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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for NOTO_VSX2_DLX2_DLX6_NKX6-1
Z-value: 0.52
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Transcription factors associated with NOTO_VSX2_DLX2_DLX6_NKX6-1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000214513.3 | notochord homeobox | |
| ENSG00000119614.2 | visual system homeobox 2 | |
| ENSG00000115844.6 | distal-less homeobox 2 | |
| ENSG00000006377.9 | distal-less homeobox 6 | |
| ENSG00000163623.5 | NK6 homeobox 1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NKX6-1 | hg19_v2_chr4_-_85419603_85419603 | 0.42 | 1.4e-10 | Click! |
| DLX6 | hg19_v2_chr7_+_96634850_96634874, hg19_v2_chr7_+_96635277_96635301 | 0.42 | 1.6e-10 | Click! |
| DLX2 | hg19_v2_chr2_-_172967621_172967637 | 0.24 | 2.6e-04 | Click! |
| NOTO | hg19_v2_chr2_+_73429386_73429386 | 0.05 | 4.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NOTO_VSX2_DLX2_DLX6_NKX6-1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 34.0 | GO:2000649 | regulation of sodium ion transmembrane transporter activity(GO:2000649) |
| 4.0 | 23.8 | GO:2000324 | positive regulation of glucocorticoid receptor signaling pathway(GO:2000324) |
| 0.0 | 17.5 | GO:0000122 | negative regulation of transcription from RNA polymerase II promoter(GO:0000122) |
| 0.2 | 15.8 | GO:0007585 | respiratory gaseous exchange(GO:0007585) |
| 0.6 | 15.7 | GO:0007638 | mechanosensory behavior(GO:0007638) |
| 0.6 | 13.5 | GO:0007597 | blood coagulation, intrinsic pathway(GO:0007597) |
| 1.1 | 13.3 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.3 | 11.8 | GO:0016486 | peptide hormone processing(GO:0016486) |
| 0.1 | 9.3 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.1 | 7.3 | GO:0042475 | odontogenesis of dentin-containing tooth(GO:0042475) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 46.6 | GO:0043209 | myelin sheath(GO:0043209) |
| 3.0 | 29.8 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.0 | 26.2 | GO:0031226 | intrinsic component of plasma membrane(GO:0031226) |
| 0.1 | 12.1 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.0 | 9.6 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 7.8 | GO:0030133 | transport vesicle(GO:0030133) |
| 0.0 | 5.3 | GO:0070820 | tertiary granule(GO:0070820) |
| 0.0 | 5.2 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.1 | 4.6 | GO:0031904 | endosome lumen(GO:0031904) |
| 0.1 | 4.5 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 35.6 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.1 | 32.8 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.2 | 19.0 | GO:0005179 | hormone activity(GO:0005179) |
| 0.2 | 16.6 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.1 | 12.9 | GO:0005178 | integrin binding(GO:0005178) |
| 0.2 | 11.9 | GO:0070888 | E-box binding(GO:0070888) |
| 0.0 | 11.9 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.4 | 11.4 | GO:0019865 | immunoglobulin binding(GO:0019865) |
| 0.1 | 11.2 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.1 | 9.9 | GO:0044325 | ion channel binding(GO:0044325) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 53.6 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 19.4 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.2 | 9.5 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.1 | 7.9 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 5.4 | PID ENDOTHELIN PATHWAY | Endothelins |
| 0.1 | 4.3 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.1 | 3.1 | NABA CORE MATRISOME | Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans |
| 0.1 | 3.0 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.1 | 2.7 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 2.7 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 14.2 | REACTOME ANDROGEN BIOSYNTHESIS | Genes involved in Androgen biosynthesis |
| 0.7 | 11.1 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.1 | 10.3 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.2 | 6.4 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 5.7 | REACTOME INTEGRATION OF ENERGY METABOLISM | Genes involved in Integration of energy metabolism |
| 0.2 | 5.3 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.1 | 5.1 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.2 | 3.1 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.1 | 3.1 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 3.0 | REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS | Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis |