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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for NKX2-1
Z-value: 0.06
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Transcription factors associated with NKX2-1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NKX2-1 | hg19_v2_chr14_-_36989336_36989354 | 0.05 | 4.6e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NKX2-1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 24.4 | GO:0042100 | B cell proliferation(GO:0042100) |
| 0.2 | 22.6 | GO:0006903 | vesicle targeting(GO:0006903) |
| 6.6 | 19.9 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 0.1 | 13.0 | GO:0001837 | epithelial to mesenchymal transition(GO:0001837) |
| 1.7 | 10.3 | GO:0070417 | cellular response to cold(GO:0070417) |
| 0.1 | 8.8 | GO:0030183 | B cell differentiation(GO:0030183) |
| 0.5 | 7.3 | GO:0006089 | lactate metabolic process(GO:0006089) |
| 0.1 | 6.2 | GO:2000401 | regulation of lymphocyte migration(GO:2000401) |
| 0.7 | 4.6 | GO:0032596 | protein transport within lipid bilayer(GO:0032594) protein transport into membrane raft(GO:0032596) |
| 0.9 | 4.3 | GO:0002032 | desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 24.3 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.3 | 22.1 | GO:0015030 | Cajal body(GO:0015030) |
| 0.3 | 21.7 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.0 | 12.9 | GO:0045121 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
| 0.1 | 6.9 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 4.4 | GO:0035579 | specific granule membrane(GO:0035579) |
| 0.0 | 4.3 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.0 | 4.3 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.6 | 3.8 | GO:0072557 | IPAF inflammasome complex(GO:0072557) |
| 0.0 | 3.1 | GO:0016605 | PML body(GO:0016605) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 24.8 | GO:0023026 | MHC class II protein complex binding(GO:0023026) |
| 6.6 | 19.9 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 0.5 | 8.8 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.4 | 8.8 | GO:0050786 | RAGE receptor binding(GO:0050786) |
| 0.3 | 8.2 | GO:0001223 | transcription coactivator binding(GO:0001223) |
| 0.0 | 7.7 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
| 1.0 | 7.3 | GO:0004459 | lactate dehydrogenase activity(GO:0004457) L-lactate dehydrogenase activity(GO:0004459) |
| 0.0 | 4.8 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 4.6 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
| 1.4 | 4.3 | GO:0031859 | platelet activating factor receptor binding(GO:0031859) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 12.8 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.2 | 10.8 | PID PI3KCI AKT PATHWAY | Class I PI3K signaling events mediated by Akt |
| 0.2 | 8.5 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.0 | 8.0 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 4.3 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 3.5 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.1 | 2.9 | PID TRAIL PATHWAY | TRAIL signaling pathway |
| 0.0 | 2.4 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 2.3 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.1 | 2.2 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 19.9 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.3 | 9.0 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.2 | 8.8 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 0.1 | 8.0 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.3 | 7.3 | REACTOME PYRUVATE METABOLISM | Genes involved in Pyruvate metabolism |
| 0.0 | 6.9 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 6.5 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 3.8 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.1 | 3.7 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.1 | 3.4 | REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS | Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |