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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for WT1_MTF1_ZBTB7B
Z-value: 1.41
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Transcription factors associated with WT1_MTF1_ZBTB7B
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000184937.8 | WT1 transcription factor | |
| ENSG00000188786.9 | metal regulatory transcription factor 1 | |
| ENSG00000160685.9 | zinc finger and BTB domain containing 7B |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZBTB7B | hg19_v2_chr1_+_154975258_154975330 | 0.73 | 7.0e-37 | Click! |
| WT1 | hg19_v2_chr11_-_32457075_32457095 | 0.36 | 4.1e-08 | Click! |
| MTF1 | hg19_v2_chr1_-_38325256_38325292 | -0.19 | 5.7e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_2906979 Show fit | 173.24 |
ENST00000380725.1
ENST00000313407.6 ENST00000430149.2 ENST00000440480.2 ENST00000414822.3 |
cyclin-dependent kinase inhibitor 1C (p57, Kip2) |
|
| chr1_+_6845384 Show fit | 159.83 |
ENST00000303635.7
|
calmodulin binding transcription activator 1 |
|
| chr16_+_58497567 Show fit | 130.00 |
ENST00000258187.5
|
NDRG family member 4 |
|
| chr1_-_20812690 Show fit | 128.16 |
ENST00000375078.3
|
calcium/calmodulin-dependent protein kinase II inhibitor 1 |
|
| chr14_+_102027688 Show fit | 127.92 |
ENST00000510508.4
ENST00000359323.3 |
deiodinase, iodothyronine, type III |
|
| chr16_+_226658 Show fit | 127.65 |
ENST00000320868.5
ENST00000397797.1 |
hemoglobin, alpha 1 |
|
| chr12_-_124457257 Show fit | 126.33 |
ENST00000545891.1
|
coiled-coil domain containing 92 |
|
| chr11_-_12030629 Show fit | 125.62 |
ENST00000396505.2
|
dickkopf WNT signaling pathway inhibitor 3 |
|
| chr14_-_81687197 Show fit | 124.37 |
ENST00000553612.1
|
general transcription factor IIA, 1, 19/37kDa |
|
| chr9_+_139873264 Show fit | 122.47 |
ENST00000446677.1
|
prostaglandin D2 synthase 21kDa (brain) |
Network of associatons between targets according to the STRING database.
First level regulatory network of WT1_MTF1_ZBTB7B
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.7 | 331.8 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 0.8 | 292.8 | GO:0043547 | positive regulation of GTPase activity(GO:0043547) |
| 10.3 | 267.3 | GO:0071294 | cellular response to zinc ion(GO:0071294) |
| 8.6 | 266.7 | GO:0009214 | cyclic nucleotide catabolic process(GO:0009214) |
| 29.3 | 263.6 | GO:0003190 | atrioventricular valve formation(GO:0003190) |
| 20.1 | 261.2 | GO:2001135 | regulation of endocytic recycling(GO:2001135) |
| 9.4 | 253.5 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 6.6 | 252.4 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 18.0 | 251.3 | GO:0030007 | cellular potassium ion homeostasis(GO:0030007) |
| 9.5 | 247.4 | GO:0034199 | activation of protein kinase A activity(GO:0034199) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 4155.6 | GO:0031224 | intrinsic component of membrane(GO:0031224) |
| 4.1 | 844.6 | GO:0060076 | excitatory synapse(GO:0060076) |
| 8.9 | 733.0 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 6.0 | 603.7 | GO:0034705 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
| 2.6 | 551.4 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 2.3 | 469.8 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 4.8 | 459.3 | GO:0043204 | perikaryon(GO:0043204) |
| 5.0 | 450.3 | GO:0005604 | basement membrane(GO:0005604) |
| 8.2 | 427.2 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 1.8 | 423.6 | GO:0045202 | synapse(GO:0045202) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 474.2 | GO:0003700 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.9 | 432.3 | GO:0005509 | calcium ion binding(GO:0005509) |
| 11.1 | 422.8 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 6.0 | 405.1 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 4.1 | 399.7 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 1.8 | 354.4 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 3.1 | 341.3 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 1.2 | 320.0 | GO:0004930 | G-protein coupled receptor activity(GO:0004930) |
| 11.1 | 300.8 | GO:0050780 | dopamine receptor binding(GO:0050780) |
| 2.8 | 289.6 | GO:0003707 | steroid hormone receptor activity(GO:0003707) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.4 | 769.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 1.9 | 631.8 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 2.4 | 585.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 12.8 | 460.4 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 5.2 | 348.1 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 7.6 | 334.2 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 2.5 | 296.9 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 6.7 | 287.6 | PID S1P S1P3 PATHWAY | S1P3 pathway |
| 6.0 | 282.7 | PID RAS PATHWAY | Regulation of Ras family activation |
| 3.9 | 282.0 | PID FGF PATHWAY | FGF signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.9 | 752.1 | REACTOME NEURONAL SYSTEM | Genes involved in Neuronal System |
| 10.5 | 569.4 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 6.6 | 417.3 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 12.8 | 357.3 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 10.4 | 354.6 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 18.9 | 340.4 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 2.0 | 329.2 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 5.1 | 280.2 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 6.4 | 275.1 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 2.9 | 270.9 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |