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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for MEIS1
Z-value: 0.31
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Transcription factors associated with MEIS1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MEIS1 | hg19_v2_chr2_+_66662690_66662711 | -0.13 | 4.9e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MEIS1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 28.7 | GO:0090383 | phagosome acidification(GO:0090383) |
| 2.6 | 20.5 | GO:1900623 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 0.2 | 19.8 | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479) |
| 0.3 | 17.2 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.9 | 16.9 | GO:0032802 | low-density lipoprotein particle receptor catabolic process(GO:0032802) |
| 0.3 | 15.2 | GO:0072583 | clathrin-mediated endocytosis(GO:0072583) |
| 0.8 | 14.0 | GO:0043562 | cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562) |
| 2.7 | 13.6 | GO:0003322 | pancreatic A cell development(GO:0003322) |
| 1.2 | 13.1 | GO:2000580 | positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582) |
| 0.5 | 12.5 | GO:0070262 | peptidyl-serine dephosphorylation(GO:0070262) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 31.8 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.1 | 25.3 | GO:0030027 | lamellipodium(GO:0030027) |
| 3.1 | 21.8 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 0.1 | 19.5 | GO:0048770 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 1.2 | 17.3 | GO:0030130 | clathrin coat of trans-Golgi network vesicle(GO:0030130) |
| 0.6 | 17.0 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 1.1 | 16.9 | GO:0036020 | endolysosome membrane(GO:0036020) |
| 0.4 | 16.8 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.3 | 15.7 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 1.4 | 14.0 | GO:0008541 | proteasome regulatory particle, lid subcomplex(GO:0008541) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 26.3 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.9 | 24.4 | GO:0050750 | low-density lipoprotein particle receptor binding(GO:0050750) |
| 0.1 | 22.8 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.8 | 22.6 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.9 | 20.1 | GO:0046961 | hydrogen-exporting ATPase activity(GO:0036442) proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
| 0.2 | 18.0 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 1.2 | 14.8 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
| 0.7 | 14.7 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.6 | 14.3 | GO:0031402 | sodium ion binding(GO:0031402) |
| 0.3 | 14.0 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 25.1 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
| 0.2 | 24.1 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.7 | 23.6 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.9 | 23.2 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.2 | 19.1 | PID NFAT 3PATHWAY | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
| 0.2 | 18.4 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.3 | 10.4 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.2 | 9.7 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.3 | 9.5 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.3 | 9.4 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 41.7 | REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 1.5 | 26.8 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.3 | 22.3 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.8 | 21.9 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.6 | 19.0 | REACTOME BOTULINUM NEUROTOXICITY | Genes involved in Botulinum neurotoxicity |
| 0.9 | 16.6 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.5 | 16.0 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.1 | 15.4 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.8 | 14.7 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.3 | 13.6 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |