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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for MLX_USF2_USF1_PAX2
Z-value: 0.60
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Transcription factors associated with MLX_USF2_USF1_PAX2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000108788.7 | MAX dimerization protein MLX | |
| ENSG00000105698.11 | upstream transcription factor 2, c-fos interacting | |
| ENSG00000158773.10 | upstream transcription factor 1 | |
| ENSG00000075891.17 | paired box 2 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| USF2 | hg19_v2_chr19_+_35759824_35759891 | 0.33 | 8.5e-07 | Click! |
| MLX | hg19_v2_chr17_+_40719073_40719092 | 0.11 | 1.0e-01 | Click! |
| PAX2 | hg19_v2_chr10_+_102505468_102505546 | 0.06 | 3.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_10764509 Show fit | 47.11 |
ENST00000591501.1
|
ILF3 antisense RNA 1 (head to head) |
|
| chr1_+_11866270 Show fit | 38.71 |
ENST00000376497.3
ENST00000376487.3 ENST00000376496.3 |
chloride channel, voltage-sensitive 6 |
|
| chr13_+_113951607 Show fit | 35.57 |
ENST00000397181.3
|
lysosomal-associated membrane protein 1 |
|
| chr19_+_1067144 Show fit | 29.60 |
ENST00000313093.2
|
histocompatibility (minor) HA-1 |
|
| chr19_+_1067492 Show fit | 29.43 |
ENST00000586866.1
|
histocompatibility (minor) HA-1 |
|
| chr1_+_11866207 Show fit | 29.28 |
ENST00000312413.6
ENST00000346436.6 |
chloride channel, voltage-sensitive 6 |
|
| chr19_+_1067271 Show fit | 29.18 |
ENST00000536472.1
ENST00000590214.1 |
histocompatibility (minor) HA-1 |
|
| chr11_+_121322832 Show fit | 28.03 |
ENST00000260197.7
|
sortilin-related receptor, L(DLR class) A repeats containing |
|
| chr19_+_10765003 Show fit | 27.40 |
ENST00000407004.3
ENST00000589998.1 ENST00000589600.1 |
interleukin enhancer binding factor 3, 90kDa |
|
| chr6_-_33385902 Show fit | 27.28 |
ENST00000374500.5
|
cutA divalent cation tolerance homolog (E. coli) |
Network of associatons between targets according to the STRING database.
First level regulatory network of MLX_USF2_USF1_PAX2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 69.7 | GO:0006884 | cell volume homeostasis(GO:0006884) |
| 1.9 | 62.0 | GO:0090383 | phagosome acidification(GO:0090383) |
| 14.8 | 59.2 | GO:0043323 | regulation of natural killer cell degranulation(GO:0043321) positive regulation of natural killer cell degranulation(GO:0043323) |
| 2.4 | 44.9 | GO:0042340 | keratan sulfate catabolic process(GO:0042340) |
| 2.6 | 40.8 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 4.3 | 38.8 | GO:1904715 | negative regulation of chaperone-mediated autophagy(GO:1904715) |
| 7.3 | 36.5 | GO:0070829 | response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829) |
| 4.1 | 36.5 | GO:0035542 | regulation of SNARE complex assembly(GO:0035542) |
| 6.4 | 32.0 | GO:0051610 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 3.1 | 31.1 | GO:0033299 | secretion of lysosomal enzymes(GO:0033299) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 168.4 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.3 | 110.7 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.1 | 88.2 | GO:0045202 | synapse(GO:0045202) |
| 7.5 | 59.7 | GO:0097208 | alveolar lamellar body(GO:0097208) |
| 1.0 | 52.9 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.3 | 52.8 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.3 | 44.4 | GO:0016605 | PML body(GO:0016605) |
| 0.5 | 44.3 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 3.0 | 42.5 | GO:0030897 | HOPS complex(GO:0030897) |
| 0.4 | 38.7 | GO:0070821 | tertiary granule membrane(GO:0070821) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 109.8 | GO:0005507 | copper ion binding(GO:0005507) |
| 3.9 | 85.4 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.7 | 68.4 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.2 | 66.7 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.2 | 63.6 | GO:0008017 | microtubule binding(GO:0008017) |
| 2.1 | 60.2 | GO:0036442 | hydrogen-exporting ATPase activity(GO:0036442) |
| 1.2 | 53.2 | GO:0050699 | WW domain binding(GO:0050699) |
| 4.3 | 47.1 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
| 2.1 | 44.9 | GO:0015929 | hexosaminidase activity(GO:0015929) |
| 7.3 | 36.5 | GO:0004489 | methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 41.0 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.5 | 38.9 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 32.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.6 | 30.9 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.6 | 29.4 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.5 | 25.1 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.8 | 24.6 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.6 | 22.3 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.6 | 20.6 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.2 | 19.6 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 95.6 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 2.0 | 64.2 | REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING | Genes involved in Transferrin endocytosis and recycling |
| 0.2 | 49.8 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 1.0 | 40.5 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.4 | 36.8 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.5 | 28.3 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 1.6 | 28.0 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 1.5 | 27.2 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.6 | 24.2 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 4.6 | 23.1 | REACTOME BINDING AND ENTRY OF HIV VIRION | Genes involved in Binding and entry of HIV virion |