Motif ID: TFEB.p2

Z-value: 2.688


Transcription factors associated with TFEB.p2:

Gene SymbolEntrez IDGene Name
TFEB 7942 transcription factor EB

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TFEBchr6_-_41810712,
chr6_-_41811916
-0.411.1e-01Click!


Activity profile for motif TFEB.p2.

activity profile for motif TFEB.p2


Sorted Z-values histogram for motif TFEB.p2

Sorted Z-values for motif TFEB.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFEB.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_+_112999538 15.229 LAMP1
lysosomal-associated membrane protein 1
chr13_+_112999462 13.625 NM_005561
LAMP1
lysosomal-associated membrane protein 1
chr13_+_112999590 11.682 LAMP1
lysosomal-associated membrane protein 1
chrX_+_102518064 10.940 NGFRAP1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr19_+_54149843 9.599 NM_004324
NM_138761
NM_138763
NM_138764
BAX



BCL2-associated X protein



chr19_+_54149941 9.590 BAX
BCL2-associated X protein
chr19_+_54149963 8.814 BAX
BCL2-associated X protein
chr1_-_151775221 8.473 NM_014624
S100A6
S100 calcium binding protein A6
chr1_-_68470585 7.697 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr3_-_49370755 7.669 NM_000581
NM_201397
GPX1

glutathione peroxidase 1

chr20_+_43953428 7.590 CTSA
cathepsin A
chr20_+_43953372 7.451 CTSA
cathepsin A
chrX_-_100801472 7.442 NM_014782
NM_177949
ARMCX2

armadillo repeat containing, X-linked 2

chr3_-_49370682 7.437 GPX1
glutathione peroxidase 1
chr5_+_34692124 7.389 NM_001145522
NM_015577
RAI14

retinoic acid induced 14

chr22_+_34107087 7.370 HMOX1
heme oxygenase (decycling) 1
chr7_-_47588652 7.189 TNS3
tensin 3
chr15_-_71712711 7.125 NM_001161363
NM_001161364
NM_012428
NM_017455
NPTN



neuroplastin



chr22_+_34107051 7.054 NM_002133
HMOX1
heme oxygenase (decycling) 1
chr12_-_47604930 6.889 NM_001143781
FKBP11
FK506 binding protein 11, 19 kDa
chrX_-_34585287 6.831 NM_031442
TMEM47
transmembrane protein 47
chr19_-_10625449 6.785 LOC147727
hypothetical LOC147727
chr1_-_151775087 6.717 S100A6
S100 calcium binding protein A6
chr6_+_151603201 6.563 AKAP12
A kinase (PRKA) anchor protein 12
chr5_+_52812165 6.495 FST
follistatin
chr5_+_34692239 6.350 RAI14
retinoic acid induced 14
chr6_+_151602787 6.293 NM_005100
AKAP12
A kinase (PRKA) anchor protein 12
chr7_-_47588160 6.222 TNS3
tensin 3
chr15_-_71712605 6.068 NPTN
neuroplastin
chr1_-_153477511 6.068 GBA
glucosidase, beta, acid
chr1_-_151775119 6.020 S100A6
S100 calcium binding protein A6
chr20_+_43953606 6.017 CTSA
cathepsin A
chr1_-_153477673 5.848 NM_001171812
NM_000157
GBA

glucosidase, beta, acid

chr20_+_43953331 5.776 CTSA
cathepsin A
chr1_-_94475840 5.746 NM_004815
ARHGAP29
Rho GTPase activating protein 29
chr7_-_47588266 5.702 TNS3
tensin 3
chr5_+_34692352 5.638 NM_001145520
RAI14
retinoic acid induced 14
chr12_-_63439456 5.357 NM_002076
GNS
glucosamine (N-acetyl)-6-sulfatase
chr2_+_46779553 5.303 NM_014011
SOCS5
suppressor of cytokine signaling 5
chr1_+_11788827 5.241 CLCN6
chloride channel 6
chrX_+_100692071 5.235 NM_016608
ARMCX1
armadillo repeat containing, X-linked 1
chr3_+_113763561 5.151 NM_017945
SLC35A5
solute carrier family 35, member A5
chr9_+_114953048 4.991 NM_001860
SLC31A2
solute carrier family 31 (copper transporters), member 2
chr17_+_39778016 4.982 NM_002087
GRN
granulin
chr10_-_32257768 4.953 NM_018287
ARHGAP12
Rho GTPase activating protein 12
chr5_+_52812236 4.882 NM_006350
NM_013409
FST

follistatin

chr2_-_227372574 4.799 IRS1
insulin receptor substrate 1
chr3_+_160002605 4.722 MFSD1
major facilitator superfamily domain containing 1
chr10_-_32257693 4.681 ARHGAP12
Rho GTPase activating protein 12
chr1_+_152459918 4.585 NM_014847
UBAP2L
ubiquitin associated protein 2-like
chr3_+_33293915 4.565 NM_012157
NM_001171713
FBXL2

F-box and leucine-rich repeat protein 2

chr17_+_39778153 4.412 GRN
granulin
chr9_+_114953087 4.283 SLC31A2
solute carrier family 31 (copper transporters), member 2
chr16_-_66072477 4.276 NM_004691
ATP6V0D1
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
chr17_+_39778191 4.231 GRN
granulin
chr7_-_27149750 4.228 NM_019102
HOXA5
homeobox A5
chr12_-_63439449 4.228 GNS
glucosamine (N-acetyl)-6-sulfatase
chr3_+_160002571 4.154 MFSD1
major facilitator superfamily domain containing 1
chr7_+_23252909 4.129 GPNMB
glycoprotein (transmembrane) nmb
chr17_+_39778180 4.063 GRN
granulin
chr3_+_51403760 4.032 NM_013286
RBM15B
RNA binding motif protein 15B
chr3_+_113763601 4.030 SLC35A5
solute carrier family 35, member A5
chr3_+_160473729 3.986 NM_001197107
NM_001197108
NM_014575
SCHIP1


schwannomin interacting protein 1


chr16_-_87450849 3.982 NM_000512
GALNS
galactosamine (N-acetyl)-6-sulfate sulfatase
chr12_-_54409107 3.976 NM_001040034
NM_001780
CD63

CD63 molecule

chr7_-_29995809 3.929 NM_001145515
NM_014766
NM_001145513
SCRN1


secernin 1


chr4_+_78297356 3.917 NM_004354
CCNG2
cyclin G2
chr6_+_151603346 3.909 AKAP12
A kinase (PRKA) anchor protein 12
chr19_+_45546369 3.881 PLD3
phospholipase D family, member 3
chr3_+_129927716 3.874 RAB7A
RAB7A, member RAS oncogene family
chr6_+_151688327 3.842 NM_144497
AKAP12
A kinase (PRKA) anchor protein 12
chrX_+_102727068 3.832 NM_001006935
NM_001006937
NM_024863
TCEAL4


transcription elongation factor A (SII)-like 4


chr3_+_160002619 3.824 MFSD1
major facilitator superfamily domain containing 1
chrX_+_55760774 3.785 NM_006064
NM_016656
RRAGB

Ras-related GTP binding B

chr1_-_94475504 3.762 ARHGAP29
Rho GTPase activating protein 29
chr3_+_133619193 3.749 NM_015268
DNAJC13
DnaJ (Hsp40) homolog, subfamily C, member 13
chr6_-_80713589 3.738 NM_022726
ELOVL4
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4
chr17_-_44043361 3.725 NM_004502
HOXB7
homeobox B7
chr7_+_23252915 3.693 GPNMB
glycoprotein (transmembrane) nmb
chr8_-_126173189 3.679 KIAA0196
KIAA0196
chr1_-_39097904 3.678 NM_022157
RRAGC
Ras-related GTP binding C
chr9_-_16860719 3.640 NM_017637
BNC2
basonuclin 2
chr16_-_87450734 3.618 GALNS
galactosamine (N-acetyl)-6-sulfate sulfatase
chr8_+_1759502 3.594 NM_014629
ARHGEF10
Rho guanine nucleotide exchange factor (GEF) 10
chr3_-_31998241 3.579 NM_001174060
NM_017784
OSBPL10

oxysterol binding protein-like 10

chr8_-_11763037 3.542 NM_001908
NM_147780
NM_147781
NM_147782
NM_147783
CTSB




cathepsin B




chr3_+_129927723 3.541 RAB7A
RAB7A, member RAS oncogene family
chr7_+_23252911 3.526 GPNMB
glycoprotein (transmembrane) nmb
chr12_-_54409059 3.520 CD63
CD63 molecule
chr5_+_150807331 3.519 NM_078483
SLC36A1
solute carrier family 36 (proton/amino acid symporter), member 1
chr12_-_54409015 3.516 CD63
CD63 molecule
chr7_+_17304707 3.480 NM_001621
AHR
aryl hydrocarbon receptor
chr8_-_126173055 3.475 KIAA0196
KIAA0196
chr3_+_129927668 3.471 NM_004637
RAB7A
RAB7A, member RAS oncogene family
chr22_+_36928972 3.466 NM_001161573
MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr8_-_126173186 3.451 KIAA0196
KIAA0196
chr16_+_30952382 3.416 NM_004604
STX4
syntaxin 4
chr13_-_49057629 3.412 RCBTB1
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
chr10_-_93382837 3.412 NM_005398
PPP1R3C
protein phosphatase 1, regulatory (inhibitor) subunit 3C
chr10_-_3817418 3.405 NM_001160124
NM_001160125
NM_001300
KLF6


Kruppel-like factor 6


chr11_+_9642226 3.404 SWAP70
SWAP switching B-cell complex 70kDa subunit
chr4_-_77354011 3.385 NM_005506
SCARB2
scavenger receptor class B, member 2
chr19_-_52710129 3.381 NM_003827
NAPA
N-ethylmaleimide-sensitive factor attachment protein, alpha
chr7_+_23252945 3.372 GPNMB
glycoprotein (transmembrane) nmb
chr1_+_11788793 3.366 NM_001286
NM_021735
NM_021736
NM_021737
CLCN6



chloride channel 6



chr13_-_109236897 3.363 NM_003749
IRS2
insulin receptor substrate 2
chr1_-_31618405 3.327 NM_004102
FABP3
fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
chr17_-_74487527 3.318 NM_005567
LGALS3BP
lectin, galactoside-binding, soluble, 3 binding protein
chr5_-_72780107 3.297 NM_004472
FOXD1
forkhead box D1
chr3_+_129927714 3.285 RAB7A
RAB7A, member RAS oncogene family
chr19_+_10625896 3.269 NM_001137673
NM_004516
NM_012218
NM_017620
NM_153464
ILF3




interleukin enhancer binding factor 3, 90kDa




chr7_-_27171673 3.240 NM_152739
HOXA9
homeobox A9
chrX_+_101862297 3.231 NM_001142524
NM_001142525
NM_001142526
NM_001142527
NM_001142528
NM_030639
BHLHB9





basic helix-loop-helix domain containing, class B, 9





chr8_-_126173108 3.231 KIAA0196
KIAA0196
chr11_-_8849485 3.204 ST5
suppression of tumorigenicity 5
chr7_-_27171648 3.160 HOXA9
homeobox A9
chr16_+_30952350 3.157 STX4
syntaxin 4
chrX_+_100549861 3.130 HNRNPH2
heterogeneous nuclear ribonucleoprotein H2 (H')
chr12_-_54409067 3.113 CD63
CD63 molecule
chr8_-_126173203 3.100 KIAA0196
KIAA0196
chr11_+_9642200 3.061 NM_015055
SWAP70
SWAP switching B-cell complex 70kDa subunit
chr4_+_128870968 3.056 NM_031291
SLC25A31
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31
chr9_-_21984414 3.036 NM_058195
CDKN2A
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
chr1_-_199742589 3.015 NM_001193571
CSRP1
cysteine and glycine-rich protein 1
chr12_-_108918411 2.984 GIT2
G protein-coupled receptor kinase interacting ArfGAP 2
chr14_-_54025414 2.982 GMFB
glia maturation factor, beta
chr19_-_5631910 2.977 NM_205767
C19orf70
chromosome 19 open reading frame 70
chr14_-_54025464 2.969 NM_004124
GMFB
glia maturation factor, beta
chr9_-_16860664 2.916 BNC2
basonuclin 2
chrX_+_102498035 2.905 NM_001006612
NM_001006613
NM_001006614
NM_016303
WBP5



WW domain binding protein 5



chrX_-_13866451 2.901 GPM6B
glycoprotein M6B
chrX_+_100549839 2.883 NM_001032393
NM_019597
HNRNPH2

heterogeneous nuclear ribonucleoprotein H2 (H')

chrX_+_100549869 2.880 HNRNPH2
heterogeneous nuclear ribonucleoprotein H2 (H')
chr9_-_130749604 2.874 NM_014908
DOLK
dolichol kinase
chrX_-_102205736 2.868 BEX1
brain expressed, X-linked 1
chr4_+_38860418 2.855 NM_025132
WDR19
WD repeat domain 19
chrX_+_100549885 2.852 HNRNPH2
heterogeneous nuclear ribonucleoprotein H2 (H')
chr18_-_20231709 2.851 OSBPL1A
oxysterol binding protein-like 1A
chr8_+_75066117 2.836 NM_001195797
NM_015364
LY96

lymphocyte antigen 96

chr1_-_239587090 2.827 NM_002924
RGS7
regulator of G-protein signaling 7
chr2_-_183611470 2.786 NM_013436
NM_205842
NCKAP1

NCK-associated protein 1

chr12_+_54396099 2.783 BLOC1S1-RDH5
BLOC1S1
BLOC1S1-RDH5 read-through transcript
biogenesis of lysosomal organelles complex-1, subunit 1
chr4_+_658250 2.769 MYL5
myosin, light chain 5, regulatory
chr5_-_150517499 2.752 ANXA6
annexin A6
chr4_+_78297418 2.749 CCNG2
cyclin G2
chr2_-_20115269 2.745 NM_014713
LAPTM4A
lysosomal protein transmembrane 4 alpha
chr10_+_45542653 2.727 NM_001169106
NM_001169107
NM_015262
FAM21C


FAM21A
family with sequence similarity 21, member C


family with sequence similarity 21, member A
chr12_-_63439415 2.697 GNS
glucosamine (N-acetyl)-6-sulfatase
chr3_+_160002582 2.682 MFSD1
major facilitator superfamily domain containing 1
chr17_+_18159294 2.656 NM_144775
SMCR8
Smith-Magenis syndrome chromosome region, candidate 8
chr1_-_239587007 2.644 RGS7
regulator of G-protein signaling 7
chr13_-_49057707 2.641 NM_018191
RCBTB1
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
chr17_-_7078446 2.639 NM_004422
DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr10_+_51497716 2.620 FAM21A
family with sequence similarity 21, member A
chr5_-_172687798 2.618 STC2
stanniocalcin 2
chr14_-_91642703 2.603 NM_001127696
NM_001127697
NM_001164774
NM_001164776
NM_001164777
NM_001164778
NM_001164779
NM_001164780
NM_001164781
NM_001164782
NM_004993
NM_030660
ATXN3











ataxin 3











chr10_-_3817205 2.585 KLF6
Kruppel-like factor 6
chr8_-_126173227 2.574 NM_014846
KIAA0196
KIAA0196
chr12_+_6703686 2.558 NM_001164093
COPS7A
COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis)
chrX_+_102770547 2.537 NM_001006639
NM_004780
TCEAL1

transcription elongation factor A (SII)-like 1

chr4_+_658312 2.500 MYL5
myosin, light chain 5, regulatory
chr20_+_56318245 2.499 RAB22A
RAB22A, member RAS oncogene family
chr8_-_95343696 2.495 GEM
GTP binding protein overexpressed in skeletal muscle
chr11_+_101485946 2.490 NM_001130145
NM_001195044
NM_006106
YAP1


Yes-associated protein 1


chrX_+_100765006 2.480 NM_177948
ARMCX3
armadillo repeat containing, X-linked 3
chr5_-_172130766 2.474 NM_004417
DUSP1
dual specificity phosphatase 1
chrX_-_106846924 2.454 NM_004089
TSC22D3
TSC22 domain family, member 3
chr14_-_68515791 2.422 NM_001102
NM_001130004
NM_001130005
ACTN1


actinin, alpha 1


chr11_-_27679617 2.418 NM_170733
BDNF
brain-derived neurotrophic factor
chr11_-_1741680 2.417 CTSD
cathepsin D
chr3_+_160002408 2.351 NM_001167903
NM_022736
MFSD1

major facilitator superfamily domain containing 1

chr2_+_238060602 2.349 NM_001042467
NM_024101
MLPH

melanophilin

chr6_-_134538762 2.344 NM_001143678
SGK1
serum/glucocorticoid regulated kinase 1
chr14_-_67353046 2.340 NM_015346
ZFYVE26
zinc finger, FYVE domain containing 26
chr8_-_95343716 2.327 NM_005261
NM_181702
GEM

GTP binding protein overexpressed in skeletal muscle

chr2_+_223625105 2.323 NM_080671
KCNE4
potassium voltage-gated channel, Isk-related family, member 4
chr5_+_149320480 2.322 NM_000112
SLC26A2
solute carrier family 26 (sulfate transporter), member 2
chr5_+_172343415 2.321 ATP6V0E1
ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
chr8_+_26296439 2.318 NM_004331
BNIP3L
BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr13_-_95094920 2.316 NM_014934
NM_198968
DZIP1

DAZ interacting protein 1

chr9_-_21984379 2.314 CDKN2A
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
chr20_+_56318155 2.309 NM_020673
RAB22A
RAB22A, member RAS oncogene family
chrX_-_102205752 2.253 NM_018476
BEX1
brain expressed, X-linked 1
chr11_-_1741663 2.238 CTSD
cathepsin D
chrX_+_100764757 2.233 NM_016607
NM_177947
ARMCX3

armadillo repeat containing, X-linked 3

chr12_+_64504408 2.228 NM_003483
NM_003484
HMGA2

high mobility group AT-hook 2

chr10_+_51497660 2.227 NM_001005751
FAM21C
FAM21A
family with sequence similarity 21, member C
family with sequence similarity 21, member A
chr17_-_7078399 2.223 DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr2_+_219751145 2.222 NM_024293
FAM134A
family with sequence similarity 134, member A
chr12_-_108918570 2.210 NM_001135213
NM_001135214
NM_014776
NM_057169
NM_057170
NM_139201
GIT2





G protein-coupled receptor kinase interacting ArfGAP 2





chr6_+_123152044 2.204 SMPDL3A
sphingomyelin phosphodiesterase, acid-like 3A
chrX_-_100759562 2.183 NM_001009584
NM_001184768
NM_019007
ARMCX6


armadillo repeat containing, X-linked 6


chr6_+_42126228 2.178 NM_138572
TAF8
TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa
chr4_-_77353929 2.173 SCARB2
scavenger receptor class B, member 2
chr5_+_172343429 2.152 ATP6V0E1
ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
chr2_+_241903395 2.150 NM_001008491
NM_006155
SEPT2

septin 2

chr3_-_79899748 2.139 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr2_+_231771623 2.135 ARMC9
armadillo repeat containing 9
chr14_+_61231795 2.118 NM_001530
NM_181054
HIF1A

hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

chr10_+_121401061 2.118 BAG3
BCL2-associated athanogene 3

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
7.09 6.16e-06 GO:0007033 vacuole organization
1.94 1.79e-05 GO:0008104 protein localization
1.80 4.15e-05 GO:0033036 macromolecule localization
1.99 1.51e-04 GO:0015031 protein transport
1.96 2.94e-04 GO:0045184 establishment of protein localization
8.29 8.91e-04 GO:0007040 lysosome organization
2.22 9.24e-04 GO:0034613 cellular protein localization
2.20 1.13e-03 GO:0070727 cellular macromolecule localization
7.30 3.20e-03 GO:0015988 energy coupled proton transport, against electrochemical gradient
7.30 3.20e-03 GO:0015991 ATP hydrolysis coupled proton transport
1.67 4.70e-03 GO:0051641 cellular localization
2.27 7.69e-03 GO:0006886 intracellular protein transport
1.67 2.15e-02 GO:0051649 establishment of localization in cell
1.78 3.66e-02 GO:0046907 intracellular transport
6.24 4.62e-02 GO:0015682 ferric iron transport
6.24 4.62e-02 GO:0033572 transferrin transport

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
4.12 7.72e-17 GO:0005773 vacuole
3.71 7.38e-11 GO:0000323 lytic vacuole
3.71 7.38e-11 GO:0005764 lysosome
4.65 1.79e-09 GO:0005774 vacuolar membrane
4.47 5.04e-09 GO:0044437 vacuolar part
4.19 2.86e-05 GO:0005765 lysosomal membrane
1.27 6.09e-05 GO:0044444 cytoplasmic part
10.13 9.58e-05 GO:0033176 proton-transporting V-type ATPase complex
2.29 1.50e-04 GO:0005768 endosome
4.05 2.19e-04 GO:0042470 melanosome
4.05 2.19e-04 GO:0048770 pigment granule
2.74 3.80e-04 GO:0010008 endosome membrane
2.72 4.62e-04 GO:0044440 endosomal part
1.11 4.70e-03 GO:0005622 intracellular
1.11 8.93e-03 GO:0044424 intracellular part
1.15 1.27e-02 GO:0005737 cytoplasm
2.92 1.29e-02 GO:0005769 early endosome
1.70 3.60e-02 GO:0031410 cytoplasmic vesicle
1.14 4.06e-02 GO:0043231 intracellular membrane-bounded organelle
1.12 4.26e-02 GO:0043229 intracellular organelle
1.14 4.68e-02 GO:0043227 membrane-bounded organelle

Gene overrepresentation in function category:

enrichment   p-value GO term description
7.24 1.91e-04 GO:0019829 cation-transporting ATPase activity
8.87 2.16e-03 GO:0046961 proton-transporting ATPase activity, rotational mechanism
9.21 4.17e-02 GO:0015929 hexosaminidase activity