4 | REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 4.3 | 21.7 | REACTOME BINDING AND ENTRY OF HIV VIRION | Genes involved in Binding and entry of HIV virion |