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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for TAL1
Z-value: 1.62
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Transcription factors associated with TAL1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TAL1 | hg19_v2_chr1_-_47697387_47697457 | 0.31 | 3.7e-06 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TAL1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.1 | 861.0 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 14.7 | 206.4 | GO:2001199 | negative regulation of dendritic cell differentiation(GO:2001199) |
| 1.0 | 134.6 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 26.6 | 106.3 | GO:0006542 | glutamine biosynthetic process(GO:0006542) |
| 19.8 | 98.8 | GO:0071279 | cellular response to cobalt ion(GO:0071279) |
| 24.0 | 96.2 | GO:0030185 | nitric oxide transport(GO:0030185) |
| 1.4 | 93.0 | GO:0006501 | C-terminal protein lipidation(GO:0006501) |
| 9.1 | 90.9 | GO:0001766 | membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580) |
| 4.2 | 88.8 | GO:0002523 | leukocyte migration involved in inflammatory response(GO:0002523) |
| 2.1 | 77.7 | GO:0018149 | peptide cross-linking(GO:0018149) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 1028.6 | GO:0005615 | extracellular space(GO:0005615) |
| 0.2 | 474.0 | GO:0031224 | intrinsic component of membrane(GO:0031224) |
| 3.0 | 469.3 | GO:0072562 | blood microparticle(GO:0072562) |
| 8.0 | 397.8 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.3 | 339.2 | GO:0031226 | intrinsic component of plasma membrane(GO:0031226) |
| 1.7 | 186.8 | GO:0005796 | Golgi lumen(GO:0005796) |
| 9.4 | 112.4 | GO:0043203 | axon hillock(GO:0043203) |
| 5.8 | 110.7 | GO:0097386 | glial cell projection(GO:0097386) |
| 0.8 | 107.1 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 4.2 | 105.8 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.0 | 518.1 | GO:0003823 | antigen binding(GO:0003823) |
| 7.2 | 397.8 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 1.6 | 334.9 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 2.9 | 314.2 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.2 | 174.2 | GO:0001071 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 26.6 | 106.3 | GO:0016211 | glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880) |
| 4.2 | 105.8 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 8.6 | 103.7 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.3 | 98.2 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 2.7 | 90.2 | GO:0008009 | chemokine activity(GO:0008009) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 398.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.8 | 300.3 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 1.0 | 175.3 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 2.0 | 109.6 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 1.7 | 104.9 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 1.7 | 80.7 | NABA COLLAGENS | Genes encoding collagen proteins |
| 3.2 | 72.5 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.9 | 62.2 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 1.7 | 61.4 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.8 | 58.1 | PID IL12 2PATHWAY | IL12-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 128.6 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 5.8 | 121.0 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 1.3 | 119.8 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.9 | 117.1 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 1.7 | 102.8 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 1.6 | 96.8 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 1.2 | 95.6 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 1.7 | 90.8 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.3 | 88.2 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 5.3 | 85.5 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |