Motif ID: BACH2.p2

Z-value: 1.177


Transcription factors associated with BACH2.p2:

Gene SymbolEntrez IDGene Name
BACH2 60468 BTB and CNC homology 1, basic leucine zipper transcription factor 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
BACH2chr6_-_910633010.185.0e-01Click!


Activity profile for motif BACH2.p2.

activity profile for motif BACH2.p2


Sorted Z-values histogram for motif BACH2.p2

Sorted Z-values for motif BACH2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of BACH2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr18_+_19706979 9.214 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chr1_+_221955876 6.815 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr1_+_151270301 6.214 NM_003125
SPRR1B
small proline-rich protein 1B
chr17_-_36996611 5.560 NM_000526
KRT14
keratin 14
chr17_-_37022465 5.268 NM_005557
KRT16
keratin 16
chr1_-_207891264 3.905 NM_001017402
LAMB3
laminin, beta 3
chr18_+_59593591 3.686 NM_003784
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr19_-_43955984 3.342 NM_002307
LGALS7
LGALS7B
lectin, galactoside-binding, soluble, 7
lectin, galactoside-binding, soluble, 7B
chr10_+_17310475 3.033 VIM
vimentin
chr1_+_221966684 2.911 NM_001748
CAPN2
calpain 2, (m/II) large subunit
chr1_+_221966835 2.898 CAPN2
calpain 2, (m/II) large subunit
chr1_+_221966849 2.845 CAPN2
calpain 2, (m/II) large subunit
chr19_+_43971689 2.834 NM_001042507
LGALS7B
lectin, galactoside-binding, soluble, 7B
chr11_-_6298284 2.830 NM_145040
PRKCDBP
protein kinase C, delta binding protein
chr11_-_2907169 2.825 NM_003311
PHLDA2
pleckstrin homology-like domain, family A, member 2
chr11_-_119499188 2.556 TRIM29
tripartite motif containing 29
chr3_-_152517204 2.535 NM_023915
GPR87
G protein-coupled receptor 87
chr1_+_181422016 2.525 LAMC2
laminin, gamma 2
chr11_-_102174102 2.377 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr11_-_102174032 2.341 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr1_-_94779727 2.341 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr1_-_150276114 2.340 NM_005620
S100A11
S100 calcium binding protein A11
chr1_+_181421984 2.296 LAMC2
laminin, gamma 2
chr11_+_67107641 2.271 NM_000852
GSTP1
glutathione S-transferase pi 1
chr11_+_67107852 2.249 GSTP1
glutathione S-transferase pi 1
chr10_+_17310263 2.207 NM_003380
VIM
vimentin
chr1_+_151223180 2.196 NM_005987
SPRR1A
small proline-rich protein 1A
chr6_-_84197477 2.167 ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr19_-_48661563 2.166 NM_014400
LYPD3
LY6/PLAUR domain containing 3
chr6_-_84197573 2.072 NM_002395
ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr12_-_105057940 2.049 NM_014840
NUAK1
NUAK family, SNF1-like kinase, 1
chr6_-_84197370 2.045 ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr6_-_84197463 2.034 ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr1_+_148747208 2.020 ECM1
extracellular matrix protein 1
chr10_+_121401076 2.003 BAG3
BCL2-associated athanogene 3
chr10_+_121400741 1.924 NM_004281
BAG3
BCL2-associated athanogene 3
chr10_+_121400881 1.918 BAG3
BCL2-associated athanogene 3
chr5_-_175776137 1.903 NM_001834
NM_007097
CLTB

clathrin, light chain B

chr1_+_148747110 1.901 NM_004425
NM_022664
ECM1

extracellular matrix protein 1

chr11_-_65424434 1.882 FOSL1
FOS-like antigen 1
chr11_-_117640166 1.803 MPZL2
myelin protein zero-like 2
chr1_+_26479208 1.784 SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr18_+_59295123 1.776 NM_002639
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr17_+_71229110 1.756 NM_000213
NM_001005731
ITGB4

integrin, beta 4

chr19_-_56215084 1.754 NM_002776
NM_001077500
KLK10

kallikrein-related peptidase 10

chr16_+_55199978 1.701 NM_005953
MT2A
metallothionein 2A
chr1_+_36394044 1.623 MAP7D1
MAP7 domain containing 1
chr16_+_56219802 1.621 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr1_+_26479173 1.620 SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr7_+_48094750 1.585 NM_181597
UPP1
uridine phosphorylase 1
chr1_+_36394338 1.569 NM_018067
MAP7D1
MAP7 domain containing 1
chr5_-_175775966 1.538 CLTB
clathrin, light chain B
chrX_+_12903145 1.527 NM_021109
NM_183049
TMSB4X
TMSL3
thymosin beta 4, X-linked
thymosin-like 3
chr11_-_65424385 1.498 FOSL1
FOS-like antigen 1
chr11_-_117640196 1.484 MPZL2
myelin protein zero-like 2
chr1_+_26480134 1.461 SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr4_-_177950658 1.449 NM_005429
VEGFC
vascular endothelial growth factor C
chr17_+_71229151 1.447 ITGB4
integrin, beta 4
chr2_-_85494639 1.359 CAPG
capping protein (actin filament), gelsolin-like
chr11_+_384238 1.357 PKP3
plakophilin 3
chr11_+_384199 1.350 NM_007183
PKP3
plakophilin 3
chr1_+_181421796 1.315 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr11_-_117640407 1.307 NM_005797
NM_144765
MPZL2

myelin protein zero-like 2

chr15_-_58477407 1.245 NM_001002857
NM_001002858
NM_001136015
NM_004039
ANXA2



annexin A2



chr16_+_55243311 1.238 NM_005947
MT1B
metallothionein 1B
chr1_-_150276091 1.232 S100A11
S100 calcium binding protein A11
chr3_-_48607596 1.230 NM_000094
COL7A1
collagen, type VII, alpha 1
chr1_+_27062215 1.224 NM_006142
SFN
stratifin
chr11_-_65424436 1.213 NM_005438
FOSL1
FOS-like antigen 1
chr3_-_12775718 1.177 NM_018306
TMEM40
transmembrane protein 40
chr18_+_59788242 1.167 NM_001031848
NM_002640
NM_198833
SERPINB8


serpin peptidase inhibitor, clade B (ovalbumin), member 8


chr1_+_154351162 1.084 LMNA
lamin A/C
chr8_-_42184350 1.070 NM_000930
NM_033011
PLAT

plasminogen activator, tissue

chr17_+_18566060 1.065 NM_001037330
TRIM16L
tripartite motif containing 16-like
chr12_-_51153788 1.057 NM_173086
KRT6C
keratin 6C
chr3_+_185499679 1.056 NM_002808
PSMD2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
chr7_+_116099648 1.045 NM_000245
NM_001127500
MET

met proto-oncogene (hepatocyte growth factor receptor)

chr10_+_70745615 1.000 NM_033496
HK1
hexokinase 1
chr6_-_134538526 0.980 SGK1
serum/glucocorticoid regulated kinase 1
chr7_-_1465487 0.980 MICALL2
MICAL-like 2
chr6_-_112034166 0.978 NM_001164281
NM_147686
TRAF3IP2

TRAF3 interacting protein 2

chr1_-_150276064 0.969 S100A11
S100 calcium binding protein A11
chr17_+_71229191 0.959 ITGB4
integrin, beta 4
chr1_+_154351200 0.945 LMNA
lamin A/C
chr11_+_101488380 0.915 NM_001195045
YAP1
Yes-associated protein 1
chr19_-_48866111 0.908 NM_001005376
NM_001005377
NM_002659
PLAUR


plasminogen activator, urokinase receptor


chr19_-_48976852 0.862 KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr11_-_8695974 0.841 ST5
suppression of tumorigenicity 5
chr11_-_33701073 0.838 NM_001127227
CD59
CD59 molecule, complement regulatory protein
chr1_-_151788341 0.824 NM_002960
S100A3
S100 calcium binding protein A3
chr4_+_169989680 0.822 NM_001166110
PALLD
palladin, cytoskeletal associated protein
chr6_-_112033752 0.799 TRAF3IP2
TRAF3 interacting protein 2
chr3_+_185499732 0.787 PSMD2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
chr16_+_88515917 0.778 NM_001197181
TUBB3
tubulin, beta 3
chr21_-_35343500 0.773 RUNX1
runt-related transcription factor 1
chr20_+_4614796 0.773 NM_000311
NM_001080121
NM_001080122
NM_183079
NM_001080123
PRNP




prion protein




chr6_-_138470160 0.770 NM_022121
PERP
PERP, TP53 apoptosis effector
chr1_+_154351082 0.769 NM_005572
NM_170707
NM_170708
LMNA


lamin A/C


chr16_-_62573 0.750 NM_022450
RHBDF1
rhomboid 5 homolog 1 (Drosophila)
chr19_-_48977247 0.743 NM_002250
KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chrX_-_48824401 0.742 WDR45
WD repeat domain 45
chr2_+_47449951 0.718 EPCAM
epithelial cell adhesion molecule
chr2_-_85494664 0.714 CAPG
capping protein (actin filament), gelsolin-like
chr1_-_17180659 0.711 NM_001135247
NM_017459
MFAP2

microfibrillar-associated protein 2

chr5_+_35892747 0.708 NM_002185
IL7R
interleukin 7 receptor
chr10_+_121401032 0.681 BAG3
BCL2-associated athanogene 3
chr8_+_26206648 0.680 NM_001177591
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr7_-_93357881 0.669 NM_006528
TFPI2
tissue factor pathway inhibitor 2
chr2_+_47449790 0.659 NM_002354
EPCAM
epithelial cell adhesion molecule
chr6_-_159159242 0.645 EZR
ezrin
chr6_+_150112549 0.644 PCMT1
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr1_-_153209625 0.637 NM_001130040
NM_183001
SHC1

SHC (Src homology 2 domain containing) transforming protein 1

chrX_-_48824504 0.637 NM_001029896
WDR45
WD repeat domain 45
chr6_-_159159186 0.611 EZR
ezrin
chr19_+_41322839 0.607 CAPNS1
calpain, small subunit 1
chr19_+_41322841 0.603 CAPNS1
calpain, small subunit 1
chrX_+_48915127 0.582 NM_002668
PLP2
proteolipid protein 2 (colonic epithelium-enriched)
chr11_+_2881080 0.581 SLC22A18
solute carrier family 22, member 18
chr12_-_15005761 0.575 NM_001175
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr6_-_159159257 0.574 NM_003379
EZR
ezrin
chr19_+_41322686 0.569 NM_001003962
NM_001749
CAPNS1

calpain, small subunit 1

chr17_+_27795633 0.567 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr6_+_30964441 0.565 NM_013994
DDR1
discoidin domain receptor tyrosine kinase 1
chr21_+_29439768 0.564 C21orf7
chromosome 21 open reading frame 7
chr7_+_142788579 0.563 ZYX
zyxin
chr6_+_150112537 0.556 PCMT1
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr20_+_43468617 0.551 NM_001048223
NM_001048224
DBNDD2

dysbindin (dystrobrevin binding protein 1) domain containing 2

chr1_+_35019376 0.544 NM_024009
GJB3
gap junction protein, beta 3, 31kDa
chr7_-_136678815 0.542 PTN
pleiotrophin
chr3_+_156280129 0.525 NM_000902
MME
membrane metallo-endopeptidase
chr4_+_74825138 0.520 NM_000584
IL8
interleukin 8
chr3_+_185377341 0.519 AP2M1
adaptor-related protein complex 2, mu 1 subunit
chr17_-_36792161 0.515 NM_021013
KRT34
keratin 34
chr1_-_6585485 0.512 NM_014851
KLHL21
kelch-like 21 (Drosophila)
chr6_-_150388292 0.508 NM_130900
RAET1L
retinoic acid early transcript 1L
chr6_+_150112511 0.503 NM_005389
PCMT1
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr11_-_102156531 0.500 NM_002425
MMP10
matrix metallopeptidase 10 (stromelysin 2)
chr19_-_56164628 0.500 NM_002774
KLK6
kallikrein-related peptidase 6
chr17_-_62793129 0.500 NM_002816
NM_174871
PSMD12

proteasome (prosome, macropain) 26S subunit, non-ATPase, 12

chr7_+_142788517 0.499 ZYX
zyxin
chr5_-_141041982 0.498 NM_022481
ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr8_-_42184194 0.496 PLAT
plasminogen activator, tissue
chr22_-_28972683 0.489 NM_002309
LIF
leukemia inhibitory factor (cholinergic differentiation factor)
chr7_+_142788569 0.486 ZYX
zyxin
chr6_-_134538762 0.485 NM_001143678
SGK1
serum/glucocorticoid regulated kinase 1
chr7_+_142788480 0.485 NM_001010972
NM_003461
ZYX

zyxin

chr3_+_171422940 0.484 PRKCI
protein kinase C, iota
chr17_-_7434113 0.481 NM_006942
SOX15
SRY (sex determining region Y)-box 15
chr12_-_54409107 0.477 NM_001040034
NM_001780
CD63

CD63 molecule

chr7_+_142788521 0.472 ZYX
zyxin
chr20_+_44070946 0.472 NM_004994
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr7_+_142788566 0.471 ZYX
zyxin
chr22_+_43451600 0.467 PRR5
proline rich 5 (renal)
chr16_+_15503623 0.460 NM_001142469
C16orf45
chromosome 16 open reading frame 45
chr6_+_41712907 0.458 MDFI
MyoD family inhibitor
chr8_-_25371708 0.452 KCTD9
potassium channel tetramerisation domain containing 9
chr3_+_156280338 0.437 NM_007287
MME
membrane metallo-endopeptidase
chr17_+_77261477 0.434 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr14_-_74713062 0.434 TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chr12_-_54409059 0.428 CD63
CD63 molecule
chr22_+_29808845 0.426 SMTN
smoothelin
chr22_-_43040063 0.425 NM_001099294
KIAA1644
KIAA1644
chr17_+_77261440 0.420 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr6_-_112033775 0.418 TRAF3IP2
TRAF3 interacting protein 2
chr3_+_101720753 0.417 TMEM45A
transmembrane protein 45A
chr12_-_54409015 0.412 CD63
CD63 molecule
chr5_-_141041933 0.410 ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr17_+_77261447 0.409 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr15_-_32875040 0.406 NM_005159
ACTC1
actin, alpha, cardiac muscle 1
chr6_+_84626113 0.404 CYB5R4
cytochrome b5 reductase 4
chr17_-_18102767 0.399 NM_002018
FLII
flightless I homolog (Drosophila)
chr7_-_136678973 0.399 PTN
pleiotrophin
chr17_-_18102594 0.393 FLII
flightless I homolog (Drosophila)
chr3_-_49370682 0.389 GPX1
glutathione peroxidase 1
chr21_+_29374743 0.386 NM_020152
C21orf7
chromosome 21 open reading frame 7
chr19_-_52710129 0.379 NM_003827
NAPA
N-ethylmaleimide-sensitive factor attachment protein, alpha
chr6_-_42017337 0.378 NM_001136125
NM_001760
CCND3

cyclin D3

chr6_+_84626083 0.377 NM_016230
CYB5R4
cytochrome b5 reductase 4
chr11_+_62405736 0.376 SLC3A2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
chr7_+_68701704 0.373 NM_001127231
NM_001127232
NM_015570
AUTS2


autism susceptibility candidate 2


chr14_-_74713086 0.370 TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chr20_+_43468046 0.370 NM_001197139
NM_001048221
NM_001048222
NM_001197140
NM_018478
DBNDD2




dysbindin (dystrobrevin binding protein 1) domain containing 2




chr12_-_54409067 0.368 CD63
CD63 molecule
chr14_-_74713012 0.367 TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chr17_+_27795645 0.367 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr6_-_153494076 0.365 NM_012419
RGS17
regulator of G-protein signaling 17
chr3_+_171422917 0.362 PRKCI
protein kinase C, iota
chr8_-_24869945 0.362 NM_006158
NEFL
neurofilament, light polypeptide
chr5_+_74016806 0.356 HEXB
hexosaminidase B (beta polypeptide)
chr18_+_59405513 0.353 NM_012397
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr17_+_77261401 0.351 NM_004712
HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr17_+_71892538 0.350 SPHK1
sphingosine kinase 1
chr17_-_18102743 0.344 FLII
flightless I homolog (Drosophila)
chrX_-_10761729 0.337 NM_033290
MID1
midline 1 (Opitz/BBB syndrome)
chr3_+_151803755 0.329 NM_016275
SELT
selenoprotein T
chr2_-_55131176 0.329 RTN4
reticulon 4
chr21_-_35181956 0.329 RUNX1
runt-related transcription factor 1
chr20_+_48240772 0.324 NM_005194
CEBPB
CCAAT/enhancer binding protein (C/EBP), beta
chr17_+_71893014 0.324 SPHK1
sphingosine kinase 1
chr7_+_142768916 0.323 ZYX
zyxin

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.46 6.80e-03 GO:0000082 G1/S transition of mitotic cell cycle
3.13 1.61e-02 GO:0008544 epidermis development
1.77 1.92e-02 GO:0043067 regulation of programmed cell death
8.13 2.24e-02 GO:0031424 keratinization
1.75 2.92e-02 GO:0010941 regulation of cell death
1.75 3.08e-02 GO:0042981 regulation of apoptosis
5.01 3.78e-02 GO:0006521 regulation of cellular amino acid metabolic process
4.14 4.42e-02 GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
5.63 8.96e-05 GO:0000502 proteasome complex
9.02 7.96e-03 GO:0001533 cornified envelope

Nothing significant found in function category.