ISMARA results: MBD2

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for MBD2

Z-value: 0.28

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Transcription factors associated with MBD2

Gene Symbol	Gene ID	Gene Info
MBD2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000134046.7	methyl-CpG binding domain protein 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
MBD2	hg19_v2_chr18_-_51750948_51751059	0.43	2.6e-11	Click!

Activity profile of MBD2 motif

Sorted Z-values of MBD2 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr18_-_51750948 Show fit	10.25	ENST00000583046.1 ENST00000398398.2	MBD2 Ensembl NCBI GeneCards UniProt NextProt Show fit	methyl-CpG binding domain protein 2
chr17_-_27278304 Show fit	10.15	ENST00000577226.1	PHF12 Ensembl NCBI GeneCards UniProt NextProt Show fit	PHD finger protein 12
chr8_-_145688231 Show fit	9.56	ENST00000530374.1	CYHR1 Ensembl NCBI GeneCards UniProt NextProt Show fit	cysteine/histidine-rich 1
chr2_+_26915584 Show fit	8.92	ENST00000302909.3	KCNK3 Ensembl NCBI GeneCards UniProt NextProt Show fit	potassium channel, subfamily K, member 3
chr20_-_39317868 Show fit	7.61	ENST00000373313.2	MAFB Ensembl NCBI GeneCards UniProt NextProt Show fit	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
chrX_+_24167828 Show fit	7.57	ENST00000379188.3 ENST00000419690.1 ENST00000379177.1 ENST00000304543.5	ZFX Ensembl NCBI GeneCards UniProt NextProt Show fit	zinc finger protein, X-linked
chr11_-_2160180 Show fit	7.26	ENST00000381406.4	IGF2 Ensembl NCBI GeneCards UniProt NextProt Show fit	insulin-like growth factor 2 (somatomedin A)
chr1_+_156698234 Show fit	7.07	ENST00000368218.4 ENST00000368216.4	RRNAD1 Ensembl NCBI GeneCards UniProt NextProt Show fit	ribosomal RNA adenine dimethylase domain containing 1
chr11_-_75236867 Show fit	6.87	ENST00000376282.3 ENST00000336898.3	GDPD5 Ensembl NCBI GeneCards UniProt NextProt Show fit	glycerophosphodiester phosphodiesterase domain containing 5
chr11_-_2160611 Show fit	6.85	ENST00000416167.2	IGF2 Ensembl NCBI GeneCards UniProt NextProt Show fit	insulin-like growth factor 2 (somatomedin A)

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of MBD2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.6	14.1	GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.0	13.9	GO:0048232	spermatogenesis(GO:0007283) male gamete generation(GO:0048232)
0.9	13.8	GO:0006346	methylation-dependent chromatin silencing(GO:0006346)
0.8	13.8	GO:0060391	positive regulation of SMAD protein import into nucleus(GO:0060391)
0.7	13.5	GO:0031167	rRNA methylation(GO:0031167)
0.8	8.9	GO:0030322	stabilization of membrane potential(GO:0030322)
0.0	7.7	GO:0050796	regulation of insulin secretion(GO:0050796)
2.5	7.6	GO:0035283	rhombomere 5 development(GO:0021571) central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.6	7.2	GO:1900028	negative regulation of ruffle assembly(GO:1900028)
0.1	7.2	GO:1902600	hydrogen ion transmembrane transport(GO:1902600)

Showing 1 to 10 of 188 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	43.0	GO:0005887	integral component of plasma membrane(GO:0005887)
0.2	13.7	GO:0000792	heterochromatin(GO:0000792)
0.4	11.5	GO:0005685	U1 snRNP(GO:0005685)
0.1	10.6	GO:0032587	ruffle membrane(GO:0032587)
0.4	10.1	GO:0016580	Sin3 complex(GO:0016580)
0.1	9.0	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.1	9.0	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1	8.6	GO:0043195	terminal bouton(GO:0043195)
0.0	8.6	GO:0005743	mitochondrial inner membrane(GO:0005743)
0.0	8.6	GO:0005667	transcription factor complex(GO:0005667)

Showing 1 to 10 of 89 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	19.3	GO:0042826	histone deacetylase binding(GO:0042826)
0.5	18.7	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.1	17.4	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1	14.2	GO:0001077	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0	13.6	GO:0008270	zinc ion binding(GO:0008270)
2.7	13.5	GO:0000179	rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.0	11.8	GO:0005096	GTPase activator activity(GO:0005096)
1.6	11.5	GO:0035614	snRNA stem-loop binding(GO:0035614)
1.0	10.3	GO:0003696	satellite DNA binding(GO:0003696)
0.6	10.1	GO:0001222	transcription corepressor binding(GO:0001222)

Showing 1 to 10 of 135 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	18.8	PID HDAC CLASSI PATHWAY	Signaling events mediated by HDAC Class I
0.2	16.0	PID PTP1B PATHWAY	Signaling events mediated by PTP1B
0.3	14.6	ST P38 MAPK PATHWAY	p38 MAPK Pathway
0.2	13.2	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.2	8.6	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events
0.1	8.1	PID AVB3 INTEGRIN PATHWAY	Integrins in angiogenesis
0.1	7.8	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.1	7.6	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.1	7.2	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.1	7.2	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network

Showing 1 to 10 of 47 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	14.1	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2	10.3	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
1.3	8.9	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels
0.2	8.1	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.1	7.3	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.1	7.2	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.4	5.9	REACTOME FGFR2C LIGAND BINDING AND ACTIVATION	Genes involved in FGFR2c ligand binding and activation
0.3	5.2	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.4	5.0	REACTOME SEROTONIN RECEPTORS	Genes involved in Serotonin receptors
0.2	4.8	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation

Showing 1 to 10 of 57 entries

Results for MBD2

Z-value: 0.28

Motif logo

Transcription factors associated with MBD2

Activity-expression correlation:

Activity profile of MBD2 motif

Sorted Z-values of MBD2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of MBD2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: