ISMARA results: TFCP2L1

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for TFCP2L1

Z-value: 0.03

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Transcription factors associated with TFCP2L1

Gene Symbol	Gene ID	Gene Info
TFCP2L1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000115112.7	transcription factor CP2 like 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
TFCP2L1	hg19_v2_chr2_-_122042770_122042785	0.02	7.5e-01	Click!

Activity profile of TFCP2L1 motif

Sorted Z-values of TFCP2L1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr19_+_1071203 Show fit	15.88	ENST00000543365.1	HMHA1 Ensembl NCBI GeneCards UniProt NextProt Show fit	histocompatibility (minor) HA-1
chr2_-_136875712 Show fit	13.84	ENST00000241393.3	CXCR4 Ensembl NCBI GeneCards UniProt NextProt Show fit	chemokine (C-X-C motif) receptor 4
chr6_-_31550192 Show fit	10.18	ENST00000429299.2 ENST00000446745.2	LTB Ensembl NCBI GeneCards UniProt NextProt Show fit	lymphotoxin beta (TNF superfamily, member 3)
chr20_-_43280361 Show fit	9.72	ENST00000372874.4	ADA Ensembl NCBI GeneCards UniProt NextProt Show fit	adenosine deaminase
chr5_-_131826457 Show fit	8.72	ENST00000437654.1 ENST00000245414.4	IRF1 Ensembl NCBI GeneCards UniProt NextProt Show fit	interferon regulatory factor 1
chr20_-_43280325 Show fit	8.40	ENST00000537820.1	ADA Ensembl NCBI GeneCards UniProt NextProt Show fit	adenosine deaminase
chr1_-_111743285 Show fit	7.42	ENST00000357640.4	DENND2D Ensembl NCBI GeneCards UniProt NextProt Show fit	DENN/MADD domain containing 2D
chr1_-_161600990 Show fit	7.39	ENST00000531221.1	FCGR3B Ensembl NCBI GeneCards UniProt NextProt Show fit	Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
chr20_-_62710832 Show fit	7.24	ENST00000395042.1	RGS19 Ensembl NCBI GeneCards UniProt NextProt Show fit	regulator of G-protein signaling 19
chr1_-_161600942 Show fit	7.06	ENST00000421702.2	FCGR3B Ensembl NCBI GeneCards UniProt NextProt Show fit	Fc fragment of IgG, low affinity IIIb, receptor (CD16b)

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of TFCP2L1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	25.5	GO:0002433	immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
2.4	18.9	GO:0045084	positive regulation of interleukin-12 biosynthetic process(GO:0045084)
6.0	18.1	GO:0046102	hypoxanthine salvage(GO:0043103) inosine metabolic process(GO:0046102)
0.2	15.1	GO:0006501	C-terminal protein lipidation(GO:0006501)
2.0	13.8	GO:0044800	fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
0.6	13.6	GO:0046339	diacylglycerol metabolic process(GO:0046339)
0.1	12.2	GO:0032945	negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672)
0.1	11.7	GO:0043542	endothelial cell migration(GO:0043542)
0.0	11.7	GO:0043547	positive regulation of GTPase activity(GO:0043547)
0.1	10.2	GO:0071349	interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)

Showing 1 to 10 of 102 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	17.3	GO:0016604	nuclear body(GO:0016604)
0.1	16.4	GO:0009897	external side of plasma membrane(GO:0009897)
0.5	15.7	GO:0032839	dendrite cytoplasm(GO:0032839)
0.1	15.1	GO:0031225	anchored component of membrane(GO:0031225)
0.1	14.0	GO:0070821	tertiary granule membrane(GO:0070821)
0.1	13.8	GO:0005770	late endosome(GO:0005770)
0.0	13.5	GO:0000790	nuclear chromatin(GO:0000790)
0.0	12.1	GO:0000139	Golgi membrane(GO:0000139)
0.0	9.1	GO:0030529	intracellular ribonucleoprotein complex(GO:0030529)
0.4	8.9	GO:0031105	septin complex(GO:0031105)

Showing 1 to 10 of 59 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.8	31.6	GO:0019864	IgG binding(GO:0019864)
0.0	31.6	GO:0003677	DNA binding(GO:0003677)
2.3	18.1	GO:0004000	adenosine deaminase activity(GO:0004000)
1.4	15.1	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.1	14.6	GO:0003823	antigen binding(GO:0003823)
0.8	13.8	GO:0004143	diacylglycerol kinase activity(GO:0004143)
0.2	12.8	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.4	12.6	GO:0001965	G-protein alpha-subunit binding(GO:0001965)
0.4	8.3	GO:0070530	K63-linked polyubiquitin binding(GO:0070530)
0.2	7.9	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)

Showing 1 to 10 of 79 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	31.1	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.3	30.3	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.5	17.1	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0	11.9	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.2	10.6	PID IFNG PATHWAY	IFN-gamma pathway
0.1	7.2	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
0.2	6.2	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.1	6.1	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.1	5.9	PID RETINOIC ACID PATHWAY	Retinoic acid receptors-mediated signaling
0.2	5.2	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions

Showing 1 to 10 of 24 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	18.1	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.2	17.1	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1	14.3	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
2.8	13.8	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
1.0	13.6	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.1	8.8	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.2	8.7	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION	Genes involved in TRAF6 mediated IRF7 activation
0.2	7.7	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.1	7.0	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events
0.1	6.3	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling

Showing 1 to 10 of 37 entries

Results for TFCP2L1

Z-value: 0.03

Motif logo

Transcription factors associated with TFCP2L1

Activity-expression correlation:

Activity profile of TFCP2L1 motif

Sorted Z-values of TFCP2L1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of TFCP2L1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: