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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for ZNF784
Z-value: 1.76
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Transcription factors associated with ZNF784
Network of associatons between targets according to the STRING database.
First level regulatory network of ZNF784
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.5 | 159.7 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 10.4 | 82.9 | GO:0060075 | regulation of resting membrane potential(GO:0060075) |
| 14.5 | 72.4 | GO:0051945 | negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) regulation of peroxidase activity(GO:2000468) positive regulation of peroxidase activity(GO:2000470) |
| 2.0 | 61.3 | GO:0050650 | chondroitin sulfate proteoglycan biosynthetic process(GO:0050650) |
| 19.9 | 59.8 | GO:2000097 | regulation of smooth muscle cell-matrix adhesion(GO:2000097) |
| 15.6 | 46.7 | GO:0050760 | negative regulation of thymidylate synthase biosynthetic process(GO:0050760) |
| 3.8 | 45.5 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 5.4 | 43.5 | GO:0014049 | positive regulation of glutamate secretion(GO:0014049) |
| 10.7 | 42.9 | GO:0030185 | nitric oxide transport(GO:0030185) |
| 0.6 | 41.7 | GO:0007602 | phototransduction(GO:0007602) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 31.4 | 156.9 | GO:0098843 | postsynaptic endocytic zone(GO:0098843) |
| 11.8 | 82.9 | GO:0044326 | dendritic spine neck(GO:0044326) |
| 2.3 | 72.1 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.1 | 71.8 | GO:0043025 | neuronal cell body(GO:0043025) |
| 0.4 | 51.6 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.0 | 49.7 | GO:0016021 | integral component of membrane(GO:0016021) |
| 7.1 | 49.5 | GO:1990761 | growth cone lamellipodium(GO:1990761) |
| 3.2 | 45.5 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.5 | 44.7 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 3.6 | 43.5 | GO:0043203 | axon hillock(GO:0043203) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 13.1 | 156.9 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 5.9 | 82.9 | GO:1990239 | steroid hormone binding(GO:1990239) |
| 14.5 | 72.4 | GO:0060961 | phospholipase D inhibitor activity(GO:0060961) |
| 0.7 | 69.2 | GO:0005518 | collagen binding(GO:0005518) |
| 1.1 | 59.8 | GO:0015485 | cholesterol binding(GO:0015485) |
| 4.1 | 57.9 | GO:0048156 | tau protein binding(GO:0048156) |
| 1.6 | 57.0 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.5 | 55.8 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 7.1 | 42.9 | GO:0030492 | hemoglobin binding(GO:0030492) |
| 13.7 | 41.0 | GO:0015018 | galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 156.9 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.4 | 75.7 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 1.0 | 72.4 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 1.2 | 68.1 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.4 | 46.7 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.2 | 31.6 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 21.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.8 | 18.9 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.2 | 14.5 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.6 | 11.9 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.5 | 156.9 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 2.3 | 86.4 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 1.5 | 82.9 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.8 | 75.2 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.3 | 56.4 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.9 | 29.1 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.1 | 21.1 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.2 | 20.8 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 1.1 | 20.5 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.6 | 17.5 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |