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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for RELB
Z-value: 0.82
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Transcription factors associated with RELB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RELB | hg19_v2_chr19_+_45504688_45504782 | 0.30 | 6.8e-06 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of RELB
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 36.7 | GO:0030449 | regulation of complement activation(GO:0030449) |
| 0.2 | 23.6 | GO:0031295 | T cell costimulation(GO:0031295) |
| 0.2 | 20.4 | GO:0005977 | glycogen metabolic process(GO:0005977) |
| 0.3 | 19.1 | GO:0050885 | neuromuscular process controlling balance(GO:0050885) |
| 3.6 | 17.9 | GO:0002906 | mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906) |
| 0.2 | 16.9 | GO:0042100 | B cell proliferation(GO:0042100) |
| 0.1 | 16.6 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 2.0 | 16.1 | GO:1901552 | positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142) |
| 0.4 | 15.9 | GO:0006536 | glutamate metabolic process(GO:0006536) |
| 4.9 | 14.7 | GO:2000777 | positive regulation of oocyte maturation(GO:1900195) negative regulation of NLRP3 inflammasome complex assembly(GO:1900226) positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia(GO:2000777) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 66.7 | GO:0005615 | extracellular space(GO:0005615) |
| 1.3 | 25.2 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.1 | 18.6 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 2.6 | 17.9 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 2.5 | 17.5 | GO:0019815 | B cell receptor complex(GO:0019815) |
| 0.5 | 16.1 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 1.6 | 14.7 | GO:0072687 | meiotic spindle(GO:0072687) |
| 0.1 | 14.5 | GO:0072562 | blood microparticle(GO:0072562) |
| 1.0 | 11.5 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.1 | 9.5 | GO:0031225 | anchored component of membrane(GO:0031225) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 55.6 | GO:0003823 | antigen binding(GO:0003823) |
| 1.7 | 21.8 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 4.1 | 20.6 | GO:0047820 | D-glutamate cyclase activity(GO:0047820) |
| 2.6 | 20.4 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
| 3.6 | 17.9 | GO:0042289 | MHC class II protein binding(GO:0042289) |
| 4.9 | 14.7 | GO:0034739 | histone deacetylase activity (H4-K16 specific)(GO:0034739) |
| 0.7 | 11.9 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
| 1.8 | 10.7 | GO:0042577 | lipid phosphatase activity(GO:0042577) |
| 0.8 | 10.3 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.3 | 9.4 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 24.2 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.1 | 19.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.5 | 17.9 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
| 0.1 | 14.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.3 | 9.6 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 7.7 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.2 | 7.4 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.3 | 7.2 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.1 | 7.2 | PID ENDOTHELIN PATHWAY | Endothelins |
| 0.1 | 6.8 | PID TNF PATHWAY | TNF receptor signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 24.7 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.4 | 17.5 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.4 | 16.1 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.6 | 14.5 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.1 | 14.1 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.6 | 11.7 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.3 | 10.7 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.4 | 10.5 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.2 | 10.3 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.2 | 9.1 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |