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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for PROX1

Z-value: 0.52

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Transcription factors associated with PROX1

Gene Symbol Gene ID Gene Info
PROX1
ENSG00000117707.11 prospero homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PROX1hg19_v2_chr1_+_214161854_214161892-0.244.4e-04Click!

Activity profile of PROX1 motif

Sorted Z-values of PROX1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_225434538 13.98 ENST00000409096.1
CUL3
cullin 3
chr6_-_8102279 13.09 ENST00000488226.2
EEF1E1
eukaryotic translation elongation factor 1 epsilon 1
chr19_+_6361754 9.19 ENST00000597326.1
CLPP
caseinolytic mitochondrial matrix peptidase proteolytic subunit
chr11_-_82997371 8.51 ENST00000525503.1
CCDC90B
coiled-coil domain containing 90B
chr21_-_26979786 8.29 ENST00000419219.1
ENST00000352957.4
ENST00000307301.7
MRPL39
mitochondrial ribosomal protein L39
chr7_-_25164969 7.99 ENST00000305786.2
CYCS
cytochrome c, somatic
chrX_+_118602363 7.91 ENST00000317881.8
SLC25A5
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
chr11_-_82997013 7.75 ENST00000529073.1
ENST00000529611.1
CCDC90B
coiled-coil domain containing 90B
chr1_+_165864821 7.12 ENST00000470820.1
UCK2
uridine-cytidine kinase 2
chr15_-_91537723 7.08 ENST00000394249.3
ENST00000559811.1
ENST00000442656.2
ENST00000557905.1
ENST00000361919.3
PRC1
protein regulator of cytokinesis 1
chr1_+_10459111 7.08 ENST00000541529.1
ENST00000270776.8
ENST00000483936.1
ENST00000538557.1
PGD
phosphogluconate dehydrogenase
chr10_-_121296045 7.06 ENST00000392865.1
RGS10
regulator of G-protein signaling 10
chr17_+_66243715 6.98 ENST00000359904.3
AMZ2
archaelysin family metallopeptidase 2
chr1_+_165864800 6.69 ENST00000469256.2
UCK2
uridine-cytidine kinase 2
chr13_+_37581115 6.69 ENST00000481013.1
EXOSC8
exosome component 8
chr5_+_154320623 6.42 ENST00000523037.1
ENST00000265229.8
ENST00000439747.3
ENST00000522038.1
MRPL22
mitochondrial ribosomal protein L22
chr4_-_103747011 6.38 ENST00000350435.7
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr16_-_28857677 6.24 ENST00000313511.3
TUFM
Tu translation elongation factor, mitochondrial
chr1_-_225616515 5.74 ENST00000338179.2
ENST00000425080.1
LBR
lamin B receptor
chr16_-_23607598 5.60 ENST00000562133.1
ENST00000570319.1
ENST00000007516.3
NDUFAB1
NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa
chr6_+_34725263 5.57 ENST00000374018.1
ENST00000374017.3
SNRPC
small nuclear ribonucleoprotein polypeptide C
chr5_-_157002775 5.30 ENST00000257527.4
ADAM19
ADAM metallopeptidase domain 19
chr4_-_103746683 5.23 ENST00000504211.1
ENST00000508476.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr2_-_42588338 5.10 ENST00000234301.2
COX7A2L
cytochrome c oxidase subunit VIIa polypeptide 2 like
chr11_+_60609537 4.94 ENST00000227520.5
CCDC86
coiled-coil domain containing 86
chr4_-_103746924 4.91 ENST00000505207.1
ENST00000502404.1
ENST00000507845.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr10_+_60028818 4.79 ENST00000333926.5
CISD1
CDGSH iron sulfur domain 1
chr15_-_101835110 4.72 ENST00000560496.1
SNRPA1
small nuclear ribonucleoprotein polypeptide A'
chr2_+_108443388 4.45 ENST00000354986.4
ENST00000408999.3
RGPD4
RANBP2-like and GRIP domain containing 4
chr10_+_54074033 4.31 ENST00000373970.3
DKK1
dickkopf WNT signaling pathway inhibitor 1
chr4_-_69215467 4.27 ENST00000579690.1
YTHDC1
YTH domain containing 1
chr1_+_203830703 4.19 ENST00000414487.2
SNRPE
small nuclear ribonucleoprotein polypeptide E
chr5_+_162930114 4.19 ENST00000280969.5
MAT2B
methionine adenosyltransferase II, beta
chr5_+_145826867 4.13 ENST00000296702.5
ENST00000394421.2
TCERG1
transcription elongation regulator 1
chr1_+_171454659 4.01 ENST00000367742.3
ENST00000338920.4
PRRC2C
proline-rich coiled-coil 2C
chr1_-_28241226 4.00 ENST00000373912.3
ENST00000373909.3
RPA2
replication protein A2, 32kDa
chrX_-_152486108 3.76 ENST00000356661.5
MAGEA1
melanoma antigen family A, 1 (directs expression of antigen MZ2-E)
chr16_+_85832146 3.76 ENST00000565078.1
COX4I1
cytochrome c oxidase subunit IV isoform 1
chr18_+_2571510 3.72 ENST00000261597.4
ENST00000575515.1
NDC80
NDC80 kinetochore complex component
chr4_-_69215699 3.70 ENST00000510746.1
ENST00000344157.4
ENST00000355665.3
YTHDC1
YTH domain containing 1
chr17_+_26646121 3.63 ENST00000226230.6
TMEM97
transmembrane protein 97
chr7_+_48128194 3.58 ENST00000416681.1
ENST00000331803.4
ENST00000432131.1
UPP1
uridine phosphorylase 1
chr7_-_25164868 3.52 ENST00000409409.1
ENST00000409764.1
ENST00000413447.1
CYCS
cytochrome c, somatic
chr17_+_16593539 3.52 ENST00000340621.5
ENST00000399273.1
ENST00000443444.2
ENST00000360524.8
ENST00000456009.1
CCDC144A
coiled-coil domain containing 144A
chr7_+_48128316 3.48 ENST00000341253.4
UPP1
uridine phosphorylase 1
chr17_+_36908984 3.46 ENST00000225426.4
ENST00000579088.1
PSMB3
proteasome (prosome, macropain) subunit, beta type, 3
chr6_+_37321823 3.45 ENST00000487950.1
ENST00000469731.1
RNF8
ring finger protein 8, E3 ubiquitin protein ligase
chr12_-_117628333 3.23 ENST00000427718.2
FBXO21
F-box protein 21
chr12_+_98987369 3.22 ENST00000401722.3
ENST00000188376.5
ENST00000228318.3
ENST00000551917.1
ENST00000548046.1
ENST00000552981.1
ENST00000551265.1
ENST00000550695.1
ENST00000547534.1
ENST00000549338.1
ENST00000548847.1
SLC25A3
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
chr2_+_97001491 3.21 ENST00000240423.4
ENST00000427946.1
ENST00000435975.1
ENST00000456906.1
ENST00000455200.1
NCAPH
non-SMC condensin I complex, subunit H
chr22_-_32058166 3.12 ENST00000435900.1
ENST00000336566.4
PISD
phosphatidylserine decarboxylase
chr18_-_21166841 3.09 ENST00000269228.5
NPC1
Niemann-Pick disease, type C1
chr3_-_48723268 3.03 ENST00000439518.1
ENST00000416649.2
ENST00000341520.4
ENST00000294129.2
NCKIPSD
NCK interacting protein with SH3 domain
chr19_-_9546177 2.99 ENST00000592292.1
ENST00000588221.1
ZNF266
zinc finger protein 266
chr3_-_33138286 2.98 ENST00000416695.2
ENST00000342462.4
ENST00000399402.3
TMPPE
GLB1
transmembrane protein with metallophosphoesterase domain
galactosidase, beta 1
chr2_-_107084826 2.95 ENST00000304514.7
ENST00000409886.3
RGPD3
RANBP2-like and GRIP domain containing 3
chr6_-_7911042 2.94 ENST00000379757.4
TXNDC5
thioredoxin domain containing 5 (endoplasmic reticulum)
chr7_+_150759634 2.91 ENST00000392826.2
ENST00000461735.1
SLC4A2
solute carrier family 4 (anion exchanger), member 2
chr11_-_57298187 2.85 ENST00000525158.1
ENST00000257245.4
ENST00000525587.1
TIMM10
translocase of inner mitochondrial membrane 10 homolog (yeast)
chr14_-_23426322 2.78 ENST00000555367.1
HAUS4
HAUS augmin-like complex, subunit 4
chr1_+_161719552 2.75 ENST00000367943.4
DUSP12
dual specificity phosphatase 12
chr8_+_91013577 2.73 ENST00000220764.2
DECR1
2,4-dienoyl CoA reductase 1, mitochondrial
chr10_+_112327425 2.70 ENST00000361804.4
SMC3
structural maintenance of chromosomes 3
chr3_-_33138624 2.59 ENST00000445488.2
ENST00000307377.8
ENST00000440656.1
ENST00000436768.1
ENST00000307363.5
GLB1
galactosidase, beta 1
chr14_-_23426270 2.59 ENST00000557591.1
ENST00000397409.4
ENST00000490506.1
ENST00000554406.1
HAUS4
HAUS augmin-like complex, subunit 4
chr19_+_23945768 2.59 ENST00000486528.1
ENST00000496398.1
RPSAP58
ribosomal protein SA pseudogene 58
chr19_-_9546227 2.52 ENST00000361451.2
ENST00000361151.1
ZNF266
zinc finger protein 266
chr3_+_9839335 2.44 ENST00000453882.1
ARPC4-TTLL3
ARPC4-TTLL3 readthrough
chr19_+_6361440 2.43 ENST00000245816.4
CLPP
caseinolytic mitochondrial matrix peptidase proteolytic subunit
chr14_-_23426337 2.42 ENST00000342454.8
ENST00000555986.1
ENST00000541587.1
ENST00000554516.1
ENST00000347758.2
ENST00000206474.7
ENST00000555040.1
HAUS4
HAUS augmin-like complex, subunit 4
chr1_-_28241024 2.38 ENST00000313433.7
ENST00000444045.1
RPA2
replication protein A2, 32kDa
chr9_+_131218698 2.37 ENST00000434106.3
ENST00000546203.1
ENST00000446274.1
ENST00000421776.2
ENST00000432065.2
ODF2
outer dense fiber of sperm tails 2
chr10_-_96122682 2.26 ENST00000371361.3
NOC3L
nucleolar complex associated 3 homolog (S. cerevisiae)
chr5_-_156569754 2.17 ENST00000420343.1
MED7
mediator complex subunit 7
chr6_-_25042231 2.15 ENST00000510784.2
FAM65B
family with sequence similarity 65, member B
chr15_+_85523671 2.14 ENST00000310298.4
ENST00000557957.1
PDE8A
phosphodiesterase 8A
chr17_+_55183261 2.14 ENST00000576295.1
AKAP1
A kinase (PRKA) anchor protein 1
chr1_+_179050512 2.09 ENST00000367627.3
TOR3A
torsin family 3, member A
chr10_+_71075552 2.08 ENST00000298649.3
HK1
hexokinase 1
chr12_-_117628253 2.07 ENST00000330622.5
FBXO21
F-box protein 21
chr5_+_156693159 2.05 ENST00000347377.6
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr19_+_45754505 2.02 ENST00000262891.4
ENST00000300843.4
MARK4
MAP/microtubule affinity-regulating kinase 4
chr16_+_50300427 1.99 ENST00000394697.2
ENST00000566433.2
ENST00000538642.1
ADCY7
adenylate cyclase 7
chr1_+_171454639 1.89 ENST00000392078.3
ENST00000426496.2
PRRC2C
proline-rich coiled-coil 2C
chr14_+_73603126 1.89 ENST00000557356.1
ENST00000556864.1
ENST00000556533.1
ENST00000556951.1
ENST00000557293.1
ENST00000553719.1
ENST00000553599.1
ENST00000556011.1
ENST00000394157.3
ENST00000357710.4
ENST00000324501.5
ENST00000560005.2
ENST00000555254.1
ENST00000261970.3
ENST00000344094.3
ENST00000554131.1
ENST00000557037.1
PSEN1
presenilin 1
chr8_+_145064215 1.86 ENST00000313269.5
GRINA
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
chr1_-_108735440 1.82 ENST00000370041.4
SLC25A24
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
chr16_+_29817399 1.75 ENST00000545521.1
MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chr1_+_93297622 1.72 ENST00000315741.5
RPL5
ribosomal protein L5
chr14_+_24563262 1.70 ENST00000559250.1
ENST00000216780.4
ENST00000560736.1
ENST00000396973.4
ENST00000559837.1
PCK2
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
chr1_-_151431909 1.70 ENST00000361398.3
ENST00000271715.2
POGZ
pogo transposable element with ZNF domain
chrX_-_53461305 1.68 ENST00000168216.6
HSD17B10
hydroxysteroid (17-beta) dehydrogenase 10
chr20_+_56964253 1.64 ENST00000395802.3
VAPB
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr20_-_7921090 1.64 ENST00000378789.3
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr6_-_90529418 1.59 ENST00000439638.1
ENST00000369393.3
ENST00000428876.1
MDN1
MDN1, midasin homolog (yeast)
chr2_+_131862872 1.54 ENST00000439822.2
PLEKHB2
pleckstrin homology domain containing, family B (evectins) member 2
chr2_+_101179152 1.54 ENST00000264254.6
PDCL3
phosducin-like 3
chr8_+_145064233 1.53 ENST00000529301.1
ENST00000395068.4
GRINA
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
chr1_-_246729544 1.52 ENST00000544618.1
ENST00000366514.4
TFB2M
transcription factor B2, mitochondrial
chr3_-_197025447 1.50 ENST00000346964.2
ENST00000357674.4
ENST00000314062.3
ENST00000448528.2
ENST00000419553.1
DLG1
discs, large homolog 1 (Drosophila)
chr13_-_36788718 1.47 ENST00000317764.6
ENST00000379881.3
SOHLH2
spermatogenesis and oogenesis specific basic helix-loop-helix 2
chr14_-_68141535 1.46 ENST00000554659.1
VTI1B
vesicle transport through interaction with t-SNAREs 1B
chr11_+_73882311 1.44 ENST00000398427.4
ENST00000544401.1
PPME1
protein phosphatase methylesterase 1
chr9_+_71789133 1.44 ENST00000348208.4
ENST00000265384.7
TJP2
tight junction protein 2
chr19_+_36119929 1.42 ENST00000588161.1
ENST00000262633.4
ENST00000592202.1
ENST00000586618.1
RBM42
RNA binding motif protein 42
chr9_-_130890662 1.35 ENST00000277462.5
ENST00000338961.6
PTGES2
prostaglandin E synthase 2
chr8_+_110552831 1.33 ENST00000530629.1
EBAG9
estrogen receptor binding site associated, antigen, 9
chr3_-_47950745 1.33 ENST00000429422.1
MAP4
microtubule-associated protein 4
chr11_+_73882144 1.29 ENST00000328257.8
PPME1
protein phosphatase methylesterase 1
chr12_-_46766577 1.28 ENST00000256689.5
SLC38A2
solute carrier family 38, member 2
chr5_+_179125368 1.27 ENST00000502296.1
ENST00000504734.1
ENST00000415618.2
CANX
calnexin
chr8_-_143696833 1.25 ENST00000356613.2
ARC
activity-regulated cytoskeleton-associated protein
chr9_+_131267052 1.22 ENST00000539582.1
GLE1
GLE1 RNA export mediator
chr19_+_36120009 1.22 ENST00000589871.1
RBM42
RNA binding motif protein 42
chr17_-_40273348 1.21 ENST00000225916.5
KAT2A
K(lysine) acetyltransferase 2A
chr16_+_57279004 1.20 ENST00000219204.3
ARL2BP
ADP-ribosylation factor-like 2 binding protein
chr16_+_57279248 1.19 ENST00000562023.1
ENST00000563234.1
ARL2BP
ADP-ribosylation factor-like 2 binding protein
chr1_-_154909329 1.14 ENST00000368467.3
PMVK
phosphomevalonate kinase
chr16_+_28722809 1.13 ENST00000566866.1
EIF3C
eukaryotic translation initiation factor 3, subunit C
chrX_+_151883090 1.08 ENST00000370293.2
ENST00000423993.1
ENST00000447530.1
ENST00000458057.1
ENST00000331220.2
ENST00000422085.1
ENST00000453150.1
ENST00000409560.1
MAGEA2B
melanoma antigen family A, 2B
chr12_-_58240470 1.08 ENST00000548823.1
ENST00000398073.2
CTDSP2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
chr7_-_99716952 1.05 ENST00000523306.1
ENST00000344095.4
ENST00000417349.1
ENST00000493322.1
ENST00000520135.1
ENST00000418432.2
ENST00000460673.2
ENST00000452041.1
ENST00000452438.2
ENST00000451699.1
ENST00000453269.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr14_+_22320634 1.05 ENST00000390435.1
TRAV8-3
T cell receptor alpha variable 8-3
chr8_+_110552046 1.04 ENST00000529931.1
EBAG9
estrogen receptor binding site associated, antigen, 9
chr1_+_93297582 1.01 ENST00000370321.3
RPL5
ribosomal protein L5
chr9_+_34990219 0.98 ENST00000541010.1
ENST00000454002.2
ENST00000545841.1
DNAJB5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr3_+_12525931 0.98 ENST00000446004.1
ENST00000314571.7
ENST00000454502.2
ENST00000383797.5
ENST00000402228.3
ENST00000284995.6
ENST00000444864.1
TSEN2
TSEN2 tRNA splicing endonuclease subunit
chrX_-_151922340 0.90 ENST00000370284.1
ENST00000543232.1
ENST00000393876.1
ENST00000393872.3
MAGEA2
melanoma antigen family A, 2
chr1_-_94050668 0.87 ENST00000539242.1
BCAR3
breast cancer anti-estrogen resistance 3
chr6_+_37321748 0.87 ENST00000373479.4
ENST00000394443.4
RNF8
ring finger protein 8, E3 ubiquitin protein ligase
chr11_+_64009072 0.82 ENST00000535135.1
ENST00000394540.3
FKBP2
FK506 binding protein 2, 13kDa
chr2_+_163175394 0.81 ENST00000446271.1
ENST00000429691.2
GCA
grancalcin, EF-hand calcium binding protein
chr14_-_105420241 0.77 ENST00000557457.1
AHNAK2
AHNAK nucleoprotein 2
chr15_+_81489213 0.73 ENST00000559383.1
ENST00000394660.2
IL16
interleukin 16
chr16_+_28722684 0.71 ENST00000331666.6
ENST00000395587.1
ENST00000569690.1
ENST00000564243.1
EIF3C
eukaryotic translation initiation factor 3, subunit C
chr19_+_49535169 0.69 ENST00000474913.1
ENST00000359342.6
CGB2
chorionic gonadotropin, beta polypeptide 2
chr5_-_132113083 0.67 ENST00000296873.7
SEPT8
septin 8
chr10_+_104005272 0.65 ENST00000369983.3
GBF1
golgi brefeldin A resistant guanine nucleotide exchange factor 1
chr19_+_36119975 0.63 ENST00000589559.1
ENST00000360475.4
RBM42
RNA binding motif protein 42
chr19_-_46234119 0.63 ENST00000317683.3
FBXO46
F-box protein 46
chr2_+_131862900 0.63 ENST00000438882.2
ENST00000538982.1
ENST00000404460.1
PLEKHB2
pleckstrin homology domain containing, family B (evectins) member 2
chr3_+_190105909 0.62 ENST00000456423.1
CLDN16
claudin 16
chr7_+_66093851 0.59 ENST00000275532.3
KCTD7
potassium channel tetramerization domain containing 7
chr15_-_75249793 0.58 ENST00000322177.5
RPP25
ribonuclease P/MRP 25kDa subunit
chr5_+_64859066 0.57 ENST00000261308.5
ENST00000535264.1
ENST00000538977.1
PPWD1
peptidylprolyl isomerase domain and WD repeat containing 1
chr12_+_113229737 0.57 ENST00000551052.1
ENST00000415485.3
RPH3A
rabphilin 3A homolog (mouse)
chr10_-_92681033 0.53 ENST00000371697.3
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr10_+_16478942 0.53 ENST00000535784.2
ENST00000423462.2
ENST00000378000.1
PTER
phosphotriesterase related
chr2_+_128403720 0.52 ENST00000272644.3
GPR17
G protein-coupled receptor 17
chr15_+_59279851 0.52 ENST00000348370.4
ENST00000434298.1
ENST00000559160.1
RNF111
ring finger protein 111
chr16_-_18801643 0.50 ENST00000322989.4
ENST00000563390.1
RPS15A
ribosomal protein S15a
chr1_-_159046617 0.47 ENST00000368130.4
AIM2
absent in melanoma 2
chr12_+_113229543 0.45 ENST00000447659.2
RPH3A
rabphilin 3A homolog (mouse)
chr2_+_128403439 0.44 ENST00000544369.1
GPR17
G protein-coupled receptor 17
chr8_-_146176199 0.43 ENST00000532351.1
ENST00000276816.4
ENST00000394909.2
ZNF16
zinc finger protein 16
chr9_+_72873837 0.43 ENST00000361138.5
SMC5
structural maintenance of chromosomes 5
chr1_+_6640108 0.40 ENST00000377674.4
ENST00000488936.1
ZBTB48
zinc finger and BTB domain containing 48
chr15_-_58357932 0.40 ENST00000347587.3
ALDH1A2
aldehyde dehydrogenase 1 family, member A2
chr1_+_35544968 0.37 ENST00000359858.4
ENST00000373330.1
ZMYM1
zinc finger, MYM-type 1
chr12_+_113229452 0.37 ENST00000389385.4
RPH3A
rabphilin 3A homolog (mouse)
chr17_-_48546232 0.35 ENST00000258969.4
CHAD
chondroadherin
chr2_-_89247338 0.34 ENST00000496168.1
IGKV1-5
immunoglobulin kappa variable 1-5
chr10_-_69455873 0.32 ENST00000433211.2
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr2_-_163175133 0.30 ENST00000421365.2
ENST00000263642.2
IFIH1
interferon induced with helicase C domain 1
chr18_+_33767473 0.29 ENST00000261326.5
MOCOS
molybdenum cofactor sulfurase
chr5_-_157002749 0.28 ENST00000517905.1
ENST00000430702.2
ENST00000394020.1
ADAM19
ADAM metallopeptidase domain 19
chrX_+_117861535 0.25 ENST00000371666.3
ENST00000371642.1
IL13RA1
interleukin 13 receptor, alpha 1
chr22_-_43539346 0.24 ENST00000327555.5
ENST00000290429.6
MCAT
malonyl CoA:ACP acyltransferase (mitochondrial)
chr18_+_60190226 0.23 ENST00000269499.5
ZCCHC2
zinc finger, CCHC domain containing 2
chr1_+_222817629 0.23 ENST00000340535.7
MIA3
melanoma inhibitory activity family, member 3
chr6_-_31628512 0.19 ENST00000375911.1
C6orf47
chromosome 6 open reading frame 47
chr11_+_61522844 0.18 ENST00000265460.5
MYRF
myelin regulatory factor
chr1_+_179262905 0.16 ENST00000539888.1
ENST00000540564.1
ENST00000535686.1
ENST00000367619.3
SOAT1
sterol O-acyltransferase 1
chr5_-_132113036 0.14 ENST00000378706.1
SEPT8
septin 8
chr4_-_38666430 0.10 ENST00000436901.1
AC021860.1
Uncharacterized protein
chr11_-_4719072 0.08 ENST00000396950.3
ENST00000532598.1
OR51E2
olfactory receptor, family 51, subfamily E, member 2
chrX_+_16668278 0.06 ENST00000380200.3
S100G
S100 calcium binding protein G
chr6_-_134495992 0.04 ENST00000475719.2
ENST00000367857.5
ENST00000237305.7
SGK1
serum/glucocorticoid regulated kinase 1
chr6_+_29141311 0.03 ENST00000377167.2
OR2J2
olfactory receptor, family 2, subfamily J, member 2
chr17_-_7307358 0.01 ENST00000576017.1
ENST00000302422.3
ENST00000535512.1
TMEM256
TMEM256-PLSCR3
transmembrane protein 256
TMEM256-PLSCR3 readthrough (NMD candidate)

Network of associatons between targets according to the STRING database.

First level regulatory network of PROX1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 14.0 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831)
3.5 13.8 GO:0046035 CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035)
2.4 7.1 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
1.8 7.1 GO:0006218 uridine catabolic process(GO:0006218) uridine metabolic process(GO:0046108)
1.7 6.7 GO:0034476 U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476)
1.4 4.3 GO:0003308 negative regulation of Wnt signaling pathway involved in heart development(GO:0003308) negative regulation of cell fate specification(GO:0009996)
1.3 7.9 GO:1901029 adenine transport(GO:0015853) negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029)
1.1 5.6 GO:1904016 response to Thyroglobulin triiodothyronine(GO:1904016)
1.0 4.2 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
1.0 20.4 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.8 12.5 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.7 2.7 GO:2000434 regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435)
0.6 4.4 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
0.6 5.6 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.6 4.3 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.6 2.4 GO:0018094 protein polyglycylation(GO:0018094)
0.6 1.7 GO:0070901 mitochondrial tRNA methylation(GO:0070901)
0.6 5.6 GO:0009249 protein lipoylation(GO:0009249)
0.5 2.7 GO:1903301 positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301)
0.5 1.8 GO:0015866 ADP transport(GO:0015866)
0.4 2.7 GO:0044789 modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791)
0.4 1.2 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.4 3.2 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.4 3.1 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.4 1.5 GO:0046116 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.4 1.5 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.4 1.1 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.4 7.1 GO:0000022 mitotic spindle elongation(GO:0000022)
0.4 5.4 GO:0051383 kinetochore organization(GO:0051383)
0.4 16.5 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.3 1.0 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.3 2.9 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.3 1.9 GO:0051563 smooth endoplasmic reticulum calcium ion homeostasis(GO:0051563)
0.3 1.2 GO:2000969 positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000969)
0.3 6.4 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.3 7.4 GO:0006376 mRNA splice site selection(GO:0006376)
0.3 2.0 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.2 1.3 GO:0051012 microtubule sliding(GO:0051012)
0.2 1.3 GO:0032328 alanine transport(GO:0032328)
0.2 1.7 GO:0006116 NADH oxidation(GO:0006116)
0.2 3.8 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.2 1.5 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.2 2.1 GO:0072656 maintenance of protein location in mitochondrion(GO:0072656)
0.2 4.8 GO:0043457 regulation of cellular respiration(GO:0043457)
0.2 1.6 GO:0009441 fatty acid alpha-oxidation(GO:0001561) glycolate metabolic process(GO:0009441)
0.2 1.8 GO:1902416 positive regulation of mRNA binding(GO:1902416)
0.2 1.4 GO:1903760 regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1903760)
0.2 1.6 GO:0006987 activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.2 12.5 GO:0070126 mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126)
0.2 2.2 GO:0045595 regulation of cell differentiation(GO:0045595)
0.2 0.7 GO:0035964 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.2 3.4 GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236)
0.2 3.2 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.1 1.4 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
0.1 0.4 GO:0034093 positive regulation of maintenance of sister chromatid cohesion(GO:0034093) positive regulation of maintenance of mitotic sister chromatid cohesion(GO:0034184)
0.1 4.2 GO:0008334 histone mRNA metabolic process(GO:0008334)
0.1 3.3 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.1 5.6 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.1 0.6 GO:0006449 regulation of translational termination(GO:0006449)
0.1 3.8 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.1 2.9 GO:0000042 protein targeting to Golgi(GO:0000042)
0.1 4.9 GO:0016032 viral process(GO:0016032)
0.1 6.2 GO:0006414 translational elongation(GO:0006414)
0.1 1.3 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.1 2.0 GO:0071361 cellular response to ethanol(GO:0071361)
0.1 2.1 GO:1903206 negative regulation of hydrogen peroxide-induced cell death(GO:1903206)
0.1 3.0 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 0.3 GO:0034344 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
0.1 2.4 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.1 7.8 GO:0051225 spindle assembly(GO:0051225)
0.1 2.7 GO:0006482 protein demethylation(GO:0006482) protein dealkylation(GO:0008214)
0.1 0.5 GO:0070269 pyroptosis(GO:0070269)
0.1 5.7 GO:0006695 cholesterol biosynthetic process(GO:0006695)
0.1 0.5 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.1 0.8 GO:0001778 plasma membrane repair(GO:0001778)
0.1 4.3 GO:0045454 cell redox homeostasis(GO:0045454)
0.1 4.7 GO:0035722 interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)
0.1 0.2 GO:1900154 regulation of bone trabecula formation(GO:1900154) negative regulation of bone trabecula formation(GO:1900155)
0.1 0.4 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
0.1 3.7 GO:0055092 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.1 0.9 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.0 1.6 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 0.4 GO:0035799 ureter maturation(GO:0035799)
0.0 0.6 GO:1903830 magnesium ion transmembrane transport(GO:1903830)
0.0 1.5 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.0 0.6 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.0 3.5 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.0 2.0 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 0.3 GO:0006777 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720)
0.0 0.3 GO:0086042 cardiac muscle cell-cardiac muscle cell adhesion(GO:0086042) bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.0 3.0 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.0 1.4 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 1.7 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.0 0.9 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.0 0.7 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.0 1.0 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 2.9 GO:0051453 regulation of intracellular pH(GO:0051453)
0.0 0.7 GO:0030728 ovulation(GO:0030728)
0.0 2.4 GO:0007286 spermatid development(GO:0007286)
0.0 0.2 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.0 0.1 GO:1900133 regulation of renin secretion into blood stream(GO:1900133)
0.0 0.2 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 6.7 GO:0051260 protein homooligomerization(GO:0051260)
0.0 1.1 GO:0036498 IRE1-mediated unfolded protein response(GO:0036498)
0.0 1.1 GO:0042795 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 2.7 GO:0000209 protein polyubiquitination(GO:0000209)
0.0 0.6 GO:0048477 oogenesis(GO:0048477)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 11.6 GO:0009368 endopeptidase Clp complex(GO:0009368)
1.6 14.0 GO:0005827 polar microtubule(GO:0005827)
1.4 4.2 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
1.3 7.9 GO:0071817 MMXD complex(GO:0071817)
1.2 3.7 GO:0031262 Ndc80 complex(GO:0031262)
0.9 2.7 GO:0034991 nuclear meiotic cohesin complex(GO:0034991)
0.9 7.8 GO:0070652 HAUS complex(GO:0070652)
0.8 3.2 GO:0000799 nuclear condensin complex(GO:0000799)
0.7 7.1 GO:0070938 contractile ring(GO:0070938)
0.6 13.1 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.6 6.7 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.6 5.6 GO:0000243 commitment complex(GO:0000243)
0.5 4.2 GO:0005683 U7 snRNP(GO:0005683) pICln-Sm protein complex(GO:0034715)
0.4 6.4 GO:0005662 DNA replication factor A complex(GO:0005662)
0.4 14.7 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.4 2.9 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.3 2.4 GO:0001520 outer dense fiber(GO:0001520)
0.3 11.5 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.3 1.7 GO:0030678 mitochondrial ribonuclease P complex(GO:0030678)
0.3 4.7 GO:0005686 U2 snRNP(GO:0005686)
0.3 5.7 GO:0044453 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.3 3.8 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.2 1.0 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.2 3.5 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.2 4.5 GO:0035861 site of double-strand break(GO:0035861)
0.2 1.9 GO:0070765 gamma-secretase complex(GO:0070765)
0.1 7.8 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 2.4 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 10.7 GO:0005746 mitochondrial respiratory chain(GO:0005746)
0.1 1.3 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.1 1.4 GO:0097025 lateral loop(GO:0043219) MPP7-DLG1-LIN7 complex(GO:0097025)
0.1 2.3 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.1 10.7 GO:0035578 azurophil granule lumen(GO:0035578)
0.1 0.6 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.1 0.6 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.1 2.0 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 2.1 GO:0097228 sperm principal piece(GO:0097228)
0.1 1.8 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.1 0.5 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.1 1.9 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.1 3.0 GO:0008180 COP9 signalosome(GO:0008180)
0.1 2.2 GO:0016592 mediator complex(GO:0016592)
0.1 1.6 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 3.6 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 22.0 GO:0010008 endosome membrane(GO:0010008)
0.0 3.6 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 8.3 GO:0044309 dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.0 22.2 GO:0005740 mitochondrial envelope(GO:0005740)
0.0 1.6 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 2.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.8 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.3 GO:0005916 fascia adherens(GO:0005916)
0.0 9.5 GO:0016607 nuclear speck(GO:0016607)
0.0 1.4 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 0.8 GO:0043034 costamere(GO:0043034)
0.0 1.3 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0 2.1 GO:0005923 bicellular tight junction(GO:0005923)
0.0 4.1 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 1.3 GO:0005903 brush border(GO:0005903)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.8 11.5 GO:0045155 electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity(GO:0045155)
3.5 14.0 GO:0031208 POZ domain binding(GO:0031208)
2.4 7.1 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
2.0 7.9 GO:0015207 ATP:ADP antiporter activity(GO:0005471) adenine transmembrane transporter activity(GO:0015207)
2.0 13.8 GO:0004849 uridine kinase activity(GO:0004849)
1.9 5.7 GO:0050613 delta14-sterol reductase activity(GO:0050613)
1.9 5.6 GO:0000035 acyl binding(GO:0000035) phosphopantetheine binding(GO:0031177)
1.9 5.6 GO:0030627 pre-mRNA 5'-splice site binding(GO:0030627)
1.8 7.1 GO:0004850 uridine phosphorylase activity(GO:0004850)
1.4 5.6 GO:0016936 galactoside binding(GO:0016936)
1.0 3.1 GO:0004609 phosphatidylserine decarboxylase activity(GO:0004609)
0.7 2.7 GO:0008670 2,4-dienoyl-CoA reductase (NADPH) activity(GO:0008670)
0.7 2.7 GO:0036033 mediator complex binding(GO:0036033)
0.6 6.4 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.6 8.0 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.6 2.4 GO:0070735 protein-glycine ligase activity(GO:0070735)
0.6 2.4 GO:0016504 peptidase activator activity(GO:0016504) peptidase activator activity involved in apoptotic process(GO:0016505) peptidase regulator activity(GO:0061134)
0.6 4.7 GO:0030620 U2 snRNA binding(GO:0030620)
0.6 1.7 GO:0004613 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.5 1.6 GO:0033149 FFAT motif binding(GO:0033149)
0.5 1.6 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.5 3.2 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.5 4.2 GO:1990446 U1 snRNP binding(GO:1990446)
0.5 1.9 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.5 1.8 GO:0015217 adenine nucleotide transmembrane transporter activity(GO:0000295) purine ribonucleotide transmembrane transporter activity(GO:0005346) ATP transmembrane transporter activity(GO:0005347) purine nucleotide transmembrane transporter activity(GO:0015216) ADP transmembrane transporter activity(GO:0015217)
0.4 4.3 GO:0039706 co-receptor binding(GO:0039706)
0.3 1.4 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.3 1.0 GO:0000213 tRNA-intron endonuclease activity(GO:0000213)
0.3 1.5 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.3 8.9 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.3 1.5 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.3 13.9 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.3 2.7 GO:1990948 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
0.3 13.1 GO:0004364 glutathione transferase activity(GO:0004364)
0.3 2.1 GO:0004340 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.2 6.2 GO:0003746 translation elongation factor activity(GO:0003746)
0.2 1.2 GO:0010484 H3 histone acetyltransferase activity(GO:0010484)
0.2 4.8 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.2 7.1 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.2 1.1 GO:0008420 CTD phosphatase activity(GO:0008420)
0.2 0.6 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.2 6.7 GO:0017091 AU-rich element binding(GO:0017091)
0.2 0.5 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.2 0.5 GO:0032184 SUMO polymer binding(GO:0032184)
0.2 3.2 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)
0.2 2.9 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.2 2.9 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.1 1.5 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.1 4.1 GO:0070064 proline-rich region binding(GO:0070064)
0.1 1.4 GO:0008430 selenium binding(GO:0008430) phosphate ion binding(GO:0042301)
0.1 1.4 GO:0097016 L27 domain binding(GO:0097016)
0.1 7.1 GO:0019894 kinesin binding(GO:0019894)
0.1 3.5 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 2.0 GO:0050321 tau-protein kinase activity(GO:0050321)
0.1 4.3 GO:0008536 Ran GTPase binding(GO:0008536)
0.1 1.7 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.1 2.0 GO:0004383 guanylate cyclase activity(GO:0004383)
0.1 1.3 GO:0034185 apolipoprotein binding(GO:0034185)
0.1 1.1 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.1 0.2 GO:0042954 lipoprotein transporter activity(GO:0042954)
0.1 2.7 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.1 3.2 GO:0015485 cholesterol binding(GO:0015485)
0.1 2.8 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 0.3 GO:0030151 molybdenum ion binding(GO:0030151)
0.1 11.2 GO:0008237 metallopeptidase activity(GO:0008237)
0.0 1.2 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 1.4 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.6 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 1.8 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 0.4 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.0 4.7 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 0.6 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 3.8 GO:0051087 chaperone binding(GO:0051087)
0.0 0.3 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.0 0.4 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.0 0.7 GO:0042609 CD4 receptor binding(GO:0042609)
0.0 8.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.9 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.0 10.7 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 0.6 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.2 GO:0004312 fatty acid synthase activity(GO:0004312)
0.0 1.0 GO:0004950 G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.0 3.7 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.8 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 3.2 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.0 2.9 GO:0044325 ion channel binding(GO:0044325)
0.0 4.0 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 1.6 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.6 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 2.7 GO:0003735 structural constituent of ribosome(GO:0003735)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 14.0 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.4 16.5 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.2 13.2 PID PLK1 PATHWAY PLK1 signaling events
0.2 9.5 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.2 6.4 PID FANCONI PATHWAY Fanconi anemia pathway
0.1 4.1 PID WNT SIGNALING PATHWAY Wnt signaling network
0.1 6.8 PID ATM PATHWAY ATM pathway
0.1 2.0 PID LPA4 PATHWAY LPA4-mediated signaling events
0.1 6.2 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.1 1.9 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.1 3.2 PID AURORA B PATHWAY Aurora B signaling
0.1 3.4 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 3.1 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.7 PID ARF 3PATHWAY Arf1 pathway
0.0 1.7 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 3.2 PID CMYB PATHWAY C-MYB transcription factor network
0.0 2.0 PID LKB1 PATHWAY LKB1 signaling events
0.0 1.2 PID MYC PATHWAY C-MYC pathway
0.0 0.3 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.0 2.1 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.2 ST JAK STAT PATHWAY Jak-STAT Pathway
0.0 2.1 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.1 PID BMP PATHWAY BMP receptor signaling
0.0 0.9 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.8 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 3.3 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.2 PID IFNG PATHWAY IFN-gamma pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 6.7 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.6 20.9 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.5 6.4 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.4 16.5 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.4 13.1 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.3 5.6 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.3 26.0 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.3 4.2 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.2 6.9 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.2 2.0 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.2 7.8 REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.2 2.7 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1 1.2 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 1.9 REACTOME SIGNALING BY NOTCH2 Genes involved in Signaling by NOTCH2
0.1 2.1 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.1 0.7 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.1 1.4 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1 1.3 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 2.9 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 6.4 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 16.4 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 1.7 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 1.4 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 1.0 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.1 1.3 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 2.9 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 4.2 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation
0.0 8.8 REACTOME METABOLISM OF CARBOHYDRATES Genes involved in Metabolism of carbohydrates
0.0 2.3 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 4.2 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 2.9 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 2.4 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 2.2 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.3 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 1.1 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.6 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.5 REACTOME INFLAMMASOMES Genes involved in Inflammasomes