ISMARA results: MESP1

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for MESP1

Z-value: 0.61

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Transcription factors associated with MESP1

Gene Symbol	Gene ID	Gene Info
MESP1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000166823.5	mesoderm posterior bHLH transcription factor 1

Activity profile of MESP1 motif

Sorted Z-values of MESP1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr7_+_116165754 Show fit	26.96	ENST00000405348.1	CAV1 Ensembl NCBI GeneCards UniProt NextProt Show fit	caveolin 1, caveolae protein, 22kDa
chr3_-_182833863 Show fit	26.41	ENST00000492597.1	MCCC1 Ensembl NCBI GeneCards UniProt NextProt Show fit	methylcrotonoyl-CoA carboxylase 1 (alpha)
chr7_+_116166331 Show fit	23.66	ENST00000393468.1 ENST00000393467.1	CAV1 Ensembl NCBI GeneCards UniProt NextProt Show fit	caveolin 1, caveolae protein, 22kDa
chr19_+_16186903 Show fit	20.32	ENST00000588507.1	TPM4 Ensembl NCBI GeneCards UniProt NextProt Show fit	tropomyosin 4
chr1_-_24126023 Show fit	19.71	ENST00000429356.1	GALE Ensembl NCBI GeneCards UniProt NextProt Show fit	UDP-galactose-4-epimerase
chr12_+_53342625 Show fit	17.00	ENST00000388837.2 ENST00000550600.1 ENST00000388835.3	KRT18 Ensembl NCBI GeneCards UniProt NextProt Show fit	keratin 18
chr1_-_95392635 Show fit	16.89	ENST00000538964.1 ENST00000394202.4 ENST00000370206.4	CNN3 Ensembl NCBI GeneCards UniProt NextProt Show fit	calponin 3, acidic
chr7_+_12727250 Show fit	16.07	ENST00000404894.1	ARL4A Ensembl NCBI GeneCards UniProt NextProt Show fit	ADP-ribosylation factor-like 4A
chr11_+_86511569 Show fit	15.82	ENST00000441050.1	PRSS23 Ensembl NCBI GeneCards UniProt NextProt Show fit	protease, serine, 23
chr19_+_41725088 Show fit	15.54	ENST00000301178.4	AXL Ensembl NCBI GeneCards UniProt NextProt Show fit	AXL receptor tyrosine kinase

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of MESP1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	61.2	GO:0043687	post-translational protein modification(GO:0043687)
16.9	50.6	GO:1900085	negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
0.7	49.3	GO:0010257	NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.5	48.7	GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
1.3	40.5	GO:0008045	motor neuron axon guidance(GO:0008045)
0.8	34.0	GO:0070979	protein K11-linked ubiquitination(GO:0070979)
2.8	33.6	GO:1900028	negative regulation of ruffle assembly(GO:1900028)
2.4	31.4	GO:0019388	galactose catabolic process(GO:0019388)
5.2	31.2	GO:1902766	skeletal muscle satellite cell migration(GO:1902766)
1.9	30.7	GO:0045793	positive regulation of cell size(GO:0045793)

Showing 1 to 10 of 310 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	96.3	GO:0070062	extracellular exosome(GO:0070062)
1.2	53.9	GO:0045095	keratin filament(GO:0045095)
3.6	50.6	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
1.2	35.4	GO:0005680	anaphase-promoting complex(GO:0005680)
1.8	34.9	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.0	33.9	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
5.7	28.3	GO:0097149	centralspindlin complex(GO:0097149)
0.5	28.3	GO:0030964	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
4.0	28.1	GO:0035692	macrophage migration inhibitory factor receptor complex(GO:0035692)
2.4	26.7	GO:0005614	interstitial matrix(GO:0005614)

Showing 1 to 10 of 171 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
16.9	50.6	GO:0070320	inward rectifier potassium channel inhibitor activity(GO:0070320)
1.1	48.4	GO:0061650	ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650)
1.1	43.8	GO:0003785	actin monomer binding(GO:0003785)
0.4	37.6	GO:0017048	Rho GTPase binding(GO:0017048)
6.8	34.0	GO:0047179	platelet-activating factor acetyltransferase activity(GO:0047179)
1.2	32.6	GO:0098641	cadherin binding involved in cell-cell adhesion(GO:0098641)
0.6	32.1	GO:0008137	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
10.5	31.4	GO:0003974	UDP-N-acetylglucosamine 4-epimerase activity(GO:0003974) UDP-glucose 4-epimerase activity(GO:0003978)
0.1	31.2	GO:0003924	GTPase activity(GO:0003924)
5.3	26.4	GO:0004485	methylcrotonoyl-CoA carboxylase activity(GO:0004485)

Showing 1 to 10 of 226 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	51.2	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
1.6	50.6	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
1.2	43.0	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.3	42.4	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
1.0	41.3	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.5	31.6	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.5	28.3	PID PLK1 PATHWAY	PLK1 signaling events
0.7	24.2	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.4	24.2	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.6	24.0	PID NECTIN PATHWAY	Nectin adhesion pathway

Showing 1 to 10 of 61 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.0	66.5	REACTOME ENOS ACTIVATION AND REGULATION	Genes involved in eNOS activation and regulation
0.7	51.7	REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC	Genes involved in Regulation of ornithine decarboxylase (ODC)
1.0	41.4	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.9	37.9	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.7	36.4	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
1.3	35.4	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.4	32.1	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
1.7	31.5	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.8	28.0	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
1.0	27.0	REACTOME SEMA3A PAK DEPENDENT AXON REPULSION	Genes involved in Sema3A PAK dependent Axon repulsion

Showing 1 to 10 of 99 entries

Results for MESP1

Z-value: 0.61

Motif logo

Transcription factors associated with MESP1

Activity profile of MESP1 motif

Sorted Z-values of MESP1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of MESP1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: