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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for MYF6
Z-value: 0.01
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Transcription factors associated with MYF6
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MYF6 | hg19_v2_chr12_+_81101277_81101321 | 0.02 | 7.4e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MYF6
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 67.7 | GO:2000649 | regulation of sodium ion transmembrane transporter activity(GO:2000649) |
| 2.8 | 36.2 | GO:2000680 | rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680) |
| 2.8 | 25.5 | GO:0071787 | endoplasmic reticulum tubular network assembly(GO:0071787) |
| 1.4 | 25.1 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.8 | 24.3 | GO:0090383 | phagosome acidification(GO:0090383) |
| 0.1 | 21.7 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 5.6 | 16.8 | GO:1904395 | retinal rod cell differentiation(GO:0060221) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) |
| 0.1 | 14.1 | GO:0065004 | protein-DNA complex assembly(GO:0065004) |
| 1.3 | 13.8 | GO:0001886 | endothelial cell morphogenesis(GO:0001886) |
| 4.5 | 13.6 | GO:0033693 | neurofilament bundle assembly(GO:0033693) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 40.1 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 3.0 | 36.2 | GO:0097487 | multivesicular body, internal vesicle(GO:0097487) |
| 1.6 | 31.1 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.0 | 27.9 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 1.7 | 26.9 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.3 | 26.9 | GO:0005604 | basement membrane(GO:0005604) |
| 1.0 | 24.3 | GO:0016471 | vacuolar proton-transporting V-type ATPase complex(GO:0016471) |
| 1.6 | 21.3 | GO:0097418 | neurofibrillary tangle(GO:0097418) |
| 0.0 | 17.2 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.1 | 16.2 | GO:0099572 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 68.6 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.1 | 56.7 | GO:0005525 | GTP binding(GO:0005525) |
| 0.0 | 32.8 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.1 | 30.6 | GO:0031625 | ubiquitin protein ligase binding(GO:0031625) |
| 0.9 | 26.9 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 1.8 | 23.9 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.2 | 23.7 | GO:0016820 | hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) |
| 0.1 | 20.3 | GO:0004866 | endopeptidase inhibitor activity(GO:0004866) |
| 4.2 | 16.8 | GO:0035373 | chondroitin sulfate proteoglycan binding(GO:0035373) |
| 0.2 | 15.7 | GO:0005518 | collagen binding(GO:0005518) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 41.2 | PID INTEGRIN1 PATHWAY | Beta1 integrin cell surface interactions |
| 0.2 | 41.0 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.3 | 30.4 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.2 | 21.2 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.4 | 19.1 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.1 | 19.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.5 | 17.1 | ST GAQ PATHWAY | G alpha q Pathway |
| 0.5 | 16.3 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.1 | 11.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 11.6 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 55.4 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.4 | 28.4 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 1.2 | 24.4 | REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.8 | 24.3 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.4 | 23.5 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.6 | 18.9 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.5 | 16.8 | REACTOME BOTULINUM NEUROTOXICITY | Genes involved in Botulinum neurotoxicity |
| 0.1 | 15.3 | REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 0.3 | 12.5 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 1.7 | 12.2 | REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS | Genes involved in Tandem pore domain potassium channels |