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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for NKX2-6

Z-value: 0.22

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Transcription factors associated with NKX2-6

Gene Symbol Gene ID Gene Info
NKX2-6
ENSG00000180053.6 NK2 homeobox 6

Activity profile of NKX2-6 motif

Sorted Z-values of NKX2-6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_121379739 27.47 ENST00000428394.2
ENST00000314583.3
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr12_-_15103621 21.47 ENST00000536592.1
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr14_-_60337684 14.32 ENST00000267484.5
RTN1
reticulon 1
chr6_+_33043703 14.24 ENST00000418931.2
ENST00000535465.1
HLA-DPB1
major histocompatibility complex, class II, DP beta 1
chr7_+_142498725 11.94 ENST00000466254.1
TRBC2
T cell receptor beta constant 2
chr22_-_37882395 11.60 ENST00000416983.3
ENST00000424765.2
ENST00000356998.3
MFNG
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr1_+_158900568 9.16 ENST00000458222.1
PYHIN1
pyrin and HIN domain family, member 1
chr17_-_26903900 7.57 ENST00000395319.3
ENST00000581807.1
ENST00000584086.1
ENST00000395321.2
ALDOC
aldolase C, fructose-bisphosphate
chr1_+_110162448 7.45 ENST00000342115.4
ENST00000469039.2
ENST00000474459.1
ENST00000528667.1
AMPD2
adenosine monophosphate deaminase 2
chr17_-_56606705 7.22 ENST00000317268.3
SEPT4
septin 4
chr8_+_20054878 6.54 ENST00000276390.2
ENST00000519667.1
ATP6V1B2
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2
chr17_-_56606664 6.53 ENST00000580844.1
SEPT4
septin 4
chr17_-_29624343 6.52 ENST00000247271.4
OMG
oligodendrocyte myelin glycoprotein
chr22_-_50523760 6.41 ENST00000395876.2
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr9_-_137809718 6.36 ENST00000371806.3
FCN1
ficolin (collagen/fibrinogen domain containing) 1
chr22_+_23229960 6.26 ENST00000526893.1
ENST00000532223.2
ENST00000531372.1
IGLL5
immunoglobulin lambda-like polypeptide 5
chr1_+_158969752 6.16 ENST00000566111.1
IFI16
interferon, gamma-inducible protein 16
chr14_+_100531615 6.03 ENST00000392920.3
EVL
Enah/Vasp-like
chr11_-_6640585 5.95 ENST00000533371.1
ENST00000528657.1
ENST00000436873.2
ENST00000299427.6
TPP1
tripeptidyl peptidase I
chr12_-_50294033 5.62 ENST00000552669.1
FAIM2
Fas apoptotic inhibitory molecule 2
chr17_-_56606639 5.58 ENST00000579371.1
SEPT4
septin 4
chr19_+_3178736 5.53 ENST00000246115.3
S1PR4
sphingosine-1-phosphate receptor 4
chr15_+_42694573 5.31 ENST00000397200.4
ENST00000569827.1
CAPN3
calpain 3, (p94)
chr1_+_16767167 5.11 ENST00000337132.5
NECAP2
NECAP endocytosis associated 2
chr9_+_134065506 5.07 ENST00000483497.2
NUP214
nucleoporin 214kDa
chr22_-_24096562 4.91 ENST00000398465.3
VPREB3
pre-B lymphocyte 3
chr8_-_101571933 4.76 ENST00000520311.1
ANKRD46
ankyrin repeat domain 46
chr8_-_17942432 4.67 ENST00000381733.4
ENST00000314146.10
ASAH1
N-acylsphingosine amidohydrolase (acid ceramidase) 1
chr8_-_101571964 4.61 ENST00000520552.1
ENST00000521345.1
ENST00000523000.1
ENST00000335659.3
ENST00000358990.3
ENST00000519597.1
ANKRD46
ankyrin repeat domain 46
chr5_-_169725231 4.60 ENST00000046794.5
LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr8_-_120651020 4.58 ENST00000522826.1
ENST00000520066.1
ENST00000259486.6
ENST00000075322.6
ENPP2
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr4_-_156875003 4.42 ENST00000433477.3
CTSO
cathepsin O
chr15_+_81475047 4.38 ENST00000559388.1
IL16
interleukin 16
chr12_-_8088871 4.33 ENST00000075120.7
SLC2A3
solute carrier family 2 (facilitated glucose transporter), member 3
chr1_+_158223923 4.29 ENST00000289429.5
CD1A
CD1a molecule
chr1_+_110163202 4.29 ENST00000531203.1
ENST00000256578.3
AMPD2
adenosine monophosphate deaminase 2
chr1_+_158259558 4.15 ENST00000368170.3
CD1C
CD1c molecule
chr5_-_111091948 4.14 ENST00000447165.2
NREP
neuronal regeneration related protein
chr7_+_121513143 4.11 ENST00000393386.2
PTPRZ1
protein tyrosine phosphatase, receptor-type, Z polypeptide 1
chr1_+_16767195 4.07 ENST00000504551.2
ENST00000457722.2
ENST00000406746.1
ENST00000443980.2
NECAP2
NECAP endocytosis associated 2
chr22_-_24096630 4.03 ENST00000248948.3
VPREB3
pre-B lymphocyte 3
chr2_-_175462934 3.97 ENST00000392546.2
ENST00000436221.1
WIPF1
WAS/WASL interacting protein family, member 1
chr17_+_25621102 3.87 ENST00000581440.1
ENST00000262394.2
ENST00000583742.1
ENST00000579733.1
ENST00000583193.1
ENST00000581185.1
ENST00000427287.2
ENST00000348811.2
WSB1
WD repeat and SOCS box containing 1
chr12_-_50290839 3.86 ENST00000552863.1
FAIM2
Fas apoptotic inhibitory molecule 2
chr3_+_37035289 3.60 ENST00000455445.2
ENST00000441265.1
ENST00000435176.1
ENST00000429117.1
ENST00000536378.1
MLH1
mutL homolog 1
chr1_+_205225319 3.59 ENST00000329800.7
TMCC2
transmembrane and coiled-coil domain family 2
chr3_+_37034823 3.55 ENST00000231790.2
ENST00000456676.2
MLH1
mutL homolog 1
chr9_+_125132803 3.51 ENST00000540753.1
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr2_-_175462456 3.49 ENST00000409891.1
ENST00000410117.1
WIPF1
WAS/WASL interacting protein family, member 1
chr1_-_21377447 3.37 ENST00000374937.3
ENST00000264211.8
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr19_+_7701985 3.36 ENST00000595950.1
ENST00000441779.2
ENST00000221283.5
ENST00000414284.2
STXBP2
syntaxin binding protein 2
chr1_+_171217622 3.36 ENST00000433267.1
ENST00000367750.3
FMO1
flavin containing monooxygenase 1
chr15_-_55563072 3.34 ENST00000567380.1
ENST00000565972.1
ENST00000569493.1
RAB27A
RAB27A, member RAS oncogene family
chr4_+_113739244 2.89 ENST00000503271.1
ENST00000503423.1
ENST00000506722.1
ANK2
ankyrin 2, neuronal
chr11_-_65624415 2.84 ENST00000524553.1
ENST00000527344.1
CFL1
cofilin 1 (non-muscle)
chr12_+_113354341 2.81 ENST00000553152.1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr13_+_27998681 2.80 ENST00000381140.4
GTF3A
general transcription factor IIIA
chr1_+_171217677 2.75 ENST00000402921.2
FMO1
flavin containing monooxygenase 1
chr13_+_115000521 2.74 ENST00000252457.5
ENST00000375308.1
CDC16
cell division cycle 16
chr15_-_72668805 2.74 ENST00000268097.5
HEXA
hexosaminidase A (alpha polypeptide)
chr1_-_21377383 2.69 ENST00000374935.3
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr19_+_17186577 2.69 ENST00000595618.1
ENST00000594824.1
MYO9B
myosin IXB
chr1_-_21113105 2.62 ENST00000375000.1
ENST00000419490.1
ENST00000414993.1
ENST00000443615.1
ENST00000312239.5
HP1BP3
heterochromatin protein 1, binding protein 3
chr17_-_47723943 2.55 ENST00000510476.1
ENST00000503676.1
SPOP
speckle-type POZ protein
chr3_-_46249878 2.45 ENST00000296140.3
CCR1
chemokine (C-C motif) receptor 1
chr12_+_54674482 2.35 ENST00000547708.1
ENST00000340913.6
ENST00000551702.1
ENST00000330752.8
ENST00000547276.1
HNRNPA1
heterogeneous nuclear ribonucleoprotein A1
chr3_+_42544084 2.32 ENST00000543411.1
ENST00000438259.2
ENST00000439731.1
ENST00000325123.4
VIPR1
vasoactive intestinal peptide receptor 1
chr1_-_31538517 2.27 ENST00000440538.2
ENST00000423018.2
ENST00000424085.2
ENST00000426105.2
ENST00000257075.5
ENST00000373747.3
ENST00000525843.1
ENST00000373742.2
PUM1
pumilio RNA-binding family member 1
chr13_+_115000556 2.24 ENST00000252458.6
CDC16
cell division cycle 16
chr1_-_175712829 2.20 ENST00000367674.2
TNR
tenascin R
chr19_+_58144529 2.17 ENST00000347302.3
ENST00000254182.7
ENST00000391703.3
ENST00000541801.1
ENST00000299871.5
ENST00000544273.1
ZNF211
zinc finger protein 211
chr8_+_85097110 2.15 ENST00000517638.1
ENST00000522647.1
RALYL
RALY RNA binding protein-like
chr4_+_17579110 2.15 ENST00000606142.1
LAP3
leucine aminopeptidase 3
chr2_-_87088995 2.06 ENST00000393759.2
ENST00000349455.3
ENST00000331469.2
ENST00000431506.2
ENST00000393761.2
ENST00000390655.6
CD8B
CD8b molecule
chr16_-_20367584 2.01 ENST00000570689.1
UMOD
uromodulin
chr2_-_25565377 1.95 ENST00000264709.3
ENST00000406659.3
DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr15_-_20170354 1.95 ENST00000338912.5
IGHV1OR15-9
immunoglobulin heavy variable 1/OR15-9 (non-functional)
chr12_-_371994 1.94 ENST00000343164.4
ENST00000436453.1
ENST00000445055.2
ENST00000546319.1
SLC6A13
solute carrier family 6 (neurotransmitter transporter), member 13
chr17_-_7216939 1.86 ENST00000573684.1
GPS2
G protein pathway suppressor 2
chr11_+_65627865 1.83 ENST00000308110.4
MUS81
MUS81 structure-specific endonuclease subunit
chrX_-_47518498 1.83 ENST00000335890.2
UXT
ubiquitously-expressed, prefoldin-like chaperone
chr19_-_49552006 1.78 ENST00000391869.3
CGB1
chorionic gonadotropin, beta polypeptide 1
chr14_-_106805716 1.74 ENST00000438142.2
IGHV4-31
immunoglobulin heavy variable 4-31
chr6_+_42584847 1.70 ENST00000372883.3
UBR2
ubiquitin protein ligase E3 component n-recognin 2
chr7_+_110731062 1.53 ENST00000308478.5
ENST00000451085.1
ENST00000422987.3
ENST00000421101.1
LRRN3
leucine rich repeat neuronal 3
chr11_-_64684672 1.47 ENST00000377264.3
ENST00000421419.2
ATG2A
autophagy related 2A
chr11_-_62521614 1.45 ENST00000527994.1
ENST00000394807.3
ZBTB3
zinc finger and BTB domain containing 3
chr1_-_200638964 1.45 ENST00000367348.3
ENST00000447706.2
ENST00000331314.6
DDX59
DEAD (Asp-Glu-Ala-Asp) box polypeptide 59
chr16_+_69796209 1.43 ENST00000359154.2
ENST00000561780.1
ENST00000563659.1
ENST00000448661.1
WWP2
WW domain containing E3 ubiquitin protein ligase 2
chr19_-_49552363 1.39 ENST00000448456.3
ENST00000355414.2
CGB8
chorionic gonadotropin, beta polypeptide 8
chr5_+_78407602 1.37 ENST00000274353.5
ENST00000524080.1
BHMT
betaine--homocysteine S-methyltransferase
chrX_-_47518527 1.36 ENST00000333119.3
UXT
ubiquitously-expressed, prefoldin-like chaperone
chr7_+_101917407 1.31 ENST00000487284.1
CUX1
cut-like homeobox 1
chr10_+_18629628 1.27 ENST00000377329.4
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr1_-_160001737 1.26 ENST00000368090.2
PIGM
phosphatidylinositol glycan anchor biosynthesis, class M
chr2_+_70142232 1.26 ENST00000540449.1
MXD1
MAX dimerization protein 1
chr11_-_61687739 1.20 ENST00000531922.1
ENST00000301773.5
RAB3IL1
RAB3A interacting protein (rabin3)-like 1
chr10_-_6019455 1.14 ENST00000530685.1
ENST00000397255.3
ENST00000379971.1
ENST00000528354.1
ENST00000397250.2
ENST00000429135.2
IL15RA
interleukin 15 receptor, alpha
chr10_-_6019552 1.14 ENST00000379977.3
ENST00000397251.3
ENST00000397248.2
IL15RA
interleukin 15 receptor, alpha
chr10_-_6019984 1.14 ENST00000525219.2
IL15RA
interleukin 15 receptor, alpha
chr7_-_150777949 1.14 ENST00000482571.1
FASTK
Fas-activated serine/threonine kinase
chr5_-_42825983 1.11 ENST00000506577.1
SEPP1
selenoprotein P, plasma, 1
chr19_+_55897297 1.10 ENST00000431533.2
ENST00000428193.2
ENST00000558815.1
ENST00000560583.1
ENST00000560055.1
ENST00000559463.1
RPL28
ribosomal protein L28
chr7_-_150777920 1.07 ENST00000353841.2
ENST00000297532.6
FASTK
Fas-activated serine/threonine kinase
chr9_+_116263639 1.05 ENST00000343817.5
RGS3
regulator of G-protein signaling 3
chr22_+_31160239 1.04 ENST00000445781.1
ENST00000401475.1
OSBP2
oxysterol binding protein 2
chr9_+_125133315 0.98 ENST00000223423.4
ENST00000362012.2
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr6_-_34664612 0.95 ENST00000374023.3
ENST00000374026.3
C6orf106
chromosome 6 open reading frame 106
chr2_-_69870747 0.95 ENST00000409068.1
AAK1
AP2 associated kinase 1
chr15_-_65579177 0.93 ENST00000444347.2
ENST00000261888.6
PARP16
poly (ADP-ribose) polymerase family, member 16
chr3_+_121796697 0.93 ENST00000482356.1
ENST00000393627.2
CD86
CD86 molecule
chr11_-_104827425 0.90 ENST00000393150.3
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr7_+_5938386 0.84 ENST00000537980.1
CCZ1
CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)
chr7_-_112430647 0.83 ENST00000312814.6
TMEM168
transmembrane protein 168
chr12_+_60083118 0.80 ENST00000261187.4
ENST00000543448.1
SLC16A7
solute carrier family 16 (monocarboxylate transporter), member 7
chr2_+_219246746 0.78 ENST00000233202.6
SLC11A1
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
chr4_-_48082192 0.77 ENST00000507351.1
TXK
TXK tyrosine kinase
chr12_-_57039739 0.72 ENST00000552959.1
ENST00000551020.1
ENST00000553007.2
ENST00000552919.1
ENST00000552104.1
ENST00000262030.3
ATP5B
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
chr17_+_66521936 0.71 ENST00000592800.1
PRKAR1A
protein kinase, cAMP-dependent, regulatory, type I, alpha
chr5_-_177210399 0.71 ENST00000510276.1
FAM153A
family with sequence similarity 153, member A
chr22_+_42017987 0.68 ENST00000405506.1
XRCC6
X-ray repair complementing defective repair in Chinese hamster cells 6
chr3_+_186435137 0.67 ENST00000447445.1
KNG1
kininogen 1
chr3_-_15106747 0.65 ENST00000449354.2
ENST00000444840.2
ENST00000253686.2
MRPS25
mitochondrial ribosomal protein S25
chr17_+_41150290 0.64 ENST00000589037.1
ENST00000253788.5
RPL27
ribosomal protein L27
chr2_-_69870835 0.64 ENST00000409085.4
ENST00000406297.3
AAK1
AP2 associated kinase 1
chr17_+_41150479 0.59 ENST00000589913.1
RPL27
ribosomal protein L27
chr10_+_115939008 0.58 ENST00000369282.1
ENST00000251864.2
ENST00000369281.2
ENST00000422662.1
TDRD1
tudor domain containing 1
chr19_+_52074502 0.56 ENST00000545217.1
ENST00000262259.2
ENST00000596504.1
ZNF175
zinc finger protein 175
chr9_-_215744 0.56 ENST00000382387.2
C9orf66
chromosome 9 open reading frame 66
chr11_+_66360665 0.52 ENST00000310190.4
CCS
copper chaperone for superoxide dismutase
chr11_+_118754475 0.52 ENST00000292174.4
CXCR5
chemokine (C-X-C motif) receptor 5
chr20_-_21494654 0.50 ENST00000377142.4
NKX2-2
NK2 homeobox 2
chr6_-_26216872 0.49 ENST00000244601.3
HIST1H2BG
histone cluster 1, H2bg
chr6_-_32977345 0.49 ENST00000450833.2
ENST00000374813.1
ENST00000229829.5
HLA-DOA
major histocompatibility complex, class II, DO alpha
chr7_-_150777874 0.49 ENST00000540185.1
FASTK
Fas-activated serine/threonine kinase
chr13_-_48669232 0.47 ENST00000258648.2
ENST00000378586.1
MED4
mediator complex subunit 4
chr10_+_135204338 0.47 ENST00000468317.2
RP11-108K14.8
Mitochondrial GTPase 1
chr7_+_5938351 0.46 ENST00000325974.6
CCZ1
CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)
chr21_-_31311818 0.45 ENST00000535441.1
ENST00000309434.7
ENST00000327783.4
ENST00000389124.2
ENST00000389125.3
ENST00000399913.1
GRIK1
glutamate receptor, ionotropic, kainate 1
chr11_+_122709200 0.40 ENST00000227348.4
CRTAM
cytotoxic and regulatory T cell molecule
chr11_+_94277017 0.37 ENST00000358752.2
FUT4
fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
chr2_+_70142189 0.34 ENST00000264444.2
MXD1
MAX dimerization protein 1
chr17_-_44896047 0.34 ENST00000225512.5
WNT3
wingless-type MMTV integration site family, member 3
chr7_-_6865826 0.30 ENST00000538180.1
CCZ1B
CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
chr4_-_70080449 0.30 ENST00000446444.1
UGT2B11
UDP glucuronosyltransferase 2 family, polypeptide B11
chr16_-_20556492 0.30 ENST00000568098.1
ACSM2B
acyl-CoA synthetase medium-chain family member 2B
chrX_+_47053208 0.28 ENST00000442035.1
ENST00000457753.1
ENST00000335972.6
UBA1
ubiquitin-like modifier activating enzyme 1
chr12_-_56236690 0.25 ENST00000322569.4
MMP19
matrix metallopeptidase 19
chr9_+_131452239 0.25 ENST00000372688.4
ENST00000372686.5
SET
SET nuclear oncogene
chr11_-_76381029 0.25 ENST00000407242.2
ENST00000421973.1
LRRC32
leucine rich repeat containing 32
chr17_+_41150793 0.25 ENST00000586277.1
RPL27
ribosomal protein L27
chr11_+_27062860 0.24 ENST00000528583.1
BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr5_+_173763250 0.21 ENST00000515513.1
ENST00000507361.1
ENST00000510234.1
RP11-267A15.1
RP11-267A15.1
chr16_-_23724518 0.20 ENST00000457008.2
ERN2
endoplasmic reticulum to nucleus signaling 2
chr8_+_136469684 0.19 ENST00000355849.5
KHDRBS3
KH domain containing, RNA binding, signal transduction associated 3
chr4_+_70146217 0.15 ENST00000335568.5
ENST00000511240.1
UGT2B28
UDP glucuronosyltransferase 2 family, polypeptide B28
chr17_-_62493131 0.15 ENST00000539111.2
POLG2
polymerase (DNA directed), gamma 2, accessory subunit
chr11_+_27062272 0.15 ENST00000529202.1
ENST00000533566.1
BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr1_-_31902614 0.15 ENST00000596131.1
AC114494.1
HCG1787699; Uncharacterized protein
chr1_-_173793458 0.14 ENST00000356198.2
CENPL
centromere protein L
chr3_+_32726774 0.11 ENST00000538368.1
CNOT10
CCR4-NOT transcription complex, subunit 10
chr11_-_111383064 0.11 ENST00000525791.1
ENST00000456861.2
ENST00000356018.2
BTG4
B-cell translocation gene 4
chr7_-_107880508 0.09 ENST00000425651.2
NRCAM
neuronal cell adhesion molecule
chr17_+_49337881 0.08 ENST00000225298.7
UTP18
UTP18 small subunit (SSU) processome component homolog (yeast)
chr19_-_42746714 0.07 ENST00000222330.3
GSK3A
glycogen synthase kinase 3 alpha
chr11_+_27062502 0.07 ENST00000263182.3
BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr4_-_73434498 0.07 ENST00000286657.4
ADAMTS3
ADAM metallopeptidase with thrombospondin type 1 motif, 3
chr5_+_175487692 0.07 ENST00000510151.1
FAM153B
family with sequence similarity 153, member B
chr9_+_71944241 0.06 ENST00000257515.8
FAM189A2
family with sequence similarity 189, member A2
chr1_-_78444776 0.04 ENST00000370767.1
ENST00000421641.1
FUBP1
far upstream element (FUSE) binding protein 1
chr12_-_71182695 0.01 ENST00000342084.4
PTPRR
protein tyrosine phosphatase, receptor type, R

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
5.4 21.5 GO:0071461 cellular response to redox state(GO:0071461)
3.9 19.3 GO:0030382 sperm mitochondrion organization(GO:0030382)
2.4 7.1 GO:0051311 meiotic metaphase I plate congression(GO:0043060) meiotic spindle midzone assembly(GO:0051257) meiotic metaphase plate congression(GO:0051311)
2.1 6.4 GO:0002752 cell surface pattern recognition receptor signaling pathway(GO:0002752)
1.6 27.5 GO:0045651 positive regulation of granulocyte differentiation(GO:0030854) positive regulation of macrophage differentiation(GO:0045651)
1.4 4.3 GO:0070837 dehydroascorbic acid transport(GO:0070837)
1.2 11.7 GO:0032264 IMP salvage(GO:0032264)
1.0 2.9 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.9 11.1 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.9 5.3 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
0.8 6.1 GO:0070995 NADPH oxidation(GO:0070995)
0.7 8.4 GO:0048007 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.6 9.5 GO:0021694 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.6 2.4 GO:1903935 response to sodium arsenite(GO:1903935) cellular response to sodium arsenite(GO:1903936)
0.6 2.8 GO:0051510 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) regulation of barbed-end actin filament capping(GO:2000812) positive regulation of barbed-end actin filament capping(GO:2000814)
0.6 3.3 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.5 4.1 GO:0070444 oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445)
0.5 6.0 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.5 1.8 GO:0072423 response to cell cycle checkpoint signaling(GO:0072396) response to DNA integrity checkpoint signaling(GO:0072402) response to DNA damage checkpoint signaling(GO:0072423)
0.4 2.1 GO:0048690 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.4 6.4 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.4 2.5 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.4 7.6 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.4 2.0 GO:0072233 thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233)
0.4 5.5 GO:0090520 sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520)
0.4 2.0 GO:0090116 C-5 methylation of cytosine(GO:0090116)
0.3 2.3 GO:1900246 positive regulation of RIG-I signaling pathway(GO:1900246)
0.3 0.9 GO:0070213 protein auto-ADP-ribosylation(GO:0070213)
0.3 0.9 GO:0032641 negative regulation of tolerance induction(GO:0002644) lymphotoxin A production(GO:0032641) interleukin-4 biosynthetic process(GO:0042097) lymphotoxin A biosynthetic process(GO:0042109) regulation of interleukin-4 biosynthetic process(GO:0045402) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.3 4.6 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.3 20.1 GO:0006910 phagocytosis, recognition(GO:0006910)
0.3 1.7 GO:0071233 cellular response to leucine(GO:0071233)
0.3 2.7 GO:0035385 Roundabout signaling pathway(GO:0035385)
0.3 4.5 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.3 0.8 GO:0055073 cadmium ion homeostasis(GO:0055073)
0.2 1.4 GO:0031335 regulation of sulfur amino acid metabolic process(GO:0031335) regulation of homocysteine metabolic process(GO:0050666)
0.2 1.3 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.2 4.4 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.2 6.5 GO:0090383 phagosome acidification(GO:0090383)
0.2 0.8 GO:0060332 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
0.2 0.5 GO:0015680 intracellular copper ion transport(GO:0015680)
0.2 0.3 GO:0060061 Spemann organizer formation(GO:0060061)
0.2 0.5 GO:0021530 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.2 0.5 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
0.2 12.7 GO:0032729 positive regulation of interferon-gamma production(GO:0032729)
0.1 2.4 GO:0090026 positive regulation of monocyte chemotaxis(GO:0090026)
0.1 2.7 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.1 6.2 GO:0032731 positive regulation of interleukin-1 beta production(GO:0032731)
0.1 3.2 GO:0047497 establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
0.1 5.9 GO:0080171 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.1 2.6 GO:0070828 heterochromatin organization(GO:0070828)
0.1 0.7 GO:0071475 cellular hyperosmotic salinity response(GO:0071475)
0.1 5.0 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.1 1.9 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.1 0.8 GO:0006848 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.1 0.9 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.1 4.5 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.1 0.7 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.1 8.0 GO:0045576 mast cell activation(GO:0045576)
0.1 0.3 GO:0001554 luteolysis(GO:0001554)
0.1 6.5 GO:0050771 negative regulation of axonogenesis(GO:0050771)
0.1 0.4 GO:0002857 positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.1 2.8 GO:0009303 rRNA transcription(GO:0009303)
0.1 6.1 GO:0010507 negative regulation of autophagy(GO:0010507)
0.1 2.9 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.1 0.6 GO:0034587 piRNA metabolic process(GO:0034587)
0.1 1.8 GO:0030728 ovulation(GO:0030728)
0.1 1.5 GO:0044804 nucleophagy(GO:0044804)
0.1 1.0 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.1 1.3 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.1 8.9 GO:0002377 immunoglobulin production(GO:0002377)
0.1 4.7 GO:0006687 ceramide metabolic process(GO:0006672) glycosphingolipid metabolic process(GO:0006687)
0.1 1.6 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.1 0.4 GO:0019317 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.0 7.5 GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
0.0 0.5 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.0 1.4 GO:0070534 protein K63-linked ubiquitination(GO:0070534)
0.0 2.8 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 0.1 GO:2000466 negative regulation of glycogen (starch) synthase activity(GO:2000466)
0.0 0.5 GO:0048535 lymph node development(GO:0048535)
0.0 0.1 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.0 1.3 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0 1.4 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 1.1 GO:1903146 regulation of mitophagy(GO:1903146)
0.0 1.5 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.2 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.0 2.9 GO:0043484 regulation of RNA splicing(GO:0043484)
0.0 0.1 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.4 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0 3.4 GO:0002250 adaptive immune response(GO:0002250)
0.0 2.3 GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger(GO:0007187)
0.0 0.2 GO:0032042 mitochondrial DNA metabolic process(GO:0032042)
0.0 2.7 GO:0000209 protein polyubiquitination(GO:0000209)
0.0 0.2 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 7.1 GO:0005715 late recombination nodule(GO:0005715)
2.1 6.3 GO:0072534 perineuronal net(GO:0072534)
1.7 5.1 GO:1990876 cytoplasmic side of nuclear pore(GO:1990876)
1.4 19.3 GO:0097227 sperm annulus(GO:0097227)
1.1 6.4 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.9 4.6 GO:0036398 TCR signalosome(GO:0036398)
0.7 14.7 GO:0042613 MHC class II protein complex(GO:0042613)
0.5 6.5 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.4 20.1 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.4 3.4 GO:0044194 cytolytic granule(GO:0044194)
0.3 11.6 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.3 3.3 GO:0033093 Weibel-Palade body(GO:0033093)
0.3 6.1 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.2 5.0 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 0.9 GO:0072557 IPAF inflammasome complex(GO:0072557)
0.1 12.2 GO:1904724 tertiary granule lumen(GO:1904724)
0.1 0.7 GO:0043564 Ku70:Ku80 complex(GO:0043564)
0.1 2.0 GO:0001741 XY body(GO:0001741)
0.1 3.2 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 0.6 GO:0071546 pi-body(GO:0071546)
0.1 9.5 GO:0030315 T-tubule(GO:0030315)
0.1 0.7 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
0.1 3.7 GO:0030125 clathrin vesicle coat(GO:0030125)
0.1 0.5 GO:0070847 core mediator complex(GO:0070847)
0.1 10.0 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 2.1 GO:0042101 T cell receptor complex(GO:0042101)
0.1 6.4 GO:0005901 caveola(GO:0005901)
0.1 1.5 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.1 0.2 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.1 8.7 GO:0043202 lysosomal lumen(GO:0043202)
0.1 27.5 GO:0005667 transcription factor complex(GO:0005667)
0.1 27.1 GO:0016607 nuclear speck(GO:0016607)
0.1 1.0 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.1 2.0 GO:0060170 ciliary membrane(GO:0060170)
0.0 4.0 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.0 1.0 GO:0097440 apical dendrite(GO:0097440)
0.0 4.5 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 12.7 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 0.3 GO:1990909 Wnt signalosome(GO:1990909)
0.0 2.8 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 4.4 GO:0005884 actin filament(GO:0005884)
0.0 2.4 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 3.5 GO:0031225 anchored component of membrane(GO:0031225)
0.0 2.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.9 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 6.3 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 9.9 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 1.6 GO:0043195 terminal bouton(GO:0043195)
0.0 3.2 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.1 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0 2.2 GO:0030496 midbody(GO:0030496)
0.0 0.1 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 14.3 GO:0031410 cytoplasmic vesicle(GO:0031410)
0.0 2.9 GO:0000151 ubiquitin ligase complex(GO:0000151)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 11.6 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
2.1 21.5 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
1.4 4.3 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
1.3 11.7 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
1.2 4.7 GO:0017040 ceramidase activity(GO:0017040)
1.1 4.6 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
1.1 4.5 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.9 5.5 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.9 2.7 GO:0033867 Fas-activated serine/threonine kinase activity(GO:0033867)
0.9 7.1 GO:0032137 guanine/thymine mispair binding(GO:0032137)
0.8 8.4 GO:0030884 lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
0.8 2.4 GO:0061752 telomeric repeat-containing RNA binding(GO:0061752)
0.7 7.6 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.7 6.1 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.7 3.4 GO:0030348 syntaxin-3 binding(GO:0030348)
0.6 10.6 GO:0005522 profilin binding(GO:0005522)
0.5 2.3 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.5 5.1 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.5 5.5 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.5 1.4 GO:0047150 betaine-homocysteine S-methyltransferase activity(GO:0047150)
0.5 6.4 GO:0033691 sialic acid binding(GO:0033691)
0.4 2.0 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.4 5.3 GO:0031432 titin binding(GO:0031432)
0.4 14.2 GO:0042605 peptide antigen binding(GO:0042605)
0.4 1.8 GO:0048256 flap endonuclease activity(GO:0048256)
0.4 20.1 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.3 2.7 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.3 1.7 GO:0070728 leucine binding(GO:0070728)
0.3 1.9 GO:0015185 gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185)
0.3 2.7 GO:0048495 Roundabout binding(GO:0048495)
0.3 2.8 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.3 6.1 GO:0000339 RNA cap binding(GO:0000339)
0.3 0.8 GO:0051139 metal ion:proton antiporter activity(GO:0051139)
0.3 7.3 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.2 2.8 GO:0008097 5S rRNA binding(GO:0008097)
0.2 0.8 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.2 4.4 GO:0042609 CD4 receptor binding(GO:0042609)
0.2 2.4 GO:0019957 C-C chemokine binding(GO:0019957)
0.2 27.7 GO:0017124 SH3 domain binding(GO:0017124)
0.2 1.3 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.1 3.3 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.1 0.5 GO:0016532 superoxide dismutase copper chaperone activity(GO:0016532)
0.1 3.3 GO:0031489 myosin V binding(GO:0031489)
0.1 2.0 GO:0019864 IgG binding(GO:0019864)
0.1 0.5 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.1 1.6 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.1 1.9 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.1 0.5 GO:0032395 MHC class II receptor activity(GO:0032395)
0.1 2.1 GO:0042288 MHC class I protein binding(GO:0042288)
0.1 3.2 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 0.4 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 0.7 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.1 0.9 GO:0050700 CARD domain binding(GO:0050700)
0.1 2.2 GO:0030145 manganese ion binding(GO:0030145)
0.1 2.9 GO:0030507 spectrin binding(GO:0030507)
0.1 14.9 GO:0000287 magnesium ion binding(GO:0000287)
0.1 0.5 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.0 0.4 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.0 0.3 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.0 2.6 GO:0031491 nucleosome binding(GO:0031491)
0.0 4.4 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.7 GO:0008603 cAMP-dependent protein kinase inhibitor activity(GO:0004862) cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 5.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.3 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.0 0.5 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 0.9 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 2.8 GO:1902936 phosphatidylinositol bisphosphate binding(GO:1902936)
0.0 4.0 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 2.3 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 1.2 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.9 GO:0015026 coreceptor activity(GO:0015026)
0.0 1.4 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.0 1.0 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.3 GO:0048018 receptor agonist activity(GO:0048018)
0.0 1.8 GO:0005179 hormone activity(GO:0005179)
0.0 1.7 GO:0003823 antigen binding(GO:0003823)
0.0 1.6 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 0.5 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.8 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.1 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 4.7 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.4 39.5 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.3 5.5 PID S1P S1P4 PATHWAY S1P4 pathway
0.3 24.2 PID RHOA REG PATHWAY Regulation of RhoA activity
0.2 2.8 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.2 5.1 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.2 9.5 PID FAS PATHWAY FAS (CD95) signaling pathway
0.1 0.9 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.1 6.5 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.1 1.9 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 2.5 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 6.4 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 3.0 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 2.7 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 5.5 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 2.3 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 1.1 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 3.2 PID E2F PATHWAY E2F transcription factor network
0.0 1.6 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 1.7 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 0.9 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.7 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 3.5 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.3 PID WNT SIGNALING PATHWAY Wnt signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 14.2 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.5 11.6 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.5 11.7 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.3 10.6 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.2 6.5 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.2 4.3 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.2 5.0 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.2 7.4 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.1 7.6 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 24.2 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 3.3 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 10.6 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.1 4.5 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.1 2.8 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.1 6.5 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.1 6.1 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 1.3 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.1 7.6 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.1 0.9 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.1 6.0 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 1.0 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.1 1.3 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 0.8 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 2.3 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 0.8 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 1.3 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.7 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.0 2.8 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 1.4 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.7 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 2.5 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 2.3 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.7 REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION Genes involved in Glucagon signaling in metabolic regulation
0.0 5.6 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.9 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 3.2 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.5 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.4 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.5 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 2.2 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 0.2 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway