ISMARA results: TFDP1

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for TFDP1

Z-value: 0.93

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Transcription factors associated with TFDP1

Gene Symbol	Gene ID	Gene Info
TFDP1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000198176.8	transcription factor Dp-1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
TFDP1	hg19_v2_chr13_+_114238997_114239077	0.64	6.3e-27	Click!

Activity profile of TFDP1 motif

Sorted Z-values of TFDP1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_+_27022839 Show fit	87.07	ENST00000457599.2	ARID1A Ensembl NCBI GeneCards UniProt NextProt Show fit	AT rich interactive domain 1A (SWI-like)
chr6_-_86352982 Show fit	79.95	ENST00000369622.3	SYNCRIP Ensembl NCBI GeneCards UniProt NextProt Show fit	synaptotagmin binding, cytoplasmic RNA interacting protein
chr17_-_73179046 Show fit	59.63	ENST00000314523.7 ENST00000420826.2	SUMO2 Ensembl NCBI GeneCards UniProt NextProt Show fit	small ubiquitin-like modifier 2
chr11_+_85955787 Show fit	53.05	ENST00000528180.1	EED Ensembl NCBI GeneCards UniProt NextProt Show fit	embryonic ectoderm development
chr17_-_73178599 Show fit	50.79	ENST00000578238.1	SUMO2 Ensembl NCBI GeneCards UniProt NextProt Show fit	small ubiquitin-like modifier 2
chrX_-_16887963 Show fit	47.90	ENST00000380084.4	RBBP7 Ensembl NCBI GeneCards UniProt NextProt Show fit	retinoblastoma binding protein 7
chr1_+_43148625 Show fit	47.83	ENST00000436427.1	YBX1 Ensembl NCBI GeneCards UniProt NextProt Show fit	Y box binding protein 1
chr17_+_34900737 Show fit	47.45	ENST00000304718.4 ENST00000485685.2	GGNBP2 Ensembl NCBI GeneCards UniProt NextProt Show fit	gametogenetin binding protein 2
chrX_+_64887512 Show fit	44.74	ENST00000360270.5	MSN Ensembl NCBI GeneCards UniProt NextProt Show fit	moesin
chr1_+_62902308 Show fit	43.59	ENST00000339950.4	USP1 Ensembl NCBI GeneCards UniProt NextProt Show fit	ubiquitin specific peptidase 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of TFDP1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
32.5	227.4	GO:0070934	CRD-mediated mRNA stabilization(GO:0070934)
2.1	176.9	GO:0071349	interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)
3.5	164.0	GO:0070911	global genome nucleotide-excision repair(GO:0070911)
18.9	132.0	GO:1903679	regulation of cap-independent translational initiation(GO:1903677) positive regulation of cap-independent translational initiation(GO:1903679) regulation of cytoplasmic translational initiation(GO:1904688) positive regulation of cytoplasmic translational initiation(GO:1904690)
23.2	116.0	GO:0003408	optic cup formation involved in camera-type eye development(GO:0003408)
2.9	94.1	GO:0061014	positive regulation of mRNA catabolic process(GO:0061014)
2.1	85.5	GO:0070979	protein K11-linked ubiquitination(GO:0070979)
2.6	85.0	GO:0060216	definitive hemopoiesis(GO:0060216)
8.4	84.1	GO:0034723	DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
16.1	80.6	GO:0070370	heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370)

Showing 1 to 10 of 525 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.1	289.0	GO:0016605	PML body(GO:0016605)
24.3	194.1	GO:0071204	histone pre-mRNA 3'end processing complex(GO:0071204)
1.4	156.7	GO:0000932	cytoplasmic mRNA processing body(GO:0000932)
6.4	154.5	GO:0071564	npBAF complex(GO:0071564)
0.5	154.2	GO:0000785	chromatin(GO:0000785)
0.7	103.4	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
4.7	99.0	GO:0000812	Swr1 complex(GO:0000812)
0.4	93.8	GO:0072562	blood microparticle(GO:0072562)
5.2	93.7	GO:0035098	ESC/E(Z) complex(GO:0035098)
0.4	93.5	GO:0031965	nuclear membrane(GO:0031965)

Showing 1 to 10 of 252 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.5	183.3	GO:0003697	single-stranded DNA binding(GO:0003697)
0.7	147.0	GO:0051015	actin filament binding(GO:0051015)
11.2	145.2	GO:1990247	N6-methyladenosine-containing RNA binding(GO:1990247)
3.2	139.7	GO:0004407	histone deacetylase activity(GO:0004407)
4.6	139.1	GO:0008143	poly(A) binding(GO:0008143)
4.2	129.6	GO:0016922	ligand-dependent nuclear receptor binding(GO:0016922)
3.2	129.4	GO:0031492	nucleosomal DNA binding(GO:0031492)
3.6	127.7	GO:0070577	lysine-acetylated histone binding(GO:0070577)
9.8	117.7	GO:0031386	protein tag(GO:0031386)
2.6	114.7	GO:0061650	ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650)

Showing 1 to 10 of 338 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.8	222.7	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
1.9	188.9	PID RB 1PATHWAY	Regulation of retinoblastoma protein
3.3	138.1	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
1.3	132.3	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
1.4	114.0	PID PTP1B PATHWAY	Signaling events mediated by PTP1B
1.7	94.8	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
1.2	91.1	PID REG GR PATHWAY	Glucocorticoid receptor regulatory network
1.7	87.0	PID FANCONI PATHWAY	Fanconi anemia pathway
2.4	82.3	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
2.6	76.0	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling

Showing 1 to 10 of 68 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.3	356.3	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing
3.7	162.7	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
2.4	152.6	REACTOME G1 PHASE	Genes involved in G1 Phase
2.4	148.6	REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
1.4	143.9	REACTOME MITOTIC M M G1 PHASES	Genes involved in Mitotic M-M/G1 phases
6.4	127.9	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
1.4	103.9	REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G	Genes involved in Vif-mediated degradation of APOBEC3G
2.6	82.1	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
4.0	68.8	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.5	68.6	REACTOME TRANSLATION	Genes involved in Translation

Showing 1 to 10 of 125 entries

Results for TFDP1

Z-value: 0.93

Motif logo

Transcription factors associated with TFDP1

Activity-expression correlation:

Activity profile of TFDP1 motif

Sorted Z-values of TFDP1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of TFDP1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: