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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for WRNIP1
Z-value: 2.01
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Transcription factors associated with WRNIP1
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_111784005 Show fit | 156.38 |
ENST00000527899.1
|
crystallin, alpha B |
|
| chr11_-_111783919 Show fit | 133.13 |
ENST00000531198.1
ENST00000533879.1 |
crystallin, alpha B |
|
| chr11_-_111783595 Show fit | 121.07 |
ENST00000528628.1
|
crystallin, alpha B |
|
| chr17_+_77681075 Show fit | 110.58 |
ENST00000397549.2
|
CTD-2116F7.1 |
|
| chr14_-_81687197 Show fit | 100.99 |
ENST00000553612.1
|
general transcription factor IIA, 1, 19/37kDa |
|
| chr11_-_111781610 Show fit | 100.22 |
ENST00000525823.1
|
crystallin, alpha B |
|
| chr17_+_1665345 Show fit | 88.78 |
ENST00000576406.1
ENST00000571149.1 |
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 |
|
| chr16_+_226658 Show fit | 88.18 |
ENST00000320868.5
ENST00000397797.1 |
hemoglobin, alpha 1 |
|
| chr11_-_111781454 Show fit | 85.51 |
ENST00000533280.1
|
crystallin, alpha B |
|
| chr16_-_30032610 Show fit | 83.52 |
ENST00000574405.1
|
double C2-like domains, alpha |
Network of associatons between targets according to the STRING database.
First level regulatory network of WRNIP1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 735.6 | GO:0043547 | positive regulation of GTPase activity(GO:0043547) |
| 40.0 | 720.3 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 37.7 | 603.9 | GO:0090361 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 11.4 | 466.9 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 8.8 | 376.4 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 23.0 | 230.1 | GO:0051610 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 16.8 | 218.7 | GO:0048712 | negative regulation of astrocyte differentiation(GO:0048712) |
| 34.1 | 204.6 | GO:0061518 | macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 13.6 | 203.6 | GO:0007196 | adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196) |
| 8.5 | 203.4 | GO:0010669 | epithelial structure maintenance(GO:0010669) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 1848.0 | GO:0016021 | integral component of membrane(GO:0016021) |
| 6.0 | 1043.4 | GO:0030426 | growth cone(GO:0030426) |
| 0.9 | 947.4 | GO:0031226 | intrinsic component of plasma membrane(GO:0031226) |
| 53.7 | 858.5 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.9 | 809.5 | GO:0005615 | extracellular space(GO:0005615) |
| 3.5 | 666.1 | GO:0060076 | excitatory synapse(GO:0060076) |
| 2.3 | 632.2 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 8.0 | 624.7 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 4.9 | 563.2 | GO:0043204 | perikaryon(GO:0043204) |
| 2.3 | 523.5 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 1103.2 | GO:0001071 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 3.6 | 995.2 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 25.0 | 775.0 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 2.0 | 530.2 | GO:0004930 | G-protein coupled receptor activity(GO:0004930) |
| 4.7 | 507.8 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 4.1 | 400.4 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.8 | 379.3 | GO:0005509 | calcium ion binding(GO:0005509) |
| 6.6 | 332.0 | GO:0030507 | spectrin binding(GO:0030507) |
| 2.1 | 323.9 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 23.1 | 299.9 | GO:0005344 | oxygen transporter activity(GO:0005344) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.0 | 733.0 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 2.8 | 724.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 2.0 | 657.9 | NABA MATRISOME ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
| 2.3 | 532.0 | NABA CORE MATRISOME | Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans |
| 2.7 | 456.0 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 6.8 | 379.6 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 4.9 | 281.7 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 4.5 | 225.5 | PID RAS PATHWAY | Regulation of Ras family activation |
| 4.6 | 210.3 | NABA COLLAGENS | Genes encoding collagen proteins |
| 3.2 | 199.8 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.7 | 511.7 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 5.9 | 375.0 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 6.1 | 334.4 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 6.2 | 334.1 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 15.5 | 324.8 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 3.4 | 312.2 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 17.0 | 305.1 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 3.3 | 294.6 | REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS | Genes involved in Class A/1 (Rhodopsin-like receptors) |
| 3.0 | 277.3 | REACTOME GPCR LIGAND BINDING | Genes involved in GPCR ligand binding |
| 2.8 | 276.6 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |