ISMARA results: ZNF274

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for ZNF274

Z-value: 1.04

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Transcription factors associated with ZNF274

Gene Symbol	Gene ID	Gene Info
ZNF274 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000171606.13	zinc finger protein 274

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
ZNF274	hg19_v2_chr19_+_58694396_58694485	0.40	1.0e-09	Click!

Activity profile of ZNF274 motif

Sorted Z-values of ZNF274 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chrX_+_119737806 Show fit	18.15	ENST00000371317.5	MCTS1 Ensembl NCBI GeneCards UniProt NextProt Show fit	malignant T cell amplified sequence 1
chr5_+_32531893 Show fit	16.05	ENST00000512913.1	SUB1 Ensembl NCBI GeneCards UniProt NextProt Show fit	SUB1 homolog (S. cerevisiae)
chr18_+_9103957 Show fit	15.47	ENST00000400033.1	NDUFV2 Ensembl NCBI GeneCards UniProt NextProt Show fit	NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa
chr12_-_54653313 Show fit	14.24	ENST00000550411.1 ENST00000439541.2	CBX5 Ensembl NCBI GeneCards UniProt NextProt Show fit	chromobox homolog 5
chr1_+_45205498 Show fit	13.68	ENST00000372218.4	KIF2C Ensembl NCBI GeneCards UniProt NextProt Show fit	kinesin family member 2C
chr11_+_16760161 Show fit	13.51	ENST00000524439.1 ENST00000422258.2 ENST00000528634.1 ENST00000525684.1	C11orf58 Ensembl NCBI GeneCards UniProt NextProt Show fit	chromosome 11 open reading frame 58
chr1_+_45205478 Show fit	13.17	ENST00000452259.1 ENST00000372224.4	KIF2C Ensembl NCBI GeneCards UniProt NextProt Show fit	kinesin family member 2C
chr16_+_29819096 Show fit	11.69	ENST00000568411.1 ENST00000563012.1 ENST00000562557.1	MAZ Ensembl NCBI GeneCards UniProt NextProt Show fit	MYC-associated zinc finger protein (purine-binding transcription factor)
chr2_-_96971259 Show fit	10.72	ENST00000349783.5	SNRNP200 Ensembl NCBI GeneCards UniProt NextProt Show fit	small nuclear ribonucleoprotein 200kDa (U5)
chr12_+_113344755 Show fit	10.71	ENST00000550883.1	OAS1 Ensembl NCBI GeneCards UniProt NextProt Show fit	2'-5'-oligoadenylate synthetase 1, 40/46kDa

Showing 1 to 10 of 35 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF274

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	37.4	GO:0006369	termination of RNA polymerase II transcription(GO:0006369)
2.7	26.9	GO:0030951	establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
6.1	18.2	GO:0002188	translation reinitiation(GO:0002188)
0.4	16.0	GO:0060261	positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261)
0.2	15.5	GO:0006120	mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0	14.2	GO:0007596	blood coagulation(GO:0007596)
3.6	10.7	GO:0000354	cis assembly of pre-catalytic spliceosome(GO:0000354)
0.3	10.7	GO:0015986	energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1	10.7	GO:0045071	negative regulation of viral genome replication(GO:0045071)
0.1	9.9	GO:0042267	natural killer cell mediated cytotoxicity(GO:0042267)

Showing 1 to 10 of 25 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	26.9	GO:0035371	microtubule plus-end(GO:0035371)
0.2	18.2	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
3.1	15.5	GO:0045272	plasma membrane respiratory chain complex I(GO:0045272)
1.0	14.2	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.0	11.7	GO:0005667	transcription factor complex(GO:0005667)
0.6	10.7	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.4	10.7	GO:0005682	U5 snRNP(GO:0005682)
0.7	9.9	GO:0005641	nuclear envelope lumen(GO:0005641)
0.2	4.0	GO:0097225	sperm midpiece(GO:0097225)
0.1	3.0	GO:0031254	uropod(GO:0001931) cell trailing edge(GO:0031254)

Showing 1 to 10 of 13 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	37.4	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
2.7	26.9	GO:0019237	centromeric DNA binding(GO:0019237)
0.2	18.2	GO:0003743	translation initiation factor activity(GO:0003743)
0.3	16.0	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.7	15.5	GO:0051537	2 iron, 2 sulfur cluster binding(GO:0051537)
0.2	14.2	GO:0035064	methylated histone binding(GO:0035064)
1.1	10.7	GO:0001730	2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.4	10.7	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1	10.7	GO:0004004	ATP-dependent RNA helicase activity(GO:0004004)
0.5	9.9	GO:0032794	GTPase activating protein binding(GO:0032794)

Showing 1 to 10 of 20 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	41.1	PID AURORA B PATHWAY	Aurora B signaling
0.1	4.7	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.1	3.7	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.2	3.0	PID S1P S1P4 PATHWAY	S1P4 pathway

Showing 1 to 4 of 4 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	26.9	REACTOME KINESINS	Genes involved in Kinesins
0.2	15.5	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.1	14.2	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.2	10.7	REACTOME MRNA SPLICING MINOR PATHWAY	Genes involved in mRNA Splicing - Minor Pathway
0.1	10.7	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.1	9.9	REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES	Genes involved in Loss of Nlp from mitotic centrosomes
0.1	4.7	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.2	3.0	REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY	Genes involved in Adenylate cyclase inhibitory pathway
0.0	1.4	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.1	1.2	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE

Showing 1 to 10 of 10 entries

Results for ZNF274

Z-value: 1.04

Motif logo

Transcription factors associated with ZNF274

Activity-expression correlation:

Activity profile of ZNF274 motif

Sorted Z-values of ZNF274 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF274

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: