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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for KLF7
Z-value: 1.01
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Transcription factors associated with KLF7
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| KLF7 | hg19_v2_chr2_-_208030647_208030689, hg19_v2_chr2_-_208031943_208031991 | 0.32 | 2.0e-06 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_39390440 Show fit | 7.22 |
ENST00000249396.7
ENST00000414941.1 ENST00000392081.2 |
sirtuin 2 |
|
| chr1_-_19229014 Show fit | 6.74 |
ENST00000538839.1
ENST00000290597.5 |
aldehyde dehydrogenase 4 family, member A1 |
|
| chr16_+_31539197 Show fit | 6.70 |
ENST00000564707.1
|
alpha hemoglobin stabilizing protein |
|
| chr1_-_19229248 Show fit | 6.69 |
ENST00000375341.3
|
aldehyde dehydrogenase 4 family, member A1 |
|
| chr19_-_39390350 Show fit | 6.60 |
ENST00000447739.1
ENST00000358931.5 ENST00000407552.1 |
sirtuin 2 |
|
| chr17_-_18218237 Show fit | 6.28 |
ENST00000542570.1
|
topoisomerase (DNA) III alpha |
|
| chr15_+_74422585 Show fit | 5.93 |
ENST00000561740.1
ENST00000435464.1 ENST00000453268.2 |
immunoglobulin superfamily containing leucine-rich repeat 2 |
|
| chr1_-_21948906 Show fit | 5.61 |
ENST00000374761.2
ENST00000599760.1 |
RAP1 GTPase activating protein |
|
| chr16_+_31539183 Show fit | 5.54 |
ENST00000302312.4
|
alpha hemoglobin stabilizing protein |
|
| chr1_-_157108266 Show fit | 5.15 |
ENST00000326786.4
|
ets variant 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of KLF7
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.6 | 13.8 | GO:2000777 | positive regulation of oocyte maturation(GO:1900195) negative regulation of NLRP3 inflammasome complex assembly(GO:1900226) positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia(GO:2000777) |
| 3.4 | 13.4 | GO:0019470 | 4-hydroxyproline catabolic process(GO:0019470) |
| 0.6 | 12.2 | GO:0020027 | hemoglobin metabolic process(GO:0020027) |
| 0.6 | 9.5 | GO:0006265 | DNA topological change(GO:0006265) |
| 2.3 | 6.8 | GO:0048611 | ectodermal digestive tract development(GO:0007439) embryonic ectodermal digestive tract development(GO:0048611) |
| 0.7 | 6.0 | GO:0001574 | ganglioside biosynthetic process(GO:0001574) |
| 0.1 | 5.9 | GO:0045773 | positive regulation of axon extension(GO:0045773) |
| 1.9 | 5.6 | GO:1903697 | negative regulation of microvillus assembly(GO:1903697) |
| 0.4 | 5.2 | GO:0097012 | cellular response to granulocyte macrophage colony-stimulating factor stimulus(GO:0097011) response to granulocyte macrophage colony-stimulating factor(GO:0097012) |
| 1.5 | 4.6 | GO:0035915 | pore formation in membrane of other organism(GO:0035915) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 13.8 | GO:0072687 | meiotic spindle(GO:0072687) |
| 0.9 | 12.2 | GO:0005833 | hemoglobin complex(GO:0005833) |
| 0.0 | 10.9 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.1 | 9.5 | GO:0016605 | PML body(GO:0016605) |
| 0.1 | 8.7 | GO:0005796 | Golgi lumen(GO:0005796) |
| 1.7 | 6.8 | GO:1990745 | EARP complex(GO:1990745) |
| 0.2 | 5.2 | GO:0090568 | nuclear transcriptional repressor complex(GO:0090568) |
| 0.1 | 3.7 | GO:0043596 | nuclear replication fork(GO:0043596) |
| 0.0 | 3.0 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.0 | 2.1 | GO:0031225 | anchored component of membrane(GO:0031225) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.6 | 13.8 | GO:0034739 | histone deacetylase activity (H4-K16 specific)(GO:0034739) |
| 0.6 | 13.4 | GO:0004029 | aldehyde dehydrogenase (NAD) activity(GO:0004029) |
| 2.0 | 12.2 | GO:0030492 | hemoglobin binding(GO:0030492) |
| 1.6 | 9.5 | GO:0003917 | DNA topoisomerase type I activity(GO:0003917) |
| 0.1 | 6.8 | GO:0019905 | syntaxin binding(GO:0019905) |
| 0.9 | 6.0 | GO:0003828 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828) |
| 0.0 | 5.6 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.3 | 5.2 | GO:0017151 | DEAD/H-box RNA helicase binding(GO:0017151) |
| 0.0 | 3.8 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 3.7 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 13.8 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.2 | 9.5 | PID ATM PATHWAY | ATM pathway |
| 0.1 | 7.5 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
| 0.0 | 2.7 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.0 | 2.5 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 2.1 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 0.3 | PID CD40 PATHWAY | CD40/CD40L signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 13.4 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.1 | 9.5 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.5 | 8.7 | REACTOME DEFENSINS | Genes involved in Defensins |
| 0.2 | 6.0 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.1 | 5.6 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.2 | 3.8 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.1 | 3.1 | REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI | Genes involved in RIP-mediated NFkB activation via DAI |
| 0.0 | 2.9 | REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE | Genes involved in Cell death signalling via NRAGE, NRIF and NADE |
| 0.1 | 2.1 | REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE | Genes involved in Formation of Fibrin Clot (Clotting Cascade) |
| 0.0 | 0.8 | REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX | Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex |