Project
GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for TCF3_MYOG
Z-value: 0.87
Motif logo
Transcription factors associated with TCF3_MYOG
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MYOG | hg19_v2_chr1_-_203055129_203055164 | -0.53 | 2.1e-17 | Click! |
| TCF3 | hg19_v2_chr19_-_1650666_1650744 | -0.22 | 8.5e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TCF3_MYOG
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 118.7 | GO:0031424 | keratinization(GO:0031424) |
| 1.3 | 102.1 | GO:0033275 | muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275) |
| 1.0 | 73.4 | GO:0010257 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 12.9 | 51.7 | GO:0002317 | plasma cell differentiation(GO:0002317) |
| 3.8 | 49.7 | GO:2000680 | rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680) |
| 4.6 | 46.4 | GO:0007144 | female meiosis I(GO:0007144) |
| 15.3 | 45.9 | GO:1900085 | negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609) |
| 0.5 | 44.2 | GO:0032392 | DNA geometric change(GO:0032392) |
| 0.3 | 43.2 | GO:0043488 | regulation of mRNA stability(GO:0043488) |
| 4.1 | 41.4 | GO:0000722 | telomere maintenance via recombination(GO:0000722) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 116.2 | GO:0045095 | keratin filament(GO:0045095) |
| 0.5 | 95.0 | GO:1904813 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 4.5 | 84.8 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.2 | 80.4 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.4 | 66.1 | GO:0000922 | spindle pole(GO:0000922) |
| 0.8 | 57.9 | GO:0032154 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.1 | 54.8 | GO:0005925 | focal adhesion(GO:0005925) |
| 4.1 | 49.7 | GO:0097487 | multivesicular body, internal vesicle(GO:0097487) |
| 1.2 | 45.7 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.7 | 45.1 | GO:0000313 | organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 97.7 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.2 | 86.7 | GO:0031625 | ubiquitin protein ligase binding(GO:0031625) |
| 1.2 | 56.7 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 17.2 | 51.7 | GO:0048030 | disaccharide binding(GO:0048030) |
| 2.2 | 50.8 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 1.8 | 49.2 | GO:0000400 | four-way junction DNA binding(GO:0000400) |
| 2.3 | 47.9 | GO:0070628 | proteasome binding(GO:0070628) |
| 0.3 | 47.6 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 15.3 | 45.9 | GO:0070320 | inward rectifier potassium channel inhibitor activity(GO:0070320) |
| 0.3 | 35.6 | GO:0044822 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 80.3 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.4 | 50.7 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 3.3 | 46.4 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 1.1 | 44.2 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.5 | 43.0 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 1.2 | 38.9 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.8 | 36.5 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.7 | 36.3 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.5 | 33.5 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 1.3 | 33.1 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 106.3 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 2.2 | 64.3 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 1.9 | 53.1 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 1.7 | 46.4 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 3.5 | 41.4 | REACTOME IRAK1 RECRUITS IKK COMPLEX | Genes involved in IRAK1 recruits IKK complex |
| 1.0 | 39.9 | REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS | Genes involved in TGF-beta receptor signaling activates SMADs |
| 1.2 | 39.1 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.3 | 34.0 | REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION | Genes involved in Influenza Viral RNA Transcription and Replication |
| 0.2 | 33.7 | REACTOME METABOLISM OF CARBOHYDRATES | Genes involved in Metabolism of carbohydrates |
| 0.6 | 31.3 | REACTOME G1 PHASE | Genes involved in G1 Phase |