Motif ID: TFEB.p2

Z-value: 2.688


Transcription factors associated with TFEB.p2:

Gene SymbolEntrez IDGene Name
TFEB 7942 transcription factor EB

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TFEBchr6_-_41810712,
chr6_-_41811916		-0.411.1e-01Click!


Activity profile for motif TFEB.p2.

activity profile for motif TFEB.p2


Sorted Z-values histogram for motif TFEB.p2

Sorted Z-values for motif TFEB.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFEB.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_+_112999538 15.229 LAMP1
lysosomal-associated membrane protein 1
chr13_+_112999462 13.625 NM_005561
 LAMP1
lysosomal-associated membrane protein 1
chr13_+_112999590 11.682 LAMP1
lysosomal-associated membrane protein 1
chrX_+_102518064 10.940 NGFRAP1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr19_+_54149843 9.599 NM_004324
NM_138761
NM_138763
NM_138764
 BAX



BCL2-associated X protein



chr19_+_54149941 9.590 BAX
BCL2-associated X protein
chr19_+_54149963 8.814 BAX
BCL2-associated X protein
chr1_-_151775221 8.473 NM_014624
 S100A6
S100 calcium binding protein A6
chr1_-_68470585 7.697 NM_001002292
NM_001193334
NM_024911
 WLS


wntless homolog (Drosophila)


chr3_-_49370755 7.669 NM_000581
NM_201397
 GPX1

glutathione peroxidase 1

chr20_+_43953428 7.590 CTSA
cathepsin A
chr20_+_43953372 7.451 CTSA
cathepsin A
chrX_-_100801472 7.442 NM_014782
NM_177949
 ARMCX2

armadillo repeat containing, X-linked 2

chr3_-_49370682 7.437 GPX1
glutathione peroxidase 1
chr5_+_34692124 7.389 NM_001145522
NM_015577
 RAI14

retinoic acid induced 14

chr22_+_34107087 7.370 HMOX1
heme oxygenase (decycling) 1
chr7_-_47588652 7.189 TNS3
tensin 3
chr15_-_71712711 7.125 NM_001161363
NM_001161364
NM_012428
NM_017455
 NPTN



neuroplastin



chr22_+_34107051 7.054 NM_002133
 HMOX1
heme oxygenase (decycling) 1
chr12_-_47604930 6.889 NM_001143781
 FKBP11
FK506 binding protein 11, 19 kDa

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 16 of 16 entries
enrichment   p-value GO term description
8.29 8.91e-04 GO:0007040 lysosome organization
7.30 3.20e-03 GO:0015988 energy coupled proton transport, against electrochemical gradient
7.30 3.20e-03 GO:0015991 ATP hydrolysis coupled proton transport
7.09 6.16e-06 GO:0007033 vacuole organization
6.24 4.62e-02 GO:0015682 ferric iron transport
6.24 4.62e-02 GO:0033572 transferrin transport
2.27 7.69e-03 GO:0006886 intracellular protein transport
2.22 9.24e-04 GO:0034613 cellular protein localization
2.20 1.13e-03 GO:0070727 cellular macromolecule localization
1.99 1.51e-04 GO:0015031 protein transport
1.96 2.94e-04 GO:0045184 establishment of protein localization
1.94 1.79e-05 GO:0008104 protein localization
1.80 4.15e-05 GO:0033036 macromolecule localization
1.78 3.66e-02 GO:0046907 intracellular transport
1.67 4.70e-03 GO:0051641 cellular localization
1.67 2.15e-02 GO:0051649 establishment of localization in cell

Gene overrepresentation in compartment category:

Showing 1 to 20 of 21 entries
enrichment   p-value GO term description
10.13 9.58e-05 GO:0033176 proton-transporting V-type ATPase complex
4.65 1.79e-09 GO:0005774 vacuolar membrane
4.47 5.04e-09 GO:0044437 vacuolar part
4.19 2.86e-05 GO:0005765 lysosomal membrane
4.12 7.72e-17 GO:0005773 vacuole
4.05 2.19e-04 GO:0042470 melanosome
4.05 2.19e-04 GO:0048770 pigment granule
3.71 7.38e-11 GO:0000323 lytic vacuole
3.71 7.38e-11 GO:0005764 lysosome
2.92 1.29e-02 GO:0005769 early endosome
2.74 3.80e-04 GO:0010008 endosome membrane
2.72 4.62e-04 GO:0044440 endosomal part
2.29 1.50e-04 GO:0005768 endosome
1.70 3.60e-02 GO:0031410 cytoplasmic vesicle
1.27 6.09e-05 GO:0044444 cytoplasmic part
1.15 1.27e-02 GO:0005737 cytoplasm
1.14 4.06e-02 GO:0043231 intracellular membrane-bounded organelle
1.14 4.68e-02 GO:0043227 membrane-bounded organelle
1.12 4.26e-02 GO:0043229 intracellular organelle
1.11 4.70e-03 GO:0005622 intracellular

Gene overrepresentation in function category:

Showing 1 to 3 of 3 entries
enrichment   p-value GO term description
9.21 4.17e-02 GO:0015929 hexosaminidase activity
8.87 2.16e-03 GO:0046961 proton-transporting ATPase activity, rotational mechanism
7.24 1.91e-04 GO:0019829 cation-transporting ATPase activity