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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for TBX3

Z-value: 0.31

Motif logo

Transcription factors associated with TBX3

Gene Symbol Gene ID Gene Info
ENSG00000135111.10 T-box transcription factor 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TBX3hg19_v2_chr12_-_115121962_1151219870.321.0e-06Click!

Activity profile of TBX3 motif

Sorted Z-values of TBX3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr22_+_23237555 13.43 ENST00000390321.2
immunoglobulin lambda constant 1 (Mcg marker)
chr5_-_39425222 11.53 ENST00000320816.6
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
chr2_-_89310012 11.10 ENST00000493819.1
immunoglobulin kappa variable 1-9
chr16_+_55512742 10.21 ENST00000568715.1
ENST00000219070.4
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr2_-_89266286 9.63 ENST00000464162.1
immunoglobulin kappa variable 1-6
chr2_-_89513402 9.49 ENST00000498435.1
immunoglobulin kappa variable 1-27
chr14_-_106642049 8.61 ENST00000390605.2
immunoglobulin heavy variable 1-18
chr2_-_209118974 8.42 ENST00000415913.1
ENST00000415282.1
ENST00000446179.1
isocitrate dehydrogenase 1 (NADP+), soluble
chr6_-_52668605 8.00 ENST00000334575.5
glutathione S-transferase alpha 1
chr11_-_327537 7.67 ENST00000602735.1
interferon induced transmembrane protein 3
chr17_-_40575535 7.54 ENST00000357037.5
polymerase I and transcript release factor
chr14_-_107283278 7.42 ENST00000390639.2
immunoglobulin heavy variable 7-81 (non-functional)
chr12_-_56120865 6.88 ENST00000548898.1
ENST00000552067.1
CD63 molecule
chr2_-_209119831 6.86 ENST00000345146.2
isocitrate dehydrogenase 1 (NADP+), soluble
chr12_-_56121612 6.60 ENST00000546939.1
CD63 molecule
chr12_-_56121580 6.46 ENST00000550776.1
CD63 molecule
chrX_-_65259914 5.96 ENST00000374737.4
ENST00000455586.2
V-set and immunoglobulin domain containing 4
chr16_+_58283814 5.90 ENST00000443128.2
ENST00000219299.4
coiled-coil domain containing 113
chrX_-_65259900 5.82 ENST00000412866.2
V-set and immunoglobulin domain containing 4
chr3_+_149192475 5.77 ENST00000465758.1
transmembrane 4 L six family member 4
chr7_+_22766766 5.68 ENST00000426291.1
ENST00000401651.1
ENST00000258743.5
ENST00000420258.2
ENST00000407492.1
ENST00000401630.3
ENST00000406575.1
interleukin 6 (interferon, beta 2)
chrX_+_16737718 5.65 ENST00000380155.3
synapse associated protein 1
chr22_+_24999114 5.40 ENST00000412658.1
ENST00000445029.1
ENST00000419133.1
ENST00000400382.1
ENST00000438643.2
ENST00000452551.1
ENST00000400383.1
ENST00000412898.1
ENST00000400380.1
ENST00000455483.1
ENST00000430289.1
gamma-glutamyltransferase 1
chr22_+_24891210 5.23 ENST00000382760.2
ureidopropionase, beta
chr11_-_33744487 5.22 ENST00000426650.2
CD59 molecule, complement regulatory protein
chr12_-_56120838 5.05 ENST00000548160.1
CD63 molecule
chr7_-_93519471 4.95 ENST00000451238.1
tissue factor pathway inhibitor 2
chr20_-_44539538 4.89 ENST00000372420.1
phospholipid transfer protein
chr4_-_84030996 4.66 ENST00000411416.2
placenta-specific 8
chr19_-_51531272 4.48 ENST00000319720.7
kallikrein-related peptidase 11
chr11_+_35198243 4.22 ENST00000528455.1
CD44 molecule (Indian blood group)
chr3_+_149191723 4.13 ENST00000305354.4
transmembrane 4 L six family member 4
chr1_-_183560011 4.10 ENST00000367536.1
neutrophil cytosolic factor 2
chr19_-_51530916 4.08 ENST00000594768.1
kallikrein-related peptidase 11
chr6_+_32821924 3.98 ENST00000374859.2
ENST00000453265.2
proteasome (prosome, macropain) subunit, beta type, 9
chr3_+_52454971 3.94 ENST00000465863.1
PHD finger protein 7
chr2_+_89184868 3.87 ENST00000390243.2
immunoglobulin kappa variable 4-1
chr2_+_90153696 3.86 ENST00000417279.2
immunoglobulin kappa variable 3D-15 (gene/pseudogene)
chr2_+_90192768 3.81 ENST00000390275.2
immunoglobulin kappa variable 1D-13
chr11_-_1629693 3.72 ENST00000399685.1
keratin associated protein 5-3
chr12_+_124155652 3.69 ENST00000426174.2
ENST00000303372.5
tectonic family member 2
chr6_-_52628271 3.68 ENST00000493422.1
glutathione S-transferase alpha 2
chr4_-_83765613 3.57 ENST00000503937.1
SEC31 homolog A (S. cerevisiae)
chr4_-_83812402 3.53 ENST00000395310.2
SEC31 homolog A (S. cerevisiae)
chr11_-_33744256 3.52 ENST00000415002.2
ENST00000437761.2
ENST00000445143.2
CD59 molecule, complement regulatory protein
chr2_-_217560248 3.34 ENST00000233813.4
insulin-like growth factor binding protein 5
chr14_-_21270561 3.33 ENST00000412779.2
ribonuclease, RNase A family, 1 (pancreatic)
chr15_+_79603404 3.28 ENST00000299705.5
transmembrane emp24 protein transport domain containing 3
chr11_-_10590238 3.26 ENST00000256178.3
lymphatic vessel endothelial hyaluronan receptor 1
chr22_-_21581926 3.24 ENST00000401924.1
gamma-glutamyltransferase 2
chr6_-_32821599 3.22 ENST00000354258.4
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr5_+_148521046 3.17 ENST00000326685.7
ENST00000356541.3
ENST00000309868.7
actin binding LIM protein family, member 3
chr21_+_27011899 3.09 ENST00000425221.2
junctional adhesion molecule 2
chr11_-_73689037 3.08 ENST00000544615.1
uncoupling protein 2 (mitochondrial, proton carrier)
chr11_+_1718425 3.05 ENST00000382160.1
keratin associated protein 5-6
chr19_+_9296279 3.02 ENST00000344248.2
olfactory receptor, family 7, subfamily D, member 2
chrX_-_101726732 3.01 ENST00000457521.2
ENST00000412230.2
ENST00000453326.2
nuclear RNA export factor 2B
t-complex 11 family, X-linked 2
chr14_-_21270995 2.89 ENST00000555698.1
ENST00000397970.4
ENST00000340900.3
ribonuclease, RNase A family, 1 (pancreatic)
chr8_-_133123406 2.87 ENST00000434736.2
HERV-H LTR-associating 1
chr4_+_155484155 2.84 ENST00000509493.1
fibrinogen beta chain
chr5_+_32788945 2.83 ENST00000326958.1
AC026703.1
chr11_-_8285405 2.82 ENST00000335790.3
ENST00000534484.1
LIM domain only 1 (rhombotin 1)
chr2_-_217559517 2.69 ENST00000449583.1
insulin-like growth factor binding protein 5
chr4_-_46911223 2.65 ENST00000396533.1
cytochrome c oxidase subunit VIIb2
chr11_-_10590118 2.62 ENST00000529598.1
lymphatic vessel endothelial hyaluronan receptor 1
chr22_+_23063100 2.61 ENST00000390309.2
immunoglobulin lambda variable 3-19
chr1_+_162602244 2.59 ENST00000367922.3
ENST00000367921.3
discoidin domain receptor tyrosine kinase 2
chr3_-_81792780 2.57 ENST00000489715.1
glucan (1,4-alpha-), branching enzyme 1
chr10_+_71561704 2.57 ENST00000520267.1
collagen, type XIII, alpha 1
chrX_+_101470280 2.57 ENST00000395088.2
ENST00000330252.5
ENST00000333110.5
nuclear RNA export factor 2
t-complex 11 family, X-linked 1
chr4_-_46911248 2.55 ENST00000355591.3
ENST00000505102.1
cytochrome c oxidase subunit VIIb2
chr17_+_45286387 2.54 ENST00000572316.1
ENST00000354968.1
ENST00000576874.1
ENST00000536623.2
myosin, light chain 4, alkali; atrial, embryonic
chr16_+_72088376 2.53 ENST00000570083.1
ENST00000355906.5
ENST00000398131.2
ENST00000569639.1
ENST00000564499.1
ENST00000357763.4
ENST00000562526.1
ENST00000565574.1
ENST00000568417.2
ENST00000356967.5
haptoglobin
haptoglobin-related protein
chr2_+_65215604 2.52 ENST00000531327.1
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr7_+_150434430 2.49 ENST00000358647.3
GTPase, IMAP family member 5
chr5_+_54320078 2.48 ENST00000231009.2
granzyme K (granzyme 3; tryptase II)
chr13_-_46679144 2.48 ENST00000181383.4
carboxypeptidase B2 (plasma)
chr17_+_74372662 2.47 ENST00000591651.1
ENST00000545180.1
sphingosine kinase 1
chr19_+_41103063 2.42 ENST00000308370.7
latent transforming growth factor beta binding protein 4
chr19_+_49404041 2.42 ENST00000263273.5
ENST00000424608.1
nucleobindin 1
chr19_+_1077393 2.34 ENST00000590577.1
histocompatibility (minor) HA-1
chr4_+_15704573 2.31 ENST00000265016.4
bone marrow stromal cell antigen 1
chr2_-_165698662 2.30 ENST00000194871.6
ENST00000445474.2
cordon-bleu WH2 repeat protein-like 1
chr3_-_178984759 2.24 ENST00000349697.2
ENST00000497599.1
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr4_+_155484103 2.16 ENST00000302068.4
fibrinogen beta chain
chr19_-_51538118 2.14 ENST00000529888.1
kallikrein-related peptidase 12
chr14_-_106471723 2.11 ENST00000390595.2
immunoglobulin heavy variable 1-3
chr10_+_71561630 2.09 ENST00000398974.3
ENST00000398971.3
ENST00000398968.3
ENST00000398966.3
ENST00000398964.3
ENST00000398969.3
ENST00000356340.3
ENST00000398972.3
ENST00000398973.3
collagen, type XIII, alpha 1
chr19_+_49403562 2.09 ENST00000407032.1
ENST00000452087.1
ENST00000411700.1
nucleobindin 1
chr12_-_8815404 1.98 ENST00000359478.2
ENST00000396549.2
microfibrillar associated protein 5
chr14_+_21785693 1.96 ENST00000382933.4
ENST00000557351.1
retinitis pigmentosa GTPase regulator interacting protein 1
chr8_+_133931648 1.88 ENST00000519178.1
ENST00000542445.1
thyroglobulin
chr7_-_19748640 1.87 ENST00000222567.5
TWIST neighbor
chr17_-_1419914 1.84 ENST00000397335.3
ENST00000574561.1
inositol polyphosphate-5-phosphatase K
chr1_-_11865351 1.82 ENST00000413656.1
ENST00000376585.1
ENST00000423400.1
ENST00000431243.1
methylenetetrahydrofolate reductase (NAD(P)H)
chr12_-_7848364 1.79 ENST00000329913.3
growth differentiation factor 3
chr11_+_18433840 1.78 ENST00000541669.1
ENST00000280704.4
lactate dehydrogenase C
chr7_+_150264365 1.78 ENST00000255945.2
ENST00000461940.1
GTPase, IMAP family member 4
chr17_-_7017559 1.77 ENST00000446679.2
asialoglycoprotein receptor 2
chr8_+_23386305 1.77 ENST00000519973.1
solute carrier family 25 (mitochondrial iron transporter), member 37
chr10_+_71561649 1.77 ENST00000398978.3
ENST00000354547.3
ENST00000357811.3
collagen, type XIII, alpha 1
chr2_+_90259593 1.71 ENST00000471857.1
immunoglobulin kappa variable 1D-8
chr17_+_43861680 1.67 ENST00000314537.5
corticotropin releasing hormone receptor 1
chr19_-_51538148 1.67 ENST00000319590.4
ENST00000250351.4
kallikrein-related peptidase 12
chr2_+_242167319 1.63 ENST00000601871.1
HCG1777198, isoform CRA_a; PRO2900; Uncharacterized protein
chr11_+_71238313 1.61 ENST00000398536.4
keratin associated protein 5-7
chr6_-_41254403 1.61 ENST00000589614.1
ENST00000334475.6
ENST00000591620.1
ENST00000244709.4
triggering receptor expressed on myeloid cells 1
chr19_-_51531210 1.58 ENST00000391804.3
kallikrein-related peptidase 11
chr3_+_189349162 1.57 ENST00000264731.3
ENST00000382063.4
ENST00000418709.2
ENST00000320472.5
ENST00000392460.3
ENST00000440651.2
tumor protein p63
chr14_+_74416989 1.53 ENST00000334571.2
ENST00000554920.1
coenzyme Q6 monooxygenase
chr15_-_75017711 1.51 ENST00000567032.1
ENST00000564596.1
ENST00000566503.1
ENST00000395049.4
ENST00000395048.2
ENST00000379727.3
cytochrome P450, family 1, subfamily A, polypeptide 1
chr9_-_130679257 1.50 ENST00000361444.3
ENST00000335791.5
ENST00000343609.2
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
chr16_+_83932684 1.49 ENST00000262430.4
malonyl-CoA decarboxylase
chr14_+_96722152 1.49 ENST00000216629.6
bradykinin receptor B1
chr3_+_148709128 1.49 ENST00000345003.4
ENST00000296048.6
ENST00000483267.1
glycogenin 1
chr19_-_16682987 1.48 ENST00000431408.1
ENST00000436553.2
ENST00000595753.1
solute carrier family 35, member E1
chr1_-_182921119 1.47 ENST00000423786.1
SHC SH2-domain binding protein 1-like
chr19_-_55691377 1.47 ENST00000589172.1
synaptotagmin V
chr19_-_33360647 1.46 ENST00000590341.1
ENST00000587772.1
ENST00000023064.4
solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
chr17_-_61959202 1.44 ENST00000449787.2
ENST00000456543.2
ENST00000423893.2
ENST00000332800.7
growth hormone 2
chr7_-_99381884 1.44 ENST00000336411.2
cytochrome P450, family 3, subfamily A, polypeptide 4
chr11_+_65082289 1.43 ENST00000279249.2
CDC42 effector protein (Rho GTPase binding) 2
chr6_+_6588316 1.42 ENST00000379953.2
lymphocyte antigen 86
chr7_-_150675372 1.41 ENST00000262186.5
potassium voltage-gated channel, subfamily H (eag-related), member 2
chrX_-_65858865 1.39 ENST00000374719.3
ENST00000450752.1
ENST00000451436.2
ectodysplasin A2 receptor
chr2_+_241807870 1.38 ENST00000307503.3
alanine-glyoxylate aminotransferase
chr6_+_52285046 1.35 ENST00000371068.5
EF-hand domain (C-terminal) containing 1
chrX_-_65859096 1.34 ENST00000456230.2
ectodysplasin A2 receptor
chr1_+_154540246 1.32 ENST00000368476.3
cholinergic receptor, nicotinic, beta 2 (neuronal)
chr12_+_12223867 1.31 ENST00000308721.5
BCL2-like 14 (apoptosis facilitator)
chr5_-_137610300 1.30 ENST00000274721.3
GDNF family receptor alpha 3
chr2_-_113594279 1.28 ENST00000416750.1
ENST00000418817.1
ENST00000263341.2
interleukin 1, beta
chr1_+_32608566 1.25 ENST00000545542.1
karyopherin alpha 6 (importin alpha 7)
chr4_-_5021164 1.24 ENST00000506508.1
ENST00000509419.1
ENST00000307746.4
cytokine-like 1
chr8_+_79578282 1.22 ENST00000263849.4
zinc finger, C2HC-type containing 1A
chr1_-_212208842 1.19 ENST00000366992.3
ENST00000366993.3
ENST00000440600.2
ENST00000366994.3
integrator complex subunit 7
chr6_+_160542821 1.19 ENST00000366963.4
solute carrier family 22 (organic cation transporter), member 1
chr12_-_88535747 1.19 ENST00000309041.7
centrosomal protein 290kDa
chr22_+_41487711 1.18 ENST00000263253.7
E1A binding protein p300
chr11_-_18258342 1.16 ENST00000278222.4
serum amyloid A4, constitutive
chr19_-_47291843 1.16 ENST00000542575.2
solute carrier family 1 (neutral amino acid transporter), member 5
chr20_-_4229721 1.15 ENST00000379453.4
adrenoceptor alpha 1D
chr3_+_133118839 1.12 ENST00000302334.2
beaded filament structural protein 2, phakinin
chr6_+_52285131 1.11 ENST00000433625.2
EF-hand domain (C-terminal) containing 1
chr18_-_25616519 1.08 ENST00000399380.3
cadherin 2, type 1, N-cadherin (neuronal)
chr9_+_5231413 1.08 ENST00000239316.4
insulin-like 4 (placenta)
chr17_+_38465441 1.08 ENST00000577646.1
ENST00000254066.5
retinoic acid receptor, alpha
chr16_+_3062457 1.03 ENST00000445369.2
claudin 9
chr2_+_55459808 1.03 ENST00000404735.1
ribosomal protein S27a
chr19_+_53898380 1.02 ENST00000396408.3
ENST00000505866.1
ENST00000594030.1
zinc finger protein 765
chr6_-_33771757 1.01 ENST00000507738.1
ENST00000266003.5
ENST00000430124.2
motilin
chr6_-_11382478 1.00 ENST00000397378.3
ENST00000513989.1
ENST00000508546.1
ENST00000504387.1
neural precursor cell expressed, developmentally down-regulated 9
chr9_+_130186653 0.96 ENST00000342483.5
ENST00000543471.1
zinc finger protein 79
chr12_+_110011571 0.91 ENST00000539696.1
ENST00000228510.3
ENST00000392727.3
mevalonate kinase
chr15_-_59665062 0.90 ENST00000288235.4
myosin IE
chr7_+_99971129 0.89 ENST00000394000.2
ENST00000350573.2
paired immunoglobin-like type 2 receptor alpha
chr19_+_58281014 0.87 ENST00000391702.3
ENST00000598885.1
ENST00000598183.1
ENST00000396154.2
ENST00000599802.1
ENST00000396150.4
zinc finger protein 586
chrX_+_135570046 0.86 ENST00000370648.3
bombesin-like receptor 3
chr18_+_55018044 0.85 ENST00000324000.3
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chr8_-_72268889 0.84 ENST00000388742.4
eyes absent homolog 1 (Drosophila)
chr5_-_137610254 0.84 ENST00000378362.3
GDNF family receptor alpha 3
chr19_-_42931567 0.83 ENST00000244289.4
lipase, hormone-sensitive
chr2_+_162101247 0.83 ENST00000439050.1
ENST00000436506.1
AC009299.3
chr3_-_178976996 0.82 ENST00000485523.1
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr3_+_148447887 0.78 ENST00000475347.1
ENST00000474935.1
ENST00000461609.1
angiotensin II receptor, type 1
chr13_-_103719196 0.76 ENST00000245312.3
solute carrier family 10 (sodium/bile acid cotransporter), member 2
chr9_-_100954910 0.71 ENST00000375077.4
coronin, actin binding protein, 2A
chr3_-_45838011 0.71 ENST00000358525.4
ENST00000413781.1
solute carrier family 6 (proline IMINO transporter), member 20
chr18_+_5238055 0.69 ENST00000582363.1
ENST00000582008.1
ENST00000580082.1
long intergenic non-protein coding RNA 667
chr1_-_241799232 0.69 ENST00000366553.1
choroideremia-like (Rab escort protein 2)
chr7_-_134896234 0.68 ENST00000354475.4
ENST00000344400.5
WD repeat domain 91
chr1_+_171217622 0.68 ENST00000433267.1
ENST00000367750.3
flavin containing monooxygenase 1
chr1_-_51810778 0.66 ENST00000413473.2
ENST00000401051.3
ENST00000527205.1
tetratricopeptide repeat domain 39A
chr11_+_7506713 0.66 ENST00000329293.3
ENST00000534244.1
olfactomedin-like 1
chr1_+_36396677 0.66 ENST00000373191.4
ENST00000397828.2
argonaute RISC catalytic component 3
chr2_+_55459495 0.64 ENST00000272317.6
ENST00000449323.1
ribosomal protein S27a
chr19_+_9361606 0.63 ENST00000456448.1
olfactory receptor, family 7, subfamily E, member 24
chr1_-_13219581 0.63 ENST00000423177.1
PRAME family member 26
chr22_+_27017921 0.60 ENST00000354760.3
crystallin, beta A4
chr15_-_34635314 0.60 ENST00000557912.1
ENST00000328848.4
NOP10 ribonucleoprotein
chr7_-_2883928 0.60 ENST00000275364.3
guanine nucleotide binding protein (G protein) alpha 12
chr3_-_170626418 0.59 ENST00000474096.1
ENST00000295822.2
eukaryotic translation initiation factor 5A2
chr4_-_80247162 0.57 ENST00000286794.4
N(alpha)-acetyltransferase 11, NatA catalytic subunit
chr21_-_15918618 0.57 ENST00000400564.1
ENST00000400566.1
SAM domain, SH3 domain and nuclear localization signals 1
chr4_+_156824840 0.56 ENST00000536354.2
tryptophan 2,3-dioxygenase
chr12_+_11081828 0.53 ENST00000381847.3
ENST00000396400.3
proline-rich protein HaeIII subfamily 2
chr2_-_89545079 0.52 ENST00000468494.1
immunoglobulin kappa variable 2-30
chr12_-_88535842 0.52 ENST00000550962.1
ENST00000552810.1
centrosomal protein 290kDa
chr19_+_41257084 0.52 ENST00000601393.1
small nuclear ribonucleoprotein polypeptide A
chr13_+_28494130 0.51 ENST00000381033.4
pancreatic and duodenal homeobox 1
chr15_-_74501310 0.51 ENST00000423167.2
ENST00000432245.2
stimulated by retinoic acid 6
chr4_+_187148556 0.47 ENST00000264690.6
ENST00000446598.2
ENST00000414291.1
ENST00000513864.1
kallikrein B, plasma (Fletcher factor) 1
chr16_+_66914264 0.46 ENST00000311765.2
ENST00000568869.1
ENST00000561704.1
ENST00000568398.1
ENST00000566776.1
pyruvate dehyrogenase phosphatase catalytic subunit 2
chr1_+_151020175 0.45 ENST00000368926.5
chromosome 1 open reading frame 56
chr1_+_36396791 0.43 ENST00000246314.6
argonaute RISC catalytic component 3
chr8_-_20161466 0.39 ENST00000381569.1
leucine zipper, putative tumor suppressor 1
chr13_+_73356197 0.37 ENST00000326291.6
progesterone immunomodulatory binding factor 1
chr19_+_53868940 0.35 ENST00000474037.1
ENST00000491101.1
ENST00000467003.1
ENST00000475179.1
ENST00000593918.1
zinc finger protein 525
chr8_-_72274095 0.34 ENST00000303824.7
eyes absent homolog 1 (Drosophila)
chr12_+_133757995 0.33 ENST00000536435.2
ENST00000228289.5
ENST00000541211.2
ENST00000500625.3
ENST00000539248.2
ENST00000542711.2
ENST00000536899.2
ENST00000542986.2
ENST00000537565.1
ENST00000541975.2
zinc finger protein 268

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
5.1 15.3 GO:0006097 glyoxylate cycle(GO:0006097)
2.9 11.5 GO:0035026 leading edge cell differentiation(GO:0035026)
2.2 8.7 GO:0001971 negative regulation of activation of membrane attack complex(GO:0001971)
2.0 10.2 GO:0001957 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
2.0 6.0 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
1.9 25.0 GO:0035826 rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680)
1.9 5.7 GO:0002384 hepatic immune response(GO:0002384) response to prolactin(GO:1990637) regulation of STAT protein import into nucleus(GO:2000364) positive regulation of STAT protein import into nucleus(GO:2000366)
1.7 5.2 GO:0019482 beta-alanine metabolic process(GO:0019482)
1.2 4.9 GO:0042360 vitamin E metabolic process(GO:0042360)
0.8 2.5 GO:2000296 negative regulation of hydrogen peroxide catabolic process(GO:2000296)
0.8 2.5 GO:0046521 sphingoid catabolic process(GO:0046521)
0.8 3.2 GO:0046967 cytosol to ER transport(GO:0046967)
0.8 5.4 GO:0019344 cysteine biosynthetic process(GO:0019344)
0.7 2.8 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
0.7 1.4 GO:0009093 cysteine catabolic process(GO:0009093) L-cysteine catabolic process(GO:0019448) L-cysteine metabolic process(GO:0046439)
0.7 4.0 GO:0015811 L-cystine transport(GO:0015811)
0.6 2.5 GO:0003331 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.6 1.8 GO:0048250 mitochondrial iron ion transport(GO:0048250)
0.6 1.7 GO:0036378 calcitriol biosynthetic process from calciol(GO:0036378)
0.5 4.2 GO:1900625 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.5 0.5 GO:0010157 response to chlorate(GO:0010157)
0.5 11.8 GO:0032703 negative regulation of interleukin-2 production(GO:0032703)
0.5 1.5 GO:0018894 dibenzo-p-dioxin metabolic process(GO:0018894) cellular alkene metabolic process(GO:0043449)
0.5 5.0 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.5 4.5 GO:0072718 response to cisplatin(GO:0072718)
0.5 1.4 GO:1902303 regulation of heart rate by hormone(GO:0003064) negative regulation of potassium ion export(GO:1902303)
0.5 1.8 GO:2001153 regulation of renal water transport(GO:2001151) positive regulation of renal water transport(GO:2001153)
0.4 0.9 GO:0035166 post-embryonic hemopoiesis(GO:0035166)
0.4 1.8 GO:0048859 formation of anatomical boundary(GO:0048859)
0.4 31.6 GO:0006910 phagocytosis, recognition(GO:0006910)
0.4 8.0 GO:0043651 linoleic acid metabolic process(GO:0043651)
0.4 1.3 GO:0070487 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559) monocyte aggregation(GO:0070487)
0.4 1.6 GO:0007499 ectoderm and mesoderm interaction(GO:0007499)
0.4 1.8 GO:0033274 response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829)
0.4 7.1 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.3 1.3 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) synaptic transmission involved in micturition(GO:0060084)
0.3 3.1 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.3 7.7 GO:0035455 response to interferon-alpha(GO:0035455)
0.3 0.9 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.3 1.5 GO:0036115 fatty-acyl-CoA catabolic process(GO:0036115) malonyl-CoA metabolic process(GO:2001293)
0.3 1.8 GO:0019249 lactate biosynthetic process(GO:0019249)
0.3 1.2 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.3 1.2 GO:0036229 glutamine secretion(GO:0010585) L-glutamine import(GO:0036229) L-glutamine import into cell(GO:1903803)
0.3 1.2 GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001994)
0.3 3.2 GO:1901750 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.3 1.1 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.3 1.6 GO:0070945 neutrophil mediated killing of gram-negative bacterium(GO:0070945)
0.3 4.7 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.3 5.9 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.2 42.8 GO:0002377 immunoglobulin production(GO:0002377)
0.2 1.7 GO:0051458 corticosterone secretion(GO:0035934) corticotropin secretion(GO:0051458) regulation of corticosterone secretion(GO:2000852)
0.2 1.2 GO:0048241 epinephrine transport(GO:0048241)
0.2 1.2 GO:0035279 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing by siRNA(GO:0090625) mRNA cleavage involved in gene silencing(GO:0098795)
0.2 1.9 GO:0015705 iodide transport(GO:0015705)
0.2 0.7 GO:0045897 positive regulation of transcription during mitosis(GO:0045897)
0.2 1.1 GO:2000809 positive regulation of synaptic vesicle clustering(GO:2000809)
0.2 2.6 GO:0090091 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) positive regulation of extracellular matrix disassembly(GO:0090091)
0.2 0.8 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.2 2.7 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.2 0.6 GO:0019442 tryptophan catabolic process to acetyl-CoA(GO:0019442)
0.2 2.9 GO:0071600 otic vesicle morphogenesis(GO:0071600)
0.2 1.4 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
0.2 0.8 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.2 0.5 GO:0002541 activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.2 3.1 GO:0005513 detection of calcium ion(GO:0005513)
0.1 4.9 GO:0071498 cellular response to fluid shear stress(GO:0071498)
0.1 2.3 GO:0051639 actin filament network formation(GO:0051639)
0.1 0.7 GO:0015824 proline transport(GO:0015824)
0.1 0.6 GO:0030920 N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920)
0.1 6.4 GO:0001958 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.1 2.6 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.1 3.7 GO:1901685 glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687)
0.1 0.6 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
0.1 1.4 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.1 4.1 GO:0045730 respiratory burst(GO:0045730)
0.1 0.9 GO:0008343 adult feeding behavior(GO:0008343)
0.1 0.9 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.1 9.9 GO:0042246 tissue regeneration(GO:0042246)
0.1 1.2 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.1 6.2 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.1 2.3 GO:2001044 regulation of integrin-mediated signaling pathway(GO:2001044)
0.1 1.1 GO:0070307 lens fiber cell development(GO:0070307)
0.1 2.4 GO:0030252 growth hormone secretion(GO:0030252)
0.1 0.4 GO:0031392 regulation of prostaglandin biosynthetic process(GO:0031392) negative regulation of natural killer cell activation(GO:0032815) regulation of unsaturated fatty acid biosynthetic process(GO:2001279)
0.1 0.7 GO:0070995 NADPH oxidation(GO:0070995)
0.1 5.7 GO:0009250 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.1 1.5 GO:0006743 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.1 2.5 GO:0002026 regulation of the force of heart contraction(GO:0002026)
0.1 0.7 GO:0018344 protein geranylgeranylation(GO:0018344)
0.1 1.5 GO:0097503 sialylation(GO:0097503)
0.1 0.6 GO:0045905 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.1 10.0 GO:0031424 keratinization(GO:0031424)
0.1 2.1 GO:0048485 sympathetic nervous system development(GO:0048485)
0.1 0.2 GO:0051344 regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051342) negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344)
0.1 0.1 GO:0014057 acetylcholine secretion, neurotransmission(GO:0014055) regulation of acetylcholine secretion, neurotransmission(GO:0014056) positive regulation of acetylcholine secretion, neurotransmission(GO:0014057)
0.1 2.0 GO:0060216 definitive hemopoiesis(GO:0060216)
0.1 1.4 GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.1 2.0 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.0 0.1 GO:0002589 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590) regulation of T cell antigen processing and presentation(GO:0002625) positive regulation of iron ion transport(GO:0034758) positive regulation of iron ion transmembrane transport(GO:0034761) regulation of iron ion import(GO:1900390) regulation of ferrous iron import into cell(GO:1903989) positive regulation of ferrous iron import into cell(GO:1903991) regulation of ferrous iron binding(GO:1904432) positive regulation of ferrous iron binding(GO:1904434) regulation of transferrin receptor binding(GO:1904435) positive regulation of transferrin receptor binding(GO:1904437) regulation of ferrous iron import across plasma membrane(GO:1904438) positive regulation of ferrous iron import across plasma membrane(GO:1904440) response to iron ion starvation(GO:1990641)
0.0 3.2 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 1.8 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.0 1.5 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 2.5 GO:0021795 cerebral cortex cell migration(GO:0021795)
0.0 5.2 GO:1902600 hydrogen ion transmembrane transport(GO:1902600)
0.0 1.5 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 1.9 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.0 0.2 GO:0051552 flavone metabolic process(GO:0051552)
0.0 3.3 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 1.0 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 3.1 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 1.6 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 3.7 GO:0007224 smoothened signaling pathway(GO:0007224)
0.0 0.6 GO:0010762 regulation of fibroblast migration(GO:0010762)
0.0 0.2 GO:0006531 aspartate metabolic process(GO:0006531)
0.0 0.2 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.0 0.6 GO:0050869 negative regulation of B cell activation(GO:0050869)
0.0 0.5 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.0 0.1 GO:0097527 necroptotic signaling pathway(GO:0097527)
0.0 0.3 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 0.8 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.0 0.4 GO:0016242 negative regulation of macroautophagy(GO:0016242)
0.0 3.5 GO:0060271 cilium morphogenesis(GO:0060271)
0.0 1.2 GO:0050918 positive chemotaxis(GO:0050918)
0.0 0.0 GO:0031547 brain-derived neurotrophic factor receptor signaling pathway(GO:0031547) regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031548)
0.0 1.2 GO:0002062 chondrocyte differentiation(GO:0002062)
0.0 3.1 GO:0007162 negative regulation of cell adhesion(GO:0007162)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 25.0 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
1.6 6.4 GO:0005600 collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936)
1.5 4.5 GO:0090498 extrinsic component of Golgi membrane(GO:0090498)
1.4 5.7 GO:0005896 interleukin-6 receptor complex(GO:0005896)
1.3 11.5 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.7 6.0 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.6 2.5 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.6 31.6 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.6 4.2 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.5 8.7 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.5 3.2 GO:0042825 TAP complex(GO:0042825)
0.5 2.6 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.5 4.1 GO:0032010 phagolysosome(GO:0032010)
0.5 4.0 GO:1990111 spermatoproteasome complex(GO:1990111)
0.4 5.4 GO:0036038 MKS complex(GO:0036038)
0.4 5.0 GO:0005577 fibrinogen complex(GO:0005577)
0.3 3.3 GO:0030126 COPI vesicle coat(GO:0030126)
0.3 7.1 GO:0030127 COPII vesicle coat(GO:0030127)
0.3 17.8 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.3 5.2 GO:0045277 respiratory chain complex IV(GO:0045277)
0.3 1.4 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.2 6.3 GO:0034451 centriolar satellite(GO:0034451)
0.2 0.7 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.2 1.5 GO:0072687 meiotic spindle(GO:0072687)
0.2 6.7 GO:0045095 keratin filament(GO:0045095)
0.1 1.2 GO:0032039 integrator complex(GO:0032039)
0.1 1.2 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.1 2.3 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.1 1.9 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.1 0.6 GO:0031429 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588) box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)
0.1 2.0 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.1 1.1 GO:0016342 catenin complex(GO:0016342)
0.1 0.6 GO:0031415 NatA complex(GO:0031415)
0.1 7.7 GO:0031902 late endosome membrane(GO:0031902)
0.1 4.7 GO:0035578 azurophil granule lumen(GO:0035578)
0.1 1.3 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 3.6 GO:0005882 intermediate filament(GO:0005882)
0.1 2.0 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 82.2 GO:0005615 extracellular space(GO:0005615)
0.0 1.4 GO:0031904 endosome lumen(GO:0031904)
0.0 2.1 GO:0031526 brush border membrane(GO:0031526)
0.0 2.5 GO:0031672 A band(GO:0031672)
0.0 0.2 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 2.5 GO:0005930 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0 3.2 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 3.1 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 1.8 GO:0045202 synapse(GO:0045202)
0.0 1.6 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 2.1 GO:0031225 anchored component of membrane(GO:0031225)
0.0 2.5 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 1.8 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.9 GO:0016459 myosin complex(GO:0016459)
0.0 1.8 GO:0031514 motile cilium(GO:0031514)
0.0 0.8 GO:0005902 microvillus(GO:0005902)
0.0 1.8 GO:0005643 nuclear pore(GO:0005643)
0.0 0.5 GO:0005685 U1 snRNP(GO:0005685)
0.0 0.8 GO:0005901 caveola(GO:0005901)
0.0 1.2 GO:0032993 protein-DNA complex(GO:0032993)
0.0 1.4 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 0.3 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 1.5 GO:1904813 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.0 1.0 GO:0030027 lamellipodium(GO:0030027)
0.0 0.6 GO:0001726 ruffle(GO:0001726)
0.0 2.8 GO:0016324 apical plasma membrane(GO:0016324)
0.0 26.0 GO:0070062 extracellular exosome(GO:0070062)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
5.1 15.3 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
1.0 6.2 GO:0004522 ribonuclease A activity(GO:0004522)
0.8 2.3 GO:0050135 NAD+ nucleosidase activity(GO:0003953) NAD(P)+ nucleosidase activity(GO:0050135)
0.7 4.0 GO:0015184 L-cystine transmembrane transporter activity(GO:0015184)
0.6 3.2 GO:0070576 vitamin D 24-hydroxylase activity(GO:0070576)
0.6 2.5 GO:0032038 myosin II heavy chain binding(GO:0032038)
0.6 5.7 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.6 8.6 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.6 31.6 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.5 6.0 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.5 3.2 GO:0046979 TAP2 binding(GO:0046979)
0.5 11.5 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.5 2.6 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.5 1.5 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.5 1.5 GO:0004947 bradykinin receptor activity(GO:0004947)
0.4 3.1 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.4 2.5 GO:0030492 hemoglobin binding(GO:0030492)
0.4 2.5 GO:0008481 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.4 4.1 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.4 1.2 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.4 1.5 GO:0008466 glycogenin glucosyltransferase activity(GO:0008466)
0.4 1.8 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.4 2.1 GO:0008046 axon guidance receptor activity(GO:0008046)
0.3 1.7 GO:0015056 corticotrophin-releasing factor receptor activity(GO:0015056)
0.3 1.8 GO:0042577 lipid phosphatase activity(GO:0042577)
0.3 1.2 GO:0005277 acetylcholine transmembrane transporter activity(GO:0005277) secondary active organic cation transmembrane transporter activity(GO:0008513) acetate ester transmembrane transporter activity(GO:1901375)
0.3 0.8 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.3 8.0 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.3 0.8 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.3 1.8 GO:0004457 lactate dehydrogenase activity(GO:0004457) L-lactate dehydrogenase activity(GO:0004459)
0.2 8.7 GO:0001848 complement binding(GO:0001848)
0.2 1.2 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.2 1.4 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.2 1.2 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.2 40.3 GO:0003823 antigen binding(GO:0003823)
0.2 1.8 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
0.2 1.4 GO:0001515 opioid peptide activity(GO:0001515)
0.2 0.8 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.2 0.6 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.2 5.4 GO:0005540 hyaluronic acid binding(GO:0005540)
0.2 5.2 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 4.5 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 0.6 GO:1990190 peptide-glutamate-N-acetyltransferase activity(GO:1990190)
0.1 1.1 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 4.0 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 1.7 GO:0051011 microtubule minus-end binding(GO:0051011)
0.1 27.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 0.9 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.1 1.6 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.1 3.1 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.1 1.8 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.1 2.4 GO:0005024 transforming growth factor beta-activated receptor activity(GO:0005024)
0.1 3.7 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 1.9 GO:0001054 RNA polymerase I activity(GO:0001054)
0.1 3.0 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.1 0.6 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.1 0.3 GO:0015361 low-affinity sodium:dicarboxylate symporter activity(GO:0015361)
0.1 7.1 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 1.1 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 2.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 6.9 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 0.5 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.1 0.7 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 0.5 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.1 1.3 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.1 0.3 GO:0000405 bubble DNA binding(GO:0000405)
0.1 1.4 GO:0008483 transaminase activity(GO:0008483)
0.1 2.3 GO:0003785 actin monomer binding(GO:0003785)
0.1 1.7 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 1.3 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 1.2 GO:0035198 miRNA binding(GO:0035198)
0.0 5.5 GO:0005179 hormone activity(GO:0005179)
0.0 1.5 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0 1.2 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 1.8 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 1.2 GO:0042056 chemoattractant activity(GO:0042056)
0.0 0.7 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.0 1.0 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.0 1.6 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.7 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.7 GO:0042288 MHC class I protein binding(GO:0042288)
0.0 3.1 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0 1.5 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 2.6 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.0 0.9 GO:0000146 microfilament motor activity(GO:0000146)
0.0 0.6 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.6 GO:0050780 dopamine receptor binding(GO:0050780)
0.0 0.2 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 1.5 GO:0097110 scaffold protein binding(GO:0097110)
0.0 1.8 GO:0005525 GTP binding(GO:0005525)
0.0 0.1 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 2.7 GO:0008201 heparin binding(GO:0008201)
0.0 0.2 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.2 GO:0005131 growth hormone receptor binding(GO:0005131)
0.0 0.0 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.0 0.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 1.0 GO:0001618 virus receptor activity(GO:0001618)
0.0 0.2 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.0 0.6 GO:0001784 phosphotyrosine binding(GO:0001784)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.7 ST STAT3 PATHWAY STAT3 Pathway
0.3 14.4 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.1 6.4 NABA COLLAGENS Genes encoding collagen proteins
0.1 11.5 PID TGFBR PATHWAY TGF-beta receptor signaling
0.1 7.5 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.1 3.1 PID INTEGRIN1 PATHWAY Beta1 integrin cell surface interactions
0.1 1.3 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 2.3 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.1 4.1 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 9.2 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 3.6 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.6 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 1.1 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 1.9 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.2 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.0 0.8 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 11.5 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.6 16.2 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.5 10.1 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.5 17.1 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.4 14.7 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.4 5.2 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.3 5.0 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.3 5.8 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.3 10.3 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.2 7.5 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.2 4.9 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.2 3.2 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.2 25.0 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.2 1.7 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.1 5.9 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 6.4 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 3.2 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.1 1.2 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.1 1.2 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.1 6.6 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 1.3 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 3.1 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.1 2.5 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 1.5 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 1.4 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.1 0.8 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 4.7 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.0 0.9 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 3.6 REACTOME ANTIGEN PROCESSING CROSS PRESENTATION Genes involved in Antigen processing-Cross presentation
0.0 0.6 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 1.3 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.5 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.0 0.7 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 2.5 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 2.6 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.0 0.8 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 1.3 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.4 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.9 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 1.4 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.0 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.3 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 1.8 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.5 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 3.1 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.0 1.0 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.3 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.8 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 1.0 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.6 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0 0.5 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 1.1 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.3 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.7 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds