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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for PTF1A
Z-value: 1.15
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Transcription factors associated with PTF1A
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_111794446 Show fit | 45.24 |
ENST00000527950.1
|
crystallin, alpha B |
|
| chrX_-_13956497 Show fit | 28.78 |
ENST00000398361.3
|
glycoprotein M6B |
|
| chrX_-_13956737 Show fit | 25.22 |
ENST00000454189.2
|
glycoprotein M6B |
|
| chr2_-_71454185 Show fit | 23.88 |
ENST00000244221.8
|
poly(A) binding protein interacting protein 2B |
|
| chr8_-_22089845 Show fit | 23.69 |
ENST00000454243.2
|
phytanoyl-CoA 2-hydroxylase interacting protein |
|
| chr8_-_22089533 Show fit | 22.62 |
ENST00000321613.3
|
phytanoyl-CoA 2-hydroxylase interacting protein |
|
| chr5_-_118324200 Show fit | 22.45 |
ENST00000515439.3
ENST00000510708.1 |
DTW domain containing 2 |
|
| chr3_+_40518599 Show fit | 19.36 |
ENST00000314686.5
ENST00000447116.2 ENST00000429348.2 ENST00000456778.1 |
zinc finger protein 619 |
|
| chr2_-_136288113 Show fit | 19.35 |
ENST00000401392.1
|
zinc finger, RAN-binding domain containing 3 |
|
| chr7_-_152373216 Show fit | 16.79 |
ENST00000359321.1
|
X-ray repair complementing defective repair in Chinese hamster cells 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of PTF1A
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.4 | 54.0 | GO:0051610 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 7.6 | 45.8 | GO:0052551 | response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565) |
| 2.5 | 45.2 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 3.9 | 31.4 | GO:0015693 | magnesium ion transport(GO:0015693) |
| 0.9 | 23.9 | GO:0045947 | negative regulation of translational initiation(GO:0045947) |
| 0.1 | 22.9 | GO:0034605 | cellular response to heat(GO:0034605) |
| 0.2 | 22.5 | GO:1903955 | positive regulation of protein targeting to mitochondrion(GO:1903955) |
| 3.9 | 19.4 | GO:0048478 | replication fork protection(GO:0048478) |
| 0.2 | 17.1 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 2.8 | 16.8 | GO:0000707 | meiotic DNA recombinase assembly(GO:0000707) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 75.6 | GO:0045121 | membrane raft(GO:0045121) |
| 1.8 | 45.8 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 2.8 | 45.2 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.2 | 32.4 | GO:0043204 | perikaryon(GO:0043204) |
| 0.0 | 25.8 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 25.6 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.0 | 24.5 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.4 | 18.3 | GO:0031228 | intrinsic component of Golgi membrane(GO:0031228) |
| 2.8 | 16.8 | GO:0033061 | DNA recombinase mediator complex(GO:0033061) Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063) |
| 0.1 | 12.9 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 45.8 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 1.5 | 45.2 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 2.3 | 32.5 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 1.2 | 23.9 | GO:0000900 | translation repressor activity, nucleic acid binding(GO:0000900) |
| 0.1 | 22.9 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.1 | 22.5 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 1.9 | 19.4 | GO:0036310 | annealing helicase activity(GO:0036310) |
| 0.0 | 19.1 | GO:0003712 | transcription cofactor activity(GO:0003712) |
| 2.7 | 19.0 | GO:0001517 | N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) |
| 1.5 | 16.8 | GO:0000150 | recombinase activity(GO:0000150) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 19.4 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 14.4 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 12.4 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 12.4 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.2 | 8.9 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.2 | 7.4 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 7.4 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.5 | 5.5 | ST IL 13 PATHWAY | Interleukin 13 (IL-13) Pathway |
| 0.1 | 4.6 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 4.4 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 56.2 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.1 | 21.6 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.6 | 19.0 | REACTOME KERATAN SULFATE BIOSYNTHESIS | Genes involved in Keratan sulfate biosynthesis |
| 0.4 | 16.6 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.3 | 14.1 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 8.9 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.2 | 8.2 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.2 | 8.0 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.1 | 7.4 | REACTOME EXTRACELLULAR MATRIX ORGANIZATION | Genes involved in Extracellular matrix organization |
| 0.3 | 6.9 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |