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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for NR4A3
Z-value: 0.45
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Transcription factors associated with NR4A3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NR4A3 | hg19_v2_chr9_+_102584128_102584144 | -0.36 | 3.0e-08 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_64059332 Show fit | 20.89 |
ENST00000540265.1
|
phosphoglucomutase 1 |
|
| chr19_+_17416609 Show fit | 12.24 |
ENST00000602206.1
|
mitochondrial ribosomal protein L34 |
|
| chr10_+_81107271 Show fit | 11.02 |
ENST00000448165.1
|
peptidylprolyl isomerase F |
|
| chr17_-_79995553 Show fit | 10.96 |
ENST00000581584.1
ENST00000577712.1 ENST00000582900.1 ENST00000579155.1 ENST00000306869.2 |
dicarbonyl/L-xylulose reductase |
|
| chr17_-_4852332 Show fit | 9.95 |
ENST00000572383.1
|
profilin 1 |
|
| chr5_+_1801503 Show fit | 9.29 |
ENST00000274137.5
ENST00000469176.1 |
NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) |
|
| chrX_-_53461288 Show fit | 9.21 |
ENST00000375298.4
ENST00000375304.5 |
hydroxysteroid (17-beta) dehydrogenase 10 |
|
| chr20_+_35807449 Show fit | 9.18 |
ENST00000237530.6
|
ribophorin II |
|
| chr19_+_17416457 Show fit | 9.00 |
ENST00000252602.1
|
mitochondrial ribosomal protein L34 |
|
| chr8_-_101718991 Show fit | 8.70 |
ENST00000517990.1
|
poly(A) binding protein, cytoplasmic 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of NR4A3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 42.4 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.5 | 36.5 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.9 | 26.4 | GO:0042776 | mitochondrial ATP synthesis coupled proton transport(GO:0042776) |
| 1.6 | 20.9 | GO:0019388 | galactose catabolic process(GO:0019388) |
| 0.3 | 18.4 | GO:0018279 | protein N-linked glycosylation via asparagine(GO:0018279) |
| 1.2 | 17.3 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
| 5.7 | 17.0 | GO:0070901 | mitochondrial tRNA methylation(GO:0070901) |
| 1.7 | 13.8 | GO:1900625 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 1.5 | 13.4 | GO:2000623 | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623) |
| 0.2 | 12.3 | GO:0006487 | protein N-linked glycosylation(GO:0006487) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 37.1 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.6 | 36.5 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.4 | 30.5 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 2.0 | 24.2 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 1.2 | 21.2 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.1 | 19.1 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.3 | 17.7 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 1.6 | 17.3 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 3.4 | 17.0 | GO:0030678 | mitochondrial ribonuclease P complex(GO:0030678) |
| 0.8 | 15.5 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 37.5 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.7 | 34.8 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.2 | 26.1 | GO:0015078 | hydrogen ion transmembrane transporter activity(GO:0015078) |
| 3.5 | 20.9 | GO:0004614 | phosphoglucomutase activity(GO:0004614) |
| 1.0 | 19.9 | GO:0003857 | 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857) |
| 1.8 | 17.8 | GO:0004579 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 0.9 | 15.5 | GO:0008494 | translation activator activity(GO:0008494) |
| 0.5 | 13.8 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 12.3 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.9 | 11.4 | GO:0004017 | adenylate kinase activity(GO:0004017) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 34.4 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.6 | 18.6 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.2 | 17.4 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.2 | 14.4 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.2 | 12.2 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.2 | 10.6 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.2 | 10.5 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 10.5 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.0 | 9.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 9.0 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 68.7 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.2 | 23.0 | REACTOME ASPARAGINE N LINKED GLYCOSYLATION | Genes involved in Asparagine N-linked glycosylation |
| 1.0 | 22.1 | REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.6 | 19.6 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.6 | 17.3 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.1 | 17.2 | REACTOME TRANSLATION | Genes involved in Translation |
| 0.4 | 15.5 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.3 | 15.0 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.5 | 14.8 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.7 | 13.6 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |