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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for POU2F1
Z-value: 0.17
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Transcription factors associated with POU2F1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| POU2F1 | hg19_v2_chr1_+_167298281_167298319 | 0.13 | 6.2e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_90060377 Show fit | 25.11 |
ENST00000436451.2
|
immunoglobulin kappa variable 6D-21 (non-functional) |
|
| chr2_-_89459813 Show fit | 23.84 |
ENST00000390256.2
|
immunoglobulin kappa variable 6-21 (non-functional) |
|
| chr2_+_90108504 Show fit | 22.98 |
ENST00000390271.2
|
immunoglobulin kappa variable 6D-41 (non-functional) |
|
| chr11_-_58343319 Show fit | 17.46 |
ENST00000395074.2
|
leupaxin |
|
| chr14_-_106642049 Show fit | 15.80 |
ENST00000390605.2
|
immunoglobulin heavy variable 1-18 |
|
| chr21_+_10862622 Show fit | 15.68 |
ENST00000302092.5
ENST00000559480.1 |
immunoglobulin heavy variable 1/OR21-1 (non-functional) |
|
| chr2_+_89890533 Show fit | 15.16 |
ENST00000429992.2
|
immunoglobulin kappa variable 2D-40 |
|
| chr14_-_106733624 Show fit | 14.72 |
ENST00000390610.2
|
immunoglobulin heavy variable 1-24 |
|
| chr14_-_106539557 Show fit | 14.57 |
ENST00000390599.2
|
immunoglobulin heavy variable 1-8 |
|
| chr3_-_121379739 Show fit | 14.00 |
ENST00000428394.2
ENST00000314583.3 |
hematopoietic cell-specific Lyn substrate 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of POU2F1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 143.0 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.5 | 78.6 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 2.2 | 17.5 | GO:0050859 | negative regulation of B cell receptor signaling pathway(GO:0050859) |
| 5.8 | 17.3 | GO:1904899 | regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922) |
| 0.6 | 16.7 | GO:0000042 | protein targeting to Golgi(GO:0000042) |
| 0.8 | 14.0 | GO:0045651 | positive regulation of granulocyte differentiation(GO:0030854) positive regulation of macrophage differentiation(GO:0045651) |
| 1.1 | 12.6 | GO:0008228 | opsonization(GO:0008228) |
| 0.1 | 11.1 | GO:0002819 | regulation of adaptive immune response(GO:0002819) |
| 0.0 | 9.9 | GO:0002250 | adaptive immune response(GO:0002250) |
| 0.6 | 9.6 | GO:0030889 | negative regulation of B cell proliferation(GO:0030889) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 65.4 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 56.1 | GO:0005615 | extracellular space(GO:0005615) |
| 0.2 | 30.3 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.4 | 22.4 | GO:0002102 | podosome(GO:0002102) |
| 0.1 | 19.8 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.1 | 13.2 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.0 | 13.2 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.1 | 12.4 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.1 | 11.1 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 10.4 | GO:0001650 | fibrillar center(GO:0001650) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 162.9 | GO:0003823 | antigen binding(GO:0003823) |
| 1.2 | 65.4 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 1.6 | 17.3 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.1 | 14.7 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |
| 0.0 | 13.5 | GO:0003700 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 1.2 | 12.4 | GO:0070053 | thrombospondin receptor activity(GO:0070053) |
| 0.2 | 8.3 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.1 | 6.4 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
| 0.0 | 6.2 | GO:0003712 | transcription cofactor activity(GO:0003712) |
| 0.1 | 6.1 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 19.7 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.2 | 15.4 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.1 | 11.6 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.1 | 6.9 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.1 | 5.2 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.0 | 3.7 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 3.6 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.3 | 3.5 | ST PAC1 RECEPTOR PATHWAY | PAC1 Receptor Pathway |
| 0.1 | 2.8 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 2.7 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 13.4 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.4 | 12.4 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.1 | 11.2 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.1 | 11.1 | REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL | Genes involved in Cell surface interactions at the vascular wall |
| 0.8 | 8.9 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
| 0.0 | 5.9 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.2 | 5.4 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.2 | 5.3 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.5 | 5.1 | REACTOME COPI MEDIATED TRANSPORT | Genes involved in COPI Mediated Transport |
| 0.1 | 3.9 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |