ISMARA results: NFATC1

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for NFATC1

Z-value: 0.03

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Transcription factors associated with NFATC1

Gene Symbol	Gene ID	Gene Info
NFATC1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000131196.13	nuclear factor of activated T cells 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NFATC1	hg19_v2_chr18_+_77155942_77155951	0.09	1.8e-01	Click!

Activity profile of NFATC1 motif

Sorted Z-values of NFATC1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_-_153517473 Show fit	26.54	ENST00000368715.1	S100A4 Ensembl NCBI GeneCards UniProt NextProt Show fit	S100 calcium binding protein A4
chr14_-_92413353 Show fit	11.81	ENST00000556154.1	FBLN5 Ensembl NCBI GeneCards UniProt NextProt Show fit	fibulin 5
chr6_-_32920794 Show fit	10.06	ENST00000395305.3 ENST00000395303.3 ENST00000374843.4 ENST00000429234.1	HLA-DMA Ensembl NCBI GeneCards UniProt NextProt Show fit XXbac-BPG181M17.5 Ensembl NCBI GeneCards UniProt NextProt Show fit	major histocompatibility complex, class II, DM alpha Uncharacterized protein
chr6_+_32407619 Show fit	9.92	ENST00000395388.2 ENST00000374982.5	HLA-DRA Ensembl NCBI GeneCards UniProt NextProt Show fit	major histocompatibility complex, class II, DR alpha
chr2_-_161349909 Show fit	9.19	ENST00000392753.3	RBMS1 Ensembl NCBI GeneCards UniProt NextProt Show fit	RNA binding motif, single stranded interacting protein 1
chr3_+_152017360 Show fit	9.01	ENST00000485910.1 ENST00000463374.1	MBNL1 Ensembl NCBI GeneCards UniProt NextProt Show fit	muscleblind-like splicing regulator 1
chr4_-_71532339 Show fit	8.88	ENST00000254801.4	IGJ Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr2_+_189839046 Show fit	8.84	ENST00000304636.3 ENST00000317840.5	COL3A1 Ensembl NCBI GeneCards UniProt NextProt Show fit	collagen, type III, alpha 1
chr3_+_151986709 Show fit	8.77	ENST00000495875.2 ENST00000493459.1 ENST00000324210.5 ENST00000459747.1	MBNL1 Ensembl NCBI GeneCards UniProt NextProt Show fit	muscleblind-like splicing regulator 1
chr1_-_226926864 Show fit	8.36	ENST00000429204.1 ENST00000366784.1	ITPKB Ensembl NCBI GeneCards UniProt NextProt Show fit	inositol-trisphosphate 3-kinase B

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of NFATC1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	23.8	GO:0043484	regulation of RNA splicing(GO:0043484)
5.0	20.0	GO:0002503	peptide antigen assembly with MHC class II protein complex(GO:0002503)
0.1	19.2	GO:0001837	epithelial to mesenchymal transition(GO:0001837)
1.5	17.9	GO:0048251	elastic fiber assembly(GO:0048251)
1.4	16.5	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
1.7	13.3	GO:0002036	regulation of L-glutamate transport(GO:0002036)
0.5	11.8	GO:0035855	megakaryocyte development(GO:0035855)
0.1	10.5	GO:0030049	muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
1.1	8.8	GO:0060414	aorta smooth muscle tissue morphogenesis(GO:0060414)
1.2	8.4	GO:0033029	regulation of neutrophil apoptotic process(GO:0033029) common myeloid progenitor cell proliferation(GO:0035726)

Showing 1 to 10 of 140 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	20.0	GO:0042613	MHC class II protein complex(GO:0042613)
1.8	17.9	GO:0071953	elastic fiber(GO:0071953)
0.0	17.5	GO:0048471	perinuclear region of cytoplasm(GO:0048471)
1.2	16.5	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.2	16.4	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	13.6	GO:0016604	nuclear body(GO:0016604)
0.9	10.8	GO:0098643	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.8	10.7	GO:0031209	SCAR complex(GO:0031209)
0.0	8.3	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.1	8.2	GO:0032154	cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)

Showing 1 to 10 of 75 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	31.6	GO:0050840	extracellular matrix binding(GO:0050840)
1.3	26.5	GO:0050786	RAGE receptor binding(GO:0050786)
0.1	18.1	GO:0005178	integrin binding(GO:0005178)
5.9	17.8	GO:0001069	regulatory region RNA binding(GO:0001069)
0.5	12.9	GO:0023026	MHC class II protein complex binding(GO:0023026)
0.4	12.8	GO:0030296	protein tyrosine kinase activator activity(GO:0030296)
0.9	12.2	GO:0032395	MHC class II receptor activity(GO:0032395)
0.4	11.5	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1	10.4	GO:0008307	structural constituent of muscle(GO:0008307)
0.1	9.2	GO:0003697	single-stranded DNA binding(GO:0003697)

Showing 1 to 10 of 111 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	22.1	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1	21.7	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.3	18.2	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.1	15.7	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.3	15.3	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.2	11.3	PID AVB3 OPN PATHWAY	Osteopontin-mediated events
0.2	10.5	NABA COLLAGENS	Genes encoding collagen proteins
0.1	10.1	PID REG GR PATHWAY	Glucocorticoid receptor regulatory network
0.2	9.9	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.3	8.6	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway

Showing 1 to 10 of 39 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	18.3	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.1	11.6	REACTOME AMYLOIDS	Genes involved in Amyloids
0.2	10.5	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.1	10.1	REACTOME MHC CLASS II ANTIGEN PRESENTATION	Genes involved in MHC class II antigen presentation
0.1	8.8	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.1	8.8	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.4	6.7	REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL	Genes involved in NF-kB is activated and signals survival
0.0	6.6	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.2	6.3	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
0.1	5.8	REACTOME RNA POL III TRANSCRIPTION	Genes involved in RNA Polymerase III Transcription

Showing 1 to 10 of 55 entries

Results for NFATC1

Z-value: 0.03

Motif logo

Transcription factors associated with NFATC1

Activity-expression correlation:

Activity profile of NFATC1 motif

Sorted Z-values of NFATC1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of NFATC1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: