Motif ID: ADNP_IRX_SIX_ZHX.p2

Z-value: 0.734


Transcription factors associated with ADNP_IRX_SIX_ZHX.p2:

Gene SymbolEntrez IDGene Name
ADNP 23394 activity-dependent neuroprotector homeobox
IRX4 50805 iroquois homeobox 4
IRX5 10265 iroquois homeobox 5
SIX2 10736 SIX homeobox 2
SIX5 147912 SIX homeobox 5
ZHX1 11244 zinc fingers and homeoboxes 1
ZHX2 22882 zinc fingers and homeoboxes 2
ZHX3 23051 zinc fingers and homeoboxes 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ZHX3chr20_-_39379533-0.581.8e-02Click!
ZHX2chr8_+_123863169,
chr8_+_123863224
-0.505.0e-02Click!
ADNPchr20_-_489808580.411.1e-01Click!
SIX5chr19_-_50964336-0.165.5e-01Click!
IRX5chr16_+_535226110.155.9e-01Click!
IRX4chr5_-_1935764-0.146.0e-01Click!
SIX2chr2_-_450900250.077.9e-01Click!


Activity profile for motif ADNP_IRX_SIX_ZHX.p2.

activity profile for motif ADNP_IRX_SIX_ZHX.p2


Sorted Z-values histogram for motif ADNP_IRX_SIX_ZHX.p2

Sorted Z-values for motif ADNP_IRX_SIX_ZHX.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ADNP_IRX_SIX_ZHX.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_-_137649180 2.496 NM_033642
FGF13
fibroblast growth factor 13
chr21_-_14840506 2.050 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr6_+_12825022 1.597 PHACTR1
phosphatase and actin regulator 1
chr4_-_91979113 1.464 NM_183049
TMSL3
thymosin-like 3
chr6_+_12825818 1.363 NM_030948
PHACTR1
phosphatase and actin regulator 1
chr5_-_88235624 1.273 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chr14_-_54720101 1.145 DLGAP5
discs, large (Drosophila) homolog-associated protein 5
chr3_-_143230124 1.062 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr10_+_70517863 1.004 SRGN
serglycin
chr10_+_70517823 0.988 NM_002727
SRGN
serglycin
chr5_+_102493155 0.964 NM_015216
PPIP5K2
diphosphoinositol pentakisphosphate kinase 2
chr11_-_33870411 0.953 NM_005574
LMO2
LIM domain only 2 (rhombotin-like 1)
chr12_+_52696908 0.895 NM_014620
NM_153693
HOXC4
HOXC6
homeobox C4
homeobox C6
chr2_+_33592445 0.859 NM_015376
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr4_-_153493133 0.823 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr1_+_196874759 0.818 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr1_-_42738535 0.813 TMSB4XP1
thymosin beta 4, X-linked pseudogene 1
chr3_+_123256902 0.769 NM_175862
CD86
CD86 molecule
chr3_-_57209319 0.768 NM_003865
HESX1
HESX homeobox 1
chr8_-_86477585 0.765 NM_001128829
NM_001128830
NM_001128831
NM_001738
CA1



carbonic anhydrase I



chr2_-_192420168 0.750 NM_004657
SDPR
serum deprivation response
chr12_-_69434330 0.749 PTPRR
protein tyrosine phosphatase, receptor type, R
chr3_-_33675484 0.733 CLASP2
cytoplasmic linker associated protein 2
chr1_+_196874839 0.724 PTPRC
protein tyrosine phosphatase, receptor type, C
chr14_-_105681377 0.643 IGHV4-31
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant gamma 1 (G1m marker)
chr1_+_196874867 0.638 PTPRC
protein tyrosine phosphatase, receptor type, C
chr12_-_101398503 0.633 NM_000618
NM_001111283
NM_001111285
IGF1


insulin-like growth factor 1 (somatomedin C)


chr20_+_29598848 0.627 HM13
histocompatibility (minor) 13
chr8_-_102872372 0.613 NCALD
neurocalcin delta
chr12_-_101398451 0.607 IGF1
insulin-like growth factor 1 (somatomedin C)
chr12_+_52697160 0.598 HOXC5
HOXC6
homeobox C5
homeobox C6
chr8_-_102872354 0.596 NCALD
neurocalcin delta
chr22_+_21065134 0.589 LOC100290481
immunoglobulin lambda light chain-like
chr5_+_141326620 0.586 NM_183399
RNF14
ring finger protein 14
chr12_-_101036407 0.582 NM_024057
NUP37
nucleoporin 37kDa
chr7_-_26198673 0.574 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr12_-_15005761 0.572 NM_001175
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr8_-_102872614 0.563 NM_032041
NCALD
neurocalcin delta
chrX_-_153698930 0.561 HMGN1P37
high-mobility group nucleosome binding domain 1 pseudogene 37
chr11_-_56951628 0.554 NM_017611
SLC43A3
solute carrier family 43, member 3
chr9_+_2005218 0.550 NM_003070
NM_139045
SMARCA2

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2

chr13_+_51933228 0.542 CKAP2
cytoskeleton associated protein 2
chr3_+_174598937 0.541 NM_014932
NLGN1
neuroligin 1
chr4_+_146250978 0.535 ABCE1
ATP-binding cassette, sub-family E (OABP), member 1
chr4_+_169250281 0.528 NM_007193
ANXA10
annexin A10
chr22_+_21116283 0.506


chr3_-_168674502 0.505 NM_006217
SERPINI2
serpin peptidase inhibitor, clade I (pancpin), member 2
chr22_+_21065207 0.502 IGLJ3
immunoglobulin lambda joining 3
chr2_-_192419896 0.497 SDPR
serum deprivation response
chr6_-_33016561 0.486 NM_002118
HLA-DMB
major histocompatibility complex, class II, DM beta
chr4_-_72868598 0.484 NM_000583
GC
group-specific component (vitamin D binding protein)
chr12_+_29267863 0.475 NM_018099
FAR2
fatty acyl CoA reductase 2
chr12_-_101398429 0.472 IGF1
insulin-like growth factor 1 (somatomedin C)
chr20_-_7869068 0.468 NM_017545
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr11_+_113280727 0.460 NM_006028
HTR3B
5-hydroxytryptamine (serotonin) receptor 3B
chrX_+_99726445 0.456 NM_022144
TNMD
tenomodulin
chr11_+_10433241 0.455 NM_001025389
AMPD3
adenosine monophosphate deaminase 3
chr7_-_13992351 0.451 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr8_-_82557956 0.447 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr1_-_156923111 0.444 NM_003126
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr12_-_101398470 0.442 IGF1
insulin-like growth factor 1 (somatomedin C)
chr17_-_10393664 0.439 NM_001100112
NM_017534
MYH2

myosin, heavy chain 2, skeletal muscle, adult

chr1_+_166516901 0.435 NM_005149
TBX19
T-box 19
chr1_+_35623688 0.428 ZMYM4
zinc finger, MYM-type 4
chr6_-_26343139 0.425 NM_005320
HIST1H1D
histone cluster 1, H1d
chr4_-_71751070 0.424 IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr17_-_10265991 0.418 NM_002472
MYH8
myosin, heavy chain 8, skeletal muscle, perinatal
chr15_-_23201740 0.417 NM_130838
UBE3A
ubiquitin protein ligase E3A
chr11_-_118405288 0.416 NM_001164280
SLC37A4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr6_-_33149244 0.416 NM_033554
HLA-DPA1
major histocompatibility complex, class II, DP alpha 1
chr16_+_33168191 0.408 NM_001099687
TP53TG3B
TP53 target 3B
chr12_+_49155798 0.405 LARP4
La ribonucleoprotein domain family, member 4
chr3_-_25658829 0.405 TOP2B
topoisomerase (DNA) II beta 180kDa
chr2_-_200033445 0.397 SATB2
SATB homeobox 2
chr2_-_61618165 0.394 XPO1
exportin 1 (CRM1 homolog, yeast)
chr10_-_69422391 0.391 HERC4
hect domain and RLD 4
chr16_+_7322751 0.388 NM_145891
NM_145892
NM_145893
RBFOX1


RNA binding protein, fox-1 homolog (C. elegans) 1


chr7_-_36992221 0.387 NM_130442
ELMO1
engulfment and cell motility 1
chr12_-_69434650 0.386 PTPRR
protein tyrosine phosphatase, receptor type, R
chr12_-_101398288 0.386 IGF1
insulin-like growth factor 1 (somatomedin C)
chr17_-_36444626 0.379 NM_030966
KRTAP1-3
keratin associated protein 1-3
chr4_+_170817787 0.377 CLCN3
chloride channel 3
chr13_-_98757634 0.377 NM_004951
GPR183
G protein-coupled receptor 183
chr2_+_169465995 0.370 NM_001081686
NM_021176
G6PC2

glucose-6-phosphatase, catalytic, 2

chr10_+_70745615 0.370 NM_033496
HK1
hexokinase 1
chr11_-_83071084 0.368 NM_001142702
DLG2
discs, large homolog 2 (Drosophila)
chrX_+_28515479 0.366 NM_014271
IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chr1_+_165565006 0.365 POU2F1
POU class 2 homeobox 1
chr7_-_16471817 0.364 NM_015464
SOSTDC1
sclerostin domain containing 1
chr22_+_21006814 0.363


chr7_-_104696678 0.359 NM_182691
SRPK2
SRSF protein kinase 2
chr10_-_98021144 0.355 NM_001114094
NM_013314
BLNK

B-cell linker

chr4_+_41395493 0.354 LIMCH1
LIM and calponin homology domains 1
chr5_-_88155360 0.351 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chrX_-_55074125 0.351 NM_000032
NM_001037967
NM_001037968
ALAS2


aminolevulinate, delta-, synthase 2


chr1_+_165564904 0.350 NM_001198783
POU2F1
POU class 2 homeobox 1
chr7_-_132371208 0.349 EEF1G
eukaryotic translation elongation factor 1 gamma
chr2_+_33514896 0.346 NM_170672
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr7_-_25234582 0.345 NM_022150
NPVF
neuropeptide VF precursor
chr8_+_77756061 0.342 NM_024721
ZFHX4
zinc finger homeobox 4
chr7_-_87694218 0.342 NM_198901
SRI
sorcin
chr5_+_44844724 0.340 NM_016640
MRPS30
mitochondrial ribosomal protein S30
chr1_-_157950898 0.338 NM_000567
CRP
C-reactive protein, pentraxin-related
chr2_+_237143118 0.337 NM_020311
CXCR7
chemokine (C-X-C motif) receptor 7
chr11_+_113672407 0.337 NNMT
nicotinamide N-methyltransferase
chr8_-_86441115 0.336 NM_001164830
CA1
carbonic anhydrase I
chr12_-_69434598 0.336 NM_130846
PTPRR
protein tyrosine phosphatase, receptor type, R
chr1_+_51208499 0.332 CDKN2C
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chr14_+_66901237 0.330 EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr17_-_64752550 0.328 NM_080282
ABCA10
ATP-binding cassette, sub-family A (ABC1), member 10
chr12_+_14429499 0.327 ATF7IP
activating transcription factor 7 interacting protein
chr17_-_10362583 0.326 NM_005963
MYH1
myosin, heavy chain 1, skeletal muscle, adult
chrX_-_13744933 0.325 GPM6B
glycoprotein M6B
chr13_-_45654296 0.325 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr7_-_26202626 0.324 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr3_+_69895651 0.324 NM_006722
MITF
microphthalmia-associated transcription factor
chr1_+_100957883 0.322 NM_001078
NM_080682
VCAM1

vascular cell adhesion molecule 1

chr2_-_136350404 0.322 MCM6
minichromosome maintenance complex component 6
chr18_+_31488530 0.320 NM_020474
GALNT1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
chr13_-_45654327 0.318 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr5_+_128468785 0.317 ISOC1
isochorismatase domain containing 1
chr6_-_22405708 0.316 NM_000948
PRL
prolactin
chr12_-_89922888 0.316 NM_004950
EPYC
epiphycan
chr11_+_113672378 0.314 NNMT
nicotinamide N-methyltransferase
chr3_-_166278969 0.314 NM_001041
SI
sucrase-isomaltase (alpha-glucosidase)
chr19_+_12995782 0.313 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr1_+_157067729 0.313 NM_002432
MNDA
myeloid cell nuclear differentiation antigen
chr17_-_37681917 0.312 NM_012448
STAT5B
signal transducer and activator of transcription 5B
chr8_+_77756077 0.312 ZFHX4
zinc finger homeobox 4
chr5_+_157090900 0.312 NM_017872
THG1L
tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
chr6_-_74284522 0.311 EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr1_+_198263352 0.311 NM_003822
NM_205860
NR5A2

nuclear receptor subfamily 5, group A, member 2

chr2_-_133145539 0.310 NM_001077427
LYPD1
LY6/PLAUR domain containing 1
chr4_-_74307637 0.306 ANKRD17
ankyrin repeat domain 17
chr12_-_8656705 0.306 NM_020661
AICDA
activation-induced cytidine deaminase
chr4_+_74825138 0.305 NM_000584
IL8
interleukin 8
chr5_-_98290117 0.304 NM_001270
CHD1
chromodomain helicase DNA binding protein 1
chrX_-_135690770 0.304 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chrX_-_135690699 0.304 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr8_+_18123456 0.304 NM_001160174
NAT1
N-acetyltransferase 1 (arylamine N-acetyltransferase)
chr2_+_172530120 0.303 HAT1
histone acetyltransferase 1
chr9_+_92629525 0.301 NM_001174167
SYK
spleen tyrosine kinase
chr2_-_170138558 0.301 NM_024622
FASTKD1
FAST kinase domains 1
chr6_-_32605898 0.299 NM_002125
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr11_+_63282639 0.299 RTN3
reticulon 3
chr1_+_51855343 0.297 OSBPL9
oxysterol binding protein-like 9
chrX_-_100999204 0.297 NM_032946
NXF5
nuclear RNA export factor 5
chr10_-_17211795 0.295 NM_001081
CUBN
cubilin (intrinsic factor-cobalamin receptor)
chr5_+_65408500 0.293 ERBB2IP
erbb2 interacting protein
chr2_+_102401580 0.290 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr4_-_71751205 0.287 NM_144646
IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr7_-_27133163 0.283 NM_153631
HOXA3
homeobox A3
chrX_+_37524250 0.282 CYBB
cytochrome b-245, beta polypeptide
chr1_+_78858675 0.282 NM_006820
IFI44L
interferon-induced protein 44-like
chr8_-_72431274 0.279 NM_172058
NM_172059
NM_172060
EYA1


eyes absent homolog 1 (Drosophila)


chr2_-_200030944 0.279 NM_001172509
SATB2
SATB homeobox 2
chr2_-_210888010 0.272 NM_079420
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr5_+_156628929 0.271 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr8_-_108579270 0.271 NM_001146
ANGPT1
angiopoietin 1
chr16_+_20682812 0.270 NM_005622
NM_202000
ACSM3

acyl-CoA synthetase medium-chain family member 3

chr1_+_149299530 0.268 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr6_+_64414389 0.268 NM_015153
PHF3
PHD finger protein 3
chr1_+_78243181 0.266 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chrX_+_100241453 0.266 NM_006733
CENPI
centromere protein I
chr1_-_51660328 0.264 NM_001159969
EPS15
epidermal growth factor receptor pathway substrate 15
chr10_-_94247450 0.263 NM_001165946
IDE
insulin-degrading enzyme
chr1_-_111544784 0.261 NM_024901
DENND2D
DENN/MADD domain containing 2D
chr1_+_149299307 0.260 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr6_-_79732391 0.260 PHIP
pleckstrin homology domain interacting protein
chr3_+_88270951 0.258 NM_018293
ZNF654
zinc finger protein 654
chr11_-_71424614 0.256


chr9_+_134843918 0.256 NM_001135031
NM_004188
GFI1B

growth factor independent 1B transcription repressor

chr14_+_31868229 0.255 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr1_+_51855133 0.254 NM_024586
NM_148906
NM_148908
NM_148909
OSBPL9



oxysterol binding protein-like 9



chr5_-_178977441 0.254 HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr2_-_99412694 0.251 REV1
REV1 homolog (S. cerevisiae)
chr21_-_38955487 0.251 NM_001136154
NM_004449
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr10_+_11087259 0.250 NM_001025077
CELF2
CUGBP, Elav-like family member 2
chr7_+_129057152 0.250 NM_001040110
NRF1
nuclear respiratory factor 1
chr1_-_149004852 0.249 CTSS
cathepsin S
chr13_+_32488477 0.248 NM_004795
KL
klotho
chr1_+_145892190 0.246 NM_001097616
GPR89C
G protein-coupled receptor 89C
chr1_+_115373937 0.245 NM_000549
TSHB
thyroid stimulating hormone, beta
chr3_+_120799411 0.245 NM_015900
PLA1A
phospholipase A1 member A
chr12_+_21417068 0.243 NM_000415
IAPP
islet amyloid polypeptide
chr4_-_176970407 0.242 GPM6A
glycoprotein M6A
chr11_+_113671744 0.241 NM_006169
NNMT
nicotinamide N-methyltransferase
chr3_+_179759181 0.238 NM_005832
KCNMB2
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr12_+_46802695 0.238 NM_001166687
NM_001166688
PFKM

phosphofructokinase, muscle

chr22_+_21559959 0.238 NM_001178126
IGLL5
IGLC1
immunoglobulin lambda-like polypeptide 5
immunoglobulin lambda constant 1 (Mcg marker)
chr1_-_239865724 0.235 NM_001821
CHML
choroideremia-like (Rab escort protein 2)
chr1_+_50347188 0.234 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr7_-_107667728 0.233 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr4_-_123761615 0.232 NM_021803
IL21
interleukin 21
chr11_+_71578606 0.229 NM_000802
FOLR1
folate receptor 1 (adult)
chr15_-_48434567 0.228 GABPB1
GA binding protein transcription factor, beta subunit 1
chr2_+_161981046 0.226 TBR1
T-box, brain, 1
chr13_-_45654292 0.226 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr10_-_74676969 0.224 NM_015190
DNAJC9
DnaJ (Hsp40) homolog, subfamily C, member 9
chr2_-_136350472 0.224 NM_005915
MCM6
minichromosome maintenance complex component 6

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.63 3.17e-03 GO:0006955 immune response

Nothing significant found in compartment category.

Nothing significant found in function category.