ISMARA results for ENCODE cell lines, expression (Ernst 2011)

ISMARA - Integrated System for Motif Actitivity Response Analysis is a free online tool that recognizes most important transcription factors that are changing their activity in a set of samples.

All motifs sorted by activity significance

Motif name Z-value Associated genes Profile Logo
E2F1..5.p2 6.392 E2F4 (E2F-4)
E2F5
E2F2 (E2F-2)
E2F1 (RBP3)
E2F3
IRF1,2,7.p3 5.024 IRF1 (MAR, IRF-1)
IRF2 (IRF-2, DKFZp686F0244)
IRF7 (IRF7A, IRF-7H)
SNAI1..3.p2 4.760 SNAI2 (SLUGH1)
SNAI1 (SNA, SLUGH2, SNAH)
SNAI3 (SMUC, Zfp293)
HNF1A.p2 4.504 HNF1A (HNF1, LFB1)
NRF1.p2 4.188 NRF1 (EWG, ALPHA-PAL)
TEAD1.p2 4.174 TEAD1 (TEF-1)
TEAD2 (ETF, TEF4, TEF-4, TEAD-2)
TEAD3 (TEF5, TEAD5, TEF-5, DTEF-1, ETFR-1, TEAD-3)
TEAD4 (TEF3, RTEF1, TEF-3, EFTR-2, TEFR-1, TCF13L1, hRTEF-1B)
FOS_FOS{B,L1}_JUN{B,D}.p2 4.087 FOS (c-fos, AP-1)
JUNB
FOSL1 (fra-1)
JUND (AP-1)
FOSB (G0S3, GOSB, GOS3, AP-1, MGC42291, DKFZp686C0818)
ZNF143.p2 4.066 ZNF143 (SBF, pHZ-1, STAF)
HNF4A_NR2F1,2.p2 4.018 NR2F1 (EAR-3, COUP-TFI, TCFCOUP1, SVP44)
NR2F2 (COUP-TFII, COUPTFB, SVP40)
HNF4A (NR2A1, HNF4)
HIC1.p2 3.945 HIC1 (ZBTB29)
POU2F1..3.p2 3.898 POU2F2 (OCT2)
POU2F1 (OCT1)
POU2F3 (OCT11, PLA-1, Skn-1a, Epoc-1)
SRF.p3 3.811 SRF (MCM1)
NFY{A,B,C}.p2 3.777 NFYC (CBF-C)
NFYB (CBF-A, HAP3)
NFYA (HAP2, CBF-B)
ELK1,4_GABP{A,B1}.p3 3.727 GABPA (E4TF1A, NFT2, NRF2, E4TF1-60, NRF2A)
GABPB1 (E4TF1-47, GABPB)
ELK4 (SAP1)
ELK1
TBP.p2 3.495 TBP (TFIID)
MYB.p2 3.304 MYB (c-myb)
YY1.p2 3.300 YY1 (NF-E1, DELTA, UCRBP, YIN-YANG-1, INO80S)
MTF1.p2 3.271 MTF1
PITX1..3.p2 3.226 PITX2 (IGDS, RS, Brx1, Otlx2, ARP1)
PITX3
PITX1 (PTX1, POTX)
HOX{A6,A7,B6,B7}.p2 3.168 HOXB6
HOXA7
HOXB7
HOXA6
NFKB1_REL_RELA.p2 3.028 RELA (p65)
REL (I-Rel)
NFKB1 (KBF1, p105)
SPI1.p2 3.017 SPI1 (PU.1, SPI-A, OF, SFPI1, SPI-1)
MYOD1.p2 2.971 MYOD1 (PUM, MYOD, bHLHc1)
KLF4.p3 2.963 KLF4 (EZF, GKLF)
MYFfamily.p2 2.831 MYOD1 (PUM, MYOD, bHLHc1)
MYF6 (MRF4, bHLHc4)
MYF5 (bHLHc2)
MYOG (bHLHc3)
RUNX1..3.p2 2.824 RUNX1 (PEBP2A2, AMLCR1)
RUNX3 (AML2, PEBP2A3)
RUNX2 (AML3, PEBP2A1, PEBP2aA1)
TLX1..3_NFIC{dimer}.p2 2.812 TLX1
TLX3 (RNX)
ARNT_ARNT2_BHLHB2_MAX_MYC_USF1.p2 2.762 ARNT (HIF-1beta, bHLHe2)
MAX (bHLHd4)
MYC (c-Myc, bHLHe39)
USF1 (UEF, MLTFI, bHLHb11)
BHLHB2 (DEC1, bHLHe40)
ARNT2 (KIAA0307, bHLHe1)
TFEB.p2 2.688 TFEB
NFIX.p2 2.670 NFIX (NF1A)
XBP1.p3 2.658 XBP1
ZEB1.p2 2.596 ZEB1 (BZP, ZEB, AREB6, NIL-2-A, Zfhep, Zfhx1a)
TFAP2{A,C}.p2 2.528 TFAP2C (AP2-GAMMA, ERF1, TFAP2G, hAP-2g)
TFAP2A (AP-2)
TCF4_dimer.p2 2.422 TCF4 (E2-2, ITF2, PTHS, SEF2, SEF2-1, SEF2-1A, SEF2-1B, bHLHb19, MGC149723, MGC149724)
DBP.p2 2.351 DBP (DABP)
NR5A1,2.p2 2.338 NR5A1 (FTZ1, SF-1, ELP, AD4BP)
NR5A2 (FTZ-F1beta, hB1F, LRH-1, FTZ-F1, hB1F-2, B1F2)
MEF2{A,B,C,D}.p2 2.334 MEF2A (RSRFC4, RSRFC9)
MEF2C
MEF2D
MEF2BNB-MEF2B (MEF2B, LOC729991-MEF2B)
MEF2B (RSRFR2, FLJ32648)
TFCP2.p2 2.323 TFCP2 (CP2, LSF, LBP-1C, TFCP2C)
GATA1..3.p2 2.275 GATA1 (ERYF1, NFE1)
GATA2 (NFE1B)
GATA3 (HDR)
ZNF148.p2 2.270 ZNF148 (BERF-1, ZBP-89, BFCOL1, HT-BETA, ZFP148, pHZ-52)
EP300.p2 2.214 EP300 (p300, KAT3B)
bHLH_family.p2 2.203 ARNTL (MOP3, JAP3, BMAL1, PASD3, bHLHe5)
MITF (WS2A, MI, bHLHe32)
MXI1 (MXD2, MAD2, MXI, bHLHc11)
TFE3 (TFEA, bHLHe33)
CLOCK (KIAA0334, KAT13D, bHLHe8)
OLIG2 (RACK17, OLIGO2, bHLHe19)
MXD4 (MAD4, MSTP149, MST149, bHLHc12)
HEY2 (bHLHb32)
HEY1 (HESR-1, CHF2, HESR1, HRT-1, CHF-2, HERP2, BHLHb31)
HEYL (bHLHb33)
MLXIPL (WS-bHLH, MIO, CHREBP, MONDOB)
HES6 (bHLHc23)
MXD3 (MAD3, bHLHc13)
ARNTL2 (BMAL2, MOP9, CLIF, PASD9, bHLHe6)
ID1 (dJ857M17.1.2, bHLHb24)
MNT (ROX, MXD6, MAD6, bHLHd3)
OLIG1 (BHLHB6, bHLHe21)
NPAS2 (MOP4, PASD4, bHLHe9)
MZF1.p2 2.177 MZF1 (MZF1B, ZSCAN6, MZF-1, Zfp98)
ATF6.p2 2.177 ATF6 (ATF6A)
HBP1_HMGB_SSRP1_UBTF.p2 2.152 HMGB2
HMGB3 (HMG2A, MGC90319)
SSRP1 (FACT80)
UBTF (UBF, NOR-90)
HBP1
EHF.p2 2.128 EHF
SPIB.p2 2.123 SPIB (SPI-B)
NHLH1,2.p2 2.113 NHLH1 (NSCL, NSCL1, bHLHa35)
NHLH2 (NSCL2, bHLHa34)
TFDP1.p2 2.097 TFDP1 (Dp-1, DRTF1, DP1)
POU5F1.p2 2.037 POU5F1 (OCT3, Oct4, MGC22487)
HES1.p2 2.007 HES1 (FLJ20408, HES-1, Hes1, bHLHb39)
PRDM1.p3 1.967 PRDM1 (PRDI-BF1)
NKX3-1.p2 1.965 NKX3-1 (NKX3.1, BAPX2)
HIF1A.p2 1.958 HIF1A (MOP1, HIF-1alpha, PASD8, HIF1)
KLF12.p2 1.934 KLF12 (AP-2rep, HSPC122, AP2REP)
RREB1.p2 1.912 RREB1 (HNT)
NFATC1..3.p2 1.903 NFATC3 (NFAT4, NFATX)
NFATC2 (NF-ATP, NFATp, NFAT1)
NFATC1 (NF-ATC, NFATc, NFAT2)
TBX4,5.p2 1.862 TBX5
TBX4
NFE2L1.p2 1.856 NFE2L1 (NRF1, LCR-F1, FLJ00380, TCF11)
IKZF1.p2 1.848 IKZF1 (hIk-1, LyF-1, Hs.54452, IKAROS)
STAT2,4,6.p2 1.819 STAT2 (STAT113)
STAT4
STAT6 (D12S1644, IL-4-STAT)
FOX{F1,F2,J1}.p2 1.813 FOXF2 (FREAC2)
FOXJ1 (HFH-4, HFH4)
FOXF1 (FREAC1)
NFE2L2.p2 1.807 NFE2L2 (NRF2)
RXR{A,B,G}.p2 1.796 RXRA (NR2B1)
RXRB (NR2B2, H-2RIIBP, RCoR-1)
RXRG (NR2B3)
TFAP2B.p2 1.782 TFAP2B (AP2-B)
GFI1.p2 1.746 GFI1
ZNF238.p2 1.732 ZNF238 (C2H2-171, TAZ-1, RP58, ZBTB18)
HSF1,2.p2 1.717 HSF1 (HSTF1)
HSF2
SMAD1..7,9.p2 1.713 SMAD5 (Dwfc, JV5-1)
SMAD1 (MADR1, JV4-1)
SMAD3 (JV15-2, HsT17436)
SMAD4 (DPC4)
SMAD2 (MADR2, JV18-1)
SMAD6 (HsT17432)
SMAD7
SMAD9
SOX17.p2 1.707 SOX17
ZNF384.p2 1.694 ZNF384 (CAGH1A, CIZ, NMP4, NP)
LEF1_TCF7_TCF7L1,2.p2 1.693 TCF7 (TCF-1)
TCF7L2 (TCF-4)
LEF1 (TCF1ALPHA)
TCF7L1
NKX3-2.p2 1.681 NKX3-2 (NKX3B, NKX3.2)
ZBTB16.p2 1.667 ZBTB16 (PLZF)
FOXA2.p3 1.656 FOXA2
FOX{I1,J2}.p2 1.638 FOXI1 (FREAC6)
FOXJ2 (FHX)
MSX1,2.p2 1.636 MSX1 (HYD1, OFC5)
MSX2 (CRS2, FPP, HOX8, MSH, PFM)
FOXD3.p2 1.631 FOXD3 (Genesis, HFH2)
ELF1,2,4.p2 1.629 ELF2 (EU32, NERF, NERF-2, NERF-1A, NERF-1B)
ELF1
ELF4 (MEF, ELFR)
SREBF1,2.p2 1.624 SREBF1 (SREBP1, bHLHd1)
SREBF2 (SREBP2, bHLHd2)
IKZF2.p2 1.623 IKZF2 (Helios)
RFX1..5_RFXANK_RFXAP.p2 1.622 RFX1 (EF-C)
RFXAP
RFX5
RFXANK (BLS, RFX-B, ANKRA1, F14150_1, MGC138628)
RFX4
RFX3
RFX2 (FLJ14226)
MAFB.p2 1.592 MAFB
HLF.p2 1.590 HLF (MGC33822)
AHR_ARNT_ARNT2.p2 1.577 ARNT (HIF-1beta, bHLHe2)
AHR
ARNT2 (KIAA0307, bHLHe1)
FEV.p2 1.576 FEV (PET-1, HSRNAFEV)
DMAP1_NCOR{1,2}_SMARC.p2 1.574 SMARCA1 (SNF2LB, NURF140, ISWI, SWI)
SMARCC2 (BAF170, Rsc8, CRACC2)
SMARCA5 (hSNF2H, hISWI, ISWI)
NCOR1 (N-CoR, hCIT529I10, TRAC1, hN-CoR, KIAA1047, MGC104216)
NCOR2 (SMRT, SMRTE, TRAC-1, CTG26, TNRC14)
DMAP1 (DNMAP1, FLJ11543, KIAA1425, DNMTAP1, EAF2, SWC4)
GTF2I.p2 1.571 GTF2I (TFII-I, BAP-135, SPIN, BTKAP1, DIWS, IB291)
POU5F1_SOX2{dimer}.p2 1.570 POU5F1 (OCT3, Oct4, MGC22487)
SOX2
GTF2A1,2.p2 1.569 GTF2A1 (TFIIA)
GTF2A2 (TFIIA, HsT18745)
GATA6.p2 1.560 GATA6
ETS1,2.p2 1.556 ETS2
ETS1 (FLJ10768, ETS-1)
FOXO1,3,4.p2 1.554 FOXO1 (FKH1)
FOXO4 (AFX1)
FOXO3 (AF6q21, FOXO2)
MAZ.p2 1.547 MAZ (ZF87, Pur-1, Zif87, ZNF801)
SOX{8,9,10}.p2 1.539 SOX9 (SRA1)
SOX8
SOX10 (DOM, WS4, WS2E)
LMO2.p2 1.520 LMO2 (TTG2, RHOM2, RBTN2)
PAX4.p2 1.516 PAX4
PATZ1.p2 1.468 PATZ1 (MAZR, dJ400N23, ZBTB19, ZSG, RIAZ, PATZ)
NKX2-3_NKX2-5.p2 1.451 NKX2-5 (CSX1, NKX2.5, NKX4-1)
NKX2-3 (NKX2.3, CSX3, NKX4-3)
ESRRA.p2 1.446 ESRRA (ERR1, ERRalpha, NR3B1, ERRa)
TFAP4.p2 1.440 TFAP4 (AP-4)
SOX2.p2 1.432 SOX2
FOXL1.p2 1.431 FOXL1 (FREAC7, FKH6)
ZFP161.p2 1.389 ZFP161 (ZNF478, ZBTB14)
SRY.p2 1.340 SRY (TDF)
HAND1,2.p2 1.312 HAND1 (eHand, Thing1, Hxt, bHLHa27)
HAND2 (dHand, Thing2, Hed, bHLHa26)
PRRX1,2.p2 1.306 PRRX2 (PRX2, PMX2)
PRRX1 (PHOX1)
FOXN1.p2 1.298 FOXN1 (FKHL20)
TP53.p2 1.293 TP53 (p53, LFS1)
ATF5_CREB3.p2 1.289 ATF5
CREB3 (LZIP, Luman)
TGIF1.p2 1.285 TGIF1
JUN.p2 1.258 JUN (c-Jun, AP-1)
JUND (AP-1)
JUNB
FOX{D1,D2}.p2 1.258 FOXD2 (FREAC9)
FOXD1 (FREAC4)
SOX5.p2 1.240 SOX5 (L-SOX5, MGC35153)
CDC5L.p2 1.233 CDC5L (PCDC5RP, hCDC5, CEF1)
ZNF423.p2 1.226 ZNF423 (KIAA0760, OAZ, Roaz, Ebfaz, Zfp104)
NKX6-1,2.p2 1.215 NKX6-1 (Nkx6.1)
NKX6-2 (NKX6B, GTX, NKX6.1)
CREB1.p2 1.207 CREB1
ATF4.p2 1.196 ATF4 (TAXREB67, CREB-2)
ESR1.p2 1.185 ESR1 (NR3A1, Era)
FOX{C1,C2}.p2 1.179 FOXC1 (FREAC3, ARA, IGDA, IHG1)
FOXC2 (MFH-1)
BACH2.p2 1.177 BACH2
AR.p2 1.176 AR (AIS, NR3C4, SMAX1, HUMARA)
CTCF.p2 1.168 CTCF
CRX.p2 1.165 CRX (CRD, LCA7, OTX3)
POU3F1..4.p2 1.159 POU3F1 (OCT6, SCIP)
POU3F3 (BRN1, OTF8)
POU3F2 (POUF3, BRN2, OCT7)
POU3F4 (BRN4, OTF9)
ONECUT1,2.p2 1.146 ONECUT2 (OC-2)
ONECUT1 (HNF-6)
NR1H4.p2 1.142 NR1H4 (FXR, RIP14, HRR1, HRR-1)
SPZ1.p2 1.142 SPZ1 (NYD-TSP1, FLJ25709)
HMX1.p2 1.142 HMX1 (H6, NKX5-3)
POU6F1.p2 1.127 POU6F1 (BRN5, MPOU, TCFB1)
ZBTB6.p2 1.120 ZBTB6 (ZID)
ATF2.p2 1.094 ATF2 (TREB7, CRE-BP1, HB16)
GFI1B.p2 1.092 GFI1B
LHX3,4.p2 1.089 LHX3
LHX4 (Gsh4)
PAX2.p2 1.084 PAX2
PAX5.p2 1.079 PAX5 (BSAP)
POU1F1.p2 1.078 POU1F1 (GHF-1)
RXRG_dimer.p3 1.073 NR1H2 (NER, NER-I, RIP15, LXR-b)
RXRA (NR2B1)
PPARG (PPARG1, PPARG2, NR1C3, PPARgamma)
PPARA (hPPAR, NR1C1)
RXRB (NR2B2, H-2RIIBP, RCoR-1)
RXRG (NR2B3)
NKX2-2,8.p2 1.072 NKX2-2 (NKX2.2)
NKX2-8 (NKX2.8, Nkx2-9)
STAT1,3.p3 1.072 STAT1 (STAT91, ISGF-3)
STAT3 (APRF)
RBPJ.p2 1.070 RBPJ (SUH, IGKJRB, RBPJK, KBF2, RBP-J, CBF1)
MYBL2.p2 1.049 MYBL2 (BMYB, B-MYB)
NANOG{mouse}.p2 1.047 NANOG (FLJ12581, FLJ40451)
FOXQ1.p2 1.037 FOXQ1 (HFH1)
ALX1.p2 1.027 ALX1
NANOG.p2 1.015 NANOG (FLJ12581, FLJ40451)
FOSL2.p2 1.003 FOSL2 (FRA2, FLJ23306)
SP1.p2 0.995 SP1
EN1,2.p2 0.988 EN1
EN2
NFE2.p2 0.975 NFE2 (NF-E2)
BPTF.p2 0.973 BPTF (FAC1, NURF301)
PPARG.p2 0.967 PPARG (PPARG1, PPARG2, NR1C3, PPARgamma)
TLX2.p2 0.949 TLX2 (Enx, Tlx2, NCX)
NFIL3.p2 0.947 NFIL3 (E4BP4, NFIL3A, NF-IL3A)
AIRE.p2 0.943 AIRE (PGA1, APS1)
GLI1..3.p2 0.939 GLI1
GLI2 (THP2, HPE9, THP1)
GLI3 (PAP-A, PAPA, PAPA1, PAPB, ACLS, PPDIV)
CEBPA,B_DDIT3.p2 0.933 DDIT3 (CHOP10, GADD153, CHOP)
CEBPA (C/EBP-alpha)
CEBPB (LAP, CRP2, NFIL6, IL6DBP)
HOX{A5,B5}.p2 0.882 HOXB5
HOXA5
RORA.p2 0.851 RORA (RZRA, ROR1, ROR2, ROR3, NR1F1)
HMGA1,2.p2 0.839 HMGA1
HMGA2 (BABL, LIPO)
FOXP3.p2 0.825 FOXP3 (JM2, XPID, AIID, PIDX, DIETER, SCURFIN)
REST.p3 0.815 REST (NRSF, XBR)
STAT5{A,B}.p2 0.802 STAT5B
STAT5A (MGF)
EBF1.p2 0.795 EBF1 (OLF1)
EWSR1-FLI1.p2 0.784 FLI1 (EWSR2, SIC-1)
EWSR1 (EWS, K984G1.4)
NR3C1.p2 0.779 NR3C1 (GR)
CDX1,2,4.p2 0.772 CDX1
CDX2
CDX4
ZIC1..3.p2 0.763 ZIC1 (ZIC, ZNF201)
ZIC2 (HPE5)
ZIC3 (HTX, ZNF203)
EGR1..3.p2 0.738 EGR3 (PILOT)
EGR1 (TIS8, G0S30, NGFI-A, KROX-24, ZIF-268, AT225, ZNF225)
EGR2
ADNP_IRX_SIX_ZHX.p2 0.734 SIX5
ZHX1
IRX4
ADNP (KIAA0784, ADNP1)
ZHX3 (KIAA0395)
ZHX2 (KIAA0854)
IRX5 (IRX-2a)
SIX2
NKX2-1,4.p2 0.727 NKX2-1 (TTF-1)
NKX2-4 (NKX2.4)
HOXA9_MEIS1.p2 0.720 MEIS1
HOXA9
CUX2.p2 0.687 CUX2 (KIAA0293, CDP2)
RXRA_VDR{dimer}.p2 0.684 VDR (NR1I1)
GZF1.p2 0.651 GZF1 (dJ322G13.2, ZBTB23)
EOMES.p2 0.643 EOMES (TBR2)
HOX{A4,D4}.p2 0.635 HOXA4
HOXD4
TAL1_TCF{3,4,12}.p2 0.631 TCF3 (E2A, ITF1, MGC129647, MGC129648, bHLHb21)
TCF4 (SEF2-1B, ITF2, bHLHb19)
TAL1 (SCL, bHLHa17)
TCF12 (HEB, HTF4, HsT17266, bHLHb20)
ARID5B.p2 0.600 ARID5B (FLJ21150, MRF2)
NR6A1.p2 0.547 NR6A1 (GCNF1, RTR)
EVI1.p2 0.539 EVI1 (MDS1-EVI1, PRDM3)
PBX1.p2 0.504 PBX1
T.p2 0.466 T
PDX1.p2 0.439 PDX1 (IDX-1, STF-1, PDX-1, MODY4)
VSX1,2.p2 0.321 VSX2 (RET1)
VSX1 (PPD)
PAX6.p2 0.301 PAX6 (D11S812E, AN, WAGR)
PAX3,7.p2 0.262 PAX7 (Hup1)
PAX3 (HUP2)
PAX8.p2 0.139 PAX8

All samples sorted alphabetically


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Project name:

Sample name Condition Replicate/Batch
Rep1_GM12878
Rep1_HepG2
Rep1_HMEC
Rep1_HSMM
Rep1_HUVEC
Rep1_K562
Rep1_NHEK
Rep1_NHLF
Rep2_GM12878
Rep2_HepG2
Rep2_HMEC
Rep2_HSMM
Rep2_HUVEC
Rep2_K562
Rep2_NHEK
Rep2_NHLF