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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for PTF1A

Z-value: 1.15

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Transcription factors associated with PTF1A

Gene Symbol Gene ID Gene Info
PTF1A
ENSG00000168267.5 pancreas associated transcription factor 1a

Activity profile of PTF1A motif

Sorted Z-values of PTF1A motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_111794446 45.24 ENST00000527950.1
CRYAB
crystallin, alpha B
chrX_-_13956497 28.78 ENST00000398361.3
GPM6B
glycoprotein M6B
chrX_-_13956737 25.22 ENST00000454189.2
GPM6B
glycoprotein M6B
chr2_-_71454185 23.88 ENST00000244221.8
PAIP2B
poly(A) binding protein interacting protein 2B
chr8_-_22089845 23.69 ENST00000454243.2
PHYHIP
phytanoyl-CoA 2-hydroxylase interacting protein
chr8_-_22089533 22.62 ENST00000321613.3
PHYHIP
phytanoyl-CoA 2-hydroxylase interacting protein
chr5_-_118324200 22.45 ENST00000515439.3
ENST00000510708.1
DTWD2
DTW domain containing 2
chr3_+_40518599 19.36 ENST00000314686.5
ENST00000447116.2
ENST00000429348.2
ENST00000456778.1
ZNF619
zinc finger protein 619
chr2_-_136288113 19.35 ENST00000401392.1
ZRANB3
zinc finger, RAN-binding domain containing 3
chr7_-_152373216 16.79 ENST00000359321.1
XRCC2
X-ray repair complementing defective repair in Chinese hamster cells 2
chr8_-_99306564 16.24 ENST00000430223.2
NIPAL2
NIPA-like domain containing 2
chr4_+_156588115 15.80 ENST00000455639.2
GUCY1A3
guanylate cyclase 1, soluble, alpha 3
chr15_+_68924327 15.75 ENST00000543950.1
CORO2B
coronin, actin binding protein, 2B
chr3_+_49027308 15.74 ENST00000383729.4
ENST00000343546.4
P4HTM
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
chr4_+_156587979 15.54 ENST00000511507.1
GUCY1A3
guanylate cyclase 1, soluble, alpha 3
chr17_-_34313685 15.47 ENST00000435911.2
ENST00000586216.1
ENST00000394509.4
CCL14
chemokine (C-C motif) ligand 14
chr8_-_99306611 15.16 ENST00000341166.3
NIPAL2
NIPA-like domain containing 2
chr22_+_23101182 15.01 ENST00000390312.2
IGLV2-14
immunoglobulin lambda variable 2-14
chr3_+_35681081 14.72 ENST00000428373.1
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr4_+_156587853 14.45 ENST00000506455.1
ENST00000511108.1
GUCY1A3
guanylate cyclase 1, soluble, alpha 3
chr3_+_167453493 14.37 ENST00000295777.5
ENST00000472747.2
SERPINI1
serpin peptidase inhibitor, clade I (neuroserpin), member 1
chr22_-_50523760 14.12 ENST00000395876.2
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr3_+_101546827 12.95 ENST00000461724.1
ENST00000483180.1
ENST00000394054.2
NFKBIZ
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr18_-_53177984 12.74 ENST00000543082.1
TCF4
transcription factor 4
chr17_-_73892992 12.61 ENST00000540128.1
ENST00000269383.3
TRIM65
tripartite motif containing 65
chr7_-_100844193 12.08 ENST00000440203.2
ENST00000379423.3
ENST00000223114.4
MOGAT3
monoacylglycerol O-acyltransferase 3
chr16_-_75569068 10.71 ENST00000336257.3
ENST00000565039.1
CHST5
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
chr18_+_5238549 10.58 ENST00000580684.1
LINC00667
long intergenic non-protein coding RNA 667
chr6_-_62996066 9.99 ENST00000281156.4
KHDRBS2
KH domain containing, RNA binding, signal transduction associated 2
chr2_-_196933536 9.76 ENST00000312428.6
ENST00000410072.1
DNAH7
dynein, axonemal, heavy chain 7
chr17_+_53342311 9.63 ENST00000226067.5
HLF
hepatic leukemia factor
chr1_+_114447763 9.52 ENST00000369563.3
DCLRE1B
DNA cross-link repair 1B
chrX_-_48216101 9.49 ENST00000298396.2
ENST00000376893.3
SSX3
synovial sarcoma, X breakpoint 3
chr1_-_45956822 9.38 ENST00000372086.3
ENST00000341771.6
TESK2
testis-specific kinase 2
chr2_+_173600514 9.09 ENST00000264111.6
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr4_-_83719884 8.97 ENST00000282709.4
ENST00000273908.4
SCD5
stearoyl-CoA desaturase 5
chr18_+_5238055 8.97 ENST00000582363.1
ENST00000582008.1
ENST00000580082.1
LINC00667
long intergenic non-protein coding RNA 667
chrX_+_48242863 8.96 ENST00000376886.2
ENST00000375517.3
SSX4
synovial sarcoma, X breakpoint 4
chr13_+_113633620 8.93 ENST00000421756.1
ENST00000375601.3
MCF2L
MCF.2 cell line derived transforming sequence-like
chr2_+_183943464 8.93 ENST00000354221.4
DUSP19
dual specificity phosphatase 19
chr11_-_207221 8.78 ENST00000486280.1
ENST00000332865.6
ENST00000529614.2
ENST00000325147.9
ENST00000410108.1
ENST00000382762.3
BET1L
Bet1 golgi vesicular membrane trafficking protein-like
chr10_+_76871454 8.77 ENST00000372687.4
SAMD8
sterile alpha motif domain containing 8
chr10_-_28571015 8.48 ENST00000375719.3
ENST00000375732.1
MPP7
membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
chr19_+_17326521 8.37 ENST00000593597.1
USE1
unconventional SNARE in the ER 1 homolog (S. cerevisiae)
chr11_-_45687128 8.27 ENST00000308064.2
CHST1
carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
chr6_+_27107053 8.23 ENST00000354348.2
HIST1H4I
histone cluster 1, H4i
chrX_-_107019181 8.11 ENST00000315660.4
ENST00000372384.2
ENST00000502650.1
ENST00000506724.1
TSC22D3
TSC22 domain family, member 3
chr4_-_82393009 7.89 ENST00000436139.2
RASGEF1B
RasGEF domain family, member 1B
chr10_+_99332198 7.89 ENST00000307518.5
ENST00000298808.5
ENST00000370655.1
ANKRD2
ankyrin repeat domain 2 (stretch responsive muscle)
chr3_+_35721106 7.87 ENST00000474696.1
ENST00000412048.1
ENST00000396482.2
ENST00000432682.1
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr21_+_44073916 7.72 ENST00000349112.3
ENST00000398224.3
PDE9A
phosphodiesterase 9A
chr1_-_9129735 7.66 ENST00000377424.4
SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr2_+_173600565 7.52 ENST00000397081.3
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chrX_+_15808569 7.45 ENST00000380308.3
ENST00000307771.7
ZRSR2
zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2
chr1_-_158301312 7.44 ENST00000368168.3
CD1B
CD1b molecule
chr17_-_33416231 7.43 ENST00000584655.1
ENST00000447669.2
ENST00000315249.7
RFFL
ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
chr17_+_12692774 7.11 ENST00000379672.5
ENST00000340825.3
ARHGAP44
Rho GTPase activating protein 44
chr2_-_89278535 7.07 ENST00000390247.2
IGKV3-7
immunoglobulin kappa variable 3-7 (non-functional)
chr2_-_237416071 7.04 ENST00000309507.5
ENST00000431676.2
IQCA1
IQ motif containing with AAA domain 1
chr14_-_77737543 7.01 ENST00000298352.4
NGB
neuroglobin
chr16_+_2802623 6.96 ENST00000576924.1
ENST00000575009.1
ENST00000576415.1
ENST00000571378.1
SRRM2
serine/arginine repetitive matrix 2
chr1_-_76076759 6.87 ENST00000370855.5
SLC44A5
solute carrier family 44, member 5
chr2_-_237416181 6.79 ENST00000409907.3
IQCA1
IQ motif containing with AAA domain 1
chr12_-_48398104 6.58 ENST00000337299.6
ENST00000380518.3
COL2A1
collagen, type II, alpha 1
chr11_+_96123158 6.34 ENST00000332349.4
ENST00000458427.1
JRKL
jerky homolog-like (mouse)
chr1_-_33647267 6.19 ENST00000291416.5
TRIM62
tripartite motif containing 62
chr16_+_71392616 6.11 ENST00000349553.5
ENST00000302628.4
ENST00000562305.1
CALB2
calbindin 2
chr17_-_3461092 5.90 ENST00000301365.4
ENST00000572519.1
TRPV3
transient receptor potential cation channel, subfamily V, member 3
chr19_+_42259329 5.81 ENST00000199764.6
CEACAM6
carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
chr4_-_89744314 5.69 ENST00000508369.1
FAM13A
family with sequence similarity 13, member A
chr4_-_89744365 5.55 ENST00000513837.1
ENST00000503556.1
FAM13A
family with sequence similarity 13, member A
chr13_-_31736132 5.34 ENST00000429785.2
HSPH1
heat shock 105kDa/110kDa protein 1
chr13_-_79979919 4.97 ENST00000267229.7
RBM26
RNA binding motif protein 26
chr15_-_89764929 4.91 ENST00000268125.5
RLBP1
retinaldehyde binding protein 1
chr10_-_1779663 4.81 ENST00000381312.1
ADARB2
adenosine deaminase, RNA-specific, B2 (non-functional)
chr16_-_15950868 4.80 ENST00000396324.3
ENST00000452625.2
ENST00000576790.2
ENST00000300036.5
MYH11
myosin, heavy chain 11, smooth muscle
chr19_-_46526304 4.72 ENST00000008938.4
PGLYRP1
peptidoglycan recognition protein 1
chr19_-_48389651 4.59 ENST00000222002.3
SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr12_+_75784850 4.56 ENST00000550916.1
ENST00000435775.1
ENST00000378689.2
ENST00000378692.3
ENST00000320460.4
ENST00000547164.1
GLIPR1L2
GLI pathogenesis-related 1 like 2
chr10_+_43572475 4.38 ENST00000355710.3
ENST00000498820.1
ENST00000340058.5
RET
ret proto-oncogene
chr9_+_4985228 4.23 ENST00000381652.3
JAK2
Janus kinase 2
chr20_+_44637526 4.21 ENST00000372330.3
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr1_-_20446020 4.17 ENST00000375105.3
PLA2G2D
phospholipase A2, group IID
chr18_+_33877654 4.10 ENST00000257209.4
ENST00000445677.1
ENST00000590592.1
ENST00000359247.4
FHOD3
formin homology 2 domain containing 3
chr16_-_2004683 4.10 ENST00000268661.7
RPL3L
ribosomal protein L3-like
chr2_-_160761179 3.89 ENST00000554112.1
ENST00000553424.1
ENST00000263636.4
ENST00000504764.1
ENST00000505052.1
LY75
LY75-CD302
lymphocyte antigen 75
LY75-CD302 readthrough
chrX_-_134305322 3.75 ENST00000276241.6
ENST00000344129.2
CXorf48
cancer/testis antigen 55
chr7_+_142458507 3.75 ENST00000492062.1
PRSS1
protease, serine, 1 (trypsin 1)
chr4_+_81951957 3.56 ENST00000282701.2
BMP3
bone morphogenetic protein 3
chr2_-_228497888 3.52 ENST00000264387.4
ENST00000409066.1
C2orf83
chromosome 2 open reading frame 83
chr13_-_79979952 3.50 ENST00000438724.1
RBM26
RNA binding motif protein 26
chr7_-_142207004 3.37 ENST00000426318.2
TRBV10-2
T cell receptor beta variable 10-2
chr1_-_231114542 3.37 ENST00000522821.1
ENST00000366661.4
ENST00000366662.4
ENST00000414259.1
ENST00000522399.1
TTC13
tetratricopeptide repeat domain 13
chr21_+_44073860 3.35 ENST00000335512.4
ENST00000539837.1
ENST00000291539.6
ENST00000380328.2
ENST00000398232.3
ENST00000398234.3
ENST00000398236.3
ENST00000328862.6
ENST00000335440.6
ENST00000398225.3
ENST00000398229.3
ENST00000398227.3
PDE9A
phosphodiesterase 9A
chr16_+_89696692 3.32 ENST00000261615.4
DPEP1
dipeptidase 1 (renal)
chr8_-_125577940 3.22 ENST00000519168.1
ENST00000395508.2
MTSS1
metastasis suppressor 1
chr6_-_46620522 2.94 ENST00000275016.2
CYP39A1
cytochrome P450, family 39, subfamily A, polypeptide 1
chr19_-_11039261 2.80 ENST00000590329.1
ENST00000587943.1
ENST00000585858.1
ENST00000586748.1
ENST00000586575.1
ENST00000253031.2
YIPF2
Yip1 domain family, member 2
chr16_-_65155833 2.78 ENST00000566827.1
ENST00000394156.3
ENST00000562998.1
CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr13_+_49280951 2.65 ENST00000282018.3
CYSLTR2
cysteinyl leukotriene receptor 2
chr19_+_42300548 2.60 ENST00000344550.4
CEACAM3
carcinoembryonic antigen-related cell adhesion molecule 3
chr4_-_107957454 2.42 ENST00000285311.3
DKK2
dickkopf WNT signaling pathway inhibitor 2
chr7_-_99097863 2.29 ENST00000426306.2
ENST00000337673.6
ZNF394
zinc finger protein 394
chr10_-_101841588 2.19 ENST00000370418.3
CPN1
carboxypeptidase N, polypeptide 1
chr6_-_24877490 2.17 ENST00000540914.1
ENST00000378023.4
FAM65B
family with sequence similarity 65, member B
chr4_-_175750364 2.14 ENST00000340217.5
ENST00000274093.3
GLRA3
glycine receptor, alpha 3
chr5_+_140557371 2.12 ENST00000239444.2
PCDHB8
protocadherin beta 8
chr1_-_9129598 2.07 ENST00000535586.1
SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr22_+_24999114 2.05 ENST00000412658.1
ENST00000445029.1
ENST00000419133.1
ENST00000400382.1
ENST00000438643.2
ENST00000452551.1
ENST00000400383.1
ENST00000412898.1
ENST00000400380.1
ENST00000455483.1
ENST00000430289.1
GGT1
gamma-glutamyltransferase 1
chr3_-_169587621 2.03 ENST00000523069.1
ENST00000316428.5
ENST00000264676.5
LRRC31
leucine rich repeat containing 31
chr11_+_64052692 2.01 ENST00000377702.4
GPR137
G protein-coupled receptor 137
chr1_-_204654826 1.95 ENST00000367177.3
LRRN2
leucine rich repeat neuronal 2
chr1_-_45956800 1.88 ENST00000538496.1
TESK2
testis-specific kinase 2
chr9_-_104145795 1.85 ENST00000259407.2
BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr4_-_123843597 1.79 ENST00000510735.1
ENST00000304430.5
NUDT6
nudix (nucleoside diphosphate linked moiety X)-type motif 6
chr2_-_89417335 1.77 ENST00000490686.1
IGKV1-17
immunoglobulin kappa variable 1-17
chr1_+_32084641 1.66 ENST00000373706.5
HCRTR1
hypocretin (orexin) receptor 1
chr4_+_40198527 1.58 ENST00000381799.5
RHOH
ras homolog family member H
chrX_+_154299690 1.52 ENST00000340647.4
ENST00000330045.7
BRCC3
BRCA1/BRCA2-containing complex, subunit 3
chr16_+_2802316 1.49 ENST00000301740.8
SRRM2
serine/arginine repetitive matrix 2
chr19_+_46801639 1.44 ENST00000244303.6
ENST00000339613.2
ENST00000533145.1
ENST00000472815.1
HIF3A
hypoxia inducible factor 3, alpha subunit
chr17_+_67498538 1.32 ENST00000589647.1
MAP2K6
mitogen-activated protein kinase kinase 6
chr19_-_10491234 1.27 ENST00000524462.1
ENST00000531836.1
ENST00000525621.1
TYK2
tyrosine kinase 2
chr8_+_32405785 1.22 ENST00000287842.3
NRG1
neuregulin 1
chr2_+_97426631 1.10 ENST00000377075.2
CNNM4
cyclin M4
chr22_-_39190116 1.00 ENST00000406622.1
ENST00000216068.4
ENST00000406199.3
SUN2
DNAL4
Sad1 and UNC84 domain containing 2
dynein, axonemal, light chain 4
chr6_-_24489842 0.97 ENST00000230036.1
GPLD1
glycosylphosphatidylinositol specific phospholipase D1
chr11_+_64052454 0.88 ENST00000539833.1
GPR137
G protein-coupled receptor 137
chr8_+_11351876 0.84 ENST00000529894.1
BLK
B lymphoid tyrosine kinase
chr5_+_169532896 0.82 ENST00000306268.6
ENST00000449804.2
FOXI1
forkhead box I1
chr6_-_56258892 0.81 ENST00000370819.1
COL21A1
collagen, type XXI, alpha 1
chr13_+_49794474 0.66 ENST00000218721.1
ENST00000398307.1
MLNR
motilin receptor
chr7_+_141811539 0.57 ENST00000550469.2
ENST00000477922.3
RP11-1220K2.2
Putative inactive maltase-glucoamylase-like protein LOC93432
chr20_+_43211149 0.43 ENST00000372886.1
PKIG
protein kinase (cAMP-dependent, catalytic) inhibitor gamma
chr8_+_32405728 0.31 ENST00000523079.1
ENST00000338921.4
ENST00000356819.4
ENST00000287845.5
ENST00000341377.5
NRG1
neuregulin 1
chr9_-_138853156 0.19 ENST00000371756.3
UBAC1
UBA domain containing 1
chr6_-_41715128 0.18 ENST00000356667.4
ENST00000373025.3
ENST00000425343.2
PGC
progastricsin (pepsinogen C)
chr11_-_102576537 0.14 ENST00000260229.4
MMP27
matrix metallopeptidase 27
chr5_-_39425290 0.12 ENST00000545653.1
DAB2
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
chr11_+_64052294 0.09 ENST00000536667.1
GPR137
G protein-coupled receptor 137
chr20_+_54823788 0.06 ENST00000243911.2
MC3R
melanocortin 3 receptor

Network of associatons between targets according to the STRING database.

First level regulatory network of PTF1A

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
7.6 45.8 GO:0052551 response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565)
5.4 54.0 GO:0051610 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
3.9 31.4 GO:0015693 magnesium ion transport(GO:0015693)
3.9 19.4 GO:0048478 replication fork protection(GO:0048478)
3.2 9.5 GO:0031627 telomeric loop formation(GO:0031627)
2.8 16.8 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
2.5 45.2 GO:0007021 tubulin complex assembly(GO:0007021)
1.9 7.4 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
1.6 4.8 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
1.6 4.7 GO:0051710 regulation of cytolysis in other organism(GO:0051710)
1.5 4.4 GO:0007497 posterior midgut development(GO:0007497)
1.4 4.2 GO:0060398 regulation of growth hormone receptor signaling pathway(GO:0060398)
1.2 8.5 GO:0071896 protein localization to adherens junction(GO:0071896)
1.2 10.7 GO:0006477 protein sulfation(GO:0006477)
1.2 3.5 GO:0015888 thiamine transport(GO:0015888) thiamine transmembrane transport(GO:0071934)
1.1 3.3 GO:0016999 antibiotic metabolic process(GO:0016999) cellular amide catabolic process(GO:0043605)
1.1 8.8 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
1.0 7.1 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
1.0 8.1 GO:0070236 regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236)
0.9 9.8 GO:0036159 inner dynein arm assembly(GO:0036159)
0.9 23.9 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.8 5.9 GO:0042636 negative regulation of hair cycle(GO:0042636)
0.8 4.2 GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.8 15.1 GO:0071397 cellular response to cholesterol(GO:0071397)
0.7 12.1 GO:0006071 glycerol metabolic process(GO:0006071)
0.7 11.1 GO:0046069 cGMP catabolic process(GO:0046069)
0.6 4.2 GO:0051549 positive regulation of keratinocyte migration(GO:0051549)
0.6 6.9 GO:0048007 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.6 6.9 GO:0015871 choline transport(GO:0015871)
0.5 6.6 GO:0060174 limb bud formation(GO:0060174)
0.5 3.2 GO:0030035 microspike assembly(GO:0030035)
0.5 7.9 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.5 7.0 GO:0015671 oxygen transport(GO:0015671)
0.4 8.9 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.4 1.3 GO:0072709 cellular response to sorbitol(GO:0072709)
0.4 2.6 GO:0061737 leukotriene signaling pathway(GO:0061737)
0.4 2.2 GO:0030070 insulin processing(GO:0030070)
0.4 8.3 GO:0006012 galactose metabolic process(GO:0006012)
0.4 4.9 GO:0006776 vitamin A metabolic process(GO:0006776)
0.4 2.9 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.3 2.1 GO:0019344 cysteine biosynthetic process(GO:0019344)
0.3 2.8 GO:0021957 corticospinal tract morphogenesis(GO:0021957)
0.3 4.1 GO:0051639 actin filament network formation(GO:0051639)
0.3 15.7 GO:0045646 regulation of erythrocyte differentiation(GO:0045646)
0.2 15.5 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.2 4.6 GO:0051923 sulfation(GO:0051923)
0.2 2.1 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.2 1.9 GO:0019530 taurine metabolic process(GO:0019530)
0.2 6.2 GO:0032897 negative regulation of viral transcription(GO:0032897)
0.2 1.5 GO:0021842 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.2 9.0 GO:0046949 fatty-acyl-CoA biosynthetic process(GO:0046949)
0.2 22.5 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.2 16.6 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.2 3.9 GO:0006954 inflammatory response(GO:0006954)
0.2 17.1 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.2 1.0 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.2 1.1 GO:1903830 magnesium ion transmembrane transport(GO:1903830)
0.1 9.6 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.1 22.9 GO:0034605 cellular response to heat(GO:0034605)
0.1 14.4 GO:0007422 peripheral nervous system development(GO:0007422)
0.1 7.5 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.1 16.8 GO:0030449 regulation of complement activation(GO:0030449)
0.1 10.0 GO:0048024 regulation of mRNA splicing, via spliceosome(GO:0048024)
0.1 4.1 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.1 8.5 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 2.5 GO:0009235 cobalamin metabolic process(GO:0009235)
0.1 11.3 GO:0007045 cell-substrate adherens junction assembly(GO:0007045) focal adhesion assembly(GO:0048041)
0.1 7.7 GO:0010508 positive regulation of autophagy(GO:0010508)
0.1 3.6 GO:0060395 SMAD protein signal transduction(GO:0060395)
0.1 8.9 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 12.7 GO:0065004 protein-DNA complex assembly(GO:0065004)
0.0 1.6 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.0 6.1 GO:0002377 immunoglobulin production(GO:0002377)
0.0 2.6 GO:0050900 leukocyte migration(GO:0050900)
0.0 1.9 GO:0090263 positive regulation of canonical Wnt signaling pathway(GO:0090263)
0.0 0.2 GO:0002803 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
0.0 0.4 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 1.3 GO:0060338 regulation of type I interferon-mediated signaling pathway(GO:0060338)
0.0 0.7 GO:0045187 regulation of circadian sleep/wake cycle, sleep(GO:0045187)
0.0 5.9 GO:0051480 regulation of cytosolic calcium ion concentration(GO:0051480)
0.0 0.4 GO:0050855 regulation of B cell receptor signaling pathway(GO:0050855)
0.0 1.4 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
0.0 2.1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.8 GO:0042472 inner ear morphogenesis(GO:0042472)
0.0 4.1 GO:0030335 positive regulation of cell migration(GO:0030335)
0.0 5.3 GO:0007264 small GTPase mediated signal transduction(GO:0007264)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 45.2 GO:0097512 cardiac myofibril(GO:0097512)
2.8 16.8 GO:0033061 DNA recombinase mediator complex(GO:0033061) Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
1.8 45.8 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
1.5 7.5 GO:0089701 U2AF(GO:0089701)
0.7 2.1 GO:0016935 glycine-gated chloride channel complex(GO:0016935)
0.7 8.5 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.7 9.8 GO:0005858 axonemal dynein complex(GO:0005858)
0.5 6.6 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.5 3.4 GO:0097013 phagocytic vesicle lumen(GO:0097013)
0.4 18.3 GO:0031228 intrinsic component of Golgi membrane(GO:0031228)
0.2 3.3 GO:0031528 microvillus membrane(GO:0031528)
0.2 32.4 GO:0043204 perikaryon(GO:0043204)
0.2 5.7 GO:0005921 gap junction(GO:0005921)
0.2 4.8 GO:0032982 myosin filament(GO:0032982)
0.2 8.4 GO:0043596 nuclear replication fork(GO:0043596)
0.2 75.6 GO:0045121 membrane raft(GO:0045121)
0.2 7.9 GO:0000791 euchromatin(GO:0000791)
0.1 1.0 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1 12.9 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 12.7 GO:0032993 protein-DNA complex(GO:0032993)
0.1 4.1 GO:0005865 striated muscle thin filament(GO:0005865) myofilament(GO:0036379)
0.1 9.5 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.1 0.1 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.1 1.5 GO:0030673 axolemma(GO:0030673)
0.0 1.6 GO:0001772 immunological synapse(GO:0001772)
0.0 7.1 GO:0043197 dendritic spine(GO:0043197)
0.0 7.4 GO:0005770 late endosome(GO:0005770)
0.0 5.8 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.3 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.0 1.9 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 24.5 GO:0000139 Golgi membrane(GO:0000139)
0.0 25.6 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 5.5 GO:0072562 blood microparticle(GO:0072562)
0.0 0.8 GO:0005581 collagen trimer(GO:0005581)
0.0 3.2 GO:0030139 endocytic vesicle(GO:0030139)
0.0 2.8 GO:0030133 transport vesicle(GO:0030133)
0.0 25.8 GO:0005615 extracellular space(GO:0005615)
0.0 1.6 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 1.7 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 1.3 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.0 12.1 GO:0003846 2-acylglycerol O-acyltransferase activity(GO:0003846)
3.0 9.0 GO:0004768 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
2.9 8.8 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
2.7 19.0 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
2.6 7.9 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
2.3 32.5 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
1.9 19.4 GO:0036310 annealing helicase activity(GO:0036310)
1.8 45.8 GO:0004383 guanylate cyclase activity(GO:0004383)
1.7 6.9 GO:0015220 choline transmembrane transporter activity(GO:0015220)
1.6 4.7 GO:0016019 peptidoglycan receptor activity(GO:0016019)
1.5 16.8 GO:0000150 recombinase activity(GO:0000150)
1.5 7.5 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
1.5 45.2 GO:0005212 structural constituent of eye lens(GO:0005212)
1.3 6.6 GO:0042289 MHC class II protein binding(GO:0042289)
1.2 4.9 GO:0005502 11-cis retinal binding(GO:0005502)
1.2 23.9 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
1.2 9.5 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
1.2 3.5 GO:0015234 thiamine transmembrane transporter activity(GO:0015234) thiamine uptake transmembrane transporter activity(GO:0015403)
1.0 12.7 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.9 8.1 GO:0043426 MRF binding(GO:0043426)
0.7 8.9 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.7 6.9 GO:0030884 lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
0.7 4.6 GO:0050294 steroid sulfotransferase activity(GO:0050294)
0.6 4.8 GO:0004000 adenosine deaminase activity(GO:0004000)
0.6 10.8 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.5 7.0 GO:0005344 oxygen transporter activity(GO:0005344)
0.5 2.6 GO:0004974 leukotriene receptor activity(GO:0004974)
0.5 4.2 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.5 3.3 GO:0070573 metallodipeptidase activity(GO:0070573)
0.4 2.1 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.4 16.6 GO:0030552 cAMP binding(GO:0030552)
0.4 10.0 GO:0008266 poly(U) RNA binding(GO:0008266)
0.4 11.1 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.4 15.5 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.3 2.4 GO:0039706 co-receptor binding(GO:0039706)
0.3 8.5 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.3 3.6 GO:0070700 BMP receptor binding(GO:0070700)
0.2 3.9 GO:0031418 L-ascorbic acid binding(GO:0031418)
0.2 1.9 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.2 4.2 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.2 0.7 GO:0016520 growth hormone-releasing hormone receptor activity(GO:0016520)
0.2 0.7 GO:0016499 orexin receptor activity(GO:0016499)
0.2 1.0 GO:0004630 phospholipase D activity(GO:0004630)
0.2 1.5 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.1 2.1 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.1 1.3 GO:0005131 growth hormone receptor binding(GO:0005131)
0.1 7.8 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 8.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 7.1 GO:0048365 Rac GTPase binding(GO:0048365)
0.1 1.6 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.1 8.5 GO:0032947 protein complex scaffold(GO:0032947)
0.1 2.9 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.1 22.9 GO:0005516 calmodulin binding(GO:0005516)
0.1 22.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 2.2 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 12.3 GO:0005088 Ras guanyl-nucleotide exchange factor activity(GO:0005088)
0.1 5.9 GO:0005262 calcium channel activity(GO:0005262)
0.0 0.4 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 2.5 GO:0002020 protease binding(GO:0002020)
0.0 0.8 GO:0008301 DNA binding, bending(GO:0008301)
0.0 9.6 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 0.3 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 19.1 GO:0003712 transcription cofactor activity(GO:0003712)
0.0 10.1 GO:0003779 actin binding(GO:0003779)
0.0 2.8 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.1 GO:0004980 melanocyte-stimulating hormone receptor activity(GO:0004980)
0.0 11.0 GO:0005509 calcium ion binding(GO:0005509)
0.0 1.8 GO:0008083 growth factor activity(GO:0008083)
0.0 13.5 GO:0032403 protein complex binding(GO:0032403)
0.0 0.4 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.2 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 1.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 5.5 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.2 7.4 NABA COLLAGENS Genes encoding collagen proteins
0.2 8.9 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.1 4.2 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.1 12.4 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.1 14.4 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 12.4 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 7.4 PID TNF PATHWAY TNF receptor signaling pathway
0.1 2.4 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.1 4.4 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 1.4 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.1 3.2 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 2.6 PID ENDOTHELIN PATHWAY Endothelins
0.1 4.6 PID E2F PATHWAY E2F transcription factor network
0.0 19.4 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 1.0 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.4 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 56.2 REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.6 19.0 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.4 16.6 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.3 5.5 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.3 2.9 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.3 4.2 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.3 14.1 REACTOME MYOGENESIS Genes involved in Myogenesis
0.3 6.9 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.2 8.0 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.2 8.2 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.2 4.6 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 2.6 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.1 1.9 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.1 7.4 REACTOME EXTRACELLULAR MATRIX ORGANIZATION Genes involved in Extracellular matrix organization
0.1 4.8 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 2.8 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 1.4 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1 1.5 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1 2.1 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 8.9 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 2.1 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.1 21.6 REACTOME GENERIC TRANSCRIPTION PATHWAY Genes involved in Generic Transcription Pathway
0.0 1.0 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling