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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for NKX6-2
Z-value: 0.87
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Transcription factors associated with NKX6-2
Network of associatons between targets according to the STRING database.
First level regulatory network of NKX6-2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.0 | 60.3 | GO:0030050 | vesicle transport along actin filament(GO:0030050) |
| 1.6 | 30.6 | GO:1904714 | regulation of chaperone-mediated autophagy(GO:1904714) |
| 1.5 | 30.2 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 1.4 | 29.5 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 9.8 | 29.3 | GO:0007412 | axon target recognition(GO:0007412) |
| 0.1 | 24.8 | GO:0000398 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398) |
| 7.5 | 22.5 | GO:1904395 | retinal rod cell differentiation(GO:0060221) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397) |
| 0.6 | 20.6 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 5.3 | 16.0 | GO:0035937 | estrogen secretion(GO:0035937) estradiol secretion(GO:0035938) regulation of estrogen secretion(GO:2000861) regulation of estradiol secretion(GO:2000864) |
| 4.9 | 14.7 | GO:1990414 | replication-born double-strand break repair via sister chromatid exchange(GO:1990414) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 64.4 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.5 | 54.3 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.1 | 33.8 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.9 | 30.2 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.6 | 29.3 | GO:1904115 | axon cytoplasm(GO:1904115) |
| 0.2 | 19.6 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.1 | 16.4 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.1 | 13.0 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 1.1 | 12.8 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
| 0.0 | 10.3 | GO:0009986 | cell surface(GO:0009986) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.0 | 60.3 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.2 | 30.5 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 1.2 | 29.5 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 7.3 | 29.3 | GO:0031694 | alpha-2A adrenergic receptor binding(GO:0031694) |
| 3.1 | 25.1 | GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315) |
| 0.1 | 24.5 | GO:0003729 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 5.6 | 22.5 | GO:0035373 | chondroitin sulfate proteoglycan binding(GO:0035373) |
| 0.4 | 20.6 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.0 | 16.5 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.2 | 15.9 | GO:0050840 | extracellular matrix binding(GO:0050840) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 33.4 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.5 | 29.5 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.5 | 29.3 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.5 | 28.9 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.1 | 20.1 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.6 | 19.1 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.1 | 17.3 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.4 | 16.0 | PID AVB3 OPN PATHWAY | Osteopontin-mediated events |
| 0.0 | 8.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.7 | 7.6 | ST PAC1 RECEPTOR PATHWAY | PAC1 Receptor Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 39.0 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.5 | 33.6 | REACTOME NUCLEAR SIGNALING BY ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
| 1.0 | 30.2 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.2 | 18.4 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.2 | 13.1 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.3 | 12.8 | REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS | Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis |
| 0.2 | 12.0 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.2 | 11.9 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.2 | 10.8 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.5 | 10.7 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |