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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for NR6A1
Z-value: 0.42
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Transcription factors associated with NR6A1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NR6A1 | hg19_v2_chr9_-_127533582_127533615 | 0.45 | 2.6e-12 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NR6A1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 75.7 | GO:0007565 | female pregnancy(GO:0007565) |
| 1.0 | 69.1 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 7.0 | 21.0 | GO:1903860 | negative regulation of dendrite extension(GO:1903860) regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800) negative regulation of branching morphogenesis of a nerve(GO:2000173) |
| 1.1 | 18.3 | GO:0071786 | endoplasmic reticulum tubular network organization(GO:0071786) |
| 3.6 | 18.1 | GO:0002378 | immunoglobulin biosynthetic process(GO:0002378) negative regulation of glucose import in response to insulin stimulus(GO:2001274) |
| 0.2 | 17.6 | GO:0050853 | B cell receptor signaling pathway(GO:0050853) |
| 1.0 | 10.4 | GO:0010918 | positive regulation of mitochondrial membrane potential(GO:0010918) |
| 0.1 | 9.4 | GO:0070268 | cornification(GO:0070268) |
| 2.2 | 8.9 | GO:0001970 | positive regulation of activation of membrane attack complex(GO:0001970) |
| 0.0 | 8.7 | GO:0048232 | spermatogenesis(GO:0007283) male gamete generation(GO:0048232) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 67.0 | GO:0042571 | immunoglobulin complex(GO:0019814) immunoglobulin complex, circulating(GO:0042571) |
| 0.1 | 19.8 | GO:0001726 | ruffle(GO:0001726) |
| 2.5 | 17.6 | GO:0019815 | B cell receptor complex(GO:0019815) |
| 0.1 | 16.7 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.8 | 15.7 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.1 | 13.7 | GO:0099572 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.1 | 12.5 | GO:0072562 | blood microparticle(GO:0072562) |
| 1.4 | 9.9 | GO:0001520 | outer dense fiber(GO:0001520) |
| 0.1 | 9.4 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.6 | 8.5 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 67.0 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.2 | 28.5 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.1 | 19.2 | GO:0003823 | antigen binding(GO:0003823) |
| 0.0 | 15.6 | GO:0004888 | transmembrane signaling receptor activity(GO:0004888) |
| 0.4 | 10.8 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.3 | 10.4 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
| 0.1 | 7.9 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 1.0 | 7.6 | GO:1990380 | Lys48-specific deubiquitinase activity(GO:1990380) |
| 0.4 | 7.2 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.4 | 7.1 | GO:0019992 | diacylglycerol binding(GO:0019992) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 18.9 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.3 | 15.9 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.1 | 12.0 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 9.6 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.2 | 9.1 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.2 | 8.5 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 8.1 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 7.7 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.1 | 7.7 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.2 | 5.0 | PID IL27 PATHWAY | IL27-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 19.9 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.1 | 15.8 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.2 | 9.1 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.3 | 8.5 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.2 | 7.3 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.3 | 6.3 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.1 | 6.3 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.4 | 6.2 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.0 | 5.3 | REACTOME TRANSLATION | Genes involved in Translation |
| 0.3 | 5.1 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |