Motif ID: SOX2.p2

Z-value: 1.432


Transcription factors associated with SOX2.p2:

Gene SymbolEntrez IDGene Name
SOX2 6657 SRY (sex determining region Y)-box 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SOX2chr3_+_182912769-0.292.8e-01Click!


Activity profile for motif SOX2.p2.

activity profile for motif SOX2.p2


Sorted Z-values histogram for motif SOX2.p2

Sorted Z-values for motif SOX2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_6103945 3.670 NM_000552
VWF
von Willebrand factor
chr6_+_12398514 3.115 NM_001168319
NM_001955
EDN1

endothelin 1

chr17_-_59817722 3.031 NM_000442
PECAM1
platelet/endothelial cell adhesion molecule
chr7_+_102340579 3.017 NM_001031692
NM_005824
LRRC17

leucine rich repeat containing 17

chr2_+_33213111 2.891 NM_000627
NM_001166264
NM_001166265
NM_001166266
LTBP1



latent transforming growth factor beta binding protein 1



chr4_-_101658094 2.789 NM_001159694
NM_016242
EMCN

endomucin

chr17_-_59817456 2.659 PECAM1
platelet/endothelial cell adhesion molecule
chr17_-_59817575 2.656 PECAM1
platelet/endothelial cell adhesion molecule
chr1_+_85819004 2.583 NM_001554
CYR61
cysteine-rich, angiogenic inducer, 61
chr17_-_59817654 2.538 PECAM1
platelet/endothelial cell adhesion molecule
chr7_-_111633620 2.486 NM_014705
DOCK4
dedicator of cytokinesis 4
chr5_-_39460687 2.461 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr2_-_188021117 2.452 NM_005795
CALCRL
calcitonin receptor-like
chr6_+_121798443 2.398 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr10_+_70517823 2.196 NM_002727
SRGN
serglycin
chrX_+_15428820 2.099 NM_203281
BMX
BMX non-receptor tyrosine kinase
chr10_+_70517863 2.083 SRGN
serglycin
chr18_+_71051713 2.082 NM_005786
TSHZ1
teashirt zinc finger homeobox 1
chr6_+_114285209 2.049 NM_002356
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr1_-_68470585 1.975 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr4_+_40953698 1.946 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr7_-_27171673 1.940 NM_152739
HOXA9
homeobox A9
chr4_+_146623405 1.835 NM_001003688
SMAD1
SMAD family member 1
chr7_+_134114957 1.820 CALD1
caldesmon 1
chr7_-_107430566 1.780 NM_002291
LAMB1
laminin, beta 1
chr5_-_111119846 1.769 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr1_-_171441234 1.764 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr7_+_93388951 1.748 NM_004126
GNG11
guanine nucleotide binding protein (G protein), gamma 11
chr8_-_6407882 1.736 NM_001118887
NM_001118888
NM_001147
ANGPT2


angiopoietin 2


chr22_-_17892859 1.730 NM_001130861
NM_003277
CLDN5

claudin 5

chr1_+_81544432 1.719 LPHN2
latrophilin 2
chr11_+_5667494 1.696 NM_006074
TRIM22
tripartite motif containing 22
chr13_-_109757442 1.650 NM_001845
COL4A1
collagen, type IV, alpha 1
chr5_-_39461054 1.630 NM_001343
DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr7_-_27186400 1.625 NM_153715
HOXA10
homeobox A10
chr5_+_15553288 1.596 NM_012304
FBXL7
F-box and leucine-rich repeat protein 7
chrX_+_100692071 1.586 NM_016608
ARMCX1
armadillo repeat containing, X-linked 1
chr4_+_40953666 1.577 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr16_+_64958025 1.548 NM_001795
CDH5
cadherin 5, type 2 (vascular endothelium)
chr4_+_40953652 1.537 NM_004181
UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr2_-_151052391 1.517 NM_005168
RND3
Rho family GTPase 3
chrX_+_100220491 1.501 NM_021637
TMEM35
transmembrane protein 35
chr1_-_95165037 1.461 CNN3
calponin 3, acidic
chr8_-_17624009 1.453 NM_001001931
MTUS1
microtubule associated tumor suppressor 1
chr5_-_39460787 1.430 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr1_+_66570363 1.424 NM_001037339
PDE4B
phosphodiesterase 4B, cAMP-specific
chr2_-_189752575 1.398 NM_000393
COL5A2
collagen, type V, alpha 2
chr5_+_34723420 1.393 NM_001145523
RAI14
retinoic acid induced 14
chr1_-_95165089 1.373 NM_001839
CNN3
calponin 3, acidic
chr10_+_17311282 1.371 VIM
vimentin
chr10_+_17311283 1.370 VIM
vimentin
chr10_+_17311307 1.353 VIM
vimentin
chr3_-_121652183 1.342 NM_007085
FSTL1
follistatin-like 1
chr10_+_17311242 1.321 VIM
vimentin
chr1_+_149299307 1.321 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr9_+_115382760 1.319 NM_021106
RGS3
regulator of G-protein signaling 3
chr9_+_115382990 1.316 RGS3
regulator of G-protein signaling 3
chr6_+_153060722 1.301 NM_025107
MYCT1
myc target 1
chr9_+_115303527 1.261 NM_130795
RGS3
regulator of G-protein signaling 3
chr1_-_85703198 1.252 DDAH1
dimethylarginine dimethylaminohydrolase 1
chr6_-_32271868 1.251 NOTCH4
notch 4
chr6_-_134680888 1.238 NM_001143676
SGK1
serum/glucocorticoid regulated kinase 1
chr1_+_99884018 1.227 NM_017734
PALMD
palmdelphin
chr10_+_17310475 1.219 VIM
vimentin
chrX_-_10605726 1.204 NM_001098624
MID1
midline 1 (Opitz/BBB syndrome)
chr12_+_47498778 1.201 NM_000725
CACNB3
calcium channel, voltage-dependent, beta 3 subunit
chrX_+_135079461 1.196 NM_001167819
FHL1
four and a half LIM domains 1
chr21_+_34112456 1.188 ITSN1
intersectin 1 (SH3 domain protein)
chr10_+_11246934 1.188 NM_001025076
NM_001083591
CELF2

CUGBP, Elav-like family member 2

chr10_+_11247059 1.185 CELF2
CUGBP, Elav-like family member 2
chrX_+_135079120 1.178 NM_001159704
FHL1
four and a half LIM domains 1
chr7_-_47588266 1.177 TNS3
tensin 3
chrX_+_55951280 1.168


chr9_-_14388981 1.161 NM_001190738
NFIB
nuclear factor I/B
chr1_-_224993498 1.159 NM_002221
ITPKB
inositol 1,4,5-trisphosphate 3-kinase B
chr1_+_66230977 1.158 NM_001037340
PDE4B
phosphodiesterase 4B, cAMP-specific
chr3_+_174598937 1.148 NM_014932
NLGN1
neuroligin 1
chr8_-_93099040 1.143 NM_175636
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr9_+_102275310 1.135 NM_003692
TMEFF1
transmembrane protein with EGF-like and two follistatin-like domains 1
chr7_-_47588160 1.129 TNS3
tensin 3
chr3_-_170347019 1.128 NM_001105078
MECOM
MDS1 and EVI1 complex locus
chr15_-_21483457 1.102 NDN
necdin homolog (mouse)
chr9_+_36026900 1.091 NM_021111
RECK
reversion-inducing-cysteine-rich protein with kazal motifs
chrX_+_80343958 1.090 NM_003022
SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr10_+_11087259 1.087 NM_001025077
CELF2
CUGBP, Elav-like family member 2
chr1_+_169421011 1.085 NM_001460
FMO2
flavin containing monooxygenase 2 (non-functional)
chr10_+_11087280 1.082 CELF2
CUGBP, Elav-like family member 2
chrX_+_12904207 1.079 TMSB4X
TMSL3
thymosin beta 4, X-linked
thymosin-like 3
chrX_+_15435351 1.079 NM_001721
BMX
BMX non-receptor tyrosine kinase
chr12_-_10142779 1.078 NM_016511
CLEC1A
C-type lectin domain family 1, member A
chr6_-_112682573 1.066 LAMA4
laminin, alpha 4
chr5_-_16989371 1.059 NM_012334
MYO10
myosin X
chr2_+_36436873 1.057 NM_016441
CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr6_+_21701942 1.044 NM_003107
SOX4
SRY (sex determining region Y)-box 4
chr2_+_189547377 1.042 COL3A1
collagen, type III, alpha 1
chr15_-_21483503 1.019 NM_002487
NDN
necdin homolog (mouse)
chr1_-_85816520 1.019 NM_001134445
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr10_-_88707299 1.013 NM_024756
MMRN2
multimerin 2
chr1_+_43539239 1.007 NM_005424
TIE1
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
chrX_-_99778340 0.997 NM_003270
TSPAN6
tetraspanin 6
chr15_-_81667773 0.995 HDGFRP3
hepatoma-derived growth factor, related protein 3
chr1_-_223907283 0.990 NM_001008493
NM_018212
ENAH

enabled homolog (Drosophila)

chr8_-_82557956 0.980 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chrX_+_80344215 0.977 SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr13_+_109935250 0.971 COL4A2
collagen, type IV, alpha 2
chr9_-_14303899 0.971 NFIB
nuclear factor I/B
chr8_-_93176618 0.959 NM_001198629
NM_001198630
NM_001198632
NM_175635
RUNX1T1



runt-related transcription factor 1; translocated to, 1 (cyclin D-related)



chr14_+_85066207 0.958 NM_013231
FLRT2
fibronectin leucine rich transmembrane protein 2
chr1_+_149299530 0.944 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chrX_+_12903145 0.941 NM_021109
NM_183049
TMSB4X
TMSL3
thymosin beta 4, X-linked
thymosin-like 3
chrX_+_80344253 0.936 SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chrX_+_135057202 0.935 NM_001159702
NM_001159703
NM_001449
FHL1


four and a half LIM domains 1


chr7_+_16759845 0.933 NM_014399
TSPAN13
tetraspanin 13
chr4_+_91035025 0.931 NM_007351
MMRN1
multimerin 1
chr1_+_149299504 0.930 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr1_-_79244948 0.927 NM_022159
ELTD1
EGF, latrophilin and seven transmembrane domain containing 1
chr17_-_3518654 0.925 NM_014604
TAX1BP3
Tax1 (human T-cell leukemia virus type I) binding protein 3
chr13_-_98428244 0.923 NM_001130048
NM_001130050
DOCK9

dedicator of cytokinesis 9

chr17_-_3518568 0.917 TAX1BP3
Tax1 (human T-cell leukemia virus type I) binding protein 3
chr1_+_149299490 0.912 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr14_+_76297885 0.911 NM_014909
VASH1
vasohibin 1
chr7_-_130891861 0.903 NM_001018111
NM_005397
PODXL

podocalyxin-like

chr1_+_161305188 0.898 NM_005613
RGS4
regulator of G-protein signaling 4
chr15_+_94670160 0.897 NM_001145155
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr8_+_70567634 0.897 SULF1
sulfatase 1
chr7_-_27171648 0.891 HOXA9
homeobox A9
chr1_+_154120170 0.891 SYT11
synaptotagmin XI
chr4_+_146622154 0.887 NM_005900
SMAD1
SMAD family member 1
chr5_+_140719773 0.885 NM_018923
NM_032096
PCDHGB2

protocadherin gamma subfamily B, 2

chr4_-_91979113 0.885 NM_183049
TMSL3
thymosin-like 3
chr10_-_29794484 0.884 SVIL
supervillin
chr15_-_81667169 0.871 NM_016073
HDGFRP3
hepatoma-derived growth factor, related protein 3
chr1_+_181871830 0.866 NM_015149
RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr8_+_79591074 0.857 PKIA
protein kinase (cAMP-dependent, catalytic) inhibitor alpha
chr7_-_11838260 0.846 NM_015204
THSD7A
thrombospondin, type I, domain containing 7A
chr7_-_27190882 0.843 HOXA11
homeobox A11
chr3_+_153469421 0.842 MBNL1
muscleblind-like (Drosophila)
chr8_+_70567581 0.838 NM_001128205
NM_001128206
SULF1

sulfatase 1

chr21_-_38792173 0.834 NM_001136155
NM_182918
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr9_-_14303509 0.822 NFIB
nuclear factor I/B
chr1_+_161305558 0.820 NM_001113381
RGS4
regulator of G-protein signaling 4
chr20_+_11846536 0.820 NM_014962
BTBD3
BTB (POZ) domain containing 3
chr3_-_150578148 0.814 TM4SF1
transmembrane 4 L six family member 1
chr7_-_41709191 0.811 NM_002192
INHBA
inhibin, beta A
chrX_-_37964924 0.803 NM_001170750
NM_001170751
NM_001170752
NM_006307
SRPX



sushi-repeat containing protein, X-linked



chr22_+_36422940 0.803 NM_001039141
TRIOBP
TRIO and F-actin binding protein
chr5_-_111120929 0.796 NM_001142482
NM_001142481
C5orf13

chromosome 5 open reading frame 13

chr3_+_161040343 0.791 NM_001197109
SCHIP1
schwannomin interacting protein 1
chr9_-_14076901 0.786 NFIB
nuclear factor I/B
chr1_-_199742871 0.783 NM_001193570
NM_004078
CSRP1

cysteine and glycine-rich protein 1

chr1_-_110085182 0.780 NM_000849
GSTM3
glutathione S-transferase mu 3 (brain)
chr15_+_65145248 0.772 NM_005902
SMAD3
SMAD family member 3
chr21_+_36429079 0.769 NM_001236
CBR3
carbonyl reductase 3
chr3_-_124822113 0.766 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr8_-_93144366 0.764 NM_004349
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr3_+_161040439 0.764 SCHIP1
schwannomin interacting protein 1
chr11_-_6633427 0.755 NM_003737
DCHS1
dachsous 1 (Drosophila)
chr10_+_53744043 0.754 NM_012242
DKK1
dickkopf homolog 1 (Xenopus laevis)
chr3_-_101316038 0.754 NM_001042459
NM_182909
FILIP1L

filamin A interacting protein 1-like

chr3_+_115099007 0.753 NM_001172105
GRAMD1C
GRAM domain containing 1C
chr3_-_124821868 0.746 MYLK
myosin light chain kinase
chr17_+_16886491 0.745 NM_015134
NM_201274
MPRIP

myosin phosphatase Rho interacting protein

chr17_-_30783631 0.740 NM_018042
SLFN12
schlafen family member 12
chr9_-_87904844 0.739 NM_177937
GOLM1
golgi membrane protein 1
chr12_-_90100679 0.736 DCN
decorin
chr11_+_129496792 0.736 APLP2
amyloid beta (A4) precursor-like protein 2
chr6_-_128883125 0.733 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr4_+_87070449 0.730 NM_031305
ARHGAP24
Rho GTPase activating protein 24
chr5_+_140871107 0.725


chr9_+_115396020 0.723 NM_144489
RGS3
regulator of G-protein signaling 3
chr1_-_199742841 0.722 CSRP1
cysteine and glycine-rich protein 1
chr5_-_111120817 0.721 NM_004772
C5orf13
chromosome 5 open reading frame 13
chr18_-_51406359 0.720 TCF4
transcription factor 4
chr17_-_3518628 0.715 TAX1BP3
Tax1 (human T-cell leukemia virus type I) binding protein 3
chr2_-_26058941 0.713 NM_002254
KIF3C
kinesin family member 3C
chr15_-_88148538 0.706 ANPEP
alanyl (membrane) aminopeptidase
chr2_+_188865634 0.705 NM_016315
GULP1
GULP, engulfment adaptor PTB domain containing 1
chr2_-_26058831 0.704 KIF3C
kinesin family member 3C
chr5_+_71538456 0.703 MAP1B
microtubule-associated protein 1B
chr14_-_91483757 0.703 NM_006329
FBLN5
fibulin 5
chr6_-_11340887 0.699 NM_006403
NM_182966
NEDD9

neural precursor cell expressed, developmentally down-regulated 9

chr12_-_90100710 0.696 DCN
decorin
chr12_+_14429499 0.694 ATF7IP
activating transcription factor 7 interacting protein
chr1_-_32574185 0.687 NM_023009
MARCKSL1
MARCKS-like 1
chr5_-_168204430 0.685


chr1_-_26105954 0.684 NM_203399
STMN1
stathmin 1
chr2_-_217248967 0.684 IGFBP5
insulin-like growth factor binding protein 5
chr8_-_27524744 0.684 NM_203339
CLU
clusterin
chr14_-_104515738 0.683 NM_138420
AHNAK2
AHNAK nucleoprotein 2
chr6_-_76022565 0.680 TMEM30A
transmembrane protein 30A
chr14_+_105012106 0.678 NM_001312
CRIP2
cysteine-rich protein 2
chr2_+_66516196 0.677 MEIS1
Meis homeobox 1
chr10_-_30064600 0.677 NM_003174
SVIL
supervillin
chr6_-_139737432 0.677 CITED2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
chr6_-_11340869 0.669 NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr9_+_4480193 0.668 NM_004170
SLC1A1
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
chr12_-_90100733 0.662 NM_001920
DCN
decorin
chr2_+_188865796 0.660 GULP1
GULP, engulfment adaptor PTB domain containing 1
chr7_+_93862137 0.660 COL1A2
PLAG1
collagen, type I, alpha 2
pleiomorphic adenoma gene 1
chr8_-_93184629 0.660 NM_001198633
NM_175634
RUNX1T1

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.55 6.75e-03 GO:2000026 regulation of multicellular organismal development
1.51 1.03e-02 GO:0051128 regulation of cellular component organization
1.18 1.12e-02 GO:0032501 multicellular organismal process
1.92 1.17e-02 GO:0001568 blood vessel development
1.36 1.47e-02 GO:0009653 anatomical structure morphogenesis
1.86 1.98e-02 GO:0001944 vasculature development
1.60 2.29e-02 GO:0006928 cellular component movement
2.30 2.51e-02 GO:0007156 homophilic cell adhesion
1.54 3.68e-02 GO:0045595 regulation of cell differentiation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.43 1.18e-04 GO:0005912 adherens junction
2.18 1.88e-03 GO:0070161 anchoring junction
1.61 3.61e-03 GO:0030054 cell junction
2.47 5.26e-03 GO:0005925 focal adhesion
2.36 8.68e-03 GO:0030055 cell-substrate junction
2.36 1.19e-02 GO:0005924 cell-substrate adherens junction

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.90 7.06e-04 GO:0003779 actin binding
1.64 2.48e-03 GO:0008092 cytoskeletal protein binding
2.38 8.62e-03 GO:0019838 growth factor binding
3.18 1.91e-02 GO:0046332 SMAD binding
1.51 2.84e-02 GO:0005509 calcium ion binding
2.46 4.55e-02 GO:0019199 transmembrane receptor protein kinase activity