ISMARA results: TBX3

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for TBX3

Z-value: 0.31

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Transcription factors associated with TBX3

Gene Symbol	Gene ID	Gene Info
TBX3 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000135111.10	T-box transcription factor 3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
TBX3	hg19_v2_chr12_-_115121962_115121987	0.32	1.0e-06	Click!

Activity profile of TBX3 motif

Sorted Z-values of TBX3 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr22_+_23237555 Show fit	13.43	ENST00000390321.2	IGLC1 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin lambda constant 1 (Mcg marker)
chr5_-_39425222 Show fit	11.53	ENST00000320816.6	DAB2 Ensembl NCBI GeneCards UniProt NextProt Show fit	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
chr2_-_89310012 Show fit	11.10	ENST00000493819.1	IGKV1-9 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin kappa variable 1-9
chr16_+_55512742 Show fit	10.21	ENST00000568715.1 ENST00000219070.4	MMP2 Ensembl NCBI GeneCards UniProt NextProt Show fit	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr2_-_89266286 Show fit	9.63	ENST00000464162.1	IGKV1-6 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin kappa variable 1-6
chr2_-_89513402 Show fit	9.49	ENST00000498435.1	IGKV1-27 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin kappa variable 1-27
chr14_-_106642049 Show fit	8.61	ENST00000390605.2	IGHV1-18 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin heavy variable 1-18
chr2_-_209118974 Show fit	8.42	ENST00000415913.1 ENST00000415282.1 ENST00000446179.1	IDH1 Ensembl NCBI GeneCards UniProt NextProt Show fit	isocitrate dehydrogenase 1 (NADP+), soluble
chr6_-_52668605 Show fit	8.00	ENST00000334575.5	GSTA1 Ensembl NCBI GeneCards UniProt NextProt Show fit	glutathione S-transferase alpha 1
chr11_-_327537 Show fit	7.67	ENST00000602735.1	IFITM3 Ensembl NCBI GeneCards UniProt NextProt Show fit	interferon induced transmembrane protein 3

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	42.8	GO:0002377	immunoglobulin production(GO:0002377)
0.4	31.6	GO:0006910	phagocytosis, recognition(GO:0006910)
1.9	25.0	GO:0035826	rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680)
5.1	15.3	GO:0006097	glyoxylate cycle(GO:0006097)
0.5	11.8	GO:0032703	negative regulation of interleukin-2 production(GO:0032703)
2.9	11.5	GO:0035026	leading edge cell differentiation(GO:0035026)
2.0	10.2	GO:0001957	intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.1	10.0	GO:0031424	keratinization(GO:0031424)
0.1	9.9	GO:0042246	tissue regeneration(GO:0042246)
2.2	8.7	GO:0001971	negative regulation of activation of membrane attack complex(GO:0001971)

Showing 1 to 10 of 126 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	82.2	GO:0005615	extracellular space(GO:0005615)
0.6	31.6	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
0.0	26.0	GO:0070062	extracellular exosome(GO:0070062)
2.1	25.0	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.3	17.8	GO:0031907	peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
1.3	11.5	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.5	8.7	GO:0031362	anchored component of external side of plasma membrane(GO:0031362)
0.1	7.7	GO:0031902	late endosome membrane(GO:0031902)
0.3	7.1	GO:0030127	COPII vesicle coat(GO:0030127)
0.2	6.7	GO:0045095	keratin filament(GO:0045095)

Showing 1 to 10 of 65 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	40.3	GO:0003823	antigen binding(GO:0003823)
0.6	31.6	GO:0034987	immunoglobulin receptor binding(GO:0034987)
0.1	27.1	GO:0004252	serine-type endopeptidase activity(GO:0004252)
5.1	15.3	GO:0004450	isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.5	11.5	GO:0035615	clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.2	8.7	GO:0001848	complement binding(GO:0001848)
0.6	8.6	GO:0036374	glutathione hydrolase activity(GO:0036374)
0.3	8.0	GO:0004602	glutathione peroxidase activity(GO:0004602)
0.1	7.1	GO:0048306	calcium-dependent protein binding(GO:0048306)
0.1	6.9	GO:0005201	extracellular matrix structural constituent(GO:0005201)

Showing 1 to 10 of 99 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	14.4	PID AVB3 OPN PATHWAY	Osteopontin-mediated events
0.1	11.5	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.0	9.2	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.1	7.5	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.1	6.4	NABA COLLAGENS	Genes encoding collagen proteins
0.3	5.7	ST STAT3 PATHWAY	STAT3 Pathway
0.1	4.1	PID RAC1 PATHWAY	RAC1 signaling pathway
0.0	3.6	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.1	3.1	PID INTEGRIN1 PATHWAY	Beta1 integrin cell surface interactions
0.1	2.3	PID RETINOIC ACID PATHWAY	Retinoic acid receptors-mediated signaling

Showing 1 to 10 of 16 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	25.0	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.5	17.1	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.6	16.2	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.4	14.7	REACTOME PEROXISOMAL LIPID METABOLISM	Genes involved in Peroxisomal lipid metabolism
0.6	11.5	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.3	10.3	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.5	10.1	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.2	7.5	REACTOME RNA POL I TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase I Transcription Termination
0.1	6.6	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.1	6.4	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation

Showing 1 to 10 of 54 entries

Results for TBX3

Z-value: 0.31

Motif logo

Transcription factors associated with TBX3

Activity-expression correlation:

Activity profile of TBX3 motif

Sorted Z-values of TBX3 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: