ISMARA results: NHLH1

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for NHLH1

Z-value: 0.71

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Transcription factors associated with NHLH1

Gene Symbol	Gene ID	Gene Info
NHLH1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000171786.5	nescient helix-loop-helix 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NHLH1	hg19_v2_chr1_+_160336851_160336868	0.24	3.6e-04	Click!

Activity profile of NHLH1 motif

Sorted Z-values of NHLH1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr16_+_23847267 Show fit	64.41	ENST00000321728.7	PRKCB Ensembl NCBI GeneCards UniProt NextProt Show fit	protein kinase C, beta
chr16_+_23847339 Show fit	47.08	ENST00000303531.7	PRKCB Ensembl NCBI GeneCards UniProt NextProt Show fit	protein kinase C, beta
chr14_+_90863327 Show fit	29.62	ENST00000356978.4	CALM1 Ensembl NCBI GeneCards UniProt NextProt Show fit	calmodulin 1 (phosphorylase kinase, delta)
chr10_+_105036909 Show fit	27.30	ENST00000369849.4	INA Ensembl NCBI GeneCards UniProt NextProt Show fit	internexin neuronal intermediate filament protein, alpha
chr8_+_24771265 Show fit	24.93	ENST00000518131.1 ENST00000437366.2	NEFM Ensembl NCBI GeneCards UniProt NextProt Show fit	neurofilament, medium polypeptide
chr8_+_24772455 Show fit	22.87	ENST00000433454.2	NEFM Ensembl NCBI GeneCards UniProt NextProt Show fit	neurofilament, medium polypeptide
chr14_+_100150622 Show fit	22.61	ENST00000261835.3	CYP46A1 Ensembl NCBI GeneCards UniProt NextProt Show fit	cytochrome P450, family 46, subfamily A, polypeptide 1
chr19_+_35521572 Show fit	19.10	ENST00000262631.5	SCN1B Ensembl NCBI GeneCards UniProt NextProt Show fit	sodium channel, voltage-gated, type I, beta subunit
chr20_+_44036900 Show fit	18.76	ENST00000443296.1	DBNDD2 Ensembl NCBI GeneCards UniProt NextProt Show fit	dysbindin (dystrobrevin binding protein 1) domain containing 2
chr20_+_44036620 Show fit	17.98	ENST00000372710.3	DBNDD2 Ensembl NCBI GeneCards UniProt NextProt Show fit	dysbindin (dystrobrevin binding protein 1) domain containing 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of NHLH1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
37.2	111.5	GO:0035408	histone H3-T6 phosphorylation(GO:0035408)
1.7	49.2	GO:2000369	regulation of clathrin-mediated endocytosis(GO:2000369)
15.9	47.8	GO:0033693	neurofilament bundle assembly(GO:0033693)
9.0	44.8	GO:0030382	sperm mitochondrion organization(GO:0030382)
10.3	41.3	GO:0006542	glutamine biosynthetic process(GO:0006542)
11.4	34.1	GO:0021966	corticospinal neuron axon guidance(GO:0021966)
1.6	31.0	GO:0006706	steroid catabolic process(GO:0006706)
9.6	28.9	GO:1905205	positive regulation of connective tissue replacement(GO:1905205)
3.9	27.3	GO:0060052	neurofilament cytoskeleton organization(GO:0060052)
3.1	25.2	GO:0051388	positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)

Showing 1 to 10 of 238 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
5.0	75.1	GO:0005883	neurofilament(GO:0005883)
0.6	57.6	GO:0005905	clathrin-coated pit(GO:0005905)
0.6	49.8	GO:0030672	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1	47.2	GO:0048471	perinuclear region of cytoplasm(GO:0048471)
0.3	45.0	GO:0000922	spindle pole(GO:0000922)
3.2	44.8	GO:0097227	sperm annulus(GO:0097227)
0.3	44.4	GO:0043204	perikaryon(GO:0043204)
2.2	41.3	GO:0097386	glial cell projection(GO:0097386)
1.2	36.2	GO:0044298	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
2.0	34.1	GO:0001518	voltage-gated sodium channel complex(GO:0001518)

Showing 1 to 10 of 105 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
37.2	111.5	GO:0035403	histone kinase activity (H3-T6 specific)(GO:0035403)
0.6	107.0	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
0.3	76.9	GO:0003924	GTPase activity(GO:0003924)
2.2	50.7	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
10.3	41.3	GO:0004356	glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.2	39.6	GO:0044325	ion channel binding(GO:0044325)
11.4	34.1	GO:0086062	voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)
2.9	28.9	GO:0033192	calmodulin-dependent protein phosphatase activity(GO:0033192)
1.1	27.4	GO:0035259	glucocorticoid receptor binding(GO:0035259)
0.9	24.3	GO:0031489	myosin V binding(GO:0031489)

Showing 1 to 10 of 159 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
5.1	111.5	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.8	52.0	ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	PI3K Pathway
0.6	28.9	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.1	21.9	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3	20.5	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.3	19.5	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.3	18.3	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.3	16.6	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.3	15.7	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.4	12.8	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III

Showing 1 to 10 of 40 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.0	111.5	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
3.2	67.4	REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR	Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
1.0	50.7	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
1.3	35.7	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
1.0	35.1	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
2.4	23.9	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.8	21.3	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.6	19.6	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.1	16.1	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.3	15.7	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels

Showing 1 to 10 of 58 entries

Results for NHLH1

Z-value: 0.71

Motif logo

Transcription factors associated with NHLH1

Activity-expression correlation:

Activity profile of NHLH1 motif

Sorted Z-values of NHLH1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of NHLH1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: