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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for UUGGUCC
Z-value: 0.34
Motif logo
miRNA associated with seed UUGGUCC
| Name | miRBASE accession |
|---|---|
|
hsa-miR-133a-3p.2
|
MIMAT0000427 |
|
hsa-miR-133b
|
MIMAT0000770 |
Activity profile of UUGGUCC motif
Sorted Z-values of UUGGUCC motif
Network of associatons between targets according to the STRING database.
First level regulatory network of UUGGUCC
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 6.8 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 2.1 | 6.3 | GO:0070318 | positive regulation of G0 to G1 transition(GO:0070318) |
| 1.1 | 3.3 | GO:2000830 | vacuolar phosphate transport(GO:0007037) positive regulation of mitotic cell cycle DNA replication(GO:1903465) positive regulation of parathyroid hormone secretion(GO:2000830) |
| 1.1 | 4.2 | GO:0061743 | motor learning(GO:0061743) |
| 1.0 | 3.1 | GO:0021718 | superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722) |
| 0.9 | 2.8 | GO:0036371 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
| 0.9 | 3.4 | GO:0014054 | positive regulation of gamma-aminobutyric acid secretion(GO:0014054) |
| 0.8 | 2.3 | GO:1901491 | negative regulation of lymphangiogenesis(GO:1901491) |
| 0.8 | 1.5 | GO:1901490 | regulation of lymphangiogenesis(GO:1901490) |
| 0.7 | 3.0 | GO:0099525 | presynaptic dense core granule exocytosis(GO:0099525) |
| 0.6 | 3.2 | GO:0061107 | prostate gland stromal morphogenesis(GO:0060741) seminal vesicle development(GO:0061107) |
| 0.6 | 3.1 | GO:0048133 | germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) positive regulation of NK T cell differentiation(GO:0051138) germline stem cell asymmetric division(GO:0098728) |
| 0.6 | 3.1 | GO:0035582 | sequestering of BMP in extracellular matrix(GO:0035582) |
| 0.6 | 1.8 | GO:0072019 | carbon dioxide transmembrane transport(GO:0035378) proximal convoluted tubule development(GO:0072019) metanephric proximal convoluted tubule development(GO:0072229) |
| 0.6 | 4.8 | GO:0001672 | regulation of chromatin assembly or disassembly(GO:0001672) |
| 0.6 | 4.7 | GO:0070445 | oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445) |
| 0.6 | 2.9 | GO:0014052 | regulation of gamma-aminobutyric acid secretion(GO:0014052) |
| 0.6 | 6.2 | GO:0090232 | peripheral nervous system myelin maintenance(GO:0032287) positive regulation of spindle checkpoint(GO:0090232) |
| 0.5 | 1.5 | GO:0070940 | dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940) |
| 0.5 | 2.9 | GO:0030035 | microspike assembly(GO:0030035) |
| 0.5 | 1.4 | GO:1990108 | protein linear deubiquitination(GO:1990108) |
| 0.5 | 6.1 | GO:0060137 | maternal process involved in parturition(GO:0060137) |
| 0.4 | 1.7 | GO:2001271 | negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271) |
| 0.4 | 3.0 | GO:0002175 | protein localization to paranode region of axon(GO:0002175) |
| 0.4 | 1.7 | GO:0014816 | skeletal muscle satellite cell differentiation(GO:0014816) |
| 0.4 | 5.7 | GO:0070050 | neuron cellular homeostasis(GO:0070050) |
| 0.4 | 1.2 | GO:1900114 | positive regulation of histone H3-K9 trimethylation(GO:1900114) |
| 0.4 | 1.6 | GO:1990535 | transformation of host cell by virus(GO:0019087) neuron projection maintenance(GO:1990535) |
| 0.4 | 2.6 | GO:0060011 | Sertoli cell proliferation(GO:0060011) |
| 0.4 | 2.9 | GO:0032482 | Rab protein signal transduction(GO:0032482) |
| 0.4 | 3.6 | GO:0044829 | positive regulation by host of viral genome replication(GO:0044829) |
| 0.3 | 2.1 | GO:2000807 | regulation of synaptic vesicle clustering(GO:2000807) |
| 0.3 | 3.0 | GO:0002447 | eosinophil activation involved in immune response(GO:0002278) eosinophil mediated immunity(GO:0002447) eosinophil degranulation(GO:0043308) |
| 0.3 | 6.7 | GO:0032011 | ARF protein signal transduction(GO:0032011) |
| 0.3 | 3.0 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
| 0.3 | 1.5 | GO:0036072 | intramembranous ossification(GO:0001957) direct ossification(GO:0036072) cellular response to vitamin E(GO:0071306) response to fluoride(GO:1902617) |
| 0.3 | 0.8 | GO:1902722 | activation of phospholipase A2 activity by calcium-mediated signaling(GO:0043006) positive regulation of prolactin secretion(GO:1902722) |
| 0.3 | 1.6 | GO:0032926 | negative regulation of activin receptor signaling pathway(GO:0032926) |
| 0.3 | 2.6 | GO:0090266 | regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504) |
| 0.3 | 1.0 | GO:0046104 | thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125) |
| 0.2 | 1.4 | GO:0046684 | response to pyrethroid(GO:0046684) |
| 0.2 | 1.6 | GO:0070294 | renal sodium ion absorption(GO:0070294) |
| 0.2 | 1.6 | GO:0021730 | trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.2 | 1.1 | GO:0097498 | endothelial tube lumen extension(GO:0097498) |
| 0.2 | 1.9 | GO:0016191 | synaptic vesicle uncoating(GO:0016191) |
| 0.2 | 1.5 | GO:0043634 | polyadenylation-dependent ncRNA catabolic process(GO:0043634) |
| 0.2 | 1.5 | GO:0006489 | dolichyl diphosphate biosynthetic process(GO:0006489) dolichyl diphosphate metabolic process(GO:0046465) |
| 0.2 | 1.8 | GO:0018026 | peptidyl-lysine monomethylation(GO:0018026) |
| 0.2 | 7.3 | GO:0051491 | positive regulation of filopodium assembly(GO:0051491) |
| 0.2 | 0.7 | GO:0035720 | intraciliary anterograde transport(GO:0035720) |
| 0.2 | 1.3 | GO:0071692 | sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) |
| 0.2 | 0.4 | GO:0051136 | regulation of NK T cell differentiation(GO:0051136) |
| 0.2 | 0.5 | GO:1900042 | positive regulation of interleukin-2 secretion(GO:1900042) |
| 0.2 | 1.3 | GO:0032286 | central nervous system myelin maintenance(GO:0032286) |
| 0.2 | 1.3 | GO:0032914 | positive regulation of transforming growth factor beta1 production(GO:0032914) |
| 0.2 | 1.6 | GO:1901409 | positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409) |
| 0.1 | 0.6 | GO:0097676 | histone H3-K36 dimethylation(GO:0097676) |
| 0.1 | 1.6 | GO:0070314 | G1 to G0 transition(GO:0070314) |
| 0.1 | 0.6 | GO:0045875 | negative regulation of sister chromatid cohesion(GO:0045875) |
| 0.1 | 0.9 | GO:0035469 | determination of pancreatic left/right asymmetry(GO:0035469) |
| 0.1 | 1.3 | GO:0010499 | proteasomal ubiquitin-independent protein catabolic process(GO:0010499) |
| 0.1 | 1.9 | GO:0010839 | negative regulation of keratinocyte proliferation(GO:0010839) |
| 0.1 | 6.6 | GO:0042073 | intraciliary transport(GO:0042073) |
| 0.1 | 3.9 | GO:0006783 | heme biosynthetic process(GO:0006783) |
| 0.1 | 1.3 | GO:0015886 | heme transport(GO:0015886) |
| 0.1 | 0.6 | GO:0006970 | response to osmotic stress(GO:0006970) |
| 0.1 | 5.3 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 0.1 | 1.8 | GO:0043562 | cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562) |
| 0.1 | 3.0 | GO:0030488 | tRNA methylation(GO:0030488) |
| 0.1 | 0.6 | GO:0048280 | vesicle fusion with Golgi apparatus(GO:0048280) |
| 0.1 | 2.1 | GO:0007614 | short-term memory(GO:0007614) |
| 0.1 | 2.5 | GO:0042753 | positive regulation of circadian rhythm(GO:0042753) |
| 0.1 | 5.5 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.1 | 0.2 | GO:0043586 | tongue development(GO:0043586) |
| 0.1 | 1.2 | GO:0010960 | magnesium ion homeostasis(GO:0010960) |
| 0.1 | 0.9 | GO:0048386 | positive regulation of retinoic acid receptor signaling pathway(GO:0048386) |
| 0.1 | 0.3 | GO:1903401 | lysine import(GO:0034226) L-lysine import(GO:0061461) L-lysine transmembrane transport(GO:1903401) L-lysine import into cell(GO:1903410) |
| 0.1 | 0.6 | GO:1904381 | Golgi apparatus mannose trimming(GO:1904381) |
| 0.1 | 0.7 | GO:0060056 | mammary gland involution(GO:0060056) |
| 0.1 | 0.7 | GO:0019227 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
| 0.1 | 2.6 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 0.1 | 0.5 | GO:0035694 | mitochondrial protein catabolic process(GO:0035694) |
| 0.1 | 1.0 | GO:0070072 | proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072) |
| 0.1 | 0.4 | GO:0033686 | oocyte growth(GO:0001555) positive regulation of luteinizing hormone secretion(GO:0033686) |
| 0.1 | 4.3 | GO:0071377 | cellular response to glucagon stimulus(GO:0071377) |
| 0.1 | 1.9 | GO:0030208 | dermatan sulfate biosynthetic process(GO:0030208) |
| 0.1 | 2.9 | GO:0046676 | negative regulation of insulin secretion(GO:0046676) |
| 0.1 | 0.4 | GO:0032455 | nerve growth factor processing(GO:0032455) |
| 0.1 | 4.0 | GO:0090102 | cochlea development(GO:0090102) |
| 0.1 | 1.8 | GO:0000729 | DNA double-strand break processing(GO:0000729) |
| 0.1 | 0.7 | GO:2000786 | positive regulation of autophagosome assembly(GO:2000786) |
| 0.1 | 2.4 | GO:0051642 | centrosome localization(GO:0051642) |
| 0.1 | 0.5 | GO:0045048 | protein insertion into ER membrane(GO:0045048) |
| 0.1 | 0.5 | GO:1903361 | protein localization to basolateral plasma membrane(GO:1903361) |
| 0.1 | 0.3 | GO:0043249 | erythrocyte maturation(GO:0043249) |
| 0.1 | 0.9 | GO:0035878 | nail development(GO:0035878) |
| 0.1 | 0.2 | GO:0032237 | activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341) |
| 0.1 | 1.6 | GO:0030539 | male genitalia development(GO:0030539) |
| 0.1 | 0.4 | GO:0016579 | protein deubiquitination(GO:0016579) |
| 0.1 | 1.3 | GO:0034389 | lipid particle organization(GO:0034389) |
| 0.1 | 0.3 | GO:0014050 | negative regulation of glutamate secretion(GO:0014050) |
| 0.1 | 5.5 | GO:0055072 | iron ion homeostasis(GO:0055072) |
| 0.1 | 2.1 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 0.1 | 1.3 | GO:2000369 | regulation of clathrin-mediated endocytosis(GO:2000369) |
| 0.0 | 0.6 | GO:0034605 | cellular response to heat(GO:0034605) |
| 0.0 | 0.4 | GO:0036066 | protein O-linked fucosylation(GO:0036066) |
| 0.0 | 0.5 | GO:0051085 | chaperone mediated protein folding requiring cofactor(GO:0051085) |
| 0.0 | 0.8 | GO:0032802 | low-density lipoprotein particle receptor catabolic process(GO:0032802) |
| 0.0 | 0.4 | GO:0001878 | response to yeast(GO:0001878) |
| 0.0 | 0.2 | GO:0070459 | prolactin secretion(GO:0070459) |
| 0.0 | 0.3 | GO:0007256 | activation of JNKK activity(GO:0007256) |
| 0.0 | 0.4 | GO:0001842 | neural fold formation(GO:0001842) |
| 0.0 | 2.8 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
| 0.0 | 3.1 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 0.0 | 1.7 | GO:0043171 | peptide catabolic process(GO:0043171) |
| 0.0 | 0.5 | GO:0031915 | positive regulation of synaptic plasticity(GO:0031915) |
| 0.0 | 1.1 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.0 | 2.0 | GO:0046677 | response to antibiotic(GO:0046677) |
| 0.0 | 4.5 | GO:0048813 | dendrite morphogenesis(GO:0048813) |
| 0.0 | 1.1 | GO:0045599 | negative regulation of fat cell differentiation(GO:0045599) |
| 0.0 | 2.3 | GO:0007368 | determination of left/right symmetry(GO:0007368) |
| 0.0 | 2.5 | GO:0032760 | positive regulation of tumor necrosis factor production(GO:0032760) |
| 0.0 | 0.3 | GO:0008625 | extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625) |
| 0.0 | 1.7 | GO:0035914 | skeletal muscle cell differentiation(GO:0035914) |
| 0.0 | 0.1 | GO:0035621 | ER to Golgi ceramide transport(GO:0035621) |
| 0.0 | 0.2 | GO:0035457 | cellular response to interferon-alpha(GO:0035457) |
| 0.0 | 0.5 | GO:0034656 | nucleobase-containing small molecule catabolic process(GO:0034656) |
| 0.0 | 0.5 | GO:0006511 | ubiquitin-dependent protein catabolic process(GO:0006511) |
| 0.0 | 0.6 | GO:0009312 | oligosaccharide biosynthetic process(GO:0009312) |
| 0.0 | 0.4 | GO:0045717 | negative regulation of fatty acid biosynthetic process(GO:0045717) |
| 0.0 | 1.7 | GO:0070830 | bicellular tight junction assembly(GO:0070830) |
| 0.0 | 0.5 | GO:0046827 | positive regulation of protein export from nucleus(GO:0046827) |
| 0.0 | 0.9 | GO:0008542 | visual learning(GO:0008542) |
| 0.0 | 0.7 | GO:0015695 | organic cation transport(GO:0015695) |
| 0.0 | 1.3 | GO:0045540 | regulation of cholesterol biosynthetic process(GO:0045540) |
| 0.0 | 1.5 | GO:0045670 | regulation of osteoclast differentiation(GO:0045670) |
| 0.0 | 0.6 | GO:0007190 | activation of adenylate cyclase activity(GO:0007190) |
| 0.0 | 0.3 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 0.0 | 0.4 | GO:0006884 | cell volume homeostasis(GO:0006884) |
| 0.0 | 0.2 | GO:0051493 | regulation of cytoskeleton organization(GO:0051493) |
| 0.0 | 0.1 | GO:0070836 | caveola assembly(GO:0070836) |
| 0.0 | 0.1 | GO:0045144 | meiotic sister chromatid segregation(GO:0045144) |
| 0.0 | 5.2 | GO:0043687 | post-translational protein modification(GO:0043687) |
| 0.0 | 0.4 | GO:0043666 | regulation of phosphoprotein phosphatase activity(GO:0043666) |
| 0.0 | 1.1 | GO:0019233 | sensory perception of pain(GO:0019233) |
| 0.0 | 0.6 | GO:0051496 | positive regulation of stress fiber assembly(GO:0051496) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 4.3 | GO:0072534 | perineuronal net(GO:0072534) |
| 1.4 | 6.8 | GO:0060201 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 1.1 | 5.6 | GO:0098843 | postsynaptic endocytic zone(GO:0098843) |
| 1.0 | 3.0 | GO:0044305 | calyx of Held(GO:0044305) |
| 1.0 | 2.9 | GO:0044393 | microspike(GO:0044393) |
| 0.9 | 2.7 | GO:0038039 | G-protein coupled receptor heterodimeric complex(GO:0038039) |
| 0.8 | 3.1 | GO:0016533 | cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533) |
| 0.7 | 3.0 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044) |
| 0.6 | 1.8 | GO:0020003 | symbiont-containing vacuole(GO:0020003) symbiont-containing vacuole membrane(GO:0020005) |
| 0.4 | 8.5 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.3 | 1.0 | GO:0043291 | RAVE complex(GO:0043291) |
| 0.3 | 4.2 | GO:0043083 | synaptic cleft(GO:0043083) |
| 0.3 | 1.6 | GO:0005899 | insulin receptor complex(GO:0005899) |
| 0.3 | 0.8 | GO:0097489 | multivesicular body, internal vesicle lumen(GO:0097489) |
| 0.3 | 3.0 | GO:0033010 | paranodal junction(GO:0033010) |
| 0.2 | 2.9 | GO:0098563 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.2 | 3.1 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.2 | 4.3 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.2 | 2.1 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
| 0.2 | 1.6 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.2 | 8.7 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.2 | 3.4 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.1 | 5.9 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.1 | 1.5 | GO:0005583 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.1 | 2.1 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.1 | 2.5 | GO:0042599 | lamellar body(GO:0042599) |
| 0.1 | 8.4 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.1 | 0.8 | GO:0071439 | clathrin complex(GO:0071439) |
| 0.1 | 2.9 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
| 0.1 | 0.3 | GO:0032279 | asymmetric synapse(GO:0032279) |
| 0.1 | 1.0 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
| 0.1 | 4.8 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.1 | 0.5 | GO:0032437 | cuticular plate(GO:0032437) |
| 0.1 | 0.5 | GO:0070033 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554) |
| 0.1 | 2.9 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.1 | 1.8 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.1 | 0.7 | GO:0097470 | ribbon synapse(GO:0097470) |
| 0.1 | 3.9 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.1 | 2.8 | GO:0031430 | M band(GO:0031430) |
| 0.1 | 1.2 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.0 | 1.4 | GO:0035145 | exon-exon junction complex(GO:0035145) |
| 0.0 | 0.5 | GO:0097025 | MPP7-DLG1-LIN7 complex(GO:0097025) |
| 0.0 | 0.9 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.0 | 0.1 | GO:0000939 | condensed chromosome inner kinetochore(GO:0000939) |
| 0.0 | 1.1 | GO:0071011 | precatalytic spliceosome(GO:0071011) |
| 0.0 | 0.5 | GO:0005664 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
| 0.0 | 5.3 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 0.2 | GO:0032541 | cortical endoplasmic reticulum(GO:0032541) |
| 0.0 | 3.0 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.0 | 0.3 | GO:0008024 | cyclin/CDK positive transcription elongation factor complex(GO:0008024) |
| 0.0 | 0.9 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.0 | 1.9 | GO:0031256 | leading edge membrane(GO:0031256) |
| 0.0 | 0.6 | GO:0031201 | SNARE complex(GO:0031201) |
| 0.0 | 1.6 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.0 | 5.5 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 0.1 | GO:0071148 | TEAD-1-YAP complex(GO:0071148) |
| 0.0 | 3.5 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.0 | 2.3 | GO:0043204 | perikaryon(GO:0043204) |
| 0.0 | 1.9 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 2.5 | GO:0000922 | spindle pole(GO:0000922) |
| 0.0 | 1.2 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.0 | 1.9 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 1.9 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 0.6 | GO:0005769 | early endosome(GO:0005769) |
| 0.0 | 1.0 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 6.2 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.0 | 0.2 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
| 0.0 | 0.5 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 1.0 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) intrinsic component of endoplasmic reticulum membrane(GO:0031227) |
| 0.0 | 1.1 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 2.6 | GO:0030424 | axon(GO:0030424) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 5.3 | GO:0032184 | SUMO polymer binding(GO:0032184) |
| 1.4 | 6.8 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 1.3 | 6.4 | GO:0035252 | UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285) |
| 1.0 | 3.1 | GO:0016534 | cyclin-dependent protein kinase 5 activator activity(GO:0016534) |
| 0.9 | 2.7 | GO:0004965 | G-protein coupled GABA receptor activity(GO:0004965) |
| 0.9 | 2.6 | GO:0008330 | protein tyrosine/threonine phosphatase activity(GO:0008330) |
| 0.6 | 1.8 | GO:0035379 | carbon dioxide transmembrane transporter activity(GO:0035379) |
| 0.6 | 4.7 | GO:0030023 | extracellular matrix constituent conferring elasticity(GO:0030023) |
| 0.6 | 3.4 | GO:0015185 | gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185) |
| 0.5 | 5.6 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 0.4 | 4.8 | GO:0001042 | RNA polymerase I core binding(GO:0001042) |
| 0.4 | 1.6 | GO:0043559 | insulin binding(GO:0043559) |
| 0.3 | 1.0 | GO:0004137 | deoxycytidine kinase activity(GO:0004137) thymidine kinase activity(GO:0004797) |
| 0.3 | 1.3 | GO:0035473 | lipase binding(GO:0035473) |
| 0.3 | 3.3 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
| 0.3 | 3.1 | GO:0036312 | phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312) |
| 0.3 | 1.8 | GO:0008310 | single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310) |
| 0.3 | 1.5 | GO:0008420 | CTD phosphatase activity(GO:0008420) |
| 0.3 | 3.1 | GO:0001206 | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206) |
| 0.3 | 1.4 | GO:0086006 | voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006) |
| 0.3 | 3.0 | GO:0016423 | tRNA (guanine) methyltransferase activity(GO:0016423) |
| 0.2 | 6.3 | GO:0001968 | fibronectin binding(GO:0001968) |
| 0.2 | 6.2 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.2 | 0.7 | GO:0016309 | 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309) |
| 0.2 | 6.2 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.2 | 5.7 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.2 | 6.2 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.2 | 2.4 | GO:0004716 | receptor signaling protein tyrosine kinase activity(GO:0004716) |
| 0.2 | 1.6 | GO:0097322 | 7SK snRNA binding(GO:0097322) |
| 0.2 | 0.6 | GO:0047273 | galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity(GO:0047273) |
| 0.2 | 0.6 | GO:0015616 | DNA translocase activity(GO:0015616) |
| 0.2 | 2.4 | GO:0008429 | phosphatidylethanolamine binding(GO:0008429) |
| 0.2 | 1.5 | GO:0004652 | polynucleotide adenylyltransferase activity(GO:0004652) |
| 0.2 | 0.9 | GO:0070097 | delta-catenin binding(GO:0070097) |
| 0.2 | 3.4 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.2 | 1.5 | GO:0005172 | vascular endothelial growth factor receptor binding(GO:0005172) |
| 0.1 | 1.4 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.1 | 1.8 | GO:0030957 | Tat protein binding(GO:0030957) |
| 0.1 | 1.3 | GO:0015232 | heme transporter activity(GO:0015232) |
| 0.1 | 0.9 | GO:0016618 | hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267) |
| 0.1 | 1.5 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.1 | 2.6 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.1 | 1.2 | GO:0010385 | double-stranded methylated DNA binding(GO:0010385) |
| 0.1 | 1.6 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
| 0.1 | 1.6 | GO:0048185 | activin binding(GO:0048185) |
| 0.1 | 0.3 | GO:0015189 | L-lysine transmembrane transporter activity(GO:0015189) |
| 0.1 | 3.2 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.1 | 1.5 | GO:0042809 | vitamin D receptor binding(GO:0042809) |
| 0.1 | 2.4 | GO:0001223 | transcription coactivator binding(GO:0001223) |
| 0.1 | 0.1 | GO:0034041 | sterol-transporting ATPase activity(GO:0034041) |
| 0.1 | 0.6 | GO:0046975 | histone methyltransferase activity (H3-K36 specific)(GO:0046975) |
| 0.1 | 1.5 | GO:0070001 | aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001) |
| 0.1 | 0.3 | GO:0070905 | serine binding(GO:0070905) |
| 0.1 | 3.6 | GO:0070063 | RNA polymerase binding(GO:0070063) |
| 0.1 | 0.8 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
| 0.1 | 1.9 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 1.6 | GO:0017081 | chloride channel regulator activity(GO:0017081) |
| 0.1 | 1.3 | GO:0005112 | Notch binding(GO:0005112) |
| 0.1 | 0.9 | GO:0004679 | AMP-activated protein kinase activity(GO:0004679) |
| 0.1 | 2.8 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.1 | 1.5 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.1 | 0.7 | GO:0019534 | toxin transporter activity(GO:0019534) |
| 0.1 | 3.7 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.1 | 6.6 | GO:0005262 | calcium channel activity(GO:0005262) |
| 0.1 | 0.5 | GO:0048495 | Roundabout binding(GO:0048495) |
| 0.1 | 1.0 | GO:0051400 | BH domain binding(GO:0051400) |
| 0.0 | 0.7 | GO:0005248 | voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030) |
| 0.0 | 1.8 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.0 | 0.5 | GO:0097016 | L27 domain binding(GO:0097016) |
| 0.0 | 0.6 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.0 | 1.7 | GO:0000983 | transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983) |
| 0.0 | 0.4 | GO:0005432 | calcium:sodium antiporter activity(GO:0005432) |
| 0.0 | 5.6 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 0.3 | GO:0004000 | adenosine deaminase activity(GO:0004000) |
| 0.0 | 0.7 | GO:0030276 | clathrin binding(GO:0030276) |
| 0.0 | 0.3 | GO:0048406 | nerve growth factor binding(GO:0048406) |
| 0.0 | 0.5 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.0 | 1.8 | GO:0002039 | p53 binding(GO:0002039) |
| 0.0 | 0.1 | GO:0017089 | glycolipid transporter activity(GO:0017089) ceramide binding(GO:0097001) |
| 0.0 | 0.5 | GO:0030506 | ankyrin binding(GO:0030506) |
| 0.0 | 0.4 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.0 | 0.5 | GO:0005521 | lamin binding(GO:0005521) |
| 0.0 | 0.4 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.0 | 1.1 | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980) |
| 0.0 | 2.9 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 0.6 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.0 | 1.0 | GO:0005215 | transporter activity(GO:0005215) |
| 0.0 | 0.3 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.0 | 0.5 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.0 | 2.4 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |
| 0.0 | 1.3 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.0 | 2.0 | GO:0008144 | drug binding(GO:0008144) |
| 0.0 | 0.3 | GO:0030742 | GTP-dependent protein binding(GO:0030742) |
| 0.0 | 0.4 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.0 | 0.4 | GO:0051428 | peptide hormone receptor binding(GO:0051428) |
| 0.0 | 2.9 | GO:0031625 | ubiquitin protein ligase binding(GO:0031625) |
| 0.0 | 0.4 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.0 | 2.1 | GO:0003723 | RNA binding(GO:0003723) |
| 0.0 | 0.8 | GO:0019003 | GDP binding(GO:0019003) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.5 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.2 | 8.9 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.1 | 2.6 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.1 | 4.6 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.1 | 3.4 | PID LYMPH ANGIOGENESIS PATHWAY | VEGFR3 signaling in lymphatic endothelium |
| 0.1 | 3.1 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.1 | 6.3 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.1 | 0.8 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.1 | 7.5 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 2.7 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 1.3 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 1.1 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 1.6 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.0 | 1.0 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 4.8 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 2.5 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 1.7 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 1.7 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.0 | 1.7 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.0 | 1.6 | PID MET PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| 0.0 | 1.9 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 1.6 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 4.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 4.7 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 0.9 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.0 | 0.6 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 9.7 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.2 | 3.3 | REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 | Genes involved in Signaling by activated point mutants of FGFR1 |
| 0.2 | 2.7 | REACTOME RETROGRADE NEUROTROPHIN SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
| 0.2 | 5.6 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.2 | 4.3 | REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA | Genes involved in G beta:gamma signalling through PLC beta |
| 0.2 | 3.1 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.1 | 2.1 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.1 | 3.7 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.1 | 5.1 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.1 | 2.7 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.1 | 1.8 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.1 | 4.6 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.1 | 3.1 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.1 | 1.5 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.1 | 1.5 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.1 | 2.0 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |
| 0.1 | 2.3 | REACTOME ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING | Genes involved in Activation of Kainate Receptors upon glutamate binding |
| 0.1 | 1.4 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.1 | 0.5 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.1 | 0.9 | REACTOME ERKS ARE INACTIVATED | Genes involved in ERKs are inactivated |
| 0.1 | 2.7 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.1 | 0.8 | REACTOME SHC1 EVENTS IN EGFR SIGNALING | Genes involved in SHC1 events in EGFR signaling |
| 0.1 | 1.9 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 1.6 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.0 | 1.6 | REACTOME ELONGATION ARREST AND RECOVERY | Genes involved in Elongation arrest and recovery |
| 0.0 | 1.7 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 0.9 | REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
| 0.0 | 1.0 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.0 | 0.5 | REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
| 0.0 | 3.1 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.0 | 1.0 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 3.1 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.0 | 1.4 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.0 | 1.6 | REACTOME L1CAM INTERACTIONS | Genes involved in L1CAM interactions |
| 0.0 | 1.4 | REACTOME IRON UPTAKE AND TRANSPORT | Genes involved in Iron uptake and transport |
| 0.0 | 0.6 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.0 | 3.9 | REACTOME G ALPHA S SIGNALLING EVENTS | Genes involved in G alpha (s) signalling events |
| 0.0 | 3.2 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 0.7 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.0 | 0.6 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 0.0 | 0.6 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |