ISMARA results: UAGUGUU

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for UAGUGUU

Z-value: 0.48

Activity profile of UAGUGUU motif

Sorted Z-values of UAGUGUU motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_+_182992545 Show fit	23.94	ENST00000258341.4	LAMC1 Ensembl NCBI GeneCards UniProt NextProt Show fit	laminin, gamma 1 (formerly LAMB2)
chr1_-_225840747 Show fit	23.78	ENST00000366843.2 ENST00000366844.3	ENAH Ensembl NCBI GeneCards UniProt NextProt Show fit	enabled homolog (Drosophila)
chr20_+_17550489 Show fit	21.08	ENST00000246069.7	DSTN Ensembl NCBI GeneCards UniProt NextProt Show fit	destrin (actin depolymerizing factor)
chr22_-_36236265 Show fit	20.50	ENST00000414461.2 ENST00000416721.2 ENST00000449924.2 ENST00000262829.7 ENST00000397305.3	RBFOX2 Ensembl NCBI GeneCards UniProt NextProt Show fit	RNA binding protein, fox-1 homolog (C. elegans) 2
chr3_+_171758344 Show fit	20.32	ENST00000336824.4 ENST00000423424.1	FNDC3B Ensembl NCBI GeneCards UniProt NextProt Show fit	fibronectin type III domain containing 3B
chr19_-_48894762 Show fit	18.53	ENST00000600980.1 ENST00000330720.2	KDELR1 Ensembl NCBI GeneCards UniProt NextProt Show fit	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
chr4_+_38869410 Show fit	17.81	ENST00000358869.2	FAM114A1 Ensembl NCBI GeneCards UniProt NextProt Show fit	family with sequence similarity 114, member A1
chr6_+_114178512 Show fit	17.47	ENST00000368635.4	MARCKS Ensembl NCBI GeneCards UniProt NextProt Show fit	myristoylated alanine-rich protein kinase C substrate
chr1_-_95392635 Show fit	17.03	ENST00000538964.1 ENST00000394202.4 ENST00000370206.4	CNN3 Ensembl NCBI GeneCards UniProt NextProt Show fit	calponin 3, acidic
chr2_-_209119831 Show fit	17.00	ENST00000345146.2	IDH1 Ensembl NCBI GeneCards UniProt NextProt Show fit	isocitrate dehydrogenase 1 (NADP+), soluble

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of UAGUGUU

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.7	30.2	GO:0006621	protein retention in ER lumen(GO:0006621)
1.6	27.1	GO:0070831	basement membrane assembly(GO:0070831)
0.5	26.9	GO:0071377	cellular response to glucagon stimulus(GO:0071377)
1.9	21.1	GO:0030043	actin filament fragmentation(GO:0030043)
3.4	20.5	GO:0010724	regulation of definitive erythrocyte differentiation(GO:0010724)
0.8	17.5	GO:0051764	actin crosslink formation(GO:0051764)
0.4	17.2	GO:0006294	nucleotide-excision repair, preincision complex assembly(GO:0006294)
5.7	17.0	GO:0006097	glyoxylate cycle(GO:0006097)
0.9	17.0	GO:0032780	negative regulation of ATPase activity(GO:0032780)
0.6	15.6	GO:0030208	dermatan sulfate biosynthetic process(GO:0030208)

Showing 1 to 10 of 145 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	33.8	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.2	29.2	GO:0043197	dendritic spine(GO:0043197)
0.2	26.2	GO:0030175	filopodium(GO:0030175)
6.0	23.9	GO:0043260	laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259) laminin-11 complex(GO:0043260)
1.7	23.5	GO:0030663	COPI-coated vesicle membrane(GO:0030663)
0.1	21.4	GO:0098857	membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.2	21.1	GO:0017053	transcriptional repressor complex(GO:0017053)
0.2	20.5	GO:0030864	cortical actin cytoskeleton(GO:0030864)
1.1	17.5	GO:0043073	germ cell nucleus(GO:0043073)
0.3	17.0	GO:0031907	peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)

Showing 1 to 10 of 96 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	34.5	GO:0003714	transcription corepressor activity(GO:0003714)
7.6	30.2	GO:0005046	KDEL sequence binding(GO:0005046)
0.3	28.3	GO:0017048	Rho GTPase binding(GO:0017048)
0.3	23.9	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.5	23.8	GO:0050699	WW domain binding(GO:0050699)
0.1	21.7	GO:0051015	actin filament binding(GO:0051015)
0.0	19.0	GO:0003723	RNA binding(GO:0003723)
0.3	17.5	GO:0005080	protein kinase C binding(GO:0005080)
5.7	17.0	GO:0004450	isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.7	17.0	GO:0098641	cadherin binding involved in cell-cell adhesion(GO:0098641)

Showing 1 to 10 of 117 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	68.2	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.4	25.7	PID BMP PATHWAY	BMP receptor signaling
1.0	23.9	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.5	18.7	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.5	17.7	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.3	17.6	SIG CHEMOTAXIS	Genes related to chemotaxis
0.7	17.4	PID ARF 3PATHWAY	Arf1 pathway
0.4	16.8	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.3	16.1	PID PLK1 PATHWAY	PLK1 signaling events
0.5	15.6	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling

Showing 1 to 10 of 41 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	25.3	REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA	Genes involved in G beta:gamma signalling through PLC beta
0.3	25.3	REACTOME L1CAM INTERACTIONS	Genes involved in L1CAM interactions
0.5	21.9	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.3	21.1	REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE	Genes involved in Cell death signalling via NRAGE, NRIF and NADE
0.4	19.9	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.3	18.9	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
1.6	17.5	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.6	17.2	REACTOME FORMATION OF INCISION COMPLEX IN GG NER	Genes involved in Formation of incision complex in GG-NER
0.5	17.0	REACTOME PEROXISOMAL LIPID METABOLISM	Genes involved in Peroxisomal lipid metabolism
0.6	15.6	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation

Showing 1 to 10 of 58 entries

Results for UAGUGUU

Z-value: 0.48

Activity profile of UAGUGUU motif

Sorted Z-values of UAGUGUU motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of UAGUGUU

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: