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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for TBX19
Z-value: 0.45
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Transcription factors associated with TBX19
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TBX19 | hg19_v2_chr1_+_168250194_168250278 | -0.06 | 4.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_2842087 Show fit | 21.37 |
ENST00000537185.1
|
serpin peptidase inhibitor, clade B (ovalbumin), member 1 |
|
| chr19_-_40331345 Show fit | 21.10 |
ENST00000597224.1
|
fibrillarin |
|
| chr16_+_84801852 Show fit | 18.67 |
ENST00000569925.1
ENST00000567526.1 |
ubiquitin specific peptidase 10 |
|
| chr6_-_36515177 Show fit | 18.46 |
ENST00000229812.7
|
serine/threonine kinase 38 |
|
| chr6_-_2842219 Show fit | 14.99 |
ENST00000380739.5
|
serpin peptidase inhibitor, clade B (ovalbumin), member 1 |
|
| chr2_-_85636928 Show fit | 14.84 |
ENST00000449030.1
|
capping protein (actin filament), gelsolin-like |
|
| chr15_-_55581954 Show fit | 14.74 |
ENST00000336787.1
|
RAB27A, member RAS oncogene family |
|
| chr9_-_116172946 Show fit | 12.93 |
ENST00000374171.4
|
polymerase (DNA directed), epsilon 3, accessory subunit |
|
| chr1_-_63988846 Show fit | 12.60 |
ENST00000283568.8
ENST00000371092.3 ENST00000271002.10 |
integrin beta 3 binding protein (beta3-endonexin) |
|
| chr10_-_95242044 Show fit | 11.96 |
ENST00000371501.4
ENST00000371502.4 ENST00000371489.1 |
myoferlin |
Network of associatons between targets according to the STRING database.
First level regulatory network of TBX19
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 38.3 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.1 | 31.1 | GO:0010951 | negative regulation of endopeptidase activity(GO:0010951) |
| 1.9 | 23.0 | GO:0001778 | plasma membrane repair(GO:0001778) |
| 0.1 | 22.1 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 5.3 | 21.1 | GO:0018364 | peptidyl-glutamine methylation(GO:0018364) |
| 0.7 | 18.8 | GO:0008053 | mitochondrial fusion(GO:0008053) |
| 0.5 | 18.7 | GO:0019985 | translesion synthesis(GO:0019985) |
| 0.2 | 18.5 | GO:0043407 | negative regulation of MAP kinase activity(GO:0043407) |
| 1.4 | 15.2 | GO:0038203 | TORC2 signaling(GO:0038203) |
| 0.7 | 14.8 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 31.3 | GO:0034774 | secretory granule lumen(GO:0034774) |
| 0.0 | 31.2 | GO:0005615 | extracellular space(GO:0005615) |
| 0.2 | 23.0 | GO:0005901 | caveola(GO:0005901) |
| 1.4 | 21.7 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 7.0 | 21.1 | GO:0031428 | box C/D snoRNP complex(GO:0031428) |
| 0.4 | 18.3 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.8 | 15.2 | GO:0031932 | TORC2 complex(GO:0031932) |
| 1.2 | 14.7 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.1 | 13.5 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.1 | 13.3 | GO:0035578 | azurophil granule lumen(GO:0035578) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 37.5 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 2.0 | 29.5 | GO:0001094 | TFIID-class transcription factor binding(GO:0001094) |
| 0.3 | 27.8 | GO:0032947 | protein complex scaffold(GO:0032947) |
| 0.2 | 27.7 | GO:0003823 | antigen binding(GO:0003823) |
| 0.1 | 21.7 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 20.1 | GO:0008134 | transcription factor binding(GO:0008134) |
| 0.2 | 18.7 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.9 | 18.5 | GO:0031435 | mitogen-activated protein kinase kinase kinase binding(GO:0031435) |
| 0.3 | 18.3 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.6 | 14.7 | GO:0031489 | myosin V binding(GO:0031489) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 40.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 21.9 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.2 | 15.2 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.1 | 12.6 | ST INTEGRIN SIGNALING PATHWAY | Integrin Signaling Pathway |
| 0.3 | 10.0 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
| 0.2 | 9.6 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.1 | 9.3 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 8.4 | PID MYC PATHWAY | C-MYC pathway |
| 0.1 | 7.9 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 6.6 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 13.4 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.6 | 12.6 | REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS | Genes involved in NRIF signals cell death from the nucleus |
| 0.4 | 10.9 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.2 | 10.0 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.3 | 9.4 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.2 | 8.4 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |
| 0.1 | 8.4 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.2 | 7.7 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.0 | 7.7 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 7.3 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |