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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for TFCP2L1

Z-value: 0.03

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Transcription factors associated with TFCP2L1

Gene Symbol Gene ID Gene Info
TFCP2L1
ENSG00000115112.7 transcription factor CP2 like 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TFCP2L1hg19_v2_chr2_-_122042770_1220427850.027.5e-01Click!

Activity profile of TFCP2L1 motif

Sorted Z-values of TFCP2L1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_1071203 15.88 ENST00000543365.1
HMHA1
histocompatibility (minor) HA-1
chr2_-_136875712 13.84 ENST00000241393.3
CXCR4
chemokine (C-X-C motif) receptor 4
chr6_-_31550192 10.18 ENST00000429299.2
ENST00000446745.2
LTB
lymphotoxin beta (TNF superfamily, member 3)
chr20_-_43280361 9.72 ENST00000372874.4
ADA
adenosine deaminase
chr5_-_131826457 8.72 ENST00000437654.1
ENST00000245414.4
IRF1
interferon regulatory factor 1
chr20_-_43280325 8.40 ENST00000537820.1
ADA
adenosine deaminase
chr1_-_111743285 7.42 ENST00000357640.4
DENND2D
DENN/MADD domain containing 2D
chr1_-_161600990 7.39 ENST00000531221.1
FCGR3B
Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
chr20_-_62710832 7.24 ENST00000395042.1
RGS19
regulator of G-protein signaling 19
chr1_-_161600942 7.06 ENST00000421702.2
FCGR3B
Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
chr1_-_153538011 6.84 ENST00000368707.4
S100A2
S100 calcium binding protein A2
chr6_+_31555045 6.79 ENST00000396101.3
ENST00000490742.1
LST1
leukocyte specific transcript 1
chr1_-_161600822 6.78 ENST00000534776.1
ENST00000540048.1
FCGR3B
FCGR3A
Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
chr14_+_64970662 6.74 ENST00000556965.1
ENST00000554015.1
ZBTB1
zinc finger and BTB domain containing 1
chr22_-_37545972 6.32 ENST00000216223.5
IL2RB
interleukin 2 receptor, beta
chrX_-_106960285 6.28 ENST00000503515.1
ENST00000372397.2
TSC22D3
TSC22 domain family, member 3
chr15_-_62352570 6.16 ENST00000261517.5
ENST00000395896.4
ENST00000395898.3
VPS13C
vacuolar protein sorting 13 homolog C (S. cerevisiae)
chr1_+_27189631 6.15 ENST00000339276.4
SFN
stratifin
chr17_-_76124711 5.83 ENST00000306591.7
ENST00000590602.1
TMC6
transmembrane channel-like 6
chr6_+_31554962 5.45 ENST00000376092.3
ENST00000376086.3
ENST00000303757.8
ENST00000376093.2
ENST00000376102.3
LST1
leukocyte specific transcript 1
chr10_-_121296045 5.41 ENST00000392865.1
RGS10
regulator of G-protein signaling 10
chr4_-_25865159 5.40 ENST00000502949.1
ENST00000264868.5
ENST00000513691.1
ENST00000514872.1
SEL1L3
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr1_-_161519579 5.32 ENST00000426740.1
FCGR3A
Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
chr17_+_75372165 5.06 ENST00000427674.2
SEPT9
septin 9
chr1_-_161519682 5.01 ENST00000367969.3
ENST00000443193.1
FCGR3A
Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
chr2_+_98330009 4.95 ENST00000264972.5
ZAP70
zeta-chain (TCR) associated protein kinase 70kDa
chr17_-_76124812 4.82 ENST00000592063.1
ENST00000589271.1
ENST00000322933.4
ENST00000589553.1
TMC6
transmembrane channel-like 6
chr14_-_107170409 4.76 ENST00000390633.2
IGHV1-69
immunoglobulin heavy variable 1-69
chr1_-_153538292 4.75 ENST00000497140.1
ENST00000368708.3
S100A2
S100 calcium binding protein A2
chr11_+_128562372 4.62 ENST00000344954.6
FLI1
Fli-1 proto-oncogene, ETS transcription factor
chr6_-_32731299 4.53 ENST00000435145.2
ENST00000437316.2
HLA-DQB2
major histocompatibility complex, class II, DQ beta 2
chr2_-_89385283 4.51 ENST00000390252.2
IGKV3-15
immunoglobulin kappa variable 3-15
chr11_+_46383121 4.46 ENST00000454345.1
DGKZ
diacylglycerol kinase, zeta
chr16_-_86542455 4.32 ENST00000595886.1
ENST00000597578.1
ENST00000593604.1
FENDRR
FOXF1 adjacent non-coding developmental regulatory RNA
chr1_-_89458636 4.10 ENST00000370486.1
ENST00000399794.2
CCBL2
RBMXL1
cysteine conjugate-beta lyase 2
RNA binding motif protein, X-linked-like 1
chr8_-_117778494 4.02 ENST00000276682.4
EIF3H
eukaryotic translation initiation factor 3, subunit H
chr17_+_16318909 4.02 ENST00000577397.1
TRPV2
transient receptor potential cation channel, subfamily V, member 2
chr4_-_83351294 4.00 ENST00000502762.1
HNRNPDL
heterogeneous nuclear ribonucleoprotein D-like
chr19_-_12721616 3.98 ENST00000311437.6
ZNF490
zinc finger protein 490
chr14_-_64971288 3.91 ENST00000394715.1
ZBTB25
zinc finger and BTB domain containing 25
chr12_+_56324756 3.87 ENST00000331886.5
ENST00000555090.1
DGKA
diacylglycerol kinase, alpha 80kDa
chr12_+_56324933 3.86 ENST00000549629.1
ENST00000555218.1
DGKA
diacylglycerol kinase, alpha 80kDa
chr17_+_75369167 3.86 ENST00000423034.2
SEPT9
septin 9
chr4_-_83351005 3.85 ENST00000295470.5
HNRNPDL
heterogeneous nuclear ribonucleoprotein D-like
chr17_+_16318850 3.85 ENST00000338560.7
TRPV2
transient receptor potential cation channel, subfamily V, member 2
chr8_+_117778736 3.83 ENST00000309822.2
ENST00000357148.3
ENST00000517814.1
ENST00000517820.1
UTP23
UTP23, small subunit (SSU) processome component, homolog (yeast)
chr14_-_106994333 3.69 ENST00000390624.2
IGHV3-48
immunoglobulin heavy variable 3-48
chr19_+_23299777 3.61 ENST00000597761.2
ZNF730
zinc finger protein 730
chr19_-_12405689 3.59 ENST00000355684.5
ZNF44
zinc finger protein 44
chr11_+_17298297 3.58 ENST00000529010.1
NUCB2
nucleobindin 2
chr6_-_31697977 3.56 ENST00000375787.2
DDAH2
dimethylarginine dimethylaminohydrolase 2
chr19_-_12405606 3.55 ENST00000356109.5
ZNF44
zinc finger protein 44
chr4_-_174255536 3.53 ENST00000446922.2
HMGB2
high mobility group box 2
chr5_+_162864575 3.52 ENST00000512163.1
ENST00000393929.1
ENST00000340828.2
ENST00000511683.2
ENST00000510097.1
ENST00000511490.2
ENST00000510664.1
CCNG1
cyclin G1
chr19_-_6481776 3.47 ENST00000543576.1
ENST00000590173.1
ENST00000381480.2
DENND1C
DENN/MADD domain containing 1C
chr21_-_16437126 3.41 ENST00000318948.4
NRIP1
nuclear receptor interacting protein 1
chr11_+_17298255 3.40 ENST00000531172.1
ENST00000533738.2
ENST00000323688.6
NUCB2
nucleobindin 2
chr1_-_89458287 3.36 ENST00000370485.2
CCBL2
cysteine conjugate-beta lyase 2
chr10_+_63661053 3.29 ENST00000279873.7
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr3_+_63953415 3.29 ENST00000484332.1
ATXN7
ataxin 7
chr11_+_46403303 3.26 ENST00000407067.1
ENST00000395565.1
MDK
midkine (neurite growth-promoting factor 2)
chr1_-_89458415 3.24 ENST00000321792.5
ENST00000370491.3
RBMXL1
CCBL2
RNA binding motif protein, X-linked-like 1
cysteine conjugate-beta lyase 2
chr1_-_98386543 3.22 ENST00000423006.2
ENST00000370192.3
ENST00000306031.5
DPYD
dihydropyrimidine dehydrogenase
chr19_+_12721725 3.15 ENST00000446165.1
ENST00000343325.4
ENST00000458122.3
ZNF791
zinc finger protein 791
chr9_+_131451480 3.12 ENST00000322030.8
SET
SET nuclear oncogene
chr18_+_21529811 2.97 ENST00000588004.1
LAMA3
laminin, alpha 3
chr1_-_89458604 2.95 ENST00000260508.4
CCBL2
cysteine conjugate-beta lyase 2
chr16_+_31366455 2.89 ENST00000268296.4
ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr2_-_161349909 2.85 ENST00000392753.3
RBMS1
RNA binding motif, single stranded interacting protein 1
chr1_+_174843548 2.82 ENST00000478442.1
ENST00000465412.1
RABGAP1L
RAB GTPase activating protein 1-like
chr12_-_53045948 2.61 ENST00000309680.3
KRT2
keratin 2
chr14_-_69445793 2.60 ENST00000538545.2
ENST00000394419.4
ACTN1
actinin, alpha 1
chr11_+_46403194 2.58 ENST00000395569.4
ENST00000395566.4
MDK
midkine (neurite growth-promoting factor 2)
chr17_+_7792101 2.57 ENST00000358181.4
ENST00000330494.7
CHD3
chromodomain helicase DNA binding protein 3
chr16_+_31366536 2.56 ENST00000562522.1
ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr7_-_64023441 2.54 ENST00000309683.6
ZNF680
zinc finger protein 680
chr6_+_84569359 2.51 ENST00000369681.5
ENST00000369679.4
CYB5R4
cytochrome b5 reductase 4
chr22_-_36925186 2.49 ENST00000541106.1
ENST00000455547.1
ENST00000432675.1
EIF3D
eukaryotic translation initiation factor 3, subunit D
chr21_-_16437255 2.49 ENST00000400199.1
ENST00000400202.1
NRIP1
nuclear receptor interacting protein 1
chr2_+_71295717 2.43 ENST00000418807.3
ENST00000443872.2
NAGK
N-acetylglucosamine kinase
chr14_+_64971292 2.42 ENST00000358738.3
ENST00000394712.2
ZBTB1
zinc finger and BTB domain containing 1
chr1_+_113161778 2.37 ENST00000263168.3
CAPZA1
capping protein (actin filament) muscle Z-line, alpha 1
chr22_-_39151463 2.36 ENST00000405510.1
ENST00000433561.1
SUN2
Sad1 and UNC84 domain containing 2
chr22_-_36924944 2.30 ENST00000405442.1
ENST00000402116.1
EIF3D
eukaryotic translation initiation factor 3, subunit D
chr22_-_39151947 2.25 ENST00000216064.4
SUN2
Sad1 and UNC84 domain containing 2
chr2_+_71295733 2.23 ENST00000443938.2
ENST00000244204.6
NAGK
N-acetylglucosamine kinase
chr20_+_44098346 2.20 ENST00000372676.3
WFDC2
WAP four-disulfide core domain 2
chr3_+_184080387 2.19 ENST00000455712.1
POLR2H
polymerase (RNA) II (DNA directed) polypeptide H
chr12_-_66563831 2.18 ENST00000358230.3
TMBIM4
transmembrane BAX inhibitor motif containing 4
chr20_+_44098385 2.17 ENST00000217425.5
ENST00000339946.3
WFDC2
WAP four-disulfide core domain 2
chr6_-_32731243 2.15 ENST00000427449.1
ENST00000411527.1
HLA-DQB2
major histocompatibility complex, class II, DQ beta 2
chr11_-_62380199 2.07 ENST00000419857.1
ENST00000394773.2
EML3
echinoderm microtubule associated protein like 3
chr1_+_9599540 2.05 ENST00000302692.6
SLC25A33
solute carrier family 25 (pyrimidine nucleotide carrier), member 33
chr14_-_69445968 2.01 ENST00000438964.2
ACTN1
actinin, alpha 1
chr14_+_93118813 1.93 ENST00000556418.1
RIN3
Ras and Rab interactor 3
chr12_-_110883346 1.90 ENST00000547365.1
ARPC3
actin related protein 2/3 complex, subunit 3, 21kDa
chr11_-_65374430 1.84 ENST00000532507.1
MAP3K11
mitogen-activated protein kinase kinase kinase 11
chr19_+_12175504 1.77 ENST00000439326.3
ZNF844
zinc finger protein 844
chr8_+_55370487 1.77 ENST00000297316.4
SOX17
SRY (sex determining region Y)-box 17
chr9_-_130829588 1.71 ENST00000373078.4
NAIF1
nuclear apoptosis inducing factor 1
chr4_+_83351715 1.71 ENST00000273920.3
ENOPH1
enolase-phosphatase 1
chr19_-_9929484 1.70 ENST00000586651.1
ENST00000586073.1
FBXL12
F-box and leucine-rich repeat protein 12
chr11_+_65190245 1.69 ENST00000499732.1
ENST00000501122.2
ENST00000601801.1
NEAT1
nuclear paraspeckle assembly transcript 1 (non-protein coding)
chr4_-_76862117 1.69 ENST00000507956.1
ENST00000507187.2
ENST00000399497.3
ENST00000286733.4
NAAA
N-acylethanolamine acid amidase
chr14_-_69446034 1.64 ENST00000193403.6
ACTN1
actinin, alpha 1
chr14_-_106471723 1.63 ENST00000390595.2
IGHV1-3
immunoglobulin heavy variable 1-3
chr11_+_46366918 1.60 ENST00000528615.1
ENST00000395574.3
DGKZ
diacylglycerol kinase, zeta
chr20_+_62152077 1.56 ENST00000370179.3
ENST00000370177.1
PPDPF
pancreatic progenitor cell differentiation and proliferation factor
chr9_+_35829208 1.56 ENST00000439587.2
ENST00000377991.4
TMEM8B
transmembrane protein 8B
chr17_-_39191107 1.55 ENST00000344363.5
KRTAP1-3
keratin associated protein 1-3
chr3_-_66551397 1.54 ENST00000383703.3
LRIG1
leucine-rich repeats and immunoglobulin-like domains 1
chr17_-_66287350 1.54 ENST00000580666.1
ENST00000583477.1
SLC16A6
solute carrier family 16, member 6
chr1_-_207206092 1.49 ENST00000359470.5
ENST00000461135.2
C1orf116
chromosome 1 open reading frame 116
chr1_-_155826967 1.48 ENST00000368331.1
ENST00000361040.5
ENST00000271883.5
GON4L
gon-4-like (C. elegans)
chr7_+_64363625 1.48 ENST00000476120.1
ENST00000319636.5
ENST00000545510.1
ZNF273
zinc finger protein 273
chr17_-_74023474 1.47 ENST00000301607.3
EVPL
envoplakin
chr12_+_124118366 1.46 ENST00000539994.1
ENST00000538845.1
ENST00000228955.7
ENST00000543341.2
ENST00000536375.1
GTF2H3
general transcription factor IIH, polypeptide 3, 34kDa
chr19_+_19779619 1.45 ENST00000444249.2
ENST00000592502.1
ZNF101
zinc finger protein 101
chr11_+_46402744 1.44 ENST00000533952.1
MDK
midkine (neurite growth-promoting factor 2)
chr4_-_2264015 1.40 ENST00000337190.2
MXD4
MAX dimerization protein 4
chr17_-_39928106 1.38 ENST00000540235.1
JUP
junction plakoglobin
chr12_-_124118296 1.35 ENST00000424014.2
ENST00000537073.1
EIF2B1
eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa
chr19_-_9929708 1.35 ENST00000247977.4
ENST00000590277.1
ENST00000588922.1
ENST00000589626.1
ENST00000592067.1
ENST00000586469.1
FBXL12
F-box and leucine-rich repeat protein 12
chr1_-_226129189 1.31 ENST00000366820.5
LEFTY2
left-right determination factor 2
chrX_+_49687267 1.28 ENST00000376091.3
CLCN5
chloride channel, voltage-sensitive 5
chr12_+_56473910 1.26 ENST00000411731.2
ERBB3
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
chr5_+_177631523 1.22 ENST00000506339.1
ENST00000355836.5
ENST00000514633.1
ENST00000515193.1
ENST00000506259.1
ENST00000504898.1
HNRNPAB
heterogeneous nuclear ribonucleoprotein A/B
chr3_-_66551351 1.21 ENST00000273261.3
LRIG1
leucine-rich repeats and immunoglobulin-like domains 1
chr10_-_103880209 1.20 ENST00000425280.1
LDB1
LIM domain binding 1
chr3_+_184081213 1.19 ENST00000429568.1
POLR2H
polymerase (RNA) II (DNA directed) polypeptide H
chr8_-_103876965 1.18 ENST00000337198.5
AZIN1
antizyme inhibitor 1
chr3_+_184080790 1.18 ENST00000430783.1
POLR2H
polymerase (RNA) II (DNA directed) polypeptide H
chr2_+_11886710 1.17 ENST00000256720.2
ENST00000441684.1
ENST00000423495.1
LPIN1
lipin 1
chr5_+_177631497 1.16 ENST00000358344.3
HNRNPAB
heterogeneous nuclear ribonucleoprotein A/B
chr7_+_77167376 1.13 ENST00000435495.2
PTPN12
protein tyrosine phosphatase, non-receptor type 12
chr22_+_40440804 1.12 ENST00000441751.1
ENST00000301923.9
TNRC6B
trinucleotide repeat containing 6B
chr8_-_144897549 1.10 ENST00000356994.2
ENST00000320476.3
SCRIB
scribbled planar cell polarity protein
chr12_+_56473939 1.08 ENST00000450146.2
ERBB3
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
chr1_-_226129083 1.04 ENST00000420304.2
LEFTY2
left-right determination factor 2
chr17_-_66287257 1.03 ENST00000327268.4
SLC16A6
solute carrier family 16, member 6
chrX_-_154688276 1.02 ENST00000369445.2
F8A3
coagulation factor VIII-associated 3
chr9_+_132815985 1.01 ENST00000372410.3
GPR107
G protein-coupled receptor 107
chr3_+_184081175 1.00 ENST00000452961.1
ENST00000296223.3
POLR2H
polymerase (RNA) II (DNA directed) polypeptide H
chr17_-_60142609 0.98 ENST00000397786.2
MED13
mediator complex subunit 13
chr2_-_10588630 0.97 ENST00000234111.4
ODC1
ornithine decarboxylase 1
chr8_-_144897138 0.96 ENST00000377533.3
SCRIB
scribbled planar cell polarity protein
chr15_+_41136216 0.93 ENST00000562057.1
ENST00000344051.4
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr9_-_127269661 0.93 ENST00000373588.4
NR5A1
nuclear receptor subfamily 5, group A, member 1
chr11_-_62323702 0.92 ENST00000530285.1
AHNAK
AHNAK nucleoprotein
chr1_+_151512775 0.87 ENST00000368849.3
ENST00000392712.3
ENST00000353024.3
ENST00000368848.2
ENST00000538902.1
TUFT1
tuftelin 1
chr17_-_42452063 0.84 ENST00000588098.1
ITGA2B
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
chr12_-_4554780 0.78 ENST00000228837.2
FGF6
fibroblast growth factor 6
chr22_+_31489344 0.77 ENST00000404574.1
SMTN
smoothelin
chr17_-_1532106 0.75 ENST00000301335.5
ENST00000382147.4
SLC43A2
solute carrier family 43 (amino acid system L transporter), member 2
chr3_+_120461484 0.75 ENST00000484715.1
ENST00000469772.1
ENST00000283875.5
ENST00000492959.1
GTF2E1
general transcription factor IIE, polypeptide 1, alpha 56kDa
chr19_+_44100727 0.74 ENST00000528387.1
ENST00000529930.1
ENST00000336564.4
ENST00000607544.1
ENST00000526798.1
ZNF576
SRRM5
zinc finger protein 576
serine/arginine repetitive matrix 5
chr3_-_48672859 0.74 ENST00000395550.2
ENST00000455886.2
ENST00000431739.1
ENST00000426599.1
ENST00000383733.3
ENST00000420764.2
ENST00000337000.8
SLC26A6
solute carrier family 26 (anion exchanger), member 6
chr19_+_48969094 0.73 ENST00000595676.1
CTC-273B12.7
Uncharacterized protein
chr19_+_44100632 0.72 ENST00000533118.1
ZNF576
zinc finger protein 576
chr9_-_129884902 0.69 ENST00000373417.1
ANGPTL2
angiopoietin-like 2
chr20_+_61867235 0.69 ENST00000342412.6
ENST00000217169.3
BIRC7
baculoviral IAP repeat containing 7
chr4_+_47487285 0.66 ENST00000273859.3
ENST00000504445.1
ATP10D
ATPase, class V, type 10D
chr1_-_28241226 0.64 ENST00000373912.3
ENST00000373909.3
RPA2
replication protein A2, 32kDa
chr1_-_155959853 0.63 ENST00000462460.2
ENST00000368316.1
ARHGEF2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr19_+_12075844 0.63 ENST00000592625.1
ENST00000586494.1
ENST00000343949.5
ENST00000545530.1
ENST00000358987.3
ZNF763
zinc finger protein 763
chr2_+_241544834 0.63 ENST00000319838.5
ENST00000403859.1
ENST00000438013.2
GPR35
G protein-coupled receptor 35
chr3_+_184081137 0.62 ENST00000443489.1
POLR2H
polymerase (RNA) II (DNA directed) polypeptide H
chr11_-_123612319 0.61 ENST00000526252.1
ENST00000530393.1
ENST00000533463.1
ENST00000336139.4
ENST00000529691.1
ENST00000528306.1
ZNF202
zinc finger protein 202
chr5_-_148758839 0.61 ENST00000261796.3
IL17B
interleukin 17B
chr3_-_50605077 0.60 ENST00000426034.1
ENST00000441239.1
C3orf18
chromosome 3 open reading frame 18
chr2_+_241564655 0.59 ENST00000407714.1
GPR35
G protein-coupled receptor 35
chr20_+_44509857 0.59 ENST00000372523.1
ENST00000372520.1
ZSWIM1
zinc finger, SWIM-type containing 1
chr3_+_40547483 0.58 ENST00000420891.1
ENST00000314529.6
ENST00000418905.1
ZNF620
zinc finger protein 620
chr12_-_66563786 0.57 ENST00000542724.1
TMBIM4
transmembrane BAX inhibitor motif containing 4
chr17_+_57642886 0.57 ENST00000251241.4
ENST00000451169.2
ENST00000425628.3
ENST00000584385.1
ENST00000580030.1
DHX40
DEAH (Asp-Glu-Ala-His) box polypeptide 40
chr7_+_43966018 0.55 ENST00000222402.3
ENST00000446008.1
ENST00000394798.4
UBE2D4
ubiquitin-conjugating enzyme E2D 4 (putative)
chr11_+_31531291 0.55 ENST00000350638.5
ENST00000379163.5
ENST00000395934.2
ELP4
elongator acetyltransferase complex subunit 4
chr9_-_129885010 0.53 ENST00000373425.3
ANGPTL2
angiopoietin-like 2
chr7_+_136553824 0.53 ENST00000320658.5
ENST00000453373.1
ENST00000397608.3
ENST00000402486.3
ENST00000401861.1
CHRM2
cholinergic receptor, muscarinic 2
chr2_+_74056066 0.53 ENST00000339566.3
ENST00000409707.1
ENST00000452725.1
ENST00000432295.2
ENST00000424659.1
ENST00000394073.1
STAMBP
STAM binding protein
chr5_-_148929848 0.53 ENST00000504676.1
ENST00000515435.1
CSNK1A1
casein kinase 1, alpha 1
chr2_+_130737223 0.51 ENST00000410061.2
RAB6C
RAB6C, member RAS oncogene family
chr2_-_219157250 0.50 ENST00000434015.2
ENST00000444183.1
ENST00000420341.1
ENST00000453281.1
ENST00000258412.3
ENST00000440422.1
TMBIM1
transmembrane BAX inhibitor motif containing 1
chr7_+_136553370 0.46 ENST00000445907.2
CHRM2
cholinergic receptor, muscarinic 2
chr6_-_31080336 0.45 ENST00000259870.3
C6orf15
chromosome 6 open reading frame 15
chr12_+_41582103 0.45 ENST00000402685.2
PDZRN4
PDZ domain containing ring finger 4
chr11_+_67776012 0.45 ENST00000539229.1
ALDH3B1
aldehyde dehydrogenase 3 family, member B1
chr21_-_28338732 0.45 ENST00000284987.5
ADAMTS5
ADAM metallopeptidase with thrombospondin type 1 motif, 5
chr2_+_74056147 0.44 ENST00000394070.2
ENST00000536064.1
STAMBP
STAM binding protein
chr12_-_121712313 0.43 ENST00000392474.2
CAMKK2
calcium/calmodulin-dependent protein kinase kinase 2, beta
chr19_-_6375860 0.42 ENST00000245810.1
PSPN
persephin
chr15_-_90233866 0.41 ENST00000561257.1
PEX11A
peroxisomal biogenesis factor 11 alpha
chr9_+_91606355 0.40 ENST00000358157.2
S1PR3
sphingosine-1-phosphate receptor 3
chr14_-_61124977 0.39 ENST00000554986.1
SIX1
SIX homeobox 1
chrX_+_69674943 0.39 ENST00000542398.1
DLG3
discs, large homolog 3 (Drosophila)
chr4_-_57301748 0.36 ENST00000264220.2
PPAT
phosphoribosyl pyrophosphate amidotransferase
chr1_+_186265399 0.33 ENST00000367486.3
ENST00000367484.3
ENST00000533951.1
ENST00000367482.4
ENST00000367483.4
ENST00000367485.4
ENST00000445192.2
PRG4
proteoglycan 4
chr2_+_233415363 0.33 ENST00000409514.1
ENST00000409098.1
ENST00000409495.1
ENST00000409167.3
ENST00000409322.1
ENST00000409394.1
EIF4E2
eukaryotic translation initiation factor 4E family member 2
chr11_-_77122928 0.32 ENST00000528203.1
ENST00000528592.1
ENST00000528633.1
ENST00000529248.1
PAK1
p21 protein (Cdc42/Rac)-activated kinase 1
chr10_+_99344104 0.30 ENST00000555577.1
ENST00000370649.3
PI4K2A
PI4K2A
phosphatidylinositol 4-kinase type 2 alpha
Phosphatidylinositol 4-kinase type 2-alpha; Uncharacterized protein

Network of associatons between targets according to the STRING database.

First level regulatory network of TFCP2L1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
6.0 18.1 GO:0046102 hypoxanthine salvage(GO:0043103) inosine metabolic process(GO:0046102)
2.4 18.9 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
2.3 9.2 GO:0002572 pro-T cell differentiation(GO:0002572)
2.1 6.2 GO:1904924 negative regulation of mitophagy in response to mitochondrial depolarization(GO:1904924)
2.0 13.8 GO:0044800 fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
1.6 4.8 GO:0001732 formation of cytoplasmic translation initiation complex(GO:0001732)
1.2 6.2 GO:0010482 epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482)
1.2 7.3 GO:0030421 defecation(GO:0030421)
1.2 4.7 GO:0006051 mannosamine metabolic process(GO:0006050) N-acetylmannosamine metabolic process(GO:0006051)
1.1 3.2 GO:0006145 purine nucleobase catabolic process(GO:0006145) beta-alanine metabolic process(GO:0019482)
0.9 2.7 GO:0032474 otolith morphogenesis(GO:0032474)
0.9 6.3 GO:0038110 interleukin-2-mediated signaling pathway(GO:0038110)
0.8 5.0 GO:0043366 beta selection(GO:0043366)
0.8 6.3 GO:0070235 regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236)
0.8 4.6 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.7 2.1 GO:0098968 neurotransmitter receptor transport postsynaptic membrane to endosome(GO:0098968)
0.7 2.0 GO:0006864 pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
0.6 3.8 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.6 1.8 GO:0009996 negative regulation of Wnt signaling pathway involved in heart development(GO:0003308) negative regulation of cell fate specification(GO:0009996) gall bladder development(GO:0061010)
0.6 13.6 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.5 2.2 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
0.4 8.9 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.4 5.9 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.4 6.2 GO:0051639 actin filament network formation(GO:0051639)
0.4 6.4 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.4 3.5 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
0.3 3.3 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.3 1.4 GO:0002159 desmosome assembly(GO:0002159) endothelial cell-cell adhesion(GO:0071603)
0.3 1.8 GO:0007256 activation of JNKK activity(GO:0007256)
0.3 0.8 GO:0006939 smooth muscle contraction(GO:0006939)
0.3 3.6 GO:0006527 arginine catabolic process(GO:0006527)
0.2 0.7 GO:0042938 dipeptide transport(GO:0042938)
0.2 0.9 GO:0007538 primary sex determination(GO:0007538)
0.2 1.6 GO:0031017 exocrine pancreas development(GO:0031017)
0.2 15.1 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.2 4.6 GO:0035855 megakaryocyte development(GO:0035855)
0.2 1.2 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.2 1.2 GO:0046985 positive regulation of hemoglobin biosynthetic process(GO:0046985)
0.2 1.2 GO:0006642 triglyceride mobilization(GO:0006642)
0.2 1.7 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.2 0.6 GO:0044314 protein K27-linked ubiquitination(GO:0044314)
0.2 1.0 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
0.2 2.6 GO:0051546 keratinocyte migration(GO:0051546)
0.1 25.5 GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
0.1 0.4 GO:0061055 myotome development(GO:0061055) positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.1 0.5 GO:1902044 regulation of Fas signaling pathway(GO:1902044)
0.1 10.2 GO:0071349 interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)
0.1 8.0 GO:0045773 positive regulation of axon extension(GO:0045773)
0.1 12.2 GO:0032945 negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672)
0.1 3.1 GO:0006337 nucleosome disassembly(GO:0006337)
0.1 6.2 GO:0050434 positive regulation of viral transcription(GO:0050434)
0.1 0.4 GO:0061762 CAMKK-AMPK signaling cascade(GO:0061762)
0.1 3.0 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 1.1 GO:2000587 negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587)
0.1 0.3 GO:0002276 basophil activation involved in immune response(GO:0002276)
0.1 0.1 GO:0072179 nephric duct formation(GO:0072179)
0.1 3.3 GO:0016577 histone demethylation(GO:0016577)
0.1 1.0 GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.1 6.7 GO:0031295 T cell costimulation(GO:0031295)
0.1 1.1 GO:0035278 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.1 0.4 GO:0045602 negative regulation of endothelial cell differentiation(GO:0045602)
0.1 0.5 GO:1904885 beta-catenin destruction complex assembly(GO:1904885)
0.1 0.9 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.1 0.4 GO:0006543 glutamine catabolic process(GO:0006543)
0.1 1.1 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.1 11.7 GO:0043542 endothelial cell migration(GO:0043542)
0.1 5.2 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.0 0.4 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.0 0.6 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.0 0.4 GO:0046185 aldehyde catabolic process(GO:0046185)
0.0 4.0 GO:0006446 regulation of translational initiation(GO:0006446)
0.0 0.7 GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
0.0 2.5 GO:0006801 superoxide metabolic process(GO:0006801)
0.0 2.8 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 1.5 GO:1903959 regulation of anion transmembrane transport(GO:1903959)
0.0 1.6 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 1.4 GO:0014003 oligodendrocyte development(GO:0014003)
0.0 1.3 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.0 0.6 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.0 2.6 GO:0016575 histone deacetylation(GO:0016575)
0.0 1.0 GO:0055090 acylglycerol homeostasis(GO:0055090) triglyceride homeostasis(GO:0070328)
0.0 0.1 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.0 0.7 GO:0034204 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.0 1.2 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.9 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.0 1.7 GO:0050848 regulation of calcium-mediated signaling(GO:0050848)
0.0 0.1 GO:0044375 regulation of peroxisome size(GO:0044375)
0.0 2.4 GO:0001837 epithelial to mesenchymal transition(GO:0001837)
0.0 11.7 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.0 0.2 GO:2000675 inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341) negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.0 0.1 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469) determination of digestive tract left/right asymmetry(GO:0071907) determination of liver left/right asymmetry(GO:0071910)
0.0 0.9 GO:0042795 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 1.5 GO:0030183 B cell differentiation(GO:0030183)
0.0 8.7 GO:0043312 neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.0 0.4 GO:0046710 GDP metabolic process(GO:0046710)
0.0 0.5 GO:0010824 regulation of centrosome duplication(GO:0010824)
0.0 1.6 GO:0007160 cell-matrix adhesion(GO:0007160)
0.0 0.9 GO:0042476 odontogenesis(GO:0042476)
0.0 5.7 GO:0008380 RNA splicing(GO:0008380)
0.0 1.8 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.0 0.3 GO:0043550 regulation of lipid kinase activity(GO:0043550)
0.0 0.2 GO:0034776 response to histamine(GO:0034776) cellular response to histamine(GO:0071420)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 8.8 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.9 6.5 GO:0032584 growth cone membrane(GO:0032584)
0.7 2.1 GO:0034750 Scrib-APC-beta-catenin complex(GO:0034750)
0.5 7.6 GO:0005916 fascia adherens(GO:0005916)
0.5 15.7 GO:0032839 dendrite cytoplasm(GO:0032839)
0.5 1.5 GO:0000438 core TFIIH complex portion of holo TFIIH complex(GO:0000438)
0.4 8.9 GO:0031105 septin complex(GO:0031105)
0.4 3.0 GO:0005610 laminin-5 complex(GO:0005610)
0.4 4.6 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.3 6.2 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.3 2.4 GO:0071203 WASH complex(GO:0071203)
0.3 6.7 GO:0042613 MHC class II protein complex(GO:0042613)
0.2 1.0 GO:0032279 asymmetric synapse(GO:0032279)
0.2 1.4 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.2 5.0 GO:0042101 T cell receptor complex(GO:0042101)
0.1 14.0 GO:0070821 tertiary granule membrane(GO:0070821)
0.1 3.8 GO:0032040 small-subunit processome(GO:0032040)
0.1 6.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 1.9 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 15.1 GO:0031225 anchored component of membrane(GO:0031225)
0.1 0.3 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.1 2.6 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 3.8 GO:0045095 keratin filament(GO:0045095)
0.1 0.3 GO:0035838 growing cell tip(GO:0035838)
0.1 0.7 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.1 4.3 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 0.5 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.1 13.8 GO:0005770 late endosome(GO:0005770)
0.1 16.4 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 1.3 GO:0030057 desmosome(GO:0030057)
0.0 6.4 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 0.7 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.6 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.4 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.1 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 3.0 GO:0005811 lipid particle(GO:0005811)
0.0 13.5 GO:0000790 nuclear chromatin(GO:0000790)
0.0 4.5 GO:0043679 axon terminus(GO:0043679)
0.0 1.2 GO:0002102 podosome(GO:0002102)
0.0 4.5 GO:0072562 blood microparticle(GO:0072562)
0.0 3.4 GO:0016363 nuclear matrix(GO:0016363)
0.0 1.0 GO:0016592 mediator complex(GO:0016592)
0.0 5.5 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 1.9 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 0.3 GO:0071437 invadopodium(GO:0071437)
0.0 17.3 GO:0016604 nuclear body(GO:0016604)
0.0 1.7 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 0.9 GO:0035579 specific granule membrane(GO:0035579)
0.0 0.2 GO:0032039 integrator complex(GO:0032039)
0.0 1.9 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 0.4 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 12.1 GO:0000139 Golgi membrane(GO:0000139)
0.0 3.2 GO:0005769 early endosome(GO:0005769)
0.0 1.7 GO:0043202 lysosomal lumen(GO:0043202)
0.0 1.4 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 0.2 GO:0005845 mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0 3.1 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 9.1 GO:0030529 intracellular ribonucleoprotein complex(GO:0030529)
0.0 3.9 GO:0005874 microtubule(GO:0005874)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 18.1 GO:0004000 adenosine deaminase activity(GO:0004000)
2.1 6.2 GO:0008426 protein kinase C inhibitor activity(GO:0008426)
1.8 31.6 GO:0019864 IgG binding(GO:0019864)
1.6 6.3 GO:0004911 interleukin-2 receptor activity(GO:0004911) interleukin-2 binding(GO:0019976)
1.6 4.7 GO:0045127 N-acetylglucosamine kinase activity(GO:0045127)
1.4 15.1 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
1.1 4.4 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.9 3.5 GO:0044378 non-sequence-specific DNA binding, bending(GO:0044378)
0.8 13.8 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.7 3.6 GO:0016403 dimethylargininase activity(GO:0016403)
0.7 6.3 GO:0043426 MRF binding(GO:0043426)
0.7 2.0 GO:0015218 pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
0.5 3.8 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.5 6.7 GO:0032395 MHC class II receptor activity(GO:0032395)
0.5 1.8 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.4 8.3 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.4 12.6 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.4 1.2 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.3 6.2 GO:0001054 RNA polymerase I activity(GO:0001054)
0.3 1.0 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.3 4.2 GO:0030280 structural constituent of epidermis(GO:0030280)
0.2 6.2 GO:0017166 vinculin binding(GO:0017166)
0.2 12.8 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.2 5.9 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.2 4.6 GO:0043495 protein anchor(GO:0043495)
0.2 5.0 GO:0000339 RNA cap binding(GO:0000339)
0.2 0.4 GO:0070052 collagen V binding(GO:0070052)
0.2 0.8 GO:0070051 fibrinogen binding(GO:0070051)
0.2 2.5 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.2 1.0 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.2 0.7 GO:0015563 uptake transmembrane transporter activity(GO:0015563)
0.2 1.2 GO:0042978 ornithine decarboxylase activator activity(GO:0042978)
0.2 7.9 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.2 1.4 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.1 1.7 GO:0038132 neuregulin binding(GO:0038132)
0.1 0.9 GO:0030021 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.1 1.2 GO:0030274 LIM domain binding(GO:0030274)
0.1 3.3 GO:0032452 histone demethylase activity(GO:0032452)
0.1 3.2 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.1 1.2 GO:0019215 intermediate filament binding(GO:0019215)
0.1 5.4 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 1.1 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.1 0.3 GO:0035651 AP-3 adaptor complex binding(GO:0035651)
0.1 1.5 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 3.1 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.1 14.6 GO:0003823 antigen binding(GO:0003823)
0.1 2.5 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 7.9 GO:0005262 calcium channel activity(GO:0005262)
0.1 1.0 GO:0042809 vitamin D receptor binding(GO:0042809)
0.1 0.6 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.1 2.6 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 0.5 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.1 5.0 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.9 GO:0044548 S100 protein binding(GO:0044548)
0.0 0.1 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.0 4.9 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 2.6 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 0.4 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0 7.4 GO:0008201 heparin binding(GO:0008201)
0.0 3.5 GO:0101005 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 0.8 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 1.5 GO:0008135 translation factor activity, RNA binding(GO:0008135)
0.0 0.4 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 2.9 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 1.4 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 0.7 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.2 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.0 0.3 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.2 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.0 1.8 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.5 GO:0005123 death receptor binding(GO:0005123)
0.0 0.4 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 6.8 GO:0003924 GTPase activity(GO:0003924)
0.0 0.7 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.8 GO:0015179 L-amino acid transmembrane transporter activity(GO:0015179)
0.0 31.6 GO:0003677 DNA binding(GO:0003677)
0.0 0.2 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.4 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.4 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 17.1 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.5 31.1 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.3 30.3 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.2 10.6 PID IFNG PATHWAY IFN-gamma pathway
0.2 6.2 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.2 5.2 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.1 5.9 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.1 6.1 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.1 7.2 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 5.0 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.1 3.7 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.1 1.4 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.1 4.4 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 4.1 PID P53 REGULATION PATHWAY p53 pathway
0.0 0.4 PID S1P S1P3 PATHWAY S1P3 pathway
0.0 1.3 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 2.5 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 11.9 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 2.6 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 2.5 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.8 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.3 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 0.6 PID ATR PATHWAY ATR signaling pathway
0.0 1.4 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 13.8 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
1.0 13.6 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.7 18.1 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.3 6.2 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.2 3.2 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.2 5.0 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.2 6.2 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.2 8.7 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.2 17.1 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.2 7.7 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.2 3.5 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 7.0 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.1 6.3 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.1 8.8 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 2.7 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.1 2.4 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.1 14.3 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 2.4 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.1 1.2 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.1 0.6 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.1 1.1 REACTOME REGULATORY RNA PATHWAYS Genes involved in Regulatory RNA pathways
0.1 0.8 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.1 4.6 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.8 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 1.3 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 4.6 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.0 0.8 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.3 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 2.4 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.0 1.0 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.5 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.4 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 2.7 REACTOME SIGNALING BY EGFR IN CANCER Genes involved in Signaling by EGFR in Cancer
0.0 0.3 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 1.2 REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0 1.2 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.7 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases