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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ
Z-value: 2.05
Motif logo
Transcription factors associated with YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
YBX1
|
ENSG00000065978.13 | Y-box binding protein 1 |
|
FOS
|
ENSG00000170345.5 | Fos proto-oncogene, AP-1 transcription factor subunit |
|
NFYC
|
ENSG00000066136.15 | nuclear transcription factor Y subunit gamma |
|
NFYA
|
ENSG00000001167.10 | nuclear transcription factor Y subunit alpha |
|
NFYB
|
ENSG00000120837.3 | nuclear transcription factor Y subunit beta |
|
CEBPZ
|
ENSG00000115816.9 | CCAAT enhancer binding protein zeta |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CEBPZ | hg19_v2_chr2_-_37458749_37458856 | 0.83 | 2.9e-56 | Click! |
| YBX1 | hg19_v2_chr1_+_43148625_43148710 | 0.78 | 1.9e-46 | Click! |
| NFYC | hg19_v2_chr1_+_41204506_41204541 | 0.69 | 5.4e-32 | Click! |
| NFYB | hg19_v2_chr12_-_104531945_104531996 | 0.54 | 4.1e-18 | Click! |
| FOS | hg19_v2_chr14_+_75745477_75745680 | -0.40 | 1.3e-09 | Click! |
| NFYA | hg19_v2_chr6_+_41040678_41040722 | -0.02 | 8.1e-01 | Click! |
Activity profile of YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ motif
Sorted Z-values of YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ motif
Network of associatons between targets according to the STRING database.
First level regulatory network of YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 114.3 | 342.9 | GO:2000775 | regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662) response to DDT(GO:0046680) histone H3-S10 phosphorylation involved in chromosome condensation(GO:2000775) |
| 104.5 | 313.6 | GO:0044878 | mitotic cytokinesis checkpoint(GO:0044878) |
| 92.5 | 740.3 | GO:0010993 | regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994) |
| 61.2 | 306.0 | GO:0016321 | female meiosis chromosome segregation(GO:0016321) |
| 54.1 | 216.5 | GO:0090579 | transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579) |
| 52.2 | 313.2 | GO:0007079 | mitotic chromosome movement towards spindle pole(GO:0007079) |
| 51.7 | 206.6 | GO:0006272 | leading strand elongation(GO:0006272) |
| 48.8 | 293.0 | GO:0014038 | regulation of Schwann cell differentiation(GO:0014038) |
| 48.0 | 383.8 | GO:0090306 | spindle assembly involved in meiosis(GO:0090306) |
| 47.8 | 334.6 | GO:0000056 | ribosomal small subunit export from nucleus(GO:0000056) |
| 47.2 | 330.7 | GO:0016128 | phytosteroid metabolic process(GO:0016128) phytosteroid biosynthetic process(GO:0016129) |
| 46.7 | 140.1 | GO:0006428 | isoleucyl-tRNA aminoacylation(GO:0006428) |
| 46.1 | 138.3 | GO:0006267 | pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299) |
| 43.6 | 740.6 | GO:0006265 | DNA topological change(GO:0006265) |
| 43.0 | 301.3 | GO:0043985 | histone H4-R3 methylation(GO:0043985) |
| 42.8 | 128.5 | GO:0090155 | negative regulation of sphingolipid biosynthetic process(GO:0090155) negative regulation of ceramide biosynthetic process(GO:1900060) |
| 35.5 | 35.5 | GO:1903405 | protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) protein localization to nucleoplasm(GO:1990173) |
| 33.0 | 165.1 | GO:0045338 | farnesyl diphosphate metabolic process(GO:0045338) |
| 33.0 | 164.9 | GO:0006398 | mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398) |
| 32.7 | 130.8 | GO:0046104 | thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125) |
| 31.7 | 380.8 | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore(GO:0051988) |
| 31.4 | 94.1 | GO:0033489 | cholesterol biosynthetic process via desmosterol(GO:0033489) cholesterol biosynthetic process via lathosterol(GO:0033490) |
| 31.3 | 156.5 | GO:0000389 | mRNA 3'-splice site recognition(GO:0000389) |
| 29.6 | 88.7 | GO:0072334 | UDP-galactose transport(GO:0015785) UDP-galactose transmembrane transport(GO:0072334) |
| 29.3 | 88.0 | GO:0021589 | hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589) |
| 28.5 | 114.1 | GO:0071163 | DNA replication preinitiation complex assembly(GO:0071163) |
| 27.3 | 54.6 | GO:0005997 | xylulose metabolic process(GO:0005997) |
| 27.0 | 81.1 | GO:0051083 | 'de novo' cotranslational protein folding(GO:0051083) |
| 25.5 | 25.5 | GO:1903181 | regulation of dopamine biosynthetic process(GO:1903179) positive regulation of dopamine biosynthetic process(GO:1903181) |
| 25.2 | 75.5 | GO:1903526 | negative regulation of membrane tubulation(GO:1903526) |
| 24.3 | 72.9 | GO:2000374 | regulation of oxygen metabolic process(GO:2000374) |
| 24.3 | 97.1 | GO:0019322 | pentose biosynthetic process(GO:0019322) |
| 24.2 | 363.3 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
| 23.7 | 47.5 | GO:0051088 | PMA-inducible membrane protein ectodomain proteolysis(GO:0051088) |
| 23.4 | 23.4 | GO:1904815 | negative regulation of protein localization to chromosome, telomeric region(GO:1904815) |
| 22.7 | 113.7 | GO:1903377 | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377) |
| 22.4 | 269.1 | GO:0035520 | monoubiquitinated protein deubiquitination(GO:0035520) |
| 22.4 | 89.5 | GO:0090296 | regulation of mitochondrial DNA replication(GO:0090296) |
| 21.5 | 364.8 | GO:0000920 | cell separation after cytokinesis(GO:0000920) |
| 21.3 | 63.8 | GO:0006435 | threonyl-tRNA aminoacylation(GO:0006435) |
| 21.1 | 105.6 | GO:0000973 | posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973) |
| 20.9 | 20.9 | GO:0031047 | gene silencing by RNA(GO:0031047) |
| 20.6 | 206.1 | GO:0061179 | negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179) |
| 20.3 | 142.1 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
| 20.0 | 20.0 | GO:0060623 | regulation of chromosome condensation(GO:0060623) |
| 19.8 | 59.4 | GO:1903926 | signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926) |
| 19.7 | 296.1 | GO:0016446 | somatic hypermutation of immunoglobulin genes(GO:0016446) |
| 19.4 | 58.3 | GO:1903630 | regulation of aminoacyl-tRNA ligase activity(GO:1903630) |
| 19.4 | 154.9 | GO:0010032 | meiotic chromosome condensation(GO:0010032) |
| 19.3 | 192.8 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 19.0 | 874.1 | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) |
| 18.9 | 94.6 | GO:0030951 | establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951) |
| 18.6 | 18.6 | GO:1904429 | regulation of t-circle formation(GO:1904429) positive regulation of t-circle formation(GO:1904431) |
| 18.3 | 55.0 | GO:0071109 | superior temporal gyrus development(GO:0071109) |
| 18.3 | 182.9 | GO:0006335 | DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723) |
| 17.4 | 104.6 | GO:0030581 | intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708) |
| 17.3 | 52.0 | GO:0006425 | glutaminyl-tRNA aminoacylation(GO:0006425) |
| 17.2 | 292.3 | GO:0090129 | positive regulation of synapse maturation(GO:0090129) |
| 16.6 | 49.9 | GO:0044210 | 'de novo' CTP biosynthetic process(GO:0044210) |
| 16.6 | 49.8 | GO:0036333 | hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772) |
| 16.5 | 33.1 | GO:0043137 | DNA replication, removal of RNA primer(GO:0043137) |
| 16.5 | 610.6 | GO:2000816 | negative regulation of mitotic sister chromatid separation(GO:2000816) |
| 16.5 | 49.5 | GO:0007290 | spermatid nucleus elongation(GO:0007290) |
| 16.3 | 162.7 | GO:0007091 | metaphase/anaphase transition of mitotic cell cycle(GO:0007091) |
| 16.2 | 81.1 | GO:0031120 | snRNA pseudouridine synthesis(GO:0031120) |
| 16.2 | 113.5 | GO:0070562 | regulation of vitamin D receptor signaling pathway(GO:0070562) |
| 16.2 | 48.5 | GO:0044209 | AMP salvage(GO:0044209) |
| 16.0 | 1022.7 | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) |
| 15.8 | 47.3 | GO:0018076 | N-terminal peptidyl-lysine acetylation(GO:0018076) |
| 15.7 | 31.5 | GO:0009211 | pyrimidine deoxyribonucleoside triphosphate metabolic process(GO:0009211) dTTP metabolic process(GO:0046075) |
| 15.7 | 47.1 | GO:1901301 | regulation of cargo loading into COPII-coated vesicle(GO:1901301) |
| 15.6 | 156.5 | GO:0015939 | pantothenate metabolic process(GO:0015939) |
| 15.6 | 78.2 | GO:0045876 | positive regulation of sister chromatid cohesion(GO:0045876) |
| 15.5 | 46.6 | GO:1904247 | positive regulation of polynucleotide adenylyltransferase activity(GO:1904247) |
| 15.5 | 93.1 | GO:0055129 | proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129) |
| 15.5 | 31.0 | GO:0009133 | ADP biosynthetic process(GO:0006172) nucleoside diphosphate biosynthetic process(GO:0009133) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180) ribonucleoside diphosphate biosynthetic process(GO:0009188) |
| 15.4 | 46.3 | GO:0048478 | replication fork protection(GO:0048478) |
| 15.4 | 184.7 | GO:0007080 | mitotic metaphase plate congression(GO:0007080) |
| 15.2 | 76.2 | GO:1904764 | late endosomal microautophagy(GO:0061738) negative regulation of fibril organization(GO:1902904) chaperone-mediated autophagy translocation complex disassembly(GO:1904764) |
| 15.2 | 1173.9 | GO:0043044 | ATP-dependent chromatin remodeling(GO:0043044) |
| 15.1 | 75.3 | GO:2000035 | regulation of stem cell division(GO:2000035) |
| 15.0 | 30.0 | GO:0035927 | RNA import into mitochondrion(GO:0035927) rRNA import into mitochondrion(GO:0035928) |
| 14.9 | 311.9 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
| 14.7 | 383.1 | GO:0032201 | telomere maintenance via semi-conservative replication(GO:0032201) |
| 14.6 | 29.2 | GO:0000912 | assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837) |
| 14.2 | 28.5 | GO:0000965 | mitochondrial RNA 3'-end processing(GO:0000965) |
| 13.9 | 55.6 | GO:2001166 | regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168) |
| 13.8 | 69.1 | GO:0002084 | protein depalmitoylation(GO:0002084) negative regulation of Golgi to plasma membrane protein transport(GO:0042997) |
| 13.7 | 123.3 | GO:0050847 | progesterone receptor signaling pathway(GO:0050847) |
| 13.6 | 40.9 | GO:0070638 | nicotinamide riboside catabolic process(GO:0006738) inosine metabolic process(GO:0046102) nicotinamide riboside metabolic process(GO:0046495) pyridine nucleoside metabolic process(GO:0070637) pyridine nucleoside catabolic process(GO:0070638) |
| 13.2 | 39.5 | GO:0006106 | fumarate metabolic process(GO:0006106) |
| 13.0 | 39.1 | GO:0070510 | regulation of histone H4-K20 methylation(GO:0070510) positive regulation of histone H4-K20 methylation(GO:0070512) |
| 12.9 | 64.4 | GO:1903588 | negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588) |
| 12.9 | 102.9 | GO:0042761 | fatty acid elongation(GO:0030497) very long-chain fatty acid biosynthetic process(GO:0042761) |
| 12.6 | 188.7 | GO:0030150 | protein import into mitochondrial matrix(GO:0030150) |
| 12.5 | 50.1 | GO:0035964 | COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205) |
| 12.2 | 48.9 | GO:0002317 | plasma cell differentiation(GO:0002317) |
| 12.1 | 12.1 | GO:0019046 | release from viral latency(GO:0019046) |
| 12.0 | 108.3 | GO:1903297 | regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903297) negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903298) |
| 12.0 | 143.6 | GO:0006388 | tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388) |
| 11.8 | 47.1 | GO:0098905 | regulation of bundle of His cell action potential(GO:0098905) |
| 11.7 | 81.8 | GO:0090224 | regulation of spindle organization(GO:0090224) |
| 11.6 | 34.9 | GO:1901355 | response to rapamycin(GO:1901355) |
| 11.6 | 81.1 | GO:0010606 | positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606) |
| 11.6 | 34.7 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
| 11.6 | 462.1 | GO:0042407 | cristae formation(GO:0042407) |
| 11.1 | 77.7 | GO:0072656 | maintenance of protein location in mitochondrion(GO:0072656) |
| 11.1 | 55.3 | GO:0006436 | tryptophanyl-tRNA aminoacylation(GO:0006436) |
| 10.7 | 85.7 | GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) |
| 10.5 | 189.4 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 10.5 | 31.5 | GO:0072237 | isoleucine catabolic process(GO:0006550) proximal convoluted tubule development(GO:0072019) metanephric proximal convoluted tubule development(GO:0072229) metanephric proximal tubule development(GO:0072237) |
| 10.3 | 51.6 | GO:0006543 | glutamine catabolic process(GO:0006543) |
| 10.3 | 615.8 | GO:0007077 | mitotic nuclear envelope disassembly(GO:0007077) |
| 10.1 | 80.7 | GO:0016139 | glycoside catabolic process(GO:0016139) |
| 10.0 | 49.9 | GO:1905098 | negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098) |
| 9.9 | 29.7 | GO:0051066 | dihydrobiopterin metabolic process(GO:0051066) |
| 9.8 | 29.5 | GO:0035087 | targeting of mRNA for destruction involved in RNA interference(GO:0030423) siRNA loading onto RISC involved in RNA interference(GO:0035087) |
| 9.8 | 108.1 | GO:2000576 | positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582) |
| 9.7 | 58.3 | GO:0043353 | enucleate erythrocyte differentiation(GO:0043353) |
| 9.5 | 47.6 | GO:2000781 | positive regulation of double-strand break repair(GO:2000781) |
| 9.5 | 37.8 | GO:0006842 | tricarboxylic acid transport(GO:0006842) citrate transport(GO:0015746) |
| 9.4 | 56.5 | GO:1903758 | regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758) |
| 9.3 | 259.9 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 9.2 | 64.6 | GO:0090650 | response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650) |
| 9.2 | 27.6 | GO:0019511 | peptidyl-proline hydroxylation(GO:0019511) |
| 9.2 | 27.6 | GO:1901873 | regulation of post-translational protein modification(GO:1901873) |
| 9.1 | 45.5 | GO:0070647 | protein modification by small protein conjugation or removal(GO:0070647) |
| 9.0 | 35.9 | GO:0071681 | response to indole-3-methanol(GO:0071680) cellular response to indole-3-methanol(GO:0071681) |
| 9.0 | 89.7 | GO:1902455 | negative regulation of stem cell population maintenance(GO:1902455) |
| 9.0 | 80.6 | GO:0006552 | leucine catabolic process(GO:0006552) |
| 8.9 | 71.1 | GO:0048194 | Golgi vesicle budding(GO:0048194) |
| 8.9 | 26.6 | GO:0021678 | fourth ventricle development(GO:0021592) third ventricle development(GO:0021678) |
| 8.9 | 70.9 | GO:2000628 | regulation of miRNA metabolic process(GO:2000628) |
| 8.7 | 26.1 | GO:0032765 | lymphotoxin A production(GO:0032641) positive regulation of mast cell cytokine production(GO:0032765) lymphotoxin A biosynthetic process(GO:0042109) |
| 8.7 | 43.4 | GO:0032380 | regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383) |
| 8.6 | 129.4 | GO:0060965 | negative regulation of gene silencing by miRNA(GO:0060965) |
| 8.6 | 333.5 | GO:0000281 | mitotic cytokinesis(GO:0000281) |
| 8.5 | 59.2 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
| 8.4 | 33.6 | GO:0010730 | negative regulation of hydrogen peroxide biosynthetic process(GO:0010730) |
| 8.4 | 386.0 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
| 8.3 | 24.8 | GO:0045658 | regulation of eosinophil differentiation(GO:0045643) positive regulation of eosinophil differentiation(GO:0045645) regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659) |
| 8.1 | 32.4 | GO:0043456 | regulation of pentose-phosphate shunt(GO:0043456) |
| 8.1 | 510.5 | GO:0032392 | DNA geometric change(GO:0032392) |
| 8.1 | 129.0 | GO:0033234 | negative regulation of protein sumoylation(GO:0033234) |
| 8.0 | 143.8 | GO:0070200 | establishment of protein localization to telomere(GO:0070200) |
| 7.9 | 71.3 | GO:0061732 | mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732) |
| 7.8 | 31.2 | GO:0031339 | negative regulation of vesicle fusion(GO:0031339) |
| 7.7 | 77.3 | GO:0002480 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480) |
| 7.7 | 23.1 | GO:0070901 | mitochondrial tRNA methylation(GO:0070901) |
| 7.7 | 46.0 | GO:0090074 | negative regulation of protein homodimerization activity(GO:0090074) |
| 7.6 | 38.2 | GO:0042816 | vitamin B6 metabolic process(GO:0042816) |
| 7.6 | 15.2 | GO:0075528 | induction by symbiont of host defense response(GO:0044416) induction of host immune response by virus(GO:0046730) active induction of host immune response by virus(GO:0046732) modulation by symbiont of host defense response(GO:0052031) induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251) modulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052255) positive regulation by symbiont of host defense response(GO:0052509) positive regulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052510) modulation by organism of immune response of other organism involved in symbiotic interaction(GO:0052552) modulation by symbiont of host immune response(GO:0052553) modulation by virus of host immune response(GO:0075528) |
| 7.6 | 189.1 | GO:0032786 | positive regulation of DNA-templated transcription, elongation(GO:0032786) |
| 7.5 | 60.4 | GO:0045723 | positive regulation of fatty acid biosynthetic process(GO:0045723) |
| 7.5 | 7.5 | GO:0090116 | C-5 methylation of cytosine(GO:0090116) |
| 7.5 | 89.7 | GO:0006449 | regulation of translational termination(GO:0006449) |
| 7.4 | 133.9 | GO:0061157 | mRNA destabilization(GO:0061157) |
| 7.4 | 52.0 | GO:0003415 | chondrocyte hypertrophy(GO:0003415) |
| 7.4 | 88.4 | GO:0071712 | ER-associated misfolded protein catabolic process(GO:0071712) |
| 7.3 | 14.6 | GO:0070314 | G1 to G0 transition(GO:0070314) |
| 7.3 | 131.8 | GO:1900363 | regulation of mRNA polyadenylation(GO:1900363) |
| 7.3 | 29.1 | GO:0070131 | positive regulation of mitochondrial translation(GO:0070131) |
| 7.2 | 28.7 | GO:0006556 | S-adenosylmethionine biosynthetic process(GO:0006556) |
| 7.0 | 105.1 | GO:0016024 | CDP-diacylglycerol biosynthetic process(GO:0016024) |
| 7.0 | 147.0 | GO:0002192 | IRES-dependent translational initiation(GO:0002192) |
| 7.0 | 14.0 | GO:0045900 | negative regulation of translational elongation(GO:0045900) |
| 6.9 | 20.7 | GO:0032773 | regulation of monophenol monooxygenase activity(GO:0032771) positive regulation of monophenol monooxygenase activity(GO:0032773) negative regulation of catagen(GO:0051796) regulation of hair cycle by canonical Wnt signaling pathway(GO:0060901) positive regulation of melanosome transport(GO:1902910) |
| 6.8 | 20.5 | GO:2000687 | negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687) |
| 6.8 | 13.5 | GO:0051295 | establishment of meiotic spindle localization(GO:0051295) |
| 6.8 | 33.8 | GO:0033591 | response to L-ascorbic acid(GO:0033591) |
| 6.8 | 33.8 | GO:0002032 | desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032) |
| 6.8 | 101.3 | GO:0043982 | histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982) |
| 6.7 | 20.2 | GO:0046900 | tetrahydrofolylpolyglutamate metabolic process(GO:0046900) |
| 6.7 | 20.0 | GO:0030860 | regulation of polarized epithelial cell differentiation(GO:0030860) |
| 6.6 | 72.7 | GO:0045835 | negative regulation of meiotic nuclear division(GO:0045835) |
| 6.6 | 26.4 | GO:0019747 | regulation of isoprenoid metabolic process(GO:0019747) |
| 6.6 | 39.6 | GO:0042866 | pyruvate biosynthetic process(GO:0042866) |
| 6.5 | 39.3 | GO:2000324 | positive regulation of glucocorticoid receptor signaling pathway(GO:2000324) |
| 6.5 | 26.0 | GO:0008616 | queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116) |
| 6.4 | 19.3 | GO:0006258 | UDP-glucose catabolic process(GO:0006258) galactose catabolic process via UDP-galactose(GO:0033499) |
| 6.4 | 460.5 | GO:1902653 | cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653) |
| 6.4 | 25.4 | GO:0072367 | regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) |
| 6.3 | 31.5 | GO:0031507 | heterochromatin assembly(GO:0031507) |
| 6.3 | 6.3 | GO:0051595 | response to methylglyoxal(GO:0051595) |
| 6.3 | 31.4 | GO:0051490 | negative regulation of filopodium assembly(GO:0051490) |
| 6.3 | 162.7 | GO:0072663 | protein targeting to peroxisome(GO:0006625) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663) |
| 6.2 | 236.3 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 6.2 | 18.5 | GO:0039534 | negative regulation of MDA-5 signaling pathway(GO:0039534) |
| 6.2 | 18.5 | GO:0030327 | prenylated protein catabolic process(GO:0030327) |
| 6.2 | 135.7 | GO:0006465 | signal peptide processing(GO:0006465) |
| 6.2 | 43.1 | GO:0090343 | positive regulation of cell aging(GO:0090343) positive regulation of cellular senescence(GO:2000774) |
| 6.1 | 6.1 | GO:0040031 | snRNA modification(GO:0040031) |
| 6.1 | 24.3 | GO:0002880 | chronic inflammatory response to non-antigenic stimulus(GO:0002545) regulation of chronic inflammatory response to non-antigenic stimulus(GO:0002880) |
| 6.0 | 6.0 | GO:0006286 | base-excision repair, base-free sugar-phosphate removal(GO:0006286) |
| 6.0 | 23.9 | GO:0017198 | N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920) |
| 6.0 | 29.8 | GO:1990834 | response to odorant(GO:1990834) |
| 5.9 | 41.5 | GO:2001032 | regulation of double-strand break repair via nonhomologous end joining(GO:2001032) |
| 5.9 | 52.9 | GO:0009113 | purine nucleobase biosynthetic process(GO:0009113) |
| 5.8 | 5.8 | GO:0042118 | endothelial cell activation(GO:0042118) |
| 5.8 | 23.2 | GO:1903288 | positive regulation of potassium ion import(GO:1903288) |
| 5.7 | 109.1 | GO:0070911 | global genome nucleotide-excision repair(GO:0070911) |
| 5.7 | 5.7 | GO:0061031 | endodermal digestive tract morphogenesis(GO:0061031) |
| 5.6 | 311.8 | GO:0018279 | protein N-linked glycosylation via asparagine(GO:0018279) |
| 5.6 | 22.3 | GO:0048496 | maintenance of organ identity(GO:0048496) |
| 5.6 | 22.2 | GO:0072308 | negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of nephron tubule epithelial cell differentiation(GO:0072183) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308) negative regulation of epithelial cell differentiation involved in kidney development(GO:2000697) |
| 5.5 | 160.9 | GO:0006301 | postreplication repair(GO:0006301) |
| 5.5 | 16.6 | GO:0002731 | negative regulation of dendritic cell cytokine production(GO:0002731) negative regulation of intracellular transport of viral material(GO:1901253) |
| 5.5 | 16.6 | GO:0042369 | vitamin D catabolic process(GO:0042369) |
| 5.5 | 22.1 | GO:2000042 | negative regulation of double-strand break repair via homologous recombination(GO:2000042) |
| 5.5 | 33.1 | GO:0006499 | N-terminal protein myristoylation(GO:0006499) |
| 5.5 | 121.2 | GO:0048025 | negative regulation of mRNA splicing, via spliceosome(GO:0048025) |
| 5.4 | 16.3 | GO:1902303 | regulation of heart rate by hormone(GO:0003064) negative regulation of potassium ion export(GO:1902303) |
| 5.3 | 10.6 | GO:0035166 | post-embryonic hemopoiesis(GO:0035166) |
| 5.3 | 21.2 | GO:0097680 | double-strand break repair via classical nonhomologous end joining(GO:0097680) |
| 5.3 | 21.2 | GO:0060751 | epithelial cell proliferation involved in mammary gland duct elongation(GO:0060750) branch elongation involved in mammary gland duct branching(GO:0060751) |
| 5.2 | 36.5 | GO:2000074 | regulation of type B pancreatic cell development(GO:2000074) |
| 5.2 | 36.4 | GO:0042791 | 5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797) |
| 5.2 | 15.5 | GO:1902031 | regulation of NADP metabolic process(GO:1902031) |
| 5.1 | 15.3 | GO:0043095 | regulation of GTP cyclohydrolase I activity(GO:0043095) negative regulation of GTP cyclohydrolase I activity(GO:0043105) |
| 5.1 | 71.4 | GO:0046602 | regulation of mitotic centrosome separation(GO:0046602) |
| 5.1 | 15.3 | GO:0072282 | metanephric nephron tubule morphogenesis(GO:0072282) |
| 5.0 | 5.0 | GO:0036506 | maintenance of unfolded protein(GO:0036506) maintenance of unfolded protein involved in ERAD pathway(GO:1904378) |
| 5.0 | 65.4 | GO:0043248 | proteasome assembly(GO:0043248) |
| 5.0 | 24.9 | GO:0033299 | secretion of lysosomal enzymes(GO:0033299) |
| 5.0 | 34.8 | GO:0031936 | negative regulation of chromatin silencing(GO:0031936) |
| 5.0 | 19.8 | GO:1903224 | regulation of endodermal cell differentiation(GO:1903224) |
| 4.9 | 34.4 | GO:0097577 | intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577) |
| 4.9 | 9.8 | GO:0002331 | pre-B cell differentiation(GO:0002329) pre-B cell allelic exclusion(GO:0002331) |
| 4.9 | 38.9 | GO:0032417 | positive regulation of sodium:proton antiporter activity(GO:0032417) |
| 4.8 | 48.5 | GO:0071578 | zinc II ion transmembrane import(GO:0071578) |
| 4.8 | 23.8 | GO:0003069 | age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571) |
| 4.7 | 14.2 | GO:0051305 | chromosome movement towards spindle pole(GO:0051305) |
| 4.7 | 9.4 | GO:1901503 | ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503) |
| 4.7 | 42.3 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 4.7 | 56.3 | GO:0006107 | oxaloacetate metabolic process(GO:0006107) |
| 4.7 | 271.9 | GO:0006342 | chromatin silencing(GO:0006342) |
| 4.5 | 340.9 | GO:0042632 | cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092) |
| 4.4 | 22.2 | GO:0009438 | methylglyoxal metabolic process(GO:0009438) |
| 4.4 | 13.3 | GO:0016260 | selenocysteine biosynthetic process(GO:0016260) |
| 4.4 | 17.7 | GO:0060762 | regulation of branching involved in mammary gland duct morphogenesis(GO:0060762) |
| 4.4 | 8.8 | GO:0006864 | pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519) |
| 4.4 | 22.1 | GO:0072385 | minus-end-directed organelle transport along microtubule(GO:0072385) |
| 4.4 | 8.8 | GO:1903626 | positive regulation of DNA catabolic process(GO:1903626) |
| 4.4 | 26.2 | GO:0000290 | deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290) |
| 4.4 | 56.7 | GO:0019054 | modulation by virus of host process(GO:0019054) |
| 4.3 | 260.0 | GO:0051439 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) |
| 4.3 | 34.0 | GO:0006689 | ganglioside catabolic process(GO:0006689) |
| 4.2 | 63.5 | GO:0000338 | protein deneddylation(GO:0000338) |
| 4.2 | 274.1 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 4.2 | 29.4 | GO:0060155 | platelet dense granule organization(GO:0060155) |
| 4.1 | 12.4 | GO:0072719 | cellular response to cisplatin(GO:0072719) |
| 4.1 | 24.8 | GO:0048096 | chromatin-mediated maintenance of transcription(GO:0048096) |
| 4.1 | 28.9 | GO:0010507 | negative regulation of autophagy(GO:0010507) |
| 4.1 | 93.7 | GO:0030214 | hyaluronan catabolic process(GO:0030214) |
| 4.0 | 36.3 | GO:0045008 | depyrimidination(GO:0045008) |
| 4.0 | 40.2 | GO:1900034 | regulation of cellular response to heat(GO:1900034) |
| 4.0 | 20.0 | GO:0000733 | DNA strand renaturation(GO:0000733) |
| 4.0 | 12.0 | GO:0006627 | protein processing involved in protein targeting to mitochondrion(GO:0006627) |
| 4.0 | 43.8 | GO:1903800 | regulation of production of small RNA involved in gene silencing by RNA(GO:0070920) regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903798) positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800) |
| 4.0 | 43.8 | GO:0006337 | nucleosome disassembly(GO:0006337) |
| 3.9 | 15.7 | GO:0007144 | female meiosis I(GO:0007144) |
| 3.9 | 62.7 | GO:1903540 | neurotransmitter receptor transport to plasma membrane(GO:0098877) neurotransmitter receptor transport to postsynaptic membrane(GO:0098969) establishment of protein localization to postsynaptic membrane(GO:1903540) |
| 3.9 | 19.5 | GO:0030047 | actin modification(GO:0030047) |
| 3.8 | 61.2 | GO:0051639 | actin filament network formation(GO:0051639) |
| 3.8 | 30.5 | GO:0009249 | protein lipoylation(GO:0009249) |
| 3.8 | 3.8 | GO:1990144 | intrinsic apoptotic signaling pathway in response to hypoxia(GO:1990144) |
| 3.8 | 18.9 | GO:0051299 | mitotic centrosome separation(GO:0007100) centrosome separation(GO:0051299) |
| 3.8 | 60.6 | GO:0042113 | B cell activation(GO:0042113) |
| 3.8 | 135.7 | GO:0006656 | phosphatidylcholine biosynthetic process(GO:0006656) |
| 3.8 | 75.0 | GO:0035855 | megakaryocyte development(GO:0035855) |
| 3.7 | 30.0 | GO:0017183 | peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183) |
| 3.7 | 7.4 | GO:0007023 | post-chaperonin tubulin folding pathway(GO:0007023) |
| 3.7 | 22.0 | GO:0070836 | caveola assembly(GO:0070836) |
| 3.7 | 3.7 | GO:0031291 | Ran protein signal transduction(GO:0031291) |
| 3.6 | 50.8 | GO:0006703 | estrogen biosynthetic process(GO:0006703) |
| 3.6 | 3.6 | GO:2000465 | regulation of glycogen (starch) synthase activity(GO:2000465) positive regulation of glycogen (starch) synthase activity(GO:2000467) |
| 3.6 | 10.8 | GO:0043132 | FAD transport(GO:0015883) FAD transmembrane transport(GO:0035350) NAD transport(GO:0043132) |
| 3.6 | 180.3 | GO:1900739 | regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740) |
| 3.6 | 25.1 | GO:0006564 | L-serine biosynthetic process(GO:0006564) |
| 3.5 | 56.0 | GO:0032802 | low-density lipoprotein particle receptor catabolic process(GO:0032802) |
| 3.5 | 10.5 | GO:0034982 | mitochondrial protein processing(GO:0034982) |
| 3.4 | 10.3 | GO:0051135 | positive regulation of NK T cell activation(GO:0051135) |
| 3.4 | 51.2 | GO:0045116 | protein neddylation(GO:0045116) |
| 3.4 | 249.1 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 3.4 | 6.8 | GO:0090427 | activation of meiosis(GO:0090427) |
| 3.4 | 70.7 | GO:0006750 | glutathione biosynthetic process(GO:0006750) |
| 3.2 | 45.1 | GO:0070389 | chaperone cofactor-dependent protein refolding(GO:0070389) |
| 3.2 | 12.7 | GO:0014894 | response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) |
| 3.2 | 22.2 | GO:0061099 | negative regulation of protein tyrosine kinase activity(GO:0061099) |
| 3.1 | 6.2 | GO:0046449 | creatinine metabolic process(GO:0046449) |
| 3.1 | 9.3 | GO:0002326 | B cell lineage commitment(GO:0002326) immunoglobulin V(D)J recombination(GO:0033152) |
| 3.0 | 6.0 | GO:0070541 | response to platinum ion(GO:0070541) |
| 3.0 | 33.0 | GO:0032876 | negative regulation of DNA endoreduplication(GO:0032876) |
| 3.0 | 33.0 | GO:0006370 | 7-methylguanosine mRNA capping(GO:0006370) |
| 3.0 | 211.1 | GO:0045454 | cell |