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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for LMX1B_MNX1_RAX2
Z-value: 0.88
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Transcription factors associated with LMX1B_MNX1_RAX2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000136944.13 | LIM homeobox transcription factor 1 beta | |
| ENSG00000130675.10 | motor neuron and pancreas homeobox 1 | |
| ENSG00000173976.11 | retina and anterior neural fold homeobox 2 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RAX2 | hg19_v2_chr19_-_3772209_3772236 | -0.37 | 2.5e-08 | Click! |
| LMX1B | hg19_v2_chr9_+_129376722_129376748 | -0.22 | 8.7e-04 | Click! |
| MNX1 | hg19_v2_chr7_-_156803329_156803362 | 0.03 | 6.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_169418195 Show fit | 26.05 |
ENST00000261509.6
ENST00000335742.7 |
palladin, cytoskeletal associated protein |
|
| chr2_-_136678123 Show fit | 15.97 |
ENST00000422708.1
|
aspartyl-tRNA synthetase |
|
| chr12_+_28410128 Show fit | 15.15 |
ENST00000381259.1
ENST00000381256.1 |
coiled-coil domain containing 91 |
|
| chr12_-_52967600 Show fit | 13.11 |
ENST00000549343.1
ENST00000305620.2 |
keratin 74 |
|
| chr15_-_37393406 Show fit | 11.10 |
ENST00000338564.5
ENST00000558313.1 ENST00000340545.5 |
Meis homeobox 2 |
|
| chr7_+_134464414 Show fit | 10.12 |
ENST00000361901.2
|
caldesmon 1 |
|
| chr7_-_107642348 Show fit | 10.08 |
ENST00000393561.1
|
laminin, beta 1 |
|
| chr7_+_77428149 Show fit | 9.60 |
ENST00000415251.2
ENST00000275575.7 |
putative homeodomain transcription factor 2 |
|
| chr3_-_141747950 Show fit | 9.20 |
ENST00000497579.1
|
transcription factor Dp-2 (E2F dimerization partner 2) |
|
| chrX_-_106243451 Show fit | 9.01 |
ENST00000355610.4
ENST00000535534.1 |
MORC family CW-type zinc finger 4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of LMX1B_MNX1_RAX2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 28.1 | GO:0003334 | keratinocyte development(GO:0003334) |
| 5.3 | 16.0 | GO:0006422 | aspartyl-tRNA aminoacylation(GO:0006422) |
| 1.3 | 15.1 | GO:0090160 | Golgi to lysosome transport(GO:0090160) |
| 0.3 | 13.1 | GO:0045104 | intermediate filament cytoskeleton organization(GO:0045104) |
| 0.2 | 12.6 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.0 | 11.6 | GO:0006936 | muscle contraction(GO:0006936) |
| 0.2 | 11.1 | GO:0008542 | visual learning(GO:0008542) |
| 0.4 | 10.2 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
| 2.5 | 10.1 | GO:0021812 | neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812) |
| 0.2 | 9.6 | GO:0051894 | positive regulation of focal adhesion assembly(GO:0051894) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 28.2 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.5 | 26.3 | GO:0002102 | podosome(GO:0002102) |
| 0.4 | 19.3 | GO:0045095 | keratin filament(GO:0045095) |
| 1.3 | 19.0 | GO:0030478 | actin cap(GO:0030478) |
| 0.8 | 16.5 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 0.0 | 15.2 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.8 | 14.6 | GO:0033162 | melanosome membrane(GO:0033162) chitosome(GO:0045009) |
| 2.9 | 14.4 | GO:0045272 | plasma membrane respiratory chain complex I(GO:0045272) |
| 0.0 | 14.2 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 13.5 | GO:0005925 | focal adhesion(GO:0005925) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 29.9 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.7 | 19.0 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 3.2 | 16.0 | GO:0004815 | aspartate-tRNA ligase activity(GO:0004815) |
| 0.0 | 15.7 | GO:0008270 | zinc ion binding(GO:0008270) |
| 0.7 | 14.4 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
| 0.0 | 13.8 | GO:0003712 | transcription cofactor activity(GO:0003712) |
| 2.2 | 13.1 | GO:1990254 | keratin filament binding(GO:1990254) |
| 0.0 | 12.5 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.3 | 8.9 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.3 | 8.9 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.5 | PID E2F PATHWAY | E2F transcription factor network |
| 0.4 | 10.1 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 10.1 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 9.6 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.1 | 8.4 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.1 | 6.7 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
| 0.1 | 6.2 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.0 | 4.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 4.6 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.1 | 4.0 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 21.3 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.5 | 16.5 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.1 | 12.6 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 11.4 | REACTOME L1CAM INTERACTIONS | Genes involved in L1CAM interactions |
| 0.3 | 9.6 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 7.6 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.1 | 7.3 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.1 | 6.3 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.2 | 6.1 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.4 | 6.0 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |