Motif ID: SOX2.p2

Z-value: 1.432


Transcription factors associated with SOX2.p2:

Gene SymbolEntrez IDGene Name
SOX2 6657 SRY (sex determining region Y)-box 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SOX2chr3_+_182912769-0.292.8e-01Click!


Activity profile for motif SOX2.p2.

activity profile for motif SOX2.p2


Sorted Z-values histogram for motif SOX2.p2

Sorted Z-values for motif SOX2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_6103945 3.670 NM_000552
 VWF
von Willebrand factor
chr6_+_12398514 3.115 NM_001168319
NM_001955
 EDN1

endothelin 1

chr17_-_59817722 3.031 NM_000442
 PECAM1
platelet/endothelial cell adhesion molecule
chr7_+_102340579 3.017 NM_001031692
NM_005824
 LRRC17

leucine rich repeat containing 17

chr2_+_33213111 2.891 NM_000627
NM_001166264
NM_001166265
NM_001166266
 LTBP1



latent transforming growth factor beta binding protein 1



chr4_-_101658094 2.789 NM_001159694
NM_016242
 EMCN

endomucin

chr17_-_59817456 2.659 PECAM1
platelet/endothelial cell adhesion molecule
chr17_-_59817575 2.656 PECAM1
platelet/endothelial cell adhesion molecule
chr1_+_85819004 2.583 NM_001554
 CYR61
cysteine-rich, angiogenic inducer, 61
chr17_-_59817654 2.538 PECAM1
platelet/endothelial cell adhesion molecule
chr7_-_111633620 2.486 NM_014705
 DOCK4
dedicator of cytokinesis 4
chr5_-_39460687 2.461 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr2_-_188021117 2.452 NM_005795
 CALCRL
calcitonin receptor-like
chr6_+_121798443 2.398 NM_000165
 GJA1
gap junction protein, alpha 1, 43kDa
chr10_+_70517823 2.196 NM_002727
 SRGN
serglycin
chrX_+_15428820 2.099 NM_203281
 BMX
BMX non-receptor tyrosine kinase
chr10_+_70517863 2.083 SRGN
serglycin
chr18_+_71051713 2.082 NM_005786
 TSHZ1
teashirt zinc finger homeobox 1
chr6_+_114285209 2.049 NM_002356
 MARCKS
myristoylated alanine-rich protein kinase C substrate
chr1_-_68470585 1.975 NM_001002292
NM_001193334
NM_024911
 WLS


wntless homolog (Drosophila)



Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 9 of 9 entries
enrichment   p-value GO term description
2.30 2.51e-02 GO:0007156 homophilic cell adhesion
1.92 1.17e-02 GO:0001568 blood vessel development
1.86 1.98e-02 GO:0001944 vasculature development
1.60 2.29e-02 GO:0006928 cellular component movement
1.55 6.75e-03 GO:2000026 regulation of multicellular organismal development
1.54 3.68e-02 GO:0045595 regulation of cell differentiation
1.51 1.03e-02 GO:0051128 regulation of cellular component organization
1.36 1.47e-02 GO:0009653 anatomical structure morphogenesis
1.18 1.12e-02 GO:0032501 multicellular organismal process

Gene overrepresentation in compartment category:

Showing 1 to 6 of 6 entries
enrichment   p-value GO term description
2.47 5.26e-03 GO:0005925 focal adhesion
2.43 1.18e-04 GO:0005912 adherens junction
2.36 8.68e-03 GO:0030055 cell-substrate junction
2.36 1.19e-02 GO:0005924 cell-substrate adherens junction
2.18 1.88e-03 GO:0070161 anchoring junction
1.61 3.61e-03 GO:0030054 cell junction

Gene overrepresentation in function category:

Showing 1 to 6 of 6 entries
enrichment   p-value GO term description
3.18 1.91e-02 GO:0046332 SMAD binding
2.46 4.55e-02 GO:0019199 transmembrane receptor protein kinase activity
2.38 8.62e-03 GO:0019838 growth factor binding
1.90 7.06e-04 GO:0003779 actin binding
1.64 2.48e-03 GO:0008092 cytoskeletal protein binding
1.51 2.84e-02 GO:0005509 calcium ion binding