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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for KLF8
Z-value: 1.69
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Transcription factors associated with KLF8
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| KLF8 | hg19_v2_chrX_+_56259316_56259480 | 0.57 | 6.4e-20 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr16_+_222846 Show fit | 53.06 |
ENST00000251595.6
ENST00000397806.1 |
hemoglobin, alpha 2 |
|
| chr6_+_31865552 Show fit | 38.14 |
ENST00000469372.1
ENST00000497706.1 |
complement component 2 |
|
| chr21_-_46330545 Show fit | 36.81 |
ENST00000320216.6
ENST00000397852.1 |
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) |
|
| chr19_-_17185848 Show fit | 34.86 |
ENST00000593360.1
|
HAUS augmin-like complex, subunit 8 |
|
| chr1_+_6845384 Show fit | 34.09 |
ENST00000303635.7
|
calmodulin binding transcription activator 1 |
|
| chr16_+_226658 Show fit | 30.94 |
ENST00000320868.5
ENST00000397797.1 |
hemoglobin, alpha 1 |
|
| chr3_+_10206545 Show fit | 27.40 |
ENST00000256458.4
|
interleukin-1 receptor-associated kinase 2 |
|
| chr6_-_33048483 Show fit | 27.18 |
ENST00000419277.1
|
major histocompatibility complex, class II, DP alpha 1 |
|
| chr15_+_69222827 Show fit | 27.07 |
ENST00000310673.3
ENST00000448182.3 ENST00000260364.5 |
sperm equatorial segment protein 1 NADPH oxidase, EF-hand calcium binding domain 5 |
|
| chr17_-_42277203 Show fit | 26.83 |
ENST00000587097.1
|
ataxin 7-like 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of KLF8
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 157.9 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 2.3 | 157.0 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 1.3 | 95.3 | GO:0071277 | cellular response to calcium ion(GO:0071277) |
| 13.3 | 79.8 | GO:1902847 | macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 6.5 | 64.6 | GO:0001766 | membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580) |
| 3.5 | 62.7 | GO:0019371 | cyclooxygenase pathway(GO:0019371) |
| 1.5 | 60.2 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 3.3 | 58.9 | GO:0002523 | leukocyte migration involved in inflammatory response(GO:0002523) |
| 16.5 | 49.6 | GO:0043012 | regulation of fusion of sperm to egg plasma membrane(GO:0043012) |
| 1.1 | 46.7 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 518.2 | GO:0016021 | integral component of membrane(GO:0016021) |
| 3.3 | 152.9 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 6.5 | 104.2 | GO:0097418 | neurofibrillary tangle(GO:0097418) |
| 0.1 | 100.8 | GO:0005615 | extracellular space(GO:0005615) |
| 0.7 | 98.6 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 4.5 | 95.5 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.3 | 83.8 | GO:0019898 | extrinsic component of membrane(GO:0019898) |
| 0.8 | 83.5 | GO:0034705 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
| 0.6 | 82.2 | GO:0032587 | ruffle membrane(GO:0032587) |
| 1.0 | 77.3 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 245.2 | GO:0003823 | antigen binding(GO:0003823) |
| 3.3 | 183.9 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.6 | 134.8 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.3 | 108.3 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 1.9 | 100.7 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 4.5 | 90.2 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 7.4 | 89.2 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 4.5 | 81.6 | GO:0019992 | diacylglycerol binding(GO:0019992) |
| 0.1 | 69.3 | GO:0003700 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.6 | 66.1 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 164.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 1.0 | 126.1 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 2.2 | 110.4 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.4 | 74.3 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 1.6 | 60.2 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 1.4 | 56.5 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 0.2 | 47.0 | NABA CORE MATRISOME | Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans |
| 0.6 | 43.3 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.7 | 39.5 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 0.9 | 35.4 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 147.2 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 1.7 | 141.5 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 2.7 | 125.8 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 3.9 | 82.7 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.9 | 80.7 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 3.5 | 80.5 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.4 | 78.6 | REACTOME G ALPHA Q SIGNALLING EVENTS | Genes involved in G alpha (q) signalling events |
| 0.4 | 70.0 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 1.3 | 66.8 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.6 | 57.1 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |