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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for KLF7

Z-value: 1.01

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Transcription factors associated with KLF7

Gene Symbol Gene ID Gene Info
KLF7
ENSG00000118263.10 Kruppel like factor 7

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
KLF7hg19_v2_chr2_-_208030647_208030689,
hg19_v2_chr2_-_208031943_208031991		0.322.0e-06Click!

Activity profile of KLF7 motif

Sorted Z-values of KLF7 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_-_39390440 7.22 ENST00000249396.7
ENST00000414941.1
ENST00000392081.2
SIRT2
sirtuin 2
chr1_-_19229014 6.74 ENST00000538839.1
ENST00000290597.5
ALDH4A1
aldehyde dehydrogenase 4 family, member A1
chr16_+_31539197 6.70 ENST00000564707.1
AHSP
alpha hemoglobin stabilizing protein
chr1_-_19229248 6.69 ENST00000375341.3
ALDH4A1
aldehyde dehydrogenase 4 family, member A1
chr19_-_39390350 6.60 ENST00000447739.1
ENST00000358931.5
ENST00000407552.1
SIRT2
sirtuin 2
chr17_-_18218237 6.28 ENST00000542570.1
TOP3A
topoisomerase (DNA) III alpha
chr15_+_74422585 5.93 ENST00000561740.1
ENST00000435464.1
ENST00000453268.2
ISLR2
immunoglobulin superfamily containing leucine-rich repeat 2
chr1_-_21948906 5.61 ENST00000374761.2
ENST00000599760.1
RAP1GAP
RAP1 GTPase activating protein
chr16_+_31539183 5.54 ENST00000302312.4
AHSP
alpha hemoglobin stabilizing protein
chr1_-_157108266 5.15 ENST00000326786.4
ETV3
ets variant 3
chr8_-_6837602 4.60 ENST00000382692.2
DEFA1
defensin, alpha 1
chr6_-_33239712 4.50 ENST00000436044.2
VPS52
vacuolar protein sorting 52 homolog (S. cerevisiae)
chr8_-_6875778 4.07 ENST00000535841.1
ENST00000327857.2
DEFA1B
DEFA3
defensin, alpha 1B
defensin, alpha 3, neutrophil-specific
chr6_+_31865552 3.78 ENST00000469372.1
ENST00000497706.1
C2
complement component 2
chrX_-_92928557 3.71 ENST00000373079.3
ENST00000475430.2
NAP1L3
nucleosome assembly protein 1-like 3
chr2_+_67624430 3.69 ENST00000272342.5
ETAA1
Ewing tumor-associated antigen 1
chr15_+_92937144 3.39 ENST00000539113.1
ENST00000555434.1
ST8SIA2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr17_-_18218270 3.23 ENST00000321105.5
TOP3A
topoisomerase (DNA) III alpha
chrX_+_102631844 2.91 ENST00000372634.1
ENST00000299872.7
NGFRAP1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr5_+_176560007 2.77 ENST00000510954.1
ENST00000354179.4
NSD1
nuclear receptor binding SET domain protein 1
chr15_+_92937058 2.56 ENST00000268164.3
ST8SIA2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr14_+_29234870 2.49 ENST00000382535.3
FOXG1
forkhead box G1
chr6_-_33239612 2.31 ENST00000482399.1
ENST00000445902.2
VPS52
vacuolar protein sorting 52 homolog (S. cerevisiae)
chr1_-_161102421 2.19 ENST00000490843.2
ENST00000368006.3
ENST00000392188.1
ENST00000545495.1
DEDD
death effector domain containing
chr1_-_161102367 2.17 ENST00000464113.1
DEDD
death effector domain containing
chr2_-_188430478 2.10 ENST00000421427.1
TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr17_-_19281203 1.78 ENST00000487415.2
B9D1
B9 protein domain 1
chr19_+_39390320 1.61 ENST00000576510.1
NFKBIB
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr7_+_49813255 1.61 ENST00000340652.4
VWC2
von Willebrand factor C domain containing 2
chr19_+_39390587 1.50 ENST00000572515.1
ENST00000392079.3
ENST00000575359.1
ENST00000313582.5
NFKBIB
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr3_-_105587879 1.47 ENST00000264122.4
ENST00000403724.1
ENST00000405772.1
CBLB
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr2_-_74710078 1.25 ENST00000290418.4
CCDC142
coiled-coil domain containing 142
chr6_-_30585009 1.24 ENST00000376511.2
PPP1R10
protein phosphatase 1, regulatory subunit 10
chr5_+_141348598 1.02 ENST00000394520.2
ENST00000347642.3
RNF14
ring finger protein 14
chr19_-_7694417 0.82 ENST00000358368.4
ENST00000534844.1
XAB2
XPA binding protein 2
chr17_+_41476327 0.78 ENST00000320033.4
ARL4D
ADP-ribosylation factor-like 4D
chr5_+_141348721 0.54 ENST00000507163.1
ENST00000394519.1
RNF14
ring finger protein 14
chr20_+_2821340 0.52 ENST00000380445.3
ENST00000380469.3
VPS16
vacuolar protein sorting 16 homolog (S. cerevisiae)
chr19_-_14629224 0.35 ENST00000254322.2
DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr9_+_130565147 0.02 ENST00000373247.2
ENST00000373245.1
ENST00000393706.2
ENST00000373228.1
FPGS
folylpolyglutamate synthase
chr13_-_108867101 0.01 ENST00000356922.4
LIG4
ligase IV, DNA, ATP-dependent

Network of associatons between targets according to the STRING database.

First level regulatory network of KLF7

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
4.6 13.8 GO:2000777 positive regulation of oocyte maturation(GO:1900195) negative regulation of NLRP3 inflammasome complex assembly(GO:1900226) positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia(GO:2000777)
3.4 13.4 GO:0019470 4-hydroxyproline catabolic process(GO:0019470)
2.3 6.8 GO:0048611 ectodermal digestive tract development(GO:0007439) embryonic ectodermal digestive tract development(GO:0048611)
1.9 5.6 GO:1903697 negative regulation of microvillus assembly(GO:1903697)
1.5 4.6 GO:0035915 pore formation in membrane of other organism(GO:0035915)
0.7 6.0 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.6 12.2 GO:0020027 hemoglobin metabolic process(GO:0020027)
0.6 9.5 GO:0006265 DNA topological change(GO:0006265)
0.4 2.8 GO:0000414 regulation of histone H3-K36 methylation(GO:0000414)
0.4 5.2 GO:0097012 cellular response to granulocyte macrophage colony-stimulating factor stimulus(GO:0097011) response to granulocyte macrophage colony-stimulating factor(GO:0097012)
0.3 3.8 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.3 2.1 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.2 4.1 GO:0002227 innate immune response in mucosa(GO:0002227)
0.2 3.7 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.1 0.8 GO:0000393 spliceosomal conformational changes to generate catalytic conformation(GO:0000393)
0.1 5.9 GO:0045773 positive regulation of axon extension(GO:0045773)
0.1 0.5 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.0 1.6 GO:0060765 regulation of androgen receptor signaling pathway(GO:0060765)
0.0 1.6 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.0 4.4 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625)
0.0 0.3 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 3.7 GO:0006334 nucleosome assembly(GO:0006334)
0.0 1.8 GO:0042733 embryonic digit morphogenesis(GO:0042733)
0.0 0.4 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 3.1 GO:0051092 positive regulation of NF-kappaB transcription factor activity(GO:0051092)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 6.8 GO:1990745 EARP complex(GO:1990745)
1.5 13.8 GO:0072687 meiotic spindle(GO:0072687)
0.9 12.2 GO:0005833 hemoglobin complex(GO:0005833)
0.2 0.8 GO:0071012 catalytic step 1 spliceosome(GO:0071012)
0.2 5.2 GO:0090568 nuclear transcriptional repressor complex(GO:0090568)
0.1 1.6 GO:0005614 interstitial matrix(GO:0005614)
0.1 1.8 GO:0036038 MKS complex(GO:0036038)
0.1 1.2 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.1 3.7 GO:0043596 nuclear replication fork(GO:0043596)
0.1 9.5 GO:0016605 PML body(GO:0016605)
0.1 8.7 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.5 GO:0030897 HOPS complex(GO:0030897)
0.0 10.9 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 3.0 GO:0055037 recycling endosome(GO:0055037)
0.0 2.1 GO:0031225 anchored component of membrane(GO:0031225)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.6 13.8 GO:0034739 histone deacetylase activity (H4-K16 specific)(GO:0034739)
2.0 12.2 GO:0030492 hemoglobin binding(GO:0030492)
1.6 9.5 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.9 2.8 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.9 6.0 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.6 13.4 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.3 5.2 GO:0017151 DEAD/H-box RNA helicase binding(GO:0017151)
0.2 1.8 GO:0008158 hedgehog receptor activity(GO:0008158)
0.1 3.7 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.1 6.8 GO:0019905 syntaxin binding(GO:0019905)
0.0 1.6 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 2.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 5.6 GO:0005096 GTPase activator activity(GO:0005096)
0.0 3.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.4 GO:0001671 ATPase activator activity(GO:0001671)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 13.8 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.2 9.5 PID ATM PATHWAY ATM pathway
0.1 7.5 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.0 2.1 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 2.7 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 2.5 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 0.3 PID CD40 PATHWAY CD40/CD40L signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 8.7 REACTOME DEFENSINS Genes involved in Defensins
0.2 6.0 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.2 3.8 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.1 5.6 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.1 9.5 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.1 3.1 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.1 2.1 REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE Genes involved in Formation of Fibrin Clot (Clotting Cascade)
0.0 13.4 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 2.9 REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE Genes involved in Cell death signalling via NRAGE, NRIF and NADE
0.0 0.8 REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex