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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for NKX2-6
Z-value: 0.22
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Transcription factors associated with NKX2-6
Network of associatons between targets according to the STRING database.
First level regulatory network of NKX2-6
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 27.5 | GO:0045651 | positive regulation of granulocyte differentiation(GO:0030854) positive regulation of macrophage differentiation(GO:0045651) |
| 5.4 | 21.5 | GO:0071461 | cellular response to redox state(GO:0071461) |
| 0.3 | 20.1 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 3.9 | 19.3 | GO:0030382 | sperm mitochondrion organization(GO:0030382) |
| 0.2 | 12.7 | GO:0032729 | positive regulation of interferon-gamma production(GO:0032729) |
| 1.2 | 11.7 | GO:0032264 | IMP salvage(GO:0032264) |
| 0.9 | 11.1 | GO:0002315 | marginal zone B cell differentiation(GO:0002315) |
| 0.6 | 9.5 | GO:0021694 | cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702) |
| 0.1 | 8.9 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.7 | 8.4 | GO:0048007 | antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 27.5 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.1 | 27.1 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.4 | 20.1 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 1.4 | 19.3 | GO:0097227 | sperm annulus(GO:0097227) |
| 0.7 | 14.7 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.0 | 14.3 | GO:0031410 | cytoplasmic vesicle(GO:0031410) |
| 0.0 | 12.7 | GO:0098857 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
| 0.1 | 12.2 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.3 | 11.6 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.1 | 10.0 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 27.7 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 2.1 | 21.5 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 0.4 | 20.1 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.1 | 14.9 | GO:0000287 | magnesium ion binding(GO:0000287) |
| 0.4 | 14.2 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 1.3 | 11.7 | GO:0047623 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
| 2.9 | 11.6 | GO:0033829 | O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829) |
| 0.6 | 10.6 | GO:0005522 | profilin binding(GO:0005522) |
| 0.8 | 8.4 | GO:0030884 | lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884) |
| 0.7 | 7.6 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 39.5 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.3 | 24.2 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.2 | 9.5 | PID FAS PATHWAY | FAS (CD95) signaling pathway |
| 0.1 | 6.5 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.0 | 6.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.3 | 5.5 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.0 | 5.5 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.2 | 5.1 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.4 | 4.7 | ST PAC1 RECEPTOR PATHWAY | PAC1 Receptor Pathway |
| 0.0 | 3.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 24.2 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.6 | 14.2 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.5 | 11.7 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 0.5 | 11.6 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.3 | 10.6 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.1 | 10.6 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.1 | 7.6 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.1 | 7.6 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.2 | 7.4 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.2 | 6.5 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |