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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for PROX1
Z-value: 0.52
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Transcription factors associated with PROX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PROX1 | hg19_v2_chr1_+_214161854_214161892 | -0.24 | 4.4e-04 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_-_225434538 Show fit | 13.98 |
ENST00000409096.1
|
cullin 3 |
|
| chr6_-_8102279 Show fit | 13.09 |
ENST00000488226.2
|
eukaryotic translation elongation factor 1 epsilon 1 |
|
| chr19_+_6361754 Show fit | 9.19 |
ENST00000597326.1
|
caseinolytic mitochondrial matrix peptidase proteolytic subunit |
|
| chr11_-_82997371 Show fit | 8.51 |
ENST00000525503.1
|
coiled-coil domain containing 90B |
|
| chr21_-_26979786 Show fit | 8.29 |
ENST00000419219.1
ENST00000352957.4 ENST00000307301.7 |
mitochondrial ribosomal protein L39 |
|
| chr7_-_25164969 Show fit | 7.99 |
ENST00000305786.2
|
cytochrome c, somatic |
|
| chrX_+_118602363 Show fit | 7.91 |
ENST00000317881.8
|
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 |
|
| chr11_-_82997013 Show fit | 7.75 |
ENST00000529073.1
ENST00000529611.1 |
coiled-coil domain containing 90B |
|
| chr1_+_165864821 Show fit | 7.12 |
ENST00000470820.1
|
uridine-cytidine kinase 2 |
|
| chr15_-_91537723 Show fit | 7.08 |
ENST00000394249.3
ENST00000559811.1 ENST00000442656.2 ENST00000557905.1 ENST00000361919.3 |
protein regulator of cytokinesis 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of PROX1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 20.4 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.4 | 16.5 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 3.5 | 14.0 | GO:0001831 | trophectodermal cellular morphogenesis(GO:0001831) |
| 3.5 | 13.8 | GO:0046035 | CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035) |
| 0.8 | 12.5 | GO:0043517 | positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) |
| 0.2 | 12.5 | GO:0070126 | mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126) |
| 1.3 | 7.9 | GO:1901029 | adenine transport(GO:0015853) negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029) |
| 0.1 | 7.8 | GO:0051225 | spindle assembly(GO:0051225) |
| 0.3 | 7.4 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 2.4 | 7.1 | GO:0009051 | pentose-phosphate shunt, oxidative branch(GO:0009051) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 22.2 | GO:0005740 | mitochondrial envelope(GO:0005740) |
| 0.0 | 22.0 | GO:0010008 | endosome membrane(GO:0010008) |
| 0.4 | 14.7 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 1.6 | 14.0 | GO:0005827 | polar microtubule(GO:0005827) |
| 0.6 | 13.1 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 2.3 | 11.6 | GO:0009368 | endopeptidase Clp complex(GO:0009368) |
| 0.3 | 11.5 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.1 | 10.7 | GO:0005746 | mitochondrial respiratory chain(GO:0005746) |
| 0.1 | 10.7 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.0 | 9.5 | GO:0016607 | nuclear speck(GO:0016607) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.5 | 14.0 | GO:0031208 | POZ domain binding(GO:0031208) |
| 0.3 | 13.9 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 2.0 | 13.8 | GO:0004849 | uridine kinase activity(GO:0004849) |
| 0.3 | 13.1 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 3.8 | 11.5 | GO:0045155 | electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity(GO:0045155) |
| 0.1 | 11.2 | GO:0008237 | metallopeptidase activity(GO:0008237) |
| 0.0 | 10.7 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.3 | 8.9 | GO:0015002 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 8.3 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.6 | 8.0 | GO:1990247 | N6-methyladenosine-containing RNA binding(GO:1990247) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 16.5 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.4 | 14.0 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.2 | 13.2 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.2 | 9.5 | PID HIV NEF PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 0.1 | 6.8 | PID ATM PATHWAY | ATM pathway |
| 0.2 | 6.4 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.1 | 6.2 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
| 0.1 | 4.1 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.1 | 3.4 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 3.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 26.0 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.6 | 20.9 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.4 | 16.5 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.1 | 16.4 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.4 | 13.1 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.0 | 8.8 | REACTOME METABOLISM OF CARBOHYDRATES | Genes involved in Metabolism of carbohydrates |
| 0.2 | 7.8 | REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS | Genes involved in Interactions of Vpr with host cellular proteins |
| 0.2 | 6.9 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.7 | 6.7 | REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |
| 0.5 | 6.4 | REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |