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Epithelial-Mesenchymal Transition, human (Scheel, 2011): : averaged replicates

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ISMARA results Epithelial-Mesenchymal Transition, human (Scheel, 2011): : averaged replicates

ISMARA - Integrated System for Motif Actitivity Response Analysis is a free online tool that recognizes most important transcription factors that are changing their activity in a set of samples.

Original results

Sample Condition
01_GSM710379_01_HMLE-24hi_a Epithelial
02_GSM710383_05_HMLE-24hi_b Epithelial
03_GSM710380_02_HMLE-msp1_a Mesenchymal
04_GSM710381_03_HMLE-msp2_a Mesenchymal
05_GSM710382_04_HMLE-msp3_a Mesenchymal
06_GSM710384_06_HMLE-msp1_b Mesenchymal
07_GSM710385_07_HMLE-msp2_b Mesenchymal
08_GSM710386_08_HMLE-msp3_b Mesenchymal

All motifs sorted by activity significance

Motif name Z-value Associated genes Profile Logo
ZEB1 12.40 small profile SeqLogo of ZEB1
ID4_TCF4_SNAI2 4.78 small profile SeqLogo of ID4_TCF4_SNAI2
MXI1_MYC_MYCN 4.03 small profile SeqLogo of MXI1_MYC_MYCN
TFAP2C 3.53 small profile SeqLogo of TFAP2C
HOXB6_PRRX2 3.39 small profile SeqLogo of HOXB6_PRRX2
IKZF1 3.28 small profile SeqLogo of IKZF1
FOSL1 3.25 small profile SeqLogo of FOSL1
ELK4_ETV5_ELK1_ELK3_ELF4 3.22 small profile SeqLogo of ELK4_ETV5_ELK1_ELK3_ELF4
KLF1 3.18 small profile SeqLogo of KLF1
TWIST1_SNAI1 3.09 small profile SeqLogo of TWIST1_SNAI1
CCCUGAG 2.84 small profile SeqLogo of CCCUGAG
MLX_USF2_USF1_PAX2 2.82 small profile SeqLogo of MLX_USF2_USF1_PAX2
BARHL1 2.72 small profile SeqLogo of BARHL1
MEIS2 2.65 small profile SeqLogo of MEIS2
ETV2 2.60 small profile SeqLogo of ETV2
WRNIP1 2.54 small profile SeqLogo of WRNIP1
TAF1 2.50 small profile SeqLogo of TAF1
ATF6 2.48 small profile SeqLogo of ATF6
SIN3A_CHD1 2.48 small profile SeqLogo of SIN3A_CHD1
AGCAGCA 2.47 small profile SeqLogo of AGCAGCA
LEF1 2.41 small profile SeqLogo of LEF1
HOXB8 2.37 small profile SeqLogo of HOXB8
HINFP 2.35 small profile SeqLogo of HINFP
RARG 2.33 small profile SeqLogo of RARG
AGCAGCG 2.30 small profile SeqLogo of AGCAGCG
CUX1 2.25 small profile SeqLogo of CUX1
EPAS1_BCL3 2.21 small profile SeqLogo of EPAS1_BCL3
IRF7 2.19 small profile SeqLogo of IRF7
NR0B1 2.12 small profile SeqLogo of NR0B1
NRF1 2.07 small profile SeqLogo of NRF1
MYBL1 2.05 small profile SeqLogo of MYBL1
HOXB3 2.04 small profile SeqLogo of HOXB3
HSF1 2.04 small profile SeqLogo of HSF1
AGCACCA 2.04 small profile SeqLogo of AGCACCA
GLI3 2.03 small profile SeqLogo of GLI3
SRF 2.02 small profile SeqLogo of SRF
AGUGCAA 2.02 small profile SeqLogo of AGUGCAA
CEBPA 2.02 small profile SeqLogo of CEBPA
TCF3_MYOG 2.01 small profile SeqLogo of TCF3_MYOG
NFATC4 2.01 small profile SeqLogo of NFATC4
HIVEP1 1.95 small profile SeqLogo of HIVEP1
TFAP2B 1.91 small profile SeqLogo of TFAP2B
E2F3 1.86 small profile SeqLogo of E2F3
MAZ_ZNF281_GTF2F1 1.86 small profile SeqLogo of MAZ_ZNF281_GTF2F1
HOXC9 1.85 small profile SeqLogo of HOXC9
NR2E1 1.85 small profile SeqLogo of NR2E1
FOSB 1.85 small profile SeqLogo of FOSB
MAFB 1.80 small profile SeqLogo of MAFB
NR2E3 1.79 small profile SeqLogo of NR2E3
ELF3_EHF 1.78 small profile SeqLogo of ELF3_EHF
OLIG3_NEUROD2_NEUROG2 1.77 small profile SeqLogo of OLIG3_NEUROD2_NEUROG2
RARB 1.77 small profile SeqLogo of RARB
STAT1_STAT3_BCL6 1.76 small profile SeqLogo of STAT1_STAT3_BCL6
AAUACUG 1.76 small profile SeqLogo of AAUACUG
MAFK 1.74 small profile SeqLogo of MAFK
GGAAUGU 1.74 small profile SeqLogo of GGAAUGU
ZBTB33_CHD2 1.74 small profile SeqLogo of ZBTB33_CHD2
ESRRB_ESRRG 1.74 small profile SeqLogo of ESRRB_ESRRG
UUGGUCC 1.70 small profile SeqLogo of UUGGUCC
TGIF1 1.68 small profile SeqLogo of TGIF1
FOXK1_FOXP2_FOXB1_FOXP3 1.68 small profile SeqLogo of FOXK1_FOXP2_FOXB1_FOXP3
ESRRA_ESR2 1.68 small profile SeqLogo of ESRRA_ESR2
TP63 1.68 small profile SeqLogo of TP63
TBP 1.67 small profile SeqLogo of TBP
PRRX1_ALX4_PHOX2A 1.67 small profile SeqLogo of PRRX1_ALX4_PHOX2A
GLI2 1.66 small profile SeqLogo of GLI2
YY1_YY2 1.64 small profile SeqLogo of YY1_YY2
MEIS1 1.63 small profile SeqLogo of MEIS1
CXXC1 1.62 small profile SeqLogo of CXXC1
XBP1 1.61 small profile SeqLogo of XBP1
HOXA5 1.61 small profile SeqLogo of HOXA5
GATA2 1.60 small profile SeqLogo of GATA2
FOSL2_SMARCC1 1.59 small profile SeqLogo of FOSL2_SMARCC1
AHR_ARNT2 1.57 small profile SeqLogo of AHR_ARNT2
HES1 1.57 small profile SeqLogo of HES1
STAT5B 1.57 small profile SeqLogo of STAT5B
AUUGCAC 1.56 small profile SeqLogo of AUUGCAC
TP53 1.56 small profile SeqLogo of TP53
BHLHE22_BHLHA15_BHLHE23 1.55 small profile SeqLogo of BHLHE22_BHLHA15_BHLHE23
SPIB 1.55 small profile SeqLogo of SPIB
GRHL1 1.53 small profile SeqLogo of GRHL1
FOXL1 1.53 small profile SeqLogo of FOXL1
UGGUCCC 1.53 small profile SeqLogo of UGGUCCC
SPIC 1.52 small profile SeqLogo of SPIC
ZBTB6 1.51 small profile SeqLogo of ZBTB6
ALX3 1.48 small profile SeqLogo of ALX3
PAX6 1.48 small profile SeqLogo of PAX6
FOXO3_FOXD2 1.46 small profile SeqLogo of FOXO3_FOXD2
MZF1 1.46 small profile SeqLogo of MZF1
GATA1_GATA4 1.46 small profile SeqLogo of GATA1_GATA4
PRDM1 1.45 small profile SeqLogo of PRDM1
ARID3A 1.45 small profile SeqLogo of ARID3A
GCUACAU 1.45 small profile SeqLogo of GCUACAU
MECOM 1.44 small profile SeqLogo of MECOM
NKX2-6 1.43 small profile SeqLogo of NKX2-6
SPI1 1.43 small profile SeqLogo of SPI1
CUX2 1.42 small profile SeqLogo of CUX2
YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ 1.39 small profile SeqLogo of YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ
SMAD1 1.38 small profile SeqLogo of SMAD1
CEBPE_CEBPD 1.36 small profile SeqLogo of CEBPE_CEBPD
NKX3-2 1.36 small profile SeqLogo of NKX3-2
IKZF2 1.36 small profile SeqLogo of IKZF2
MBD2 1.36 small profile SeqLogo of MBD2
POU3F2 1.36 small profile SeqLogo of POU3F2
ZNF143 1.35 small profile SeqLogo of ZNF143
DPRX 1.34 small profile SeqLogo of DPRX
MIXL1_GSX1_BSX_MEOX2_LHX4 1.34 small profile SeqLogo of MIXL1_GSX1_BSX_MEOX2_LHX4
TFAP4_MSC 1.34 small profile SeqLogo of TFAP4_MSC
MAFF_MAFG 1.34 small profile SeqLogo of MAFF_MAFG
SOX8 1.33 small profile SeqLogo of SOX8
NR5A2 1.32 small profile SeqLogo of NR5A2
TBX21_TBR1 1.31 small profile SeqLogo of TBX21_TBR1
ZNF691 1.30 small profile SeqLogo of ZNF691
UCCAGUU 1.30 small profile SeqLogo of UCCAGUU
MSX1 1.29 small profile SeqLogo of MSX1
AIRE 1.28 small profile SeqLogo of AIRE
TBX1 1.28 small profile SeqLogo of TBX1
ZBTB12 1.27 small profile SeqLogo of ZBTB12
GZF1 1.26 small profile SeqLogo of GZF1
AACACUG 1.25 small profile SeqLogo of AACACUG
NKX1-2_RAX 1.25 small profile SeqLogo of NKX1-2_RAX
IRF6_IRF4_IRF5 1.25 small profile SeqLogo of IRF6_IRF4_IRF5
NFATC2_NFATC3 1.24 small profile SeqLogo of NFATC2_NFATC3
NHLH1 1.24 small profile SeqLogo of NHLH1
FOXO4 1.24 small profile SeqLogo of FOXO4
EBF3 1.22 small profile SeqLogo of EBF3
CDX2 1.22 small profile SeqLogo of CDX2
NFATC1 1.21 small profile SeqLogo of NFATC1
HOXB4_LHX9 1.21 small profile SeqLogo of HOXB4_LHX9
THRA_RXRB 1.20 small profile SeqLogo of THRA_RXRB
ZBTB16 1.20 small profile SeqLogo of ZBTB16
DBP 1.19 small profile SeqLogo of DBP
HIC2 1.19 small profile SeqLogo of HIC2
NFE2L1 1.18 small profile SeqLogo of NFE2L1
SOX17 1.17 small profile SeqLogo of SOX17
RFX3_RFX2 1.16 small profile SeqLogo of RFX3_RFX2
NR1I3 1.14 small profile SeqLogo of NR1I3
SOX10_SOX15 1.14 small profile SeqLogo of SOX10_SOX15
IRF9 1.13 small profile SeqLogo of IRF9
PBX1 1.12 small profile SeqLogo of PBX1
INSM1 1.12 small profile SeqLogo of INSM1
AACAGUC 1.11 small profile SeqLogo of AACAGUC
IRX3 1.11 small profile SeqLogo of IRX3
E4F1 1.10 small profile SeqLogo of E4F1
PAX7_NOBOX 1.10 small profile SeqLogo of PAX7_NOBOX
E2F6 1.10 small profile SeqLogo of E2F6
PBX3 1.10 small profile SeqLogo of PBX3
GUAGUGU 1.09 small profile SeqLogo of GUAGUGU
JDP2 1.09 small profile SeqLogo of JDP2
ZNF711_TFAP2A_TFAP2D 1.08 small profile SeqLogo of ZNF711_TFAP2A_TFAP2D
IRF3 1.08 small profile SeqLogo of IRF3
ERG 1.08 small profile SeqLogo of ERG
ZIC1 1.08 small profile SeqLogo of ZIC1
MECP2 1.08 small profile SeqLogo of MECP2
TCF12_ASCL2 1.07 small profile SeqLogo of TCF12_ASCL2
MEF2B 1.06 small profile SeqLogo of MEF2B
FOXA2_FOXJ3 1.04 small profile SeqLogo of FOXA2_FOXJ3
SHOX2_HOXC5 1.04 small profile SeqLogo of SHOX2_HOXC5
FOXA1 1.02 small profile SeqLogo of FOXA1
CREB3L2 1.01 small profile SeqLogo of CREB3L2
HOXC12_HOXD12 1.01 small profile SeqLogo of HOXC12_HOXD12
GCAGCAU 1.00 small profile SeqLogo of GCAGCAU
UAAGGCA 1.00 small profile SeqLogo of UAAGGCA
OLIG2_NEUROD1_ATOH1 1.00 small profile SeqLogo of OLIG2_NEUROD1_ATOH1
SP3 0.99 small profile SeqLogo of SP3
DUXA 0.98 small profile SeqLogo of DUXA
HOXC8 0.98 small profile SeqLogo of HOXC8
ZNF740_ZNF219 0.96 small profile SeqLogo of ZNF740_ZNF219
SIX5_SMARCC2_HCFC1 0.95 small profile SeqLogo of SIX5_SMARCC2_HCFC1
PRDM14 0.95 small profile SeqLogo of PRDM14
MAFA 0.95 small profile SeqLogo of MAFA
TBX20 0.95 small profile SeqLogo of TBX20
PGR 0.94 small profile SeqLogo of PGR
REL 0.94 small profile SeqLogo of REL
TBX19 0.94 small profile SeqLogo of TBX19
UCACAUU 0.93 small profile SeqLogo of UCACAUU
HOXA4 0.93 small profile SeqLogo of HOXA4
AAAGUGC 0.92 small profile SeqLogo of AAAGUGC
OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4 0.91 small profile SeqLogo of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4
GAUUGUC 0.91 small profile SeqLogo of GAUUGUC
BATF 0.89 small profile SeqLogo of BATF
OSR1_OSR2 0.89 small profile SeqLogo of OSR1_OSR2
SHOX 0.88 small profile SeqLogo of SHOX
EP300 0.87 small profile SeqLogo of EP300
SP4_PML 0.87 small profile SeqLogo of SP4_PML
NANOG 0.86 small profile SeqLogo of NANOG
MYBL2 0.86 small profile SeqLogo of MYBL2
OLIG1 0.86 small profile SeqLogo of OLIG1
ETV6 0.86 small profile SeqLogo of ETV6
TFEC_MITF_ARNTL_BHLHE41 0.86 small profile SeqLogo of TFEC_MITF_ARNTL_BHLHE41
GGAAGAC 0.85 small profile SeqLogo of GGAAGAC
FUBP1 0.85 small profile SeqLogo of FUBP1
TLX2 0.85 small profile SeqLogo of TLX2
NR1H2 0.85 small profile SeqLogo of NR1H2
RFX7_RFX4_RFX1 0.85 small profile SeqLogo of RFX7_RFX4_RFX1
EVX2 0.83 small profile SeqLogo of EVX2
HOXD1 0.83 small profile SeqLogo of HOXD1
HOXB7 0.83 small profile SeqLogo of HOXB7
BARHL2 0.82 small profile SeqLogo of BARHL2
AAGGCAC 0.82 small profile SeqLogo of AAGGCAC
CDC5L 0.82 small profile SeqLogo of CDC5L
TBX5 0.82 small profile SeqLogo of TBX5
EMX2 0.81 small profile SeqLogo of EMX2
FOXQ1 0.81 small profile SeqLogo of FOXQ1
ZBTB18 0.81 small profile SeqLogo of ZBTB18
RXRG 0.81 small profile SeqLogo of RXRG
RUNX3_BCL11A 0.81 small profile SeqLogo of RUNX3_BCL11A
ELF2_GABPA_ELF5 0.81 small profile SeqLogo of ELF2_GABPA_ELF5
HOXD10 0.80 small profile SeqLogo of HOXD10
NR1H4 0.79 small profile SeqLogo of NR1H4
LHX8 0.79 small profile SeqLogo of LHX8
MYB 0.79 small profile SeqLogo of MYB
GCM1 0.79 small profile SeqLogo of GCM1
HDX 0.78 small profile SeqLogo of HDX
UAGUGUU 0.78
small profile
HOXC11 0.78 small profile SeqLogo of HOXC11
GSC_GSC2 0.78 small profile SeqLogo of GSC_GSC2
ZBTB3 0.78 small profile SeqLogo of ZBTB3
ETV1_ERF_FEV_ELF1 0.78 small profile SeqLogo of ETV1_ERF_FEV_ELF1
NR4A1 0.78 small profile SeqLogo of NR4A1
MEF2D_MEF2A 0.77 small profile SeqLogo of MEF2D_MEF2A
RXRA_NR2F6_NR2C2 0.77 small profile SeqLogo of RXRA_NR2F6_NR2C2
GLIS2 0.75 small profile SeqLogo of GLIS2
SIX1_SIX3_SIX2 0.75 small profile SeqLogo of SIX1_SIX3_SIX2
SMAD3 0.74 small profile SeqLogo of SMAD3
STAT4 0.74 small profile SeqLogo of STAT4
HNF4G 0.73 small profile SeqLogo of HNF4G
UGGCACU 0.73
small profile
ETS1 0.73 small profile SeqLogo of ETS1
HOXC6_HOXA7 0.73 small profile SeqLogo of HOXC6_HOXA7
HNF1A_HNF1B 0.72 small profile SeqLogo of HNF1A_HNF1B
AGGUAGU 0.72 small profile SeqLogo of AGGUAGU
FLI1 0.71 small profile SeqLogo of FLI1
ZNF384 0.71 small profile SeqLogo of ZNF384
MLXIPL 0.71 small profile SeqLogo of MLXIPL
UBP1 0.71 small profile SeqLogo of UBP1
EBF1 0.71 small profile SeqLogo of EBF1
PROX1 0.70 small profile SeqLogo of PROX1
PAX3 0.70 small profile SeqLogo of PAX3
ACCCUGU 0.70 small profile SeqLogo of ACCCUGU
SIX6 0.70 small profile SeqLogo of SIX6
RELA 0.70 small profile SeqLogo of RELA
MYF6 0.70 small profile SeqLogo of MYF6
GUCAGUU 0.70 small profile SeqLogo of GUCAGUU
RREB1 0.70 small profile SeqLogo of RREB1
SOX21 0.69 small profile SeqLogo of SOX21
ZNF148 0.69 small profile SeqLogo of ZNF148
GFI1 0.69 small profile SeqLogo of GFI1
HMBOX1 0.69 small profile SeqLogo of HMBOX1
NR1I2 0.69 small profile SeqLogo of NR1I2
FOXD3_FOXI1_FOXF1 0.69 small profile SeqLogo of FOXD3_FOXI1_FOXF1
CAGUGCA 0.68 small profile SeqLogo of CAGUGCA
PATZ1_KLF4 0.67 small profile SeqLogo of PATZ1_KLF4
PPARA 0.67 small profile SeqLogo of PPARA
TCF7L1 0.67 small profile SeqLogo of TCF7L1
AUAAAGU 0.67 small profile SeqLogo of AUAAAGU
SOX4 0.66 small profile SeqLogo of SOX4
NKX2-8 0.66 small profile SeqLogo of NKX2-8
DMC1 0.65 small profile SeqLogo of DMC1
SPDEF 0.65 small profile SeqLogo of SPDEF
SMAD2 0.64 small profile SeqLogo of SMAD2
SREBF2 0.64 small profile SeqLogo of SREBF2
ATF7 0.64 small profile SeqLogo of ATF7
RHOXF1 0.64 small profile SeqLogo of RHOXF1
IRF2_STAT2_IRF8_IRF1 0.64 small profile SeqLogo of IRF2_STAT2_IRF8_IRF1
BARX1 0.64 small profile SeqLogo of BARX1
SOX13_SOX12 0.63 small profile SeqLogo of SOX13_SOX12
ETV3 0.63 small profile SeqLogo of ETV3
POU2F2_POU3F1 0.63 small profile SeqLogo of POU2F2_POU3F1
LMX1B_MNX1_RAX2 0.63 small profile SeqLogo of LMX1B_MNX1_RAX2
SOX5 0.63 small profile SeqLogo of SOX5
GAGGUAG 0.63 small profile SeqLogo of GAGGUAG
HOXB13 0.63 small profile SeqLogo of HOXB13
ONECUT1 0.63 small profile SeqLogo of ONECUT1
AGUGCUU 0.62 small profile SeqLogo of AGUGCUU
MSX2 0.62 small profile SeqLogo of MSX2
GCM2 0.62 small profile SeqLogo of GCM2
DLX5 0.62 small profile SeqLogo of DLX5
CEBPB 0.62 small profile SeqLogo of CEBPB
HOXA10_HOXB9 0.61 small profile SeqLogo of HOXA10_HOXB9
MEIS3_TGIF2LX 0.61 small profile SeqLogo of MEIS3_TGIF2LX
HLF_TEF 0.61 small profile SeqLogo of HLF_TEF
LHX2 0.60 small profile SeqLogo of LHX2
NKX2-2 0.60 small profile SeqLogo of NKX2-2
HOMEZ 0.60 small profile SeqLogo of HOMEZ
REST 0.60 small profile SeqLogo of REST
SP100 0.60 small profile SeqLogo of SP100
NR2C1 0.60 small profile SeqLogo of NR2C1
PPARG 0.60 small profile SeqLogo of PPARG
NKX2-4 0.59 small profile SeqLogo of NKX2-4
TCF21 0.59 small profile SeqLogo of TCF21
DMBX1 0.59 small profile SeqLogo of DMBX1
GGCUCAG 0.59 small profile SeqLogo of GGCUCAG
SP1 0.59 small profile SeqLogo of SP1
SMAD4 0.58 small profile SeqLogo of SMAD4
MESP1 0.58 small profile SeqLogo of MESP1
HOXA13 0.58 small profile SeqLogo of HOXA13
KLF7 0.57 small profile SeqLogo of KLF7
CDX1 0.57 small profile SeqLogo of CDX1
BHLHE40 0.57 small profile SeqLogo of BHLHE40
UGCAUAG 0.57 small profile SeqLogo of UGCAUAG
HSFY2 0.56 small profile SeqLogo of HSFY2
HSF2 0.55 small profile SeqLogo of HSF2
UACAGUA 0.55 small profile SeqLogo of UACAGUA
AAGGUGC 0.55 small profile SeqLogo of AAGGUGC
ARID5A 0.54 small profile SeqLogo of ARID5A
UAAGACU 0.53 small profile SeqLogo of UAAGACU
NR4A2 0.52 small profile SeqLogo of NR4A2
GFI1B 0.52