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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for POU2F1

Z-value: 0.17

Motif logo

Transcription factors associated with POU2F1

Gene Symbol Gene ID Gene Info
ENSG00000143190.17 POU class 2 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
POU2F1hg19_v2_chr1_+_167298281_1672983190.136.2e-02Click!

Activity profile of POU2F1 motif

Sorted Z-values of POU2F1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_90060377 25.11 ENST00000436451.2
immunoglobulin kappa variable 6D-21 (non-functional)
chr2_-_89459813 23.84 ENST00000390256.2
immunoglobulin kappa variable 6-21 (non-functional)
chr2_+_90108504 22.98 ENST00000390271.2
immunoglobulin kappa variable 6D-41 (non-functional)
chr11_-_58343319 17.46 ENST00000395074.2
leupaxin
chr14_-_106642049 15.80 ENST00000390605.2
immunoglobulin heavy variable 1-18
chr21_+_10862622 15.68 ENST00000302092.5
ENST00000559480.1
immunoglobulin heavy variable 1/OR21-1 (non-functional)
chr2_+_89890533 15.16 ENST00000429992.2
immunoglobulin kappa variable 2D-40
chr14_-_106733624 14.72 ENST00000390610.2
immunoglobulin heavy variable 1-24
chr14_-_106539557 14.57 ENST00000390599.2
immunoglobulin heavy variable 1-8
chr3_-_121379739 14.00 ENST00000428394.2
ENST00000314583.3
hematopoietic cell-specific Lyn substrate 1
chr2_-_89292422 13.12 ENST00000495489.1
immunoglobulin kappa variable 1-8
chr3_-_107777208 12.39 ENST00000398258.3
CD47 molecule
chr3_-_155524049 12.34 ENST00000534941.1
ENST00000340171.2
chromosome 3 open reading frame 33
chr2_-_89521942 12.00 ENST00000482769.1
immunoglobulin kappa variable 2-28
chr2_+_89975669 11.43 ENST00000474213.1
immunoglobulin kappa variable 2D-30
chr1_-_160681593 11.12 ENST00000368045.3
ENST00000368046.3
CD48 molecule
chr14_-_107078851 10.85 ENST00000390628.2
immunoglobulin heavy variable 1-58
chr2_-_89545079 10.65 ENST00000468494.1
immunoglobulin kappa variable 2-30
chr2_-_88285309 10.51 ENST00000420840.2
RANBP2-like and GRIP domain containing 2
chr15_-_22448819 10.01 ENST00000604066.1
immunoglobulin heavy variable 1/OR15-1 (non-functional)
chr14_-_106453155 9.81 ENST00000390594.2
immunoglobulin heavy variable 1-2
chr1_+_158801095 9.64 ENST00000368141.4
myeloid cell nuclear differentiation antigen
chr1_-_25291475 9.18 ENST00000338888.3
ENST00000399916.1
runt-related transcription factor 3
chr15_-_22473353 8.96 ENST00000557788.2
immunoglobulin heavy variable 4/OR15-8 (non-functional)
chr8_-_117768023 8.27 ENST00000518949.1
ENST00000522453.1
ENST00000521861.1
ENST00000518995.1
eukaryotic translation initiation factor 3, subunit H
chr14_-_107283278 8.19 ENST00000390639.2
immunoglobulin heavy variable 7-81 (non-functional)
chr2_+_89999259 7.88 ENST00000558026.1
immunoglobulin kappa variable 2D-28
chr2_+_90458201 7.78 ENST00000603238.1
Uncharacterized protein
chr14_+_21249200 7.54 ENST00000304677.2
ribonuclease, RNase A family, k6
chr6_+_135502408 7.03 ENST00000341911.5
ENST00000442647.2
ENST00000316528.8
v-myb avian myeloblastosis viral oncogene homolog
chr14_-_106967788 6.89 ENST00000390622.2
immunoglobulin heavy variable 1-46
chr6_+_135502466 6.86 ENST00000367814.4
v-myb avian myeloblastosis viral oncogene homolog
chr14_-_106471723 6.65 ENST00000390595.2
immunoglobulin heavy variable 1-3
chr3_+_133292574 6.45 ENST00000264993.3
CDV3 homolog (mouse)
chrX_-_135962876 6.18 ENST00000431446.3
ENST00000570135.1
ENST00000320676.7
ENST00000562646.1
RNA binding motif protein, X-linked
chr5_-_98262240 6.07 ENST00000284049.3
chromodomain helicase DNA binding protein 1
chr2_+_87135076 6.05 ENST00000409776.2
RANBP2-like and GRIP domain containing 1
chr1_-_146082633 5.62 ENST00000605317.1
ENST00000604938.1
ENST00000339388.5
neuroblastoma breakpoint family, member 11
chr15_-_55541227 5.38 ENST00000566877.1
RAB27A, member RAS oncogene family
chr4_+_68424434 5.34 ENST00000265404.2
ENST00000396225.1
signal transducing adaptor family member 1
chr15_+_48623208 5.32 ENST00000559935.1
ENST00000559416.1
deoxyuridine triphosphatase
chr22_+_23029188 5.10 ENST00000390305.2
immunoglobulin lambda variable 3-25
chr10_+_79793518 5.08 ENST00000440692.1
ENST00000435275.1
ENST00000372360.3
ENST00000360830.4
ribosomal protein S24
chr11_-_14521379 5.06 ENST00000249923.3
ENST00000529866.1
ENST00000439561.2
ENST00000534771.1
coatomer protein complex, subunit beta 1
chr9_-_86593238 4.94 ENST00000351839.3
heterogeneous nuclear ribonucleoprotein K
chr4_+_70861647 4.82 ENST00000246895.4
ENST00000381060.2
statherin
chr12_-_118797475 4.79 ENST00000541786.1
ENST00000419821.2
ENST00000541878.1
TAO kinase 3
chr1_+_146373546 4.77 ENST00000446760.2
neuroblastoma breakpoint family, member 12
chr1_+_104293028 4.62 ENST00000370079.3
amylase, alpha 1C (salivary)
chr15_+_80364901 4.58 ENST00000560228.1
ENST00000559835.1
ENST00000559775.1
ENST00000558688.1
ENST00000560392.1
ENST00000560976.1
ENST00000558272.1
ENST00000558390.1
zinc finger, AN1-type domain 6
chr22_+_23089870 4.46 ENST00000390311.2
immunoglobulin lambda variable 3-16
chr2_-_152684977 4.30 ENST00000428992.2
ENST00000295087.8
ADP-ribosylation factor-like 5A
chr1_+_104159999 4.30 ENST00000414303.2
ENST00000423678.1
amylase, alpha 2A (pancreatic)
chr19_-_9731872 4.20 ENST00000424629.1
ENST00000326044.5
ENST00000354661.4
ENST00000435550.1
ENST00000444611.1
ENST00000421525.1
zinc finger protein 561
chr7_+_64838786 3.96 ENST00000450302.2
zinc finger protein 92
chr9_+_124088860 3.86 ENST00000373806.1
gelsolin
chr8_-_6837602 3.60 ENST00000382692.2
defensin, alpha 1
chr12_-_91546926 3.57 ENST00000550758.1
decorin
chr3_-_58200398 3.51 ENST00000318316.3
ENST00000460422.1
ENST00000483681.1
deoxyribonuclease I-like 3
chr7_+_64838712 3.51 ENST00000328747.7
ENST00000431504.1
ENST00000357512.2
zinc finger protein 92
chr1_-_226926864 3.48 ENST00000429204.1
ENST00000366784.1
inositol-trisphosphate 3-kinase B
chr6_+_135502501 3.46 ENST00000527615.1
ENST00000420123.2
ENST00000525369.1
ENST00000528774.1
ENST00000534121.1
ENST00000534044.1
ENST00000533624.1
v-myb avian myeloblastosis viral oncogene homolog
chr3_-_3221358 2.99 ENST00000424814.1
ENST00000450014.1
ENST00000231948.4
ENST00000432408.2
cereblon
chr6_-_152489484 2.99 ENST00000354674.4
ENST00000539504.1
spectrin repeat containing, nuclear envelope 1
chr15_-_63448973 2.96 ENST00000462430.1
ribosomal protein S27-like
chr14_-_106791536 2.86 ENST00000390613.2
immunoglobulin heavy variable 3-30
chr1_-_223308098 2.78 ENST00000342210.6
toll-like receptor 5
chr20_+_39657454 2.70 ENST00000361337.2
topoisomerase (DNA) I
chr11_-_128457446 2.50 ENST00000392668.4
v-ets avian erythroblastosis virus E26 oncogene homolog 1
chr6_-_132834184 2.50 ENST00000367941.2
ENST00000367937.4
syntaxin 7
chr2_+_162087577 2.49 ENST00000439442.1
TRAF family member-associated NFKB activator
chr5_-_176326333 2.49 ENST00000292432.5
hexokinase 3 (white cell)
chr20_+_36373032 2.48 ENST00000373473.1
catenin, beta like 1
chr10_+_13628921 2.45 ENST00000378572.3
pre-mRNA processing factor 18
chr8_+_86121448 2.42 ENST00000520225.1
E2F transcription factor 5, p130-binding
chr5_+_67588391 2.41 ENST00000523872.1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr18_-_52989217 2.33 ENST00000570287.2
transcription factor 4
chr7_+_7606497 2.30 ENST00000340080.4
ENST00000405785.1
ENST00000433635.1
missing oocyte, meiosis regulator, homolog (Drosophila)
chr21_-_33975547 2.28 ENST00000431599.1
chromosome 21 open reading frame 59
chr19_+_17858547 2.01 ENST00000600676.1
ENST00000600209.1
ENST00000596309.1
ENST00000598539.1
ENST00000597474.1
ENST00000593385.1
ENST00000598067.1
ENST00000593833.1
FCH domain only 1
chr2_-_74007193 1.85 ENST00000377706.4
ENST00000443070.1
ENST00000272444.3
dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
chr3_+_149530836 1.80 ENST00000466478.1
ENST00000491086.1
ENST00000467977.1
ring finger protein 13
chr1_+_28562617 1.75 ENST00000497986.1
ENST00000335514.5
ENST00000468425.2
ENST00000465645.1
ATPase inhibitory factor 1
chr8_-_49833978 1.58 ENST00000020945.1
snail family zinc finger 2
chr6_+_26124373 1.55 ENST00000377791.2
ENST00000602637.1
histone cluster 1, H2ac
chr4_-_153274078 1.51 ENST00000263981.5
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
chr6_-_13621126 1.49 ENST00000600057.1
Uncharacterized protein
chr3_+_196466710 1.42 ENST00000327134.3
p21 protein (Cdc42/Rac)-activated kinase 2
chr19_+_17858509 1.39 ENST00000594202.1
ENST00000252771.7
ENST00000389133.4
FCH domain only 1
chr10_-_116286563 1.39 ENST00000369253.2
actin binding LIM protein 1
chr17_+_45728427 1.37 ENST00000540627.1
karyopherin (importin) beta 1
chr8_-_93107827 1.33 ENST00000520724.1
ENST00000518844.1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr12_-_111358372 1.31 ENST00000548438.1
ENST00000228841.8
myosin, light chain 2, regulatory, cardiac, slow
chr18_+_3252206 1.19 ENST00000578562.2
myosin, light chain 12A, regulatory, non-sarcomeric
chr1_+_161736072 1.12 ENST00000367942.3
activating transcription factor 6
chr17_+_75181292 1.09 ENST00000431431.2
SEC14-like 1 (S. cerevisiae)
chr4_+_74301880 0.98 ENST00000395792.2
ENST00000226359.2
alpha-fetoprotein
chr1_+_100436065 0.97 ENST00000370153.1
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
chr4_-_100356551 0.93 ENST00000209665.4
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr2_-_113594279 0.92 ENST00000416750.1
ENST00000418817.1
ENST00000263341.2
interleukin 1, beta
chr15_-_55489097 0.87 ENST00000260443.4
ribosomal L24 domain containing 1
chr4_-_100356291 0.81 ENST00000476959.1
ENST00000482593.1
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr2_+_71205742 0.77 ENST00000360589.3
ankyrin repeat domain 53
chr9_+_135854091 0.72 ENST00000450530.1
ENST00000534944.1
growth factor independent 1B transcription repressor
chr9_+_12693336 0.72 ENST00000381137.2
ENST00000388918.5
tyrosinase-related protein 1
chr7_-_14026063 0.70 ENST00000443608.1
ENST00000438956.1
ets variant 1
chr16_+_81070792 0.69 ENST00000564241.1
ENST00000565237.1
ATM interactor
chr16_-_18908196 0.60 ENST00000565324.1
ENST00000561947.1
SMG1 phosphatidylinositol 3-kinase-related kinase
chr3_-_46249878 0.57 ENST00000296140.3
chemokine (C-C motif) receptor 1
chr17_+_34391625 0.56 ENST00000004921.3
chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
chrX_-_19988382 0.53 ENST00000356980.3
ENST00000379687.3
ENST00000379682.4
chromosome X open reading frame 23
chr16_+_33629600 0.53 ENST00000562905.2
immunoglobulin heavy variable 3/OR16-13 (non-functional)
chr5_-_111092873 0.51 ENST00000509025.1
ENST00000515855.1
neuronal regeneration related protein
chr3_+_101546827 0.50 ENST00000461724.1
ENST00000483180.1
ENST00000394054.2
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr5_-_111093081 0.47 ENST00000453526.2
ENST00000509427.1
neuronal regeneration related protein
chr1_+_152975488 0.42 ENST00000542696.1
small proline-rich protein 3
chr8_-_93107696 0.38 ENST00000436581.2
ENST00000520583.1
ENST00000519061.1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr2_+_102615416 0.30 ENST00000393414.2
interleukin 1 receptor, type II
chr4_-_110723194 0.26 ENST00000394635.3
complement factor I
chr3_+_157154578 0.25 ENST00000295927.3
pentraxin 3, long
chr10_-_115904361 0.21 ENST00000428953.1
ENST00000543782.1
chromosome 10 open reading frame 118
chr18_+_616711 0.18 ENST00000579494.1
clusterin-like 1 (retinal)
chr2_+_219524379 0.15 ENST00000443791.1
ENST00000359273.3
ENST00000392109.1
ENST00000392110.2
ENST00000423377.1
ENST00000392111.2
ENST00000412366.1
BC1 (ubiquinol-cytochrome c reductase) synthesis-like
chr17_+_7387677 0.11 ENST00000322644.6
polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
chr2_+_204571198 0.11 ENST00000374481.3
ENST00000458610.2
ENST00000324106.8
CD28 molecule
chr2_+_110551851 0.09 ENST00000272454.6
ENST00000430736.1
ENST00000016946.3
ENST00000441344.1
RANBP2-like and GRIP domain containing 5
chr1_+_25598872 0.07 ENST00000328664.4
Rh blood group, D antigen
chrX_-_130423386 0.06 ENST00000370903.3
immunoglobulin superfamily, member 1
chr2_-_113191096 0.05 ENST00000496537.1
ENST00000330575.5
ENST00000302558.3
RANBP2-like and GRIP domain containing 8
chr4_-_110723335 0.04 ENST00000394634.2
complement factor I

Network of associatons between targets according to the STRING database.

First level regulatory network of POU2F1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
5.8 17.3 GO:1904899 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
2.2 17.5 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
1.8 5.3 GO:1903973 negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973)
1.8 5.3 GO:0046081 dUTP metabolic process(GO:0046080) dUTP catabolic process(GO:0046081)
1.2 4.9 GO:0072369 regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369)
1.2 3.6 GO:0035915 pore formation in membrane of other organism(GO:0035915)
1.1 12.6 GO:0008228 opsonization(GO:0008228)
1.0 143.0 GO:0006958 complement activation, classical pathway(GO:0006958)
0.9 2.8 GO:0034146 toll-like receptor 5 signaling pathway(GO:0034146)
0.9 0.9 GO:0060559 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.9 5.4 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.8 14.0 GO:0045651 positive regulation of granulocyte differentiation(GO:0030854) positive regulation of macrophage differentiation(GO:0045651)
0.8 3.9 GO:0044858 plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906)
0.6 4.3 GO:0044245 polysaccharide digestion(GO:0044245)
0.6 9.6 GO:0030889 negative regulation of B cell proliferation(GO:0030889)
0.6 1.7 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.6 16.7 GO:0000042 protein targeting to Golgi(GO:0000042)
0.5 1.6 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.5 1.6 GO:0071030 nuclear mRNA surveillance of spliceosomal pre-mRNA splicing(GO:0071030) nuclear retention of unspliced pre-mRNA at the site of transcription(GO:0071048)
0.5 3.5 GO:0033029 regulation of neutrophil apoptotic process(GO:0033029) common myeloid progenitor cell proliferation(GO:0035726)
0.5 78.6 GO:0002377 immunoglobulin production(GO:0002377)
0.5 9.5 GO:0048935 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.4 4.8 GO:0046541 saliva secretion(GO:0046541)
0.4 2.5 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.4 6.1 GO:0043923 positive regulation by host of viral transcription(GO:0043923)
0.4 1.1 GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990)
0.4 1.9 GO:0098501 polynucleotide dephosphorylation(GO:0098501)
0.4 1.4 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.3 1.4 GO:0031291 Ran protein signal transduction(GO:0031291)
0.3 2.5 GO:0030578 PML body organization(GO:0030578)
0.3 1.5 GO:2000639 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.3 3.0 GO:0090292 nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.3 3.6 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.3 6.2 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.3 2.5 GO:1902474 positive regulation of protein localization to synapse(GO:1902474)
0.3 3.0 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.2 1.7 GO:1901526 positive regulation of macromitophagy(GO:1901526) positive regulation of mitophagy in response to mitochondrial depolarization(GO:1904925)
0.2 2.7 GO:0040016 embryonic cleavage(GO:0040016)
0.2 0.9 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.2 3.0 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.2 3.5 GO:0010623 programmed cell death involved in cell development(GO:0010623)
0.2 2.5 GO:0033120 positive regulation of RNA splicing(GO:0033120)
0.2 4.6 GO:0006625 protein targeting to peroxisome(GO:0006625) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663)
0.2 5.1 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.2 1.3 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.1 1.0 GO:0090481 pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.1 2.8 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.1 5.1 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.1 3.4 GO:0048268 clathrin coat assembly(GO:0048268)
0.1 1.1 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.1 11.1 GO:0002819 regulation of adaptive immune response(GO:0002819)
0.1 4.0 GO:0019731 antibacterial humoral response(GO:0019731)
0.1 7.6 GO:0070373 negative regulation of ERK1 and ERK2 cascade(GO:0070373)
0.1 1.7 GO:0006091 generation of precursor metabolites and energy(GO:0006091)
0.1 0.7 GO:0048023 positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.1 0.3 GO:0032690 negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712)
0.1 2.5 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
0.1 8.3 GO:0006446 regulation of translational initiation(GO:0006446)
0.1 0.6 GO:1902412 regulation of mitotic cytokinesis(GO:1902412)
0.1 0.9 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.1 2.3 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.0 9.9 GO:0002250 adaptive immune response(GO:0002250)
0.0 0.6 GO:0090026 dendritic cell chemotaxis(GO:0002407) positive regulation of monocyte chemotaxis(GO:0090026)
0.0 0.7 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.0 0.7 GO:0051569 regulation of histone H3-K4 methylation(GO:0051569)
0.0 1.8 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 0.9 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.1 GO:0017062 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0 1.2 GO:0070527 platelet aggregation(GO:0070527)
0.0 0.6 GO:0048247 lymphocyte chemotaxis(GO:0048247)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 65.4 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
1.2 6.2 GO:0044530 supraspliceosomal complex(GO:0044530)
0.9 8.3 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.9 2.7 GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330)
0.6 2.4 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.5 1.6 GO:0071020 post-spliceosomal complex(GO:0071020)
0.5 5.1 GO:0030126 COPI vesicle coat(GO:0030126)
0.4 5.4 GO:0033093 Weibel-Palade body(GO:0033093)
0.4 22.4 GO:0002102 podosome(GO:0002102)
0.3 2.3 GO:0061700 GATOR2 complex(GO:0061700)
0.3 3.6 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.2 3.0 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.2 1.5 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.2 2.6 GO:0000974 Prp19 complex(GO:0000974)
0.2 30.3 GO:0072562 blood microparticle(GO:0072562)
0.2 2.0 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.1 19.8 GO:0016363 nuclear matrix(GO:0016363)
0.1 13.2 GO:0035578 azurophil granule lumen(GO:0035578)
0.1 12.4 GO:0070821 tertiary granule membrane(GO:0070821)
0.1 8.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 11.1 GO:0031225 anchored component of membrane(GO:0031225)
0.1 1.3 GO:0097512 cardiac myofibril(GO:0097512)
0.1 1.4 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.1 10.4 GO:0001650 fibrillar center(GO:0001650)
0.1 0.7 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.1 1.7 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753)
0.0 2.5 GO:0031201 SNARE complex(GO:0031201)
0.0 56.1 GO:0005615 extracellular space(GO:0005615)
0.0 8.8 GO:0000790 nuclear chromatin(GO:0000790)
0.0 1.8 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 13.2 GO:0005667 transcription factor complex(GO:0005667)
0.0 2.2 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 2.5 GO:0101002 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.0 0.6 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.9 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.1 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.3 GO:0004170 dUTP diphosphatase activity(GO:0004170)
1.6 4.8 GO:0046848 hydroxyapatite binding(GO:0046848)
1.6 17.3 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
1.2 12.4 GO:0070053 thrombospondin receptor activity(GO:0070053)
1.2 65.4 GO:0034987 immunoglobulin receptor binding(GO:0034987)
1.1 4.3 GO:0016160 amylase activity(GO:0016160)
0.9 5.3 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.9 162.9 GO:0003823 antigen binding(GO:0003823)
0.6 1.9 GO:0098519 nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
0.6 1.7 GO:0030272 5-formyltetrahydrofolate cyclo-ligase activity(GO:0030272)
0.6 3.5 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.5 1.6 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.5 2.7 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.4 1.7 GO:0035276 aldehyde oxidase activity(GO:0004031) ethanol binding(GO:0035276)
0.4 2.5 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.3 3.9 GO:0045159 myosin II binding(GO:0045159)
0.3 2.5 GO:0004340 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.3 2.4 GO:0043559 insulin binding(GO:0043559)
0.2 2.5 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.2 3.4 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.2 5.4 GO:0031489 myosin V binding(GO:0031489)
0.2 1.5 GO:0050816 phosphothreonine binding(GO:0050816)
0.2 3.7 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.2 1.1 GO:0039552 RIG-I binding(GO:0039552)
0.2 2.3 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.2 3.0 GO:0008494 translation activator activity(GO:0008494)
0.2 8.3 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 6.1 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 1.0 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.1 5.1 GO:0031369 translation initiation factor binding(GO:0031369)
0.1 1.3 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 3.0 GO:0005521 lamin binding(GO:0005521)
0.1 4.6 GO:0031593 polyubiquitin binding(GO:0031593)
0.1 14.7 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.1 1.1 GO:0035497 cAMP response element binding(GO:0035497)
0.1 2.5 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.1 3.5 GO:0004520 endodeoxyribonuclease activity(GO:0004520)
0.1 0.3 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.1 6.4 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 1.4 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.0 4.9 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.6 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 0.1 GO:0003968 RNA-directed RNA polymerase activity(GO:0003968)
0.0 2.6 GO:0004519 endonuclease activity(GO:0004519)
0.0 1.4 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.2 GO:0046790 virion binding(GO:0046790)
0.0 5.2 GO:0001047 core promoter binding(GO:0001047)
0.0 0.7 GO:0070840 dynein complex binding(GO:0070840)
0.0 0.6 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 1.6 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 6.2 GO:0003712 transcription cofactor activity(GO:0003712)
0.0 0.6 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 13.5 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.5 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.3 19.7 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.2 15.4 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 6.9 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 5.2 PID NCADHERIN PATHWAY N-cadherin signaling events
0.1 11.6 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 1.4 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 2.8 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.1 3.6 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 0.9 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.1 2.5 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 1.5 PID MYC PATHWAY C-MYC pathway
0.0 3.7 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 2.7 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 1.1 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 1.0 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.3 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.3 PID IL1 PATHWAY IL1-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 8.9 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.5 5.1 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.4 12.4 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.2 1.7 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.2 5.4 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.2 3.6 REACTOME DEFENSINS Genes involved in Defensins
0.2 13.4 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.2 5.3 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.1 2.5 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 3.6 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.1 2.4 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 3.9 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 2.5 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 11.1 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.1 2.4 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.1 1.1 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 1.2 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.1 1.4 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 11.2 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.1 0.9 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 2.5 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 1.5 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 2.3 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 1.0 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 5.9 REACTOME GENERIC TRANSCRIPTION PATHWAY Genes involved in Generic Transcription Pathway
0.0 0.9 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction