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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for KLF3
Z-value: 0.31
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Transcription factors associated with KLF3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| KLF3 | hg19_v2_chr4_+_38665810_38665827 | 0.22 | 8.5e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of KLF3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 17.5 | GO:0071105 | response to interleukin-11(GO:0071105) |
| 1.2 | 16.3 | GO:2001199 | negative regulation of dendritic cell differentiation(GO:2001199) |
| 3.4 | 13.7 | GO:0030037 | actin filament reorganization involved in cell cycle(GO:0030037) |
| 0.1 | 12.9 | GO:0060333 | interferon-gamma-mediated signaling pathway(GO:0060333) |
| 3.1 | 12.5 | GO:0006050 | mannosamine metabolic process(GO:0006050) N-acetylmannosamine metabolic process(GO:0006051) |
| 0.1 | 11.7 | GO:0071277 | cellular response to calcium ion(GO:0071277) |
| 3.8 | 11.3 | GO:1902490 | regulation of sperm capacitation(GO:1902490) |
| 1.6 | 9.9 | GO:0070537 | histone H2A K63-linked deubiquitination(GO:0070537) |
| 1.8 | 8.8 | GO:0099590 | neurotransmitter receptor internalization(GO:0099590) |
| 0.4 | 8.6 | GO:0006853 | carnitine shuttle(GO:0006853) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 30.2 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.2 | 20.1 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.2 | 15.0 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.1 | 14.3 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.6 | 12.8 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.1 | 12.0 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.5 | 11.6 | GO:0030122 | AP-2 adaptor complex(GO:0030122) |
| 0.6 | 11.3 | GO:0097225 | sperm midpiece(GO:0097225) |
| 0.9 | 9.9 | GO:0070531 | BRCA1-A complex(GO:0070531) |
| 0.6 | 9.3 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 22.1 | GO:0031702 | type 1 angiotensin receptor binding(GO:0031702) |
| 0.2 | 18.3 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 1.2 | 17.4 | GO:0050693 | LBD domain binding(GO:0050693) |
| 0.2 | 13.2 | GO:0070063 | RNA polymerase binding(GO:0070063) |
| 0.7 | 12.5 | GO:0019992 | diacylglycerol binding(GO:0019992) |
| 0.5 | 11.6 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 3.7 | 11.0 | GO:0045127 | N-acetylglucosamine kinase activity(GO:0045127) |
| 0.5 | 10.8 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
| 0.0 | 8.7 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 1.7 | 8.6 | GO:0004095 | carnitine O-palmitoyltransferase activity(GO:0004095) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 21.6 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.2 | 17.3 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.3 | 16.8 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.2 | 13.8 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.2 | 13.0 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.2 | 12.7 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.2 | 8.9 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 8.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 8.1 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.8 | 8.0 | ST IL 13 PATHWAY | Interleukin 13 (IL-13) Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 21.2 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.4 | 19.2 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.6 | 17.1 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 0.5 | 11.1 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.3 | 9.8 | REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
| 0.4 | 8.8 | REACTOME RETROGRADE NEUROTROPHIN SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
| 0.4 | 8.0 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.1 | 7.9 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.3 | 7.7 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.1 | 6.6 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |