ISMARA results: MAFF

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for MAFF_MAFG

Z-value: 0.60

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Transcription factors associated with MAFF_MAFG

Gene Symbol	Gene ID	Gene Info
MAFF Ensembl NCBI GeneCards UniProt NextProt	ENSG00000185022.7	MAF bZIP transcription factor F
MAFG Ensembl NCBI GeneCards UniProt NextProt	ENSG00000197063.6	MAF bZIP transcription factor G

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
MAFG	hg19_v2_chr17_-_79885576_79885624, hg19_v2_chr17_-_79881408_79881423	-0.10	1.4e-01	Click!
MAFF	hg19_v2_chr22_+_38609538_38609547	-0.02	7.2e-01	Click!

Activity profile of MAFF_MAFG motif

Sorted Z-values of MAFF_MAFG motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chrY_+_2709527 Show fit	36.54	ENST00000250784.8	RPS4Y1 Ensembl NCBI GeneCards UniProt NextProt Show fit	ribosomal protein S4, Y-linked 1
chr11_-_5248294 Show fit	21.18	ENST00000335295.4	HBB Ensembl NCBI GeneCards UniProt NextProt Show fit	hemoglobin, beta
chr16_+_31539197 Show fit	15.78	ENST00000564707.1	AHSP Ensembl NCBI GeneCards UniProt NextProt Show fit	alpha hemoglobin stabilizing protein
chr16_-_25122785 Show fit	15.35	ENST00000563962.1 ENST00000569920.1	RP11-449H11.1 Ensembl NCBI GeneCards UniProt NextProt Show fit	RP11-449H11.1
chr5_-_42811986 Show fit	15.31	ENST00000511224.1 ENST00000507920.1 ENST00000510965.1	SEPP1 Ensembl NCBI GeneCards UniProt NextProt Show fit	selenoprotein P, plasma, 1
chrY_+_2709906 Show fit	15.14	ENST00000430575.1	RPS4Y1 Ensembl NCBI GeneCards UniProt NextProt Show fit	ribosomal protein S4, Y-linked 1
chr5_-_42812143 Show fit	14.96	ENST00000514985.1	SEPP1 Ensembl NCBI GeneCards UniProt NextProt Show fit	selenoprotein P, plasma, 1
chr1_+_22979474 Show fit	14.69	ENST00000509305.1	C1QB Ensembl NCBI GeneCards UniProt NextProt Show fit	complement component 1, q subcomponent, B chain
chr1_+_22979676 Show fit	14.44	ENST00000432749.2 ENST00000314933.6	C1QB Ensembl NCBI GeneCards UniProt NextProt Show fit	complement component 1, q subcomponent, B chain
chr9_-_34710066 Show fit	14.13	ENST00000378792.1 ENST00000259607.2	CCL21 Ensembl NCBI GeneCards UniProt NextProt Show fit	chemokine (C-C motif) ligand 21

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of MAFF_MAFG

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	38.9	GO:0006614	SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.3	34.5	GO:0030449	regulation of complement activation(GO:0030449)
1.4	28.9	GO:0020027	hemoglobin metabolic process(GO:0020027)
5.3	21.2	GO:0030185	nitric oxide transport(GO:0030185)
0.1	18.1	GO:0071346	cellular response to interferon-gamma(GO:0071346)
4.7	14.1	GO:0097026	dendritic cell dendrite assembly(GO:0097026) regulation of dendritic cell dendrite assembly(GO:2000547)
2.3	14.1	GO:0070458	cellular detoxification of nitrogen compound(GO:0070458)
0.1	14.0	GO:0006367	transcription initiation from RNA polymerase II promoter(GO:0006367)
1.1	13.4	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.1	9.7	GO:0006687	glycosphingolipid metabolic process(GO:0006687)

Showing 1 to 10 of 200 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	53.9	GO:0005844	polysome(GO:0005844)
0.0	29.7	GO:0005615	extracellular space(GO:0005615)
5.8	29.1	GO:0005602	complement component C1 complex(GO:0005602)
2.4	28.9	GO:0005833	hemoglobin complex(GO:0005833)
5.3	21.2	GO:0031838	haptoglobin-hemoglobin complex(GO:0031838)
0.1	17.3	GO:0032993	protein-DNA complex(GO:0032993)
0.1	16.7	GO:0016323	basolateral plasma membrane(GO:0016323)
0.1	16.0	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.3	11.8	GO:0005859	muscle myosin complex(GO:0005859)
0.1	10.5	GO:0005796	Golgi lumen(GO:0005796)

Showing 1 to 10 of 98 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
8.3	50.1	GO:0030492	hemoglobin binding(GO:0030492)
0.6	46.8	GO:0019843	rRNA binding(GO:0019843)
0.2	42.6	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.6	24.5	GO:0048020	CCR chemokine receptor binding(GO:0048020)
1.5	20.1	GO:0001087	transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.2	15.1	GO:0005518	collagen binding(GO:0005518)
0.8	14.1	GO:0043295	glutathione binding(GO:0043295)
0.4	10.9	GO:0005521	lamin binding(GO:0005521)
0.3	10.4	GO:0042605	peptide antigen binding(GO:0042605)
0.7	9.7	GO:0004065	arylsulfatase activity(GO:0004065)

Showing 1 to 10 of 145 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	41.1	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2	18.9	PID AR PATHWAY	Coregulation of Androgen receptor activity
0.0	15.8	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.2	13.3	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.2	7.9	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.0	6.8	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	6.1	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.1	5.6	PID ERBB4 PATHWAY	ErbB4 signaling events
0.2	5.5	ST G ALPHA S PATHWAY	G alpha s Pathway
0.2	5.5	PID S1P S1P1 PATHWAY	S1P1 pathway

Showing 1 to 10 of 35 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	44.2	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
2.6	29.1	REACTOME CREATION OF C4 AND C2 ACTIVATORS	Genes involved in Creation of C4 and C2 activators
0.4	20.1	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.1	15.7	REACTOME MUSCLE CONTRACTION	Genes involved in Muscle contraction
0.2	14.6	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.2	13.0	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.3	11.9	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.1	11.2	REACTOME AMYLOIDS	Genes involved in Amyloids
0.7	11.0	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
0.4	9.9	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation

Showing 1 to 10 of 61 entries

Results for MAFF_MAFG

Z-value: 0.60

Motif logo

Transcription factors associated with MAFF_MAFG

Activity-expression correlation:

Activity profile of MAFF_MAFG motif

Sorted Z-values of MAFF_MAFG motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of MAFF_MAFG

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: