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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for MBD2
Z-value: 0.28
Motif logo
Transcription factors associated with MBD2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
MBD2
|
ENSG00000134046.7 | methyl-CpG binding domain protein 2 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MBD2 | hg19_v2_chr18_-_51750948_51751059 | 0.43 | 2.6e-11 | Click! |
Activity profile of MBD2 motif
Sorted Z-values of MBD2 motif
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr18_-_51750948 | 10.25 |
ENST00000583046.1
ENST00000398398.2 |
MBD2
|
methyl-CpG binding domain protein 2 |
| chr17_-_27278304 | 10.15 |
ENST00000577226.1
|
PHF12
|
PHD finger protein 12 |
| chr8_-_145688231 | 9.56 |
ENST00000530374.1
|
CYHR1
|
cysteine/histidine-rich 1 |
| chr2_+_26915584 | 8.92 |
ENST00000302909.3
|
KCNK3
|
potassium channel, subfamily K, member 3 |
| chr20_-_39317868 | 7.61 |
ENST00000373313.2
|
MAFB
|
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B |
| chrX_+_24167828 | 7.57 |
ENST00000379188.3
ENST00000419690.1 ENST00000379177.1 ENST00000304543.5 |
ZFX
|
zinc finger protein, X-linked |
| chr11_-_2160180 | 7.26 |
ENST00000381406.4
|
IGF2
|
insulin-like growth factor 2 (somatomedin A) |
| chr1_+_156698234 | 7.07 |
ENST00000368218.4
ENST00000368216.4 |
RRNAD1
|
ribosomal RNA adenine dimethylase domain containing 1 |
| chr11_-_75236867 | 6.87 |
ENST00000376282.3
ENST00000336898.3 |
GDPD5
|
glycerophosphodiester phosphodiesterase domain containing 5 |
| chr11_-_2160611 | 6.85 |
ENST00000416167.2
|
IGF2
|
insulin-like growth factor 2 (somatomedin A) |
| chr18_-_72265035 | 6.73 |
ENST00000585279.1
ENST00000580048.1 |
LINC00909
|
long intergenic non-protein coding RNA 909 |
| chr19_-_36643329 | 6.59 |
ENST00000589154.1
|
COX7A1
|
cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) |
| chr1_+_156698708 | 6.44 |
ENST00000519086.1
|
RRNAD1
|
ribosomal RNA adenine dimethylase domain containing 1 |
| chr2_-_37193606 | 6.33 |
ENST00000379213.2
ENST00000263918.4 |
STRN
|
striatin, calmodulin binding protein |
| chr3_+_14989186 | 5.89 |
ENST00000435454.1
ENST00000323373.6 |
NR2C2
|
nuclear receptor subfamily 2, group C, member 2 |
| chr8_+_30241995 | 5.87 |
ENST00000397323.4
ENST00000339877.4 ENST00000320203.4 ENST00000287771.5 |
RBPMS
|
RNA binding protein with multiple splicing |
| chr3_-_124774802 | 5.64 |
ENST00000311127.4
|
HEG1
|
heart development protein with EGF-like domains 1 |
| chr8_+_30241934 | 5.59 |
ENST00000538486.1
|
RBPMS
|
RNA binding protein with multiple splicing |
| chr17_+_17942594 | 5.57 |
ENST00000268719.4
|
GID4
|
GID complex subunit 4 |
| chr14_-_103523745 | 5.50 |
ENST00000361246.2
|
CDC42BPB
|
CDC42 binding protein kinase beta (DMPK-like) |
| chr2_-_38604398 | 5.47 |
ENST00000443098.1
ENST00000449130.1 ENST00000378954.4 ENST00000539122.1 ENST00000419554.2 ENST00000451483.1 ENST00000406122.1 |
ATL2
|
atlastin GTPase 2 |
| chr1_+_9599540 | 5.18 |
ENST00000302692.6
|
SLC25A33
|
solute carrier family 25 (pyrimidine nucleotide carrier), member 33 |
| chr17_+_17942684 | 5.12 |
ENST00000376345.3
|
GID4
|
GID complex subunit 4 |
| chr14_+_77787227 | 4.98 |
ENST00000216465.5
ENST00000361389.4 ENST00000554279.1 ENST00000557639.1 ENST00000349555.3 ENST00000556627.1 ENST00000557053.1 |
GSTZ1
|
glutathione S-transferase zeta 1 |
| chr20_-_48532019 | 4.90 |
ENST00000289431.5
|
SPATA2
|
spermatogenesis associated 2 |
| chr1_+_19923454 | 4.88 |
ENST00000602662.1
ENST00000602293.1 ENST00000322753.6 |
MINOS1-NBL1
MINOS1
|
MINOS1-NBL1 readthrough mitochondrial inner membrane organizing system 1 |
| chr13_-_80915059 | 4.72 |
ENST00000377104.3
|
SPRY2
|
sprouty homolog 2 (Drosophila) |
| chr2_+_113033164 | 4.47 |
ENST00000409871.1
ENST00000343936.4 |
ZC3H6
|
zinc finger CCCH-type containing 6 |
| chr6_+_31865552 | 4.43 |
ENST00000469372.1
ENST00000497706.1 |
C2
|
complement component 2 |
| chrY_+_2803322 | 4.32 |
ENST00000383052.1
ENST00000155093.3 ENST00000449237.1 ENST00000443793.1 |
ZFY
|
zinc finger protein, Y-linked |
| chr17_+_19552036 | 4.28 |
ENST00000581518.1
ENST00000395575.2 ENST00000584332.2 ENST00000339618.4 ENST00000579855.1 |
ALDH3A2
|
aldehyde dehydrogenase 3 family, member A2 |
| chrX_+_18443703 | 4.27 |
ENST00000379996.3
|
CDKL5
|
cyclin-dependent kinase-like 5 |
| chr2_+_9346892 | 4.27 |
ENST00000281419.3
ENST00000315273.4 |
ASAP2
|
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 |
| chr14_-_77787198 | 4.25 |
ENST00000261534.4
|
POMT2
|
protein-O-mannosyltransferase 2 |
| chr10_-_79686284 | 4.20 |
ENST00000372391.2
ENST00000372388.2 |
DLG5
|
discs, large homolog 5 (Drosophila) |
| chr3_+_33155444 | 4.10 |
ENST00000320954.6
|
CRTAP
|
cartilage associated protein |
| chr10_+_75545391 | 4.07 |
ENST00000604524.1
ENST00000605216.1 ENST00000398706.2 |
ZSWIM8
|
zinc finger, SWIM-type containing 8 |
| chrX_+_24167746 | 4.07 |
ENST00000428571.1
ENST00000539115.1 |
ZFX
|
zinc finger protein, X-linked |
| chr14_+_21538429 | 4.03 |
ENST00000298694.4
ENST00000555038.1 |
ARHGEF40
|
Rho guanine nucleotide exchange factor (GEF) 40 |
| chr14_+_21538517 | 4.02 |
ENST00000298693.3
|
ARHGEF40
|
Rho guanine nucleotide exchange factor (GEF) 40 |
| chr14_-_100070363 | 3.96 |
ENST00000380243.4
|
CCDC85C
|
coiled-coil domain containing 85C |
| chr11_-_76381781 | 3.92 |
ENST00000260061.5
ENST00000404995.1 |
LRRC32
|
leucine rich repeat containing 32 |
| chr11_+_64851729 | 3.87 |
ENST00000526791.1
ENST00000526945.1 |
ZFPL1
|
zinc finger protein-like 1 |
| chr11_+_43380459 | 3.84 |
ENST00000299240.6
ENST00000039989.4 |
TTC17
|
tetratricopeptide repeat domain 17 |
| chr6_-_10415218 | 3.83 |
ENST00000466073.1
ENST00000498450.1 |
TFAP2A
|
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) |
| chr8_+_37654693 | 3.82 |
ENST00000412232.2
|
GPR124
|
G protein-coupled receptor 124 |
| chr10_+_75545329 | 3.80 |
ENST00000604729.1
ENST00000603114.1 |
ZSWIM8
|
zinc finger, SWIM-type containing 8 |
| chr3_-_149688896 | 3.75 |
ENST00000239940.7
|
PFN2
|
profilin 2 |
| chr13_+_98795434 | 3.72 |
ENST00000376586.2
|
FARP1
|
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) |
| chr6_+_45389893 | 3.71 |
ENST00000371432.3
|
RUNX2
|
runt-related transcription factor 2 |
| chr19_-_11373128 | 3.69 |
ENST00000294618.7
|
DOCK6
|
dedicator of cytokinesis 6 |
| chr11_-_62368696 | 3.69 |
ENST00000527204.1
|
MTA2
|
metastasis associated 1 family, member 2 |
| chr12_-_115121962 | 3.69 |
ENST00000349155.2
|
TBX3
|
T-box 3 |
| chr12_+_57482665 | 3.67 |
ENST00000300131.3
|
NAB2
|
NGFI-A binding protein 2 (EGR1 binding protein 2) |
| chr7_-_19157248 | 3.60 |
ENST00000242261.5
|
TWIST1
|
twist family bHLH transcription factor 1 |
| chr12_-_124457257 | 3.54 |
ENST00000545891.1
|
CCDC92
|
coiled-coil domain containing 92 |
| chr13_+_98795505 | 3.52 |
ENST00000319562.6
|
FARP1
|
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) |
| chr2_+_242641442 | 3.51 |
ENST00000313552.6
ENST00000406941.1 |
ING5
|
inhibitor of growth family, member 5 |
| chr4_-_11430221 | 3.50 |
ENST00000514690.1
|
HS3ST1
|
heparan sulfate (glucosamine) 3-O-sulfotransferase 1 |
| chr9_-_130617029 | 3.49 |
ENST00000373203.4
|
ENG
|
endoglin |
| chr14_+_74417192 | 3.47 |
ENST00000554320.1
|
COQ6
|
coenzyme Q6 monooxygenase |
| chr1_+_43855560 | 3.44 |
ENST00000562955.1
|
SZT2
|
seizure threshold 2 homolog (mouse) |
| chr11_+_69455855 | 3.44 |
ENST00000227507.2
ENST00000536559.1 |
CCND1
|
cyclin D1 |
| chr3_+_14989076 | 3.43 |
ENST00000413118.1
ENST00000425241.1 |
NR2C2
|
nuclear receptor subfamily 2, group C, member 2 |
| chr3_-_149688502 | 3.43 |
ENST00000481767.1
ENST00000475518.1 |
PFN2
|
profilin 2 |
| chr17_-_42277203 | 3.41 |
ENST00000587097.1
|
ATXN7L3
|
ataxin 7-like 3 |
| chr3_-_53080047 | 3.39 |
ENST00000482396.1
ENST00000358080.2 ENST00000296295.6 ENST00000394752.3 |
SFMBT1
|
Scm-like with four mbt domains 1 |
| chr2_+_48541776 | 3.37 |
ENST00000413569.1
ENST00000340553.3 |
FOXN2
|
forkhead box N2 |
| chr3_-_197024394 | 3.33 |
ENST00000434148.1
ENST00000412364.2 ENST00000436682.1 ENST00000456699.2 ENST00000392380.2 |
DLG1
|
discs, large homolog 1 (Drosophila) |
| chr9_-_130616915 | 3.32 |
ENST00000344849.3
|
ENG
|
endoglin |
| chr12_+_57482877 | 3.31 |
ENST00000342556.6
ENST00000357680.4 |
NAB2
|
NGFI-A binding protein 2 (EGR1 binding protein 2) |
| chr16_-_3450963 | 3.25 |
ENST00000573327.1
ENST00000571906.1 ENST00000573830.1 ENST00000439568.2 ENST00000422427.2 ENST00000304926.3 ENST00000396852.4 |
ZSCAN32
|
zinc finger and SCAN domain containing 32 |
| chr1_+_27561104 | 3.23 |
ENST00000361771.3
|
WDTC1
|
WD and tetratricopeptide repeats 1 |
| chrX_+_49644470 | 3.23 |
ENST00000508866.2
|
USP27X
|
ubiquitin specific peptidase 27, X-linked |
| chr10_-_11653753 | 3.22 |
ENST00000609104.1
|
USP6NL
|
USP6 N-terminal like |
| chr7_-_8301869 | 3.22 |
ENST00000402384.3
|
ICA1
|
islet cell autoantigen 1, 69kDa |
| chr1_-_40237020 | 3.17 |
ENST00000327582.5
|
OXCT2
|
3-oxoacid CoA transferase 2 |
| chr19_+_36545833 | 3.16 |
ENST00000401500.2
ENST00000270301.7 ENST00000427823.2 |
WDR62
|
WD repeat domain 62 |
| chr1_+_52608046 | 3.13 |
ENST00000357206.2
ENST00000287727.3 |
ZFYVE9
|
zinc finger, FYVE domain containing 9 |
| chr12_-_124457371 | 3.11 |
ENST00000238156.3
ENST00000545037.1 |
CCDC92
|
coiled-coil domain containing 92 |
| chr5_-_180076580 | 3.09 |
ENST00000502649.1
|
FLT4
|
fms-related tyrosine kinase 4 |
| chr7_+_129251531 | 3.07 |
ENST00000393232.1
ENST00000353868.4 ENST00000539636.1 ENST00000454688.1 ENST00000223190.4 ENST00000311967.2 |
NRF1
|
nuclear respiratory factor 1 |
| chr16_-_4166186 | 3.03 |
ENST00000294016.3
|
ADCY9
|
adenylate cyclase 9 |
| chr7_-_8301682 | 3.00 |
ENST00000396675.3
ENST00000430867.1 |
ICA1
|
islet cell autoantigen 1, 69kDa |
| chr6_+_1610681 | 2.99 |
ENST00000380874.2
|
FOXC1
|
forkhead box C1 |
| chr19_-_16653226 | 2.97 |
ENST00000198939.6
|
CHERP
|
calcium homeostasis endoplasmic reticulum protein |
| chr6_-_45983581 | 2.91 |
ENST00000339561.6
|
CLIC5
|
chloride intracellular channel 5 |
| chr14_+_74416989 | 2.89 |
ENST00000334571.2
ENST00000554920.1 |
COQ6
|
coenzyme Q6 monooxygenase |
| chr18_-_812517 | 2.89 |
ENST00000584307.1
|
YES1
|
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 |
| chrX_-_17878827 | 2.89 |
ENST00000360011.1
|
RAI2
|
retinoic acid induced 2 |
| chr7_-_17980091 | 2.88 |
ENST00000409389.1
ENST00000409604.1 ENST00000428135.3 |
SNX13
|
sorting nexin 13 |
| chr20_-_590944 | 2.87 |
ENST00000246080.3
|
TCF15
|
transcription factor 15 (basic helix-loop-helix) |
| chr17_+_77681075 | 2.87 |
ENST00000397549.2
|
CTD-2116F7.1
|
CTD-2116F7.1 |
| chr5_+_153570319 | 2.85 |
ENST00000377661.2
|
GALNT10
|
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10) |
| chr11_+_76092353 | 2.84 |
ENST00000530460.1
ENST00000321844.4 |
RP11-111M22.2
|
Homo sapiens putative uncharacterized protein FLJ37770-like (LOC100506127), mRNA. |
| chr19_+_36208877 | 2.84 |
ENST00000420124.1
ENST00000222270.7 ENST00000341701.1 |
KMT2B
|
Histone-lysine N-methyltransferase 2B |
| chr1_-_156252590 | 2.84 |
ENST00000361813.5
ENST00000368267.5 |
SMG5
|
SMG5 nonsense mediated mRNA decay factor |
| chr19_+_6739662 | 2.84 |
ENST00000313285.8
ENST00000313244.9 ENST00000596758.1 |
TRIP10
|
thyroid hormone receptor interactor 10 |
| chr16_+_2022036 | 2.81 |
ENST00000568546.1
|
TBL3
|
transducin (beta)-like 3 |
| chr16_+_3451184 | 2.80 |
ENST00000575752.1
ENST00000571936.1 ENST00000344823.5 |
ZNF174
|
zinc finger protein 174 |
| chr7_+_128470431 | 2.79 |
ENST00000325888.8
ENST00000346177.6 |
FLNC
|
filamin C, gamma |
| chr19_-_49622348 | 2.79 |
ENST00000408991.2
|
C19orf73
|
chromosome 19 open reading frame 73 |
| chr19_-_16653325 | 2.76 |
ENST00000546361.2
|
CHERP
|
calcium homeostasis endoplasmic reticulum protein |
| chr12_+_107168342 | 2.75 |
ENST00000392837.4
|
RIC8B
|
RIC8 guanine nucleotide exchange factor B |
| chr3_+_71803201 | 2.74 |
ENST00000304411.2
|
GPR27
|
G protein-coupled receptor 27 |
| chr9_+_35732312 | 2.74 |
ENST00000353704.2
|
CREB3
|
cAMP responsive element binding protein 3 |
| chr7_+_40174565 | 2.73 |
ENST00000309930.5
ENST00000401647.2 ENST00000335693.4 ENST00000413931.1 ENST00000416370.1 ENST00000540834.1 |
C7orf10
|
succinylCoA:glutarate-CoA transferase |
| chr1_+_27561007 | 2.72 |
ENST00000319394.3
|
WDTC1
|
WD and tetratricopeptide repeats 1 |
| chr12_-_57400227 | 2.72 |
ENST00000300101.2
|
ZBTB39
|
zinc finger and BTB domain containing 39 |
| chr10_-_92617671 | 2.70 |
ENST00000371721.3
|
HTR7
|
5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled |
| chr12_-_42632016 | 2.69 |
ENST00000442791.3
ENST00000327791.4 ENST00000534854.2 ENST00000380788.3 ENST00000380790.4 |
YAF2
|
YY1 associated factor 2 |
| chr1_+_28052518 | 2.67 |
ENST00000530324.1
ENST00000234549.7 ENST00000373949.1 ENST00000010299.6 |
FAM76A
|
family with sequence similarity 76, member A |
| chr19_-_10341948 | 2.64 |
ENST00000590320.1
ENST00000592342.1 ENST00000588952.1 |
S1PR2
DNMT1
|
sphingosine-1-phosphate receptor 2 DNA (cytosine-5-)-methyltransferase 1 |
| chr3_+_184279566 | 2.62 |
ENST00000330394.2
|
EPHB3
|
EPH receptor B3 |
| chr3_-_88108192 | 2.61 |
ENST00000309534.6
|
CGGBP1
|
CGG triplet repeat binding protein 1 |
| chr1_+_28052456 | 2.60 |
ENST00000373954.6
ENST00000419687.2 |
FAM76A
|
family with sequence similarity 76, member A |
| chrX_-_40594755 | 2.60 |
ENST00000324817.1
|
MED14
|
mediator complex subunit 14 |
| chrX_-_17879356 | 2.60 |
ENST00000331511.1
ENST00000415486.3 ENST00000545871.1 ENST00000451717.1 |
RAI2
|
retinoic acid induced 2 |
| chr20_-_50808236 | 2.59 |
ENST00000361387.2
|
ZFP64
|
ZFP64 zinc finger protein |
| chr3_-_88108212 | 2.58 |
ENST00000482016.1
|
CGGBP1
|
CGG triplet repeat binding protein 1 |
| chr17_+_48133459 | 2.57 |
ENST00000320031.8
|
ITGA3
|
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) |
| chr11_+_64851666 | 2.57 |
ENST00000525509.1
ENST00000294258.3 ENST00000526334.1 |
ZFPL1
|
zinc finger protein-like 1 |
| chr7_-_135194822 | 2.55 |
ENST00000428680.2
ENST00000315544.5 ENST00000423368.2 ENST00000451834.1 ENST00000361528.4 ENST00000356162.4 ENST00000541284.1 |
CNOT4
|
CCR4-NOT transcription complex, subunit 4 |
| chr19_-_11308190 | 2.55 |
ENST00000586659.1
ENST00000592903.1 ENST00000589359.1 ENST00000588724.1 ENST00000432929.2 |
KANK2
|
KN motif and ankyrin repeat domains 2 |
| chr1_-_43232649 | 2.50 |
ENST00000372526.2
ENST00000236040.4 ENST00000296388.5 ENST00000397054.3 |
LEPRE1
|
leucine proline-enriched proteoglycan (leprecan) 1 |
| chr8_+_37654424 | 2.49 |
ENST00000315215.7
|
GPR124
|
G protein-coupled receptor 124 |
| chr15_+_101142722 | 2.48 |
ENST00000332783.7
ENST00000558747.1 ENST00000343276.4 |
ASB7
|
ankyrin repeat and SOCS box containing 7 |
| chr1_+_6845384 | 2.47 |
ENST00000303635.7
|
CAMTA1
|
calmodulin binding transcription activator 1 |
| chr18_+_56530794 | 2.45 |
ENST00000590285.1
ENST00000586085.1 ENST00000589288.1 |
ZNF532
|
zinc finger protein 532 |
| chr12_+_107168418 | 2.45 |
ENST00000392839.2
ENST00000548914.1 ENST00000355478.2 ENST00000552619.1 ENST00000549643.1 |
RIC8B
|
RIC8 guanine nucleotide exchange factor B |
| chr11_-_62369291 | 2.43 |
ENST00000278823.2
|
MTA2
|
metastasis associated 1 family, member 2 |
| chr10_-_44070016 | 2.42 |
ENST00000374446.2
ENST00000426961.1 ENST00000535642.1 |
ZNF239
|
zinc finger protein 239 |
| chr20_-_48532046 | 2.41 |
ENST00000543716.1
|
SPATA2
|
spermatogenesis associated 2 |
| chr13_+_27131887 | 2.36 |
ENST00000335327.5
|
WASF3
|
WAS protein family, member 3 |
| chr5_-_39425290 | 2.35 |
ENST00000545653.1
|
DAB2
|
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) |
| chr10_-_92617437 | 2.33 |
ENST00000336152.3
ENST00000277874.6 ENST00000371719.2 |
HTR7
|
5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled |
| chr22_-_50746027 | 2.31 |
ENST00000425954.1
ENST00000449103.1 |
PLXNB2
|
plexin B2 |
| chr18_-_812231 | 2.30 |
ENST00000314574.4
|
YES1
|
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 |
| chr9_-_3525968 | 2.26 |
ENST00000382004.3
ENST00000302303.1 ENST00000449190.1 |
RFX3
|
regulatory factor X, 3 (influences HLA class II expression) |
| chr15_+_92937144 | 2.25 |
ENST00000539113.1
ENST00000555434.1 |
ST8SIA2
|
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 |
| chr2_+_176972000 | 2.24 |
ENST00000249504.5
|
HOXD11
|
homeobox D11 |
| chr1_-_160232312 | 2.24 |
ENST00000440682.1
|
DCAF8
|
DDB1 and CUL4 associated factor 8 |
| chr2_-_219537134 | 2.22 |
ENST00000295704.2
|
RNF25
|
ring finger protein 25 |
| chr1_-_156698591 | 2.22 |
ENST00000368219.1
|
ISG20L2
|
interferon stimulated exonuclease gene 20kDa-like 2 |
| chr3_-_185542817 | 2.21 |
ENST00000382199.2
|
IGF2BP2
|
insulin-like growth factor 2 mRNA binding protein 2 |
| chr3_-_185542761 | 2.19 |
ENST00000457616.2
ENST00000346192.3 |
IGF2BP2
|
insulin-like growth factor 2 mRNA binding protein 2 |
| chr22_-_50746001 | 2.17 |
ENST00000359337.4
|
PLXNB2
|
plexin B2 |
| chr2_+_219433281 | 2.17 |
ENST00000273064.6
ENST00000509807.2 ENST00000542068.1 |
RQCD1
|
RCD1 required for cell differentiation1 homolog (S. pombe) |
| chr10_+_35416223 | 2.17 |
ENST00000489321.1
ENST00000427847.2 ENST00000345491.3 ENST00000395895.2 ENST00000374728.3 ENST00000487132.1 |
CREM
|
cAMP responsive element modulator |
| chr2_+_241375069 | 2.15 |
ENST00000264039.2
|
GPC1
|
glypican 1 |
| chr20_-_30311703 | 2.13 |
ENST00000450273.1
ENST00000456404.1 ENST00000420488.1 ENST00000439267.1 |
BCL2L1
|
BCL2-like 1 |
| chr1_-_23857698 | 2.13 |
ENST00000361729.2
|
E2F2
|
E2F transcription factor 2 |
| chr6_-_10415470 | 2.11 |
ENST00000379604.2
ENST00000379613.3 |
TFAP2A
|
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) |
| chr7_-_8301768 | 2.11 |
ENST00000265577.7
|
ICA1
|
islet cell autoantigen 1, 69kDa |
| chr11_-_64684672 | 2.11 |
ENST00000377264.3
ENST00000421419.2 |
ATG2A
|
autophagy related 2A |
| chr6_+_1389989 | 2.11 |
ENST00000259806.1
|
FOXF2
|
forkhead box F2 |
| chr5_-_127873659 | 2.10 |
ENST00000262464.4
|
FBN2
|
fibrillin 2 |
| chr19_+_4007644 | 2.09 |
ENST00000262971.2
|
PIAS4
|
protein inhibitor of activated STAT, 4 |
| chr2_-_220408430 | 2.07 |
ENST00000243776.6
|
CHPF
|
chondroitin polymerizing factor |
| chr22_-_20004330 | 2.05 |
ENST00000263207.3
|
ARVCF
|
armadillo repeat gene deleted in velocardiofacial syndrome |
| chr10_-_123357910 | 2.04 |
ENST00000336553.6
ENST00000457416.2 ENST00000360144.3 ENST00000369059.1 ENST00000356226.4 ENST00000351936.6 |
FGFR2
|
fibroblast growth factor receptor 2 |
| chr20_+_20348740 | 2.04 |
ENST00000310227.1
|
INSM1
|
insulinoma-associated 1 |
| chr6_-_91296602 | 2.04 |
ENST00000369325.3
ENST00000369327.3 |
MAP3K7
|
mitogen-activated protein kinase kinase kinase 7 |
| chr17_+_46125707 | 2.03 |
ENST00000584137.1
ENST00000362042.3 ENST00000585291.1 ENST00000357480.5 |
NFE2L1
|
nuclear factor, erythroid 2-like 1 |
| chr15_+_92397051 | 2.03 |
ENST00000424469.2
|
SLCO3A1
|
solute carrier organic anion transporter family, member 3A1 |
| chr16_-_2264779 | 2.02 |
ENST00000333503.7
|
PGP
|
phosphoglycolate phosphatase |
| chr17_-_62915574 | 2.02 |
ENST00000339474.5
ENST00000581368.1 |
LRRC37A3
|
leucine rich repeat containing 37, member A3 |
| chr7_-_40174201 | 2.01 |
ENST00000306984.6
|
MPLKIP
|
M-phase specific PLK1 interacting protein |
| chr5_+_170846640 | 2.00 |
ENST00000274625.5
|
FGF18
|
fibroblast growth factor 18 |
| chr9_-_80263220 | 1.98 |
ENST00000341700.6
|
GNA14
|
guanine nucleotide binding protein (G protein), alpha 14 |
| chr5_-_171433579 | 1.96 |
ENST00000265094.5
ENST00000393802.2 |
FBXW11
|
F-box and WD repeat domain containing 11 |
| chr20_-_56284816 | 1.94 |
ENST00000395819.3
ENST00000341744.3 |
PMEPA1
|
prostate transmembrane protein, androgen induced 1 |
| chr3_-_38691119 | 1.94 |
ENST00000333535.4
ENST00000413689.1 ENST00000443581.1 ENST00000425664.1 ENST00000451551.2 |
SCN5A
|
sodium channel, voltage-gated, type V, alpha subunit |
| chr9_+_34989638 | 1.91 |
ENST00000453597.3
ENST00000335998.3 ENST00000312316.5 |
DNAJB5
|
DnaJ (Hsp40) homolog, subfamily B, member 5 |
| chr3_+_38495333 | 1.91 |
ENST00000352511.4
|
ACVR2B
|
activin A receptor, type IIB |
| chr3_+_170075436 | 1.89 |
ENST00000476188.1
ENST00000259119.4 ENST00000426052.2 |
SKIL
|
SKI-like oncogene |
| chr16_+_4897632 | 1.88 |
ENST00000262376.6
|
UBN1
|
ubinuclein 1 |
| chr1_-_149982624 | 1.87 |
ENST00000417191.1
ENST00000369135.4 |
OTUD7B
|
OTU domain containing 7B |
| chr1_+_82266053 | 1.87 |
ENST00000370715.1
ENST00000370713.1 ENST00000319517.6 ENST00000370717.2 ENST00000394879.1 ENST00000271029.4 ENST00000335786.5 |
LPHN2
|
latrophilin 2 |
| chr8_-_57123815 | 1.85 |
ENST00000316981.3
ENST00000423799.2 ENST00000429357.2 |
PLAG1
|
pleiomorphic adenoma gene 1 |
| chr6_-_91296737 | 1.85 |
ENST00000369332.3
ENST00000369329.3 |
MAP3K7
|
mitogen-activated protein kinase kinase kinase 7 |
| chr7_-_128171123 | 1.83 |
ENST00000608477.1
|
RP11-212P7.2
|
RP11-212P7.2 |
| chr10_-_123357598 | 1.82 |
ENST00000358487.5
ENST00000369058.3 ENST00000369060.4 ENST00000359354.2 |
FGFR2
|
fibroblast growth factor receptor 2 |
| chr1_-_36022979 | 1.82 |
ENST00000469892.1
ENST00000325722.3 |
KIAA0319L
|
KIAA0319-like |
| chr17_+_48638371 | 1.80 |
ENST00000360761.4
ENST00000352832.5 ENST00000354983.4 |
CACNA1G
|
calcium channel, voltage-dependent, T type, alpha 1G subunit |
| chr1_+_156084461 | 1.79 |
ENST00000347559.2
ENST00000361308.4 ENST00000368300.4 ENST00000368299.3 |
LMNA
|
lamin A/C |
| chr14_+_103851712 | 1.78 |
ENST00000440884.3
ENST00000416682.2 ENST00000429436.2 ENST00000303622.9 |
MARK3
|
MAP/microtubule affinity-regulating kinase 3 |
| chr7_+_96634850 | 1.75 |
ENST00000518156.2
|
DLX6
|
distal-less homeobox 6 |
| chr9_+_35605274 | 1.73 |
ENST00000336395.5
|
TESK1
|
testis-specific kinase 1 |
| chr5_+_76506706 | 1.72 |
ENST00000340978.3
ENST00000346042.3 ENST00000264917.5 ENST00000342343.4 ENST00000333194.4 |
PDE8B
|
phosphodiesterase 8B |
| chr11_-_89224508 | 1.71 |
ENST00000525196.1
|
NOX4
|
NADPH oxidase 4 |
| chr6_+_148663729 | 1.71 |
ENST00000367467.3
|
SASH1
|
SAM and SH3 domain containing 1 |
| chr16_+_57769635 | 1.70 |
ENST00000379661.3
ENST00000562592.1 ENST00000566726.1 |
KATNB1
|
katanin p80 (WD repeat containing) subunit B 1 |
| chr15_+_92937058 | 1.69 |
ENST00000268164.3
|
ST8SIA2
|
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 |
| chrX_+_68725084 | 1.68 |
ENST00000252338.4
|
FAM155B
|
family with sequence similarity 155, member B |
| chr12_+_68042517 | 1.68 |
ENST00000393555.3
|
DYRK2
|
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 |
| chr17_-_46690839 | 1.67 |
ENST00000498634.2
|
HOXB8
|
homeobox B8 |
| chr20_-_30310797 | 1.66 |
ENST00000422920.1
|
BCL2L1
|
BCL2-like 1 |
| chrX_+_152953505 | 1.66 |
ENST00000253122.5
|
SLC6A8
|
solute carrier family 6 (neurotransmitter transporter), member 8 |
| chr1_+_156338993 | 1.65 |
ENST00000368249.1
ENST00000368246.2 ENST00000537040.1 ENST00000400992.2 ENST00000255013.3 ENST00000451864.2 |
RHBG
|
Rh family, B glycoprotein (gene/pseudogene) |
Network of associatons between targets according to the STRING database.
First level regulatory network of MBD2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 7.6 | GO:0035283 | rhombomere 5 development(GO:0021571) central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284) |
| 2.3 | 6.8 | GO:0001300 | chronological cell aging(GO:0001300) |
| 1.7 | 5.2 | GO:0006864 | pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519) |
| 1.6 | 4.7 | GO:0060437 | lung growth(GO:0060437) |
| 1.6 | 14.1 | GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) |
| 1.5 | 5.9 | GO:0003409 | optic cup structural organization(GO:0003409) |
| 1.3 | 3.9 | GO:0060667 | fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow(GO:0035602) fibroblast growth factor receptor signaling pathway involved in hemopoiesis(GO:0035603) fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow(GO:0035604) fibroblast growth factor receptor signaling pathway involved in mammary gland specification(GO:0060595) mammary gland bud formation(GO:0060615) branch elongation involved in salivary gland morphogenesis(GO:0060667) mesenchymal cell differentiation involved in lung development(GO:0060915) |
| 1.3 | 5.0 | GO:0007198 | adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198) |
| 1.2 | 4.9 | GO:2000793 | cell proliferation involved in heart valve development(GO:2000793) |
| 1.2 | 3.6 | GO:0060926 | cardiac pacemaker cell differentiation(GO:0060920) cardiac pacemaker cell development(GO:0060926) |
| 1.0 | 3.0 | GO:0003275 | apoptotic process involved in outflow tract morphogenesis(GO:0003275) negative regulation of lymphangiogenesis(GO:1901491) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256) |
| 0.9 | 6.5 | GO:0035331 | negative regulation of hippo signaling(GO:0035331) |
| 0.9 | 13.8 | GO:0006346 | methylation-dependent chromatin silencing(GO:0006346) |
| 0.8 | 4.2 | GO:1904098 | regulation of protein O-linked glycosylation(GO:1904098) positive regulation of protein O-linked glycosylation(GO:1904100) |
| 0.8 | 2.5 | GO:1901420 | negative regulation of vitamin D receptor signaling pathway(GO:0070563) negative regulation of response to alcohol(GO:1901420) |
| 0.8 | 4.2 | GO:0006990 | positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990) |
| 0.8 | 8.9 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
| 0.8 | 5.6 | GO:0090270 | fibroblast growth factor production(GO:0090269) regulation of fibroblast growth factor production(GO:0090270) |
| 0.8 | 4.0 | GO:1902231 | positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231) |
| 0.8 | 13.8 | GO:0060391 | positive regulation of SMAD protein import into nucleus(GO:0060391) |
| 0.8 | 3.1 | GO:0061643 | chemorepulsion of dopaminergic neuron axon(GO:0036518) chemorepulsion of axon(GO:0061643) |
| 0.8 | 2.3 | GO:0002071 | glandular epithelial cell maturation(GO:0002071) type B pancreatic cell maturation(GO:0072560) |
| 0.7 | 2.9 | GO:1904491 | protein localization to ciliary transition zone(GO:1904491) |
| 0.7 | 5.7 | GO:0051533 | positive regulation of NFAT protein import into nucleus(GO:0051533) |
| 0.7 | 5.0 | GO:0006572 | tyrosine catabolic process(GO:0006572) |
| 0.7 | 7.0 | GO:1902949 | positive regulation of tau-protein kinase activity(GO:1902949) |
| 0.7 | 3.4 | GO:1901668 | regulation of superoxide dismutase activity(GO:1901668) |
| 0.7 | 6.9 | GO:0048505 | regulation of development, heterochronic(GO:0040034) regulation of timing of cell differentiation(GO:0048505) |
| 0.7 | 2.0 | GO:0003358 | noradrenergic neuron development(GO:0003358) |
| 0.7 | 13.5 | GO:0031167 | rRNA methylation(GO:0031167) |
| 0.6 | 3.2 | GO:0035617 | stress granule disassembly(GO:0035617) |
| 0.6 | 3.2 | GO:0046952 | ketone body catabolic process(GO:0046952) |
| 0.6 | 7.2 | GO:1900028 | negative regulation of ruffle assembly(GO:1900028) |
| 0.6 | 0.6 | GO:0072054 | renal inner medulla development(GO:0072053) renal outer medulla development(GO:0072054) |
| 0.6 | 0.6 | GO:0035625 | epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway(GO:0035625) |
| 0.6 | 0.6 | GO:0021913 | regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913) |
| 0.6 | 1.7 | GO:0070634 | transepithelial ammonium transport(GO:0070634) |
| 0.5 | 2.7 | GO:1900738 | positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738) |
| 0.5 | 3.8 | GO:0060154 | cellular process regulating host cell cycle in response to virus(GO:0060154) |
| 0.5 | 3.7 | GO:0086046 | membrane depolarization during SA node cell action potential(GO:0086046) |
| 0.5 | 1.5 | GO:0061386 | closure of optic fissure(GO:0061386) |
| 0.5 | 2.0 | GO:0006114 | glycerol biosynthetic process(GO:0006114) |
| 0.5 | 2.0 | GO:2000546 | positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546) |
| 0.5 | 3.9 | GO:0001574 | ganglioside biosynthetic process(GO:0001574) |
| 0.5 | 3.3 | GO:1903760 | regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1903760) |
| 0.5 | 3.7 | GO:0002051 | osteoblast fate commitment(GO:0002051) |
| 0.4 | 1.3 | GO:0003099 | vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025) positive regulation of the force of heart contraction by chemical signal(GO:0003099) |
| 0.4 | 5.7 | GO:0048227 | plasma membrane to endosome transport(GO:0048227) |
| 0.4 | 2.2 | GO:0090258 | negative regulation of mitochondrial fission(GO:0090258) |
| 0.4 | 2.2 | GO:0030200 | heparan sulfate proteoglycan catabolic process(GO:0030200) |
| 0.4 | 4.3 | GO:0001561 | fatty acid alpha-oxidation(GO:0001561) |
| 0.4 | 2.1 | GO:1990086 | lens fiber cell apoptotic process(GO:1990086) |
| 0.4 | 1.7 | GO:0031117 | positive regulation of microtubule depolymerization(GO:0031117) |
| 0.4 | 1.2 | GO:0072076 | nephrogenic mesenchyme development(GO:0072076) |
| 0.4 | 1.2 | GO:0033159 | negative regulation of protein import into nucleus, translocation(GO:0033159) |
| 0.4 | 1.6 | GO:0002028 | regulation of sodium ion transport(GO:0002028) |
| 0.4 | 1.2 | GO:0072092 | olfactory bulb mitral cell layer development(GO:0061034) ureteric bud invasion(GO:0072092) |
| 0.4 | 4.0 | GO:0090037 | positive regulation of protein kinase C signaling(GO:0090037) |
| 0.4 | 1.4 | GO:0072674 | multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675) |
| 0.4 | 2.9 | GO:0045198 | establishment of epithelial cell apical/basal polarity(GO:0045198) |
| 0.4 | 1.8 | GO:0035105 | sterol regulatory element binding protein import into nucleus(GO:0035105) |
| 0.3 | 1.7 | GO:0030047 | actin modification(GO:0030047) |
| 0.3 | 4.4 | GO:2000427 | positive regulation of apoptotic cell clearance(GO:2000427) |
| 0.3 | 1.0 | GO:1900224 | positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900224) |
| 0.3 | 1.3 | GO:0042271 | susceptibility to natural killer cell mediated cytotoxicity(GO:0042271) |
| 0.3 | 6.4 | GO:1901663 | ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663) |
| 0.3 | 1.3 | GO:0048073 | regulation of eye pigmentation(GO:0048073) |
| 0.3 | 1.0 | GO:0030860 | regulation of polarized epithelial cell differentiation(GO:0030860) |
| 0.3 | 1.0 | GO:0061743 | motor learning(GO:0061743) |
| 0.3 | 2.9 | GO:0060088 | auditory receptor cell stereocilium organization(GO:0060088) |
| 0.3 | 2.7 | GO:0035583 | sequestering of TGFbeta in extracellular matrix(GO:0035583) |
| 0.3 | 0.9 | GO:0051138 | synaptic vesicle recycling via endosome(GO:0036466) positive regulation of NK T cell differentiation(GO:0051138) |
| 0.3 | 3.4 | GO:0033601 | positive regulation of mammary gland epithelial cell proliferation(GO:0033601) |
| 0.3 | 5.9 | GO:0045717 | negative regulation of fatty acid biosynthetic process(GO:0045717) |
| 0.3 | 2.5 | GO:0032000 | positive regulation of fatty acid beta-oxidation(GO:0032000) |
| 0.3 | 1.1 | GO:0007185 | transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185) |
| 0.3 | 1.9 | GO:0032927 | positive regulation of activin receptor signaling pathway(GO:0032927) |
| 0.3 | 1.6 | GO:0016080 | synaptic vesicle targeting(GO:0016080) |
| 0.3 | 0.8 | GO:0046726 | positive regulation by virus of viral protein levels in host cell(GO:0046726) |
| 0.2 | 1.2 | GO:0042631 | cellular response to water deprivation(GO:0042631) |
| 0.2 | 3.9 | GO:0046007 | negative regulation of activated T cell proliferation(GO:0046007) |
| 0.2 | 1.9 | GO:0035871 | protein K11-linked deubiquitination(GO:0035871) |
| 0.2 | 5.1 | GO:0007183 | SMAD protein complex assembly(GO:0007183) |
| 0.2 | 0.9 | GO:0006049 | UDP-N-acetylglucosamine catabolic process(GO:0006049) |
| 0.2 | 1.1 | GO:0051532 | regulation of NFAT protein import into nucleus(GO:0051532) |
| 0.2 | 1.1 | GO:0048295 | positive regulation of isotype switching to IgE isotypes(GO:0048295) |
| 0.2 | 2.8 | GO:0072498 | embryonic skeletal joint development(GO:0072498) |
| 0.2 | 1.7 | GO:0031666 | positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666) |
| 0.2 | 1.0 | GO:0060693 | negative regulation of phosphatidylinositol biosynthetic process(GO:0010512) positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:0035793) regulation of branching involved in salivary gland morphogenesis(GO:0060693) regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:1900238) positive regulation of metanephric mesenchymal cell migration(GO:2000591) |
| 0.2 | 2.0 | GO:0060158 | phospholipase C-activating dopamine receptor signaling pathway(GO:0060158) |
| 0.2 | 6.9 | GO:0050667 | homocysteine metabolic process(GO:0050667) |
| 0.2 | 3.0 | GO:0071880 | adenylate cyclase-activating adrenergic receptor signaling pathway(GO:0071880) |
| 0.2 | 5.2 | GO:0036120 | response to platelet-derived growth factor(GO:0036119) cellular response to platelet-derived growth factor stimulus(GO:0036120) |
| 0.2 | 3.9 | GO:0002726 | positive regulation of T cell cytokine production(GO:0002726) |
| 0.2 | 2.0 | GO:0048096 | chromatin-mediated maintenance of transcription(GO:0048096) |
| 0.2 | 2.6 | GO:0022038 | corpus callosum development(GO:0022038) |
| 0.2 | 1.6 | GO:0042090 | interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075) |
| 0.2 | 2.1 | GO:0042249 | establishment of planar polarity of embryonic epithelium(GO:0042249) |
| 0.2 | 1.6 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
| 0.2 | 0.9 | GO:0051933 | amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935) |
| 0.2 | 1.7 | GO:0006600 | creatine metabolic process(GO:0006600) |
| 0.1 | 0.9 | GO:0045629 | negative regulation of T-helper 2 cell differentiation(GO:0045629) |
| 0.1 | 1.2 | GO:0070544 | histone H3-K36 demethylation(GO:0070544) |
| 0.1 | 0.7 | GO:0035811 | negative regulation of urine volume(GO:0035811) |
| 0.1 | 0.4 | GO:0021919 | BMP signaling pathway involved in spinal cord dorsal/ventral patterning(GO:0021919) |
| 0.1 | 0.4 | GO:0006109 | regulation of carbohydrate metabolic process(GO:0006109) |
| 0.1 | 0.7 | GO:0018125 | peptidyl-cysteine methylation(GO:0018125) minus-end-directed organelle transport along microtubule(GO:0072385) |
| 0.1 | 1.9 | GO:0060252 | positive regulation of glial cell proliferation(GO:0060252) |
| 0.1 | 4.5 | GO:2001222 | regulation of neuron migration(GO:2001222) |
| 0.1 | 0.4 | GO:1901873 | regulation of post-translational protein modification(GO:1901873) |
| 0.1 | 1.8 | GO:0010668 | ectodermal cell differentiation(GO:0010668) nail development(GO:0035878) |
| 0.1 | 0.6 | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) |
| 0.1 | 2.7 | GO:0070536 | protein K63-linked deubiquitination(GO:0070536) |
| 0.1 | 2.6 | GO:0097062 | dendritic spine maintenance(GO:0097062) |
| 0.1 | 4.8 | GO:0010762 | regulation of fibroblast migration(GO:0010762) |
| 0.1 | 0.6 | GO:0060117 | auditory receptor cell development(GO:0060117) |
| 0.1 | 1.0 | GO:2000096 | positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096) |
| 0.1 | 2.0 | GO:0015732 | prostaglandin transport(GO:0015732) |
| 0.1 | 5.5 | GO:0007029 | endoplasmic reticulum organization(GO:0007029) |
| 0.1 | 3.7 | GO:0006783 | heme biosynthetic process(GO:0006783) |
| 0.1 | 1.7 | GO:1990035 | calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035) |
| 0.1 | 4.3 | GO:0060999 | positive regulation of dendritic spine development(GO:0060999) |
| 0.1 | 2.6 | GO:0042753 | positive regulation of circadian rhythm(GO:0042753) |
| 0.1 | 1.6 | GO:0007016 | cytoskeletal anchoring at plasma membrane(GO:0007016) |
| 0.1 | 0.9 | GO:1900452 | regulation of long term synaptic depression(GO:1900452) |
| 0.1 | 1.6 | GO:0031643 | positive regulation of myelination(GO:0031643) |
| 0.1 | 0.9 | GO:0035999 | tetrahydrofolate interconversion(GO:0035999) |
| 0.1 | 7.0 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.1 | 2.1 | GO:0044804 | nucleophagy(GO:0044804) |
| 0.1 | 0.2 | GO:1900220 | semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220) |
| 0.1 | 1.7 | GO:0021516 | dorsal spinal cord development(GO:0021516) |
| 0.1 | 1.1 | GO:0032464 | positive regulation of protein homooligomerization(GO:0032464) |
| 0.1 | 1.3 | GO:2000311 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311) |
| 0.1 | 0.3 | GO:0072033 | renal vesicle formation(GO:0072033) |
| 0.1 | 3.2 | GO:0007099 | centriole replication(GO:0007099) |
| 0.1 | 1.2 | GO:0060716 | labyrinthine layer blood vessel development(GO:0060716) |
| 0.1 | 1.1 | GO:0090162 | establishment of epithelial cell polarity(GO:0090162) |
| 0.1 | 1.6 | GO:0010172 | embryonic body morphogenesis(GO:0010172) |
| 0.1 | 2.4 | GO:0006198 | cAMP catabolic process(GO:0006198) |
| 0.1 | 2.8 | GO:0000462 | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462) |
| 0.1 | 3.4 | GO:0048635 | negative regulation of muscle organ development(GO:0048635) |
| 0.1 | 1.1 | GO:1902187 | negative regulation of viral release from host cell(GO:1902187) |
| 0.1 | 2.8 | GO:0048747 | muscle fiber development(GO:0048747) |
| 0.1 | 0.7 | GO:0030263 | apoptotic chromosome condensation(GO:0030263) |
| 0.1 | 1.1 | GO:0006828 | manganese ion transport(GO:0006828) |
| 0.1 | 1.3 | GO:0032012 | regulation of ARF protein signal transduction(GO:0032012) |
| 0.1 | 2.0 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.1 | 3.4 | GO:0035914 | skeletal muscle cell differentiation(GO:0035914) |
| 0.1 | 7.2 | GO:1902600 | hydrogen ion transmembrane transport(GO:1902600) |
| 0.1 | 2.2 | GO:0030206 | chondroitin sulfate biosynthetic process(GO:0030206) |
| 0.1 | 1.8 | GO:0090503 | RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503) |
| 0.1 | 0.8 | GO:0043162 | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162) |
| 0.1 | 5.1 | GO:0031532 | actin cytoskeleton reorganization(GO:0031532) |
| 0.1 | 0.8 | GO:0031507 | heterochromatin assembly(GO:0031507) |
| 0.1 | 0.9 | GO:1901741 | positive regulation of myoblast fusion(GO:1901741) |
| 0.0 | 0.5 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
| 0.0 | 2.8 | GO:0032210 | regulation of telomere maintenance via telomerase(GO:0032210) |
| 0.0 | 0.1 | GO:0021722 | superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722) |
| 0.0 | 1.4 | GO:0098780 | response to mitochondrial depolarisation(GO:0098780) |
| 0.0 | 2.4 | GO:0050885 | neuromuscular process controlling balance(GO:0050885) |
| 0.0 | 3.8 | GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977) |
| 0.0 | 1.4 | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading(GO:1900026) |
| 0.0 | 4.4 | GO:0042035 | regulation of cytokine biosynthetic process(GO:0042035) |
| 0.0 | 7.7 | GO:0050796 | regulation of insulin secretion(GO:0050796) |
| 0.0 | 6.4 | GO:0008277 | regulation of G-protein coupled receptor protein signaling pathway(GO:0008277) |
| 0.0 | 2.2 | GO:0072171 | branching involved in ureteric bud morphogenesis(GO:0001658) ureteric bud morphogenesis(GO:0060675) mesonephric tubule morphogenesis(GO:0072171) |
| 0.0 | 0.6 | GO:0031440 | regulation of mRNA 3'-end processing(GO:0031440) |
| 0.0 | 1.3 | GO:0042472 | inner ear morphogenesis(GO:0042472) |
| 0.0 | 0.9 | GO:0045599 | negative regulation of fat cell differentiation(GO:0045599) |
| 0.0 | 2.2 | GO:0048384 | retinoic acid receptor signaling pathway(GO:0048384) |
| 0.0 | 0.7 | GO:0016578 | histone deubiquitination(GO:0016578) |
| 0.0 | 2.4 | GO:0030521 | androgen receptor signaling pathway(GO:0030521) |
| 0.0 | 1.3 | GO:0001541 | ovarian follicle development(GO:0001541) |
| 0.0 | 0.4 | GO:0034384 | high-density lipoprotein particle clearance(GO:0034384) |
| 0.0 | 1.3 | GO:0001954 | positive regulation of cell-matrix adhesion(GO:0001954) |
| 0.0 | 4.8 | GO:0007626 | locomotory behavior(GO:0007626) |
| 0.0 | 4.0 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
| 0.0 | 0.6 | GO:0045747 | positive regulation of Notch signaling pathway(GO:0045747) |
| 0.0 | 0.4 | GO:0001709 | cell fate determination(GO:0001709) |
| 0.0 | 13.9 | GO:0048232 | spermatogenesis(GO:0007283) male gamete generation(GO:0048232) |
| 0.0 | 3.8 | GO:0044782 | cilium organization(GO:0044782) |
| 0.0 | 0.1 | GO:0045212 | negative regulation of synaptic transmission, cholinergic(GO:0032223) neurotransmitter receptor biosynthetic process(GO:0045212) neurotransmitter receptor metabolic process(GO:0045213) |
| 0.0 | 0.1 | GO:0010643 | cell communication by chemical coupling(GO:0010643) |
| 0.0 | 1.1 | GO:0007077 | mitotic nuclear envelope disassembly(GO:0007077) |
| 0.0 | 1.2 | GO:0006284 | base-excision repair(GO:0006284) |
| 0.0 | 0.2 | GO:1900122 | positive regulation of receptor binding(GO:1900122) |
| 0.0 | 0.8 | GO:0043966 | histone H3 acetylation(GO:0043966) |
| 0.0 | 0.4 | GO:0006893 | Golgi to plasma membrane transport(GO:0006893) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 6.8 | GO:0072563 | endothelial microparticle(GO:0072563) |
| 0.9 | 2.6 | GO:0034667 | integrin alpha3-beta1 complex(GO:0034667) |
| 0.7 | 4.9 | GO:0061617 | MICOS complex(GO:0061617) |
| 0.6 | 1.8 | GO:0034676 | integrin alpha6-beta4 complex(GO:0034676) |
| 0.6 | 3.4 | GO:1990130 | Iml1 complex(GO:1990130) |
| 0.6 | 2.8 | GO:0034388 | Pwp2p-containing subcomplex of 90S preribosome(GO:0034388) |
| 0.5 | 4.3 | GO:0044294 | dendritic growth cone(GO:0044294) |
| 0.5 | 2.6 | GO:0070847 | core mediator complex(GO:0070847) |
| 0.4 | 2.2 | GO:0045298 | tubulin complex(GO:0045298) |
| 0.4 | 6.9 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
| 0.4 | 10.1 | GO:0016580 | Sin3 complex(GO:0016580) |
| 0.4 | 6.6 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.4 | 2.3 | GO:0032444 | activin responsive factor complex(GO:0032444) |
| 0.4 | 1.1 | GO:0097058 | CRLF-CLCF1 complex(GO:0097058) CNTFR-CLCF1 complex(GO:0097059) |
| 0.4 | 11.5 | GO:0005685 | U1 snRNP(GO:0005685) |
| 0.4 | 3.5 | GO:0070775 | H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776) |
| 0.3 | 7.3 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.3 | 2.3 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
| 0.3 | 4.2 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
| 0.3 | 3.9 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 0.3 | 3.3 | GO:0097025 | lateral loop(GO:0043219) MPP7-DLG1-LIN7 complex(GO:0097025) |
| 0.3 | 0.8 | GO:0005677 | chromatin silencing complex(GO:0005677) |
| 0.2 | 1.8 | GO:0005638 | lamin filament(GO:0005638) |
| 0.2 | 1.0 | GO:0044214 | spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717) |
| 0.2 | 6.3 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.2 | 3.2 | GO:0005682 | U5 snRNP(GO:0005682) |
| 0.2 | 1.1 | GO:0061689 | tricellular tight junction(GO:0061689) |
| 0.2 | 3.8 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.2 | 2.6 | GO:0030014 | CCR4-NOT complex(GO:0030014) |
| 0.2 | 13.7 | GO:0000792 | heterochromatin(GO:0000792) |
| 0.1 | 2.8 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.1 | 1.9 | GO:0036038 | MKS complex(GO:0036038) |
| 0.1 | 1.6 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.1 | 2.7 | GO:0001527 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.1 | 1.8 | GO:0000124 | SAGA complex(GO:0000124) |
| 0.1 | 1.4 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
| 0.1 | 1.9 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.1 | 0.7 | GO:0070381 | endosome to plasma membrane transport vesicle(GO:0070381) |
| 0.1 | 8.6 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.1 | 2.1 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
| 0.1 | 0.4 | GO:0098592 | cytoplasmic side of apical plasma membrane(GO:0098592) |
| 0.1 | 8.2 | GO:0099501 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.1 | 2.8 | GO:0005697 | telomerase holoenzyme complex(GO:0005697) |
| 0.1 | 1.6 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.1 | 1.7 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
| 0.1 | 3.6 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.1 | 0.7 | GO:0061574 | ASAP complex(GO:0061574) |
| 0.1 | 9.0 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.1 | 10.6 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.1 | 5.2 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.1 | 1.1 | GO:0035869 | ciliary transition zone(GO:0035869) |
| 0.1 | 0.5 | GO:0016012 | sarcoglycan complex(GO:0016012) |
| 0.1 | 6.6 | GO:0005746 | mitochondrial respiratory chain(GO:0005746) |
| 0.1 | 2.2 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.1 | 6.0 | GO:0016528 | sarcoplasm(GO:0016528) |
| 0.1 | 1.5 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
| 0.1 | 6.6 | GO:0005814 | centriole(GO:0005814) |
| 0.1 | 2.5 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.1 | 2.9 | GO:0036064 | ciliary basal body(GO:0036064) |
| 0.1 | 5.6 | GO:0042641 | actomyosin(GO:0042641) |
| 0.1 | 6.5 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.1 | 9.0 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.1 | 1.4 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 5.8 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 3.6 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.0 | 6.8 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.0 | 1.7 | GO:0044450 | microtubule organizing center part(GO:0044450) |
| 0.0 | 0.9 | GO:0099738 | cell cortex region(GO:0099738) |
| 0.0 | 3.5 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.0 | 1.3 | GO:0044665 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 0.0 | 2.9 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.0 | 5.6 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 0.1 | GO:0016533 | cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533) |
| 0.0 | 1.4 | GO:0097014 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
| 0.0 | 2.4 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.0 | 2.4 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.0 | 3.2 | GO:0031514 | motile cilium(GO:0031514) |
| 0.0 | 1.4 | GO:0000786 | nucleosome(GO:0000786) |
| 0.0 | 0.6 | GO:0032420 | stereocilium(GO:0032420) |
| 0.0 | 43.0 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.0 | 8.6 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.0 | 8.6 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 2.0 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.0 | 1.2 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 6.3 | GO:0005813 | centrosome(GO:0005813) |
| 0.0 | 2.0 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 1.5 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.0 | 0.5 | GO:0048770 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.0 | 0.4 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 13.5 | GO:0000179 | rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) |
| 1.7 | 5.2 | GO:0015218 | pyrimidine nucleotide transmembrane transporter activity(GO:0015218) |
| 1.7 | 6.9 | GO:0008889 | glycerophosphodiester phosphodiesterase activity(GO:0008889) |
| 1.6 | 11.5 | GO:0035614 | snRNA stem-loop binding(GO:0035614) |
| 1.4 | 4.3 | GO:0016899 | oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899) |
| 1.0 | 10.3 | GO:0003696 | satellite DNA binding(GO:0003696) |
| 0.9 | 8.9 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
| 0.9 | 6.8 | GO:0005534 | galactose binding(GO:0005534) |
| 0.8 | 3.2 | GO:0008410 | CoA-transferase activity(GO:0008410) |
| 0.7 | 4.2 | GO:0004169 | dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169) |
| 0.7 | 2.1 | GO:0050510 | N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510) |
| 0.7 | 2.0 | GO:0098519 | nucleotide phosphatase activity, acting on free nucleotides(GO:0098519) |
| 0.7 | 6.6 | GO:0019826 | oxygen sensor activity(GO:0019826) |
| 0.6 | 1.9 | GO:0086062 | voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062) |
| 0.6 | 10.1 | GO:0001222 | transcription corepressor binding(GO:0001222) |
| 0.6 | 1.8 | GO:0008332 | low voltage-gated calcium channel activity(GO:0008332) |
| 0.6 | 3.5 | GO:0008467 | [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467) |
| 0.6 | 3.9 | GO:0003828 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828) |
| 0.6 | 1.7 | GO:0015275 | stretch-activated, cation-selective, calcium channel activity(GO:0015275) |
| 0.5 | 2.2 | GO:0099609 | microtubule lateral binding(GO:0099609) |
| 0.5 | 5.1 | GO:1990380 | Lys48-specific deubiquitinase activity(GO:1990380) |
| 0.5 | 3.1 | GO:1904929 | coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929) |
| 0.5 | 18.7 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
| 0.5 | 1.4 | GO:0004616 | phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616) |
| 0.4 | 1.3 | GO:0004939 | beta-adrenergic receptor activity(GO:0004939) |
| 0.4 | 4.7 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.4 | 5.0 | GO:0051378 | amine binding(GO:0043176) serotonin binding(GO:0051378) |
| 0.4 | 2.1 | GO:0061665 | SUMO ligase activity(GO:0061665) |
| 0.4 | 1.2 | GO:0047696 | beta-adrenergic receptor kinase activity(GO:0047696) |
| 0.4 | 3.9 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
| 0.4 | 4.2 | GO:0051434 | BH3 domain binding(GO:0051434) |
| 0.4 | 2.1 | GO:0003886 | DNA (cytosine-5-)-methyltransferase activity(GO:0003886) |
| 0.3 | 2.7 | GO:0030023 | extracellular matrix constituent conferring elasticity(GO:0030023) |
| 0.3 | 4.0 | GO:0005021 | vascular endothelial growth factor-activated receptor activity(GO:0005021) |
| 0.3 | 1.6 | GO:0042289 | MHC class II protein binding(GO:0042289) |
| 0.3 | 6.3 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.3 | 1.2 | GO:0050509 | N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity(GO:0050509) |
| 0.3 | 3.3 | GO:0097016 | L27 domain binding(GO:0097016) |
| 0.3 | 1.5 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
| 0.3 | 1.5 | GO:0004095 | carnitine O-palmitoyltransferase activity(GO:0004095) |
| 0.3 | 3.0 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.3 | 1.1 | GO:0005105 | type 1 fibroblast growth factor receptor binding(GO:0005105) |
| 0.3 | 0.9 | GO:0030272 | 5-formyltetrahydrofolate cyclo-ligase activity(GO:0030272) |
| 0.3 | 6.8 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.3 | 1.7 | GO:0008568 | microtubule-severing ATPase activity(GO:0008568) |
| 0.3 | 1.9 | GO:0017002 | activin-activated receptor activity(GO:0017002) |
| 0.3 | 1.6 | GO:0003998 | acylphosphatase activity(GO:0003998) |
| 0.2 | 0.9 | GO:0003827 | alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827) |
| 0.2 | 6.6 | GO:0016676 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.2 | 7.9 | GO:0043236 | laminin binding(GO:0043236) |
| 0.2 | 1.1 | GO:0005127 | ciliary neurotrophic factor receptor binding(GO:0005127) |
| 0.2 | 0.6 | GO:0032041 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
| 0.2 | 1.2 | GO:0004118 | cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) |
| 0.2 | 8.9 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.2 | 5.0 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.2 | 4.4 | GO:0030506 | ankyrin binding(GO:0030506) |
| 0.2 | 2.6 | GO:0042809 | vitamin D receptor binding(GO:0042809) |
| 0.2 | 0.8 | GO:0008420 | CTD phosphatase activity(GO:0008420) |
| 0.2 | 2.2 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.2 | 2.7 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.2 | 0.9 | GO:0015272 | ATP-activated inward rectifier potassium channel activity(GO:0015272) |
| 0.2 | 3.8 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.2 | 4.2 | GO:0008301 | DNA binding, bending(GO:0008301) |
| 0.1 | 1.2 | GO:0051864 | histone demethylase activity (H3-K36 specific)(GO:0051864) |
| 0.1 | 5.0 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.1 | 1.3 | GO:0005113 | patched binding(GO:0005113) |
| 0.1 | 19.3 | GO:0042826 | histone deacetylase binding(GO:0042826) |
| 0.1 | 1.4 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
| 0.1 | 1.0 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.1 | 1.5 | GO:0005049 | nuclear export signal receptor activity(GO:0005049) |
| 0.1 | 4.4 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
| 0.1 | 1.2 | GO:0034483 | heparan sulfate sulfotransferase activity(GO:0034483) |
| 0.1 | 3.1 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.1 | 2.3 | GO:0070411 | I-SMAD binding(GO:0070411) |
| 0.1 | 6.4 | GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) |
| 0.1 | 2.2 | GO:0042800 | histone methyltransferase activity (H3-K4 specific)(GO:0042800) |
| 0.1 | 7.9 | GO:0003713 | transcription coactivator activity(GO:0003713) |
| 0.1 | 5.0 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
| 0.1 | 2.6 | GO:0005003 | ephrin receptor activity(GO:0005003) |
| 0.1 | 17.4 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.1 | 1.3 | GO:0001075 | transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075) |
| 0.1 | 6.1 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.1 | 1.7 | GO:0031435 | mitogen-activated protein kinase kinase kinase binding(GO:0031435) |
| 0.1 | 1.3 | GO:0000983 | transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983) |
| 0.1 | 2.8 | GO:0030515 | snoRNA binding(GO:0030515) |
| 0.1 | 8.9 | GO:0003707 | steroid hormone receptor activity(GO:0003707) |
| 0.1 | 0.3 | GO:0070026 | cystathionine beta-synthase activity(GO:0004122) oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor(GO:0016662) nitrite reductase (NO-forming) activity(GO:0050421) carbon monoxide binding(GO:0070025) nitric oxide binding(GO:0070026) nitrite reductase activity(GO:0098809) |
| 0.1 | 6.9 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.1 | 2.2 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.1 | 1.3 | GO:0070679 | inositol 1,4,5 trisphosphate binding(GO:0070679) |
| 0.1 | 2.9 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.1 | 0.6 | GO:0005138 | interleukin-6 receptor binding(GO:0005138) |
| 0.1 | 1.6 | GO:0008603 | cAMP-dependent protein kinase inhibitor activity(GO:0004862) cAMP-dependent protein kinase regulator activity(GO:0008603) |
| 0.1 | 1.6 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.1 | 1.7 | GO:0005328 | neurotransmitter:sodium symporter activity(GO:0005328) modified amino acid transmembrane transporter activity(GO:0072349) |
| 0.1 | 0.6 | GO:0004652 | polynucleotide adenylyltransferase activity(GO:0004652) |
| 0.1 | 5.2 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 0.1 | 4.4 | GO:0098811 | transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811) |
| 0.1 | 4.3 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.1 | 7.4 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.1 | 2.4 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.1 | 2.0 | GO:0015347 | sodium-independent organic anion transmembrane transporter activity(GO:0015347) |
| 0.1 | 1.3 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.1 | 0.6 | GO:0035612 | AP-2 adaptor complex binding(GO:0035612) |
| 0.1 | 1.8 | GO:0000175 | 3'-5'-exoribonuclease activity(GO:0000175) |
| 0.1 | 0.5 | GO:0090599 | alpha-glucosidase activity(GO:0090599) |
| 0.1 | 1.9 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.1 | 14.2 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.1 | 3.4 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
| 0.0 | 0.4 | GO:0043559 | insulin binding(GO:0043559) |
| 0.0 | 1.4 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.0 | 0.8 | GO:0098748 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.0 | 1.8 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 0.0 | 0.7 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.0 | 0.4 | GO:0045545 | syndecan binding(GO:0045545) |
| 0.0 | 1.8 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.0 | 5.7 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.0 | 1.0 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.0 | 11.8 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 0.6 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.0 | 0.1 | GO:0030158 | protein xylosyltransferase activity(GO:0030158) |
| 0.0 | 0.9 | GO:0008188 | neuropeptide receptor activity(GO:0008188) |
| 0.0 | 0.8 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.0 | 4.6 | GO:0061659 | ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659) |
| 0.0 | 2.1 | GO:0019003 | GDP binding(GO:0019003) |
| 0.0 | 6.6 | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981) |
| 0.0 | 0.6 | GO:0031683 | G-protein beta/gamma-subunit complex binding(GO:0031683) |
| 0.0 | 0.9 | GO:0005160 | transforming growth factor beta receptor binding(GO:0005160) |
| 0.0 | 1.9 | GO:0051087 | chaperone binding(GO:0051087) |
| 0.0 | 13.6 | GO:0008270 | zinc ion binding(GO:0008270) |
| 0.0 | 1.3 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.0 | 3.4 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 0.5 | GO:0032947 | protein complex scaffold(GO:0032947) |
| 0.0 | 4.4 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 0.4 | GO:0035064 | methylated histone binding(GO:0035064) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 14.6 | ST P38 MAPK PATHWAY | p38 MAPK Pathway |
| 0.3 | 4.5 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.2 | 6.3 | PID ER NONGENOMIC PATHWAY | Plasma membrane estrogen receptor signaling |
| 0.2 | 4.0 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.2 | 18.8 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.2 | 3.8 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.2 | 16.0 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.2 | 5.2 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.2 | 2.9 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.2 | 13.2 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.2 | 3.8 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.2 | 8.6 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.1 | 3.0 | PID S1P S1P3 PATHWAY | S1P3 pathway |
| 0.1 | 7.2 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.1 | 7.8 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 1.9 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.1 | 3.6 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.1 | 1.0 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.1 | 5.9 | PID FGF PATHWAY | FGF signaling pathway |
| 0.1 | 2.2 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 2.2 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.1 | 7.6 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 8.1 | PID AVB3 INTEGRIN PATHWAY | Integrins in angiogenesis |
| 0.1 | 2.6 | PID EPHB FWD PATHWAY | EPHB forward signaling |
| 0.1 | 7.2 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 2.2 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.1 | 1.2 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.1 | 3.0 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 3.3 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.1 | 4.0 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.1 | 1.1 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.1 | 1.6 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.1 | 2.6 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.1 | 3.3 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.1 | 1.3 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 3.3 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 1.0 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.0 | 1.0 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 2.1 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 0.4 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 1.3 | PID PI3KCI PATHWAY | Class I PI3K signaling events |
| 0.0 | 4.7 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 1.5 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 0.6 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.0 | 0.9 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.0 | 0.9 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 2.7 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 8.9 | REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS | Genes involved in Tandem pore domain potassium channels |
| 0.5 | 14.1 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.4 | 3.9 | REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION | Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
| 0.4 | 5.0 | REACTOME SEROTONIN RECEPTORS | Genes involved in Serotonin receptors |
| 0.4 | 5.9 | REACTOME FGFR2C LIGAND BINDING AND ACTIVATION | Genes involved in FGFR2c ligand binding and activation |
| 0.3 | 2.6 | REACTOME ACTIVATION OF NF KAPPAB IN B CELLS | Genes involved in Activation of NF-kappaB in B Cells |
| 0.3 | 3.8 | REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY | Genes involved in Adenylate cyclase activating pathway |
| 0.3 | 5.2 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.2 | 4.7 | REACTOME SPRY REGULATION OF FGF SIGNALING | Genes involved in Spry regulation of FGF signaling |
| 0.2 | 8.1 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.2 | 4.4 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.2 | 4.0 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.2 | 4.8 | REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.2 | 2.0 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.2 | 10.3 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.2 | 1.2 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.2 | 1.7 | REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
| 0.2 | 4.5 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 7.2 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.1 | 1.6 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.1 | 0.6 | REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.1 | 4.2 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.1 | 3.3 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.1 | 2.3 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.1 | 2.5 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.1 | 1.5 | REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION | Genes involved in RORA Activates Circadian Expression |
| 0.1 | 3.7 | REACTOME INFLAMMASOMES | Genes involved in Inflammasomes |
| 0.1 | 7.3 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 1.5 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.1 | 3.7 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.1 | 0.9 | REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
| 0.1 | 2.0 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |
| 0.1 | 0.7 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.1 | 1.6 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.1 | 2.1 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.1 | 2.4 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.1 | 2.6 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.1 | 2.2 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.1 | 1.9 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 2.5 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.0 | 1.3 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 4.6 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.0 | 0.8 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.0 | 1.3 | REACTOME AMINE LIGAND BINDING RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.0 | 1.5 | REACTOME REGULATION OF BETA CELL DEVELOPMENT | Genes involved in Regulation of beta-cell development |
| 0.0 | 1.3 | REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter |
| 0.0 | 0.6 | REACTOME PROCESSING OF INTRONLESS PRE MRNAS | Genes involved in Processing of Intronless Pre-mRNAs |
| 0.0 | 1.3 | REACTOME TRAFFICKING OF AMPA RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.0 | 1.2 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.0 | 0.8 | REACTOME SIGNALING BY NOTCH1 | Genes involved in Signaling by NOTCH1 |
| 0.0 | 0.5 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.0 | 3.1 | REACTOME DIABETES PATHWAYS | Genes involved in Diabetes pathways |
| 0.0 | 0.4 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.0 | 2.2 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 0.3 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.0 | 0.4 | REACTOME G ALPHA S SIGNALLING EVENTS | Genes involved in G alpha (s) signalling events |
| 0.0 | 0.6 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |