Motif ID: REST.p3

Z-value: 0.815


Transcription factors associated with REST.p3:

Gene SymbolEntrez IDGene Name
REST 5978 RE1-silencing transcription factor

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RESTchr4_+_57468847-0.361.7e-01Click!


Activity profile for motif REST.p3.

activity profile for motif REST.p3


Sorted Z-values histogram for motif REST.p3

Sorted Z-values for motif REST.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of REST.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_207892420 2.980 NM_000228
LAMB3
laminin, beta 3
chrX_-_152794592 1.980 NM_000425
NM_001143963
NM_024003
L1CAM


L1 cell adhesion molecule


chr20_+_61798512 1.804 TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr20_+_61798446 1.786 NM_003823
TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr3_+_62280435 1.552 NM_020685
C3orf14
chromosome 3 open reading frame 14
chr3_+_62279707 1.322 C3orf14
chromosome 3 open reading frame 14
chr10_+_102780974 1.001 NM_030971
SFXN3
sideroflexin 3
chr3_+_195336625 0.918 NM_005524
HES1
hairy and enhancer of split 1, (Drosophila)
chr3_+_195336631 0.852 HES1
hairy and enhancer of split 1, (Drosophila)
chr19_-_50619015 0.748 NM_001166049
NM_001983
ERCC1

excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)

chr19_-_50618982 0.734 ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr19_-_50618599 0.723 ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr19_-_50618659 0.715 NM_202001
ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr2_+_46377952 0.695 NM_001430
EPAS1
endothelial PAS domain protein 1
chr19_-_50618921 0.662 ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr7_+_145444385 0.527 NM_014141
CNTNAP2
contactin associated protein-like 2
chrX_-_47364173 0.392 NM_006950
NM_133499
SYN1

synapsin I

chr17_-_37022465 0.339 NM_005557
KRT16
keratin 16
chr19_+_38867273 0.321 NM_022467
CHST8
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
chr16_+_24174975 0.310 CACNG3
calcium channel, voltage-dependent, gamma subunit 3
chr12_+_46133 0.309 NM_001170738
IQSEC3
IQ motif and Sec7 domain 3
chr15_+_92575767 0.281 MCTP2
multiple C2 domains, transmembrane 2
chr17_-_3248453 0.276 NM_003553
OR1E1
olfactory receptor, family 1, subfamily E, member 1
chr17_-_3283884 0.243 NM_003554
OR1E2
olfactory receptor, family 1, subfamily E, member 2
chr16_+_24175173 0.207 CACNG3
calcium channel, voltage-dependent, gamma subunit 3
chr16_+_2959362 0.182 PAQR4
progestin and adipoQ receptor family member IV
chr5_+_33972247 0.181 NM_016568
RXFP3
relaxin/insulin-like family peptide receptor 3
chr9_-_122852356 0.175 NM_001735
C5
complement component 5
chr3_-_48675321 0.170 NM_001407
CELSR3
cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)
chrX_-_48943582 0.169 NM_003179
SYP
synaptophysin
chr16_+_2959342 0.167 NM_152341
PAQR4
progestin and adipoQ receptor family member IV
chr4_+_158361185 0.154 NM_000826
NM_001083619
NM_001083620
GRIA2


glutamate receptor, ionotropic, AMPA 2


chr10_-_102780840 0.147 PDZD7
PDZ domain containing 7
chr11_-_123030091 0.141 SCN3B
sodium channel, voltage-gated, type III, beta
chr14_+_92459244 0.137 CHGA
chromogranin A (parathyroid secretory protein 1)
chr11_+_64565118 0.136 SAC3D1
SAC3 domain containing 1
chr10_-_102780867 0.131 NM_001195263
NM_024895
PDZD7

PDZ domain containing 7

chr14_+_92459197 0.130 NM_001275
CHGA
chromogranin A (parathyroid secretory protein 1)
chr20_+_44091219 0.126 NM_020708
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr9_+_139153409 0.122 NM_000832
NM_001185090
NM_001185091
NM_007327
NM_021569
GRIN1




glutamate receptor, ionotropic, N-methyl D-aspartate 1




chr6_+_138767007 0.117 NM_014320
HEBP2
heme binding protein 2
chrX_+_152891184 0.117 NM_003492
TMEM187
transmembrane protein 187
chr6_+_154402135 0.106 NM_000914
NM_001008503
NM_001008504
NM_001008505
NM_001145282
NM_001145283
NM_001145285
NM_001145286
NM_001145284
OPRM1








opioid receptor, mu 1








chr20_+_44091265 0.103 SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr8_+_11703368 0.099 FDFT1
farnesyl-diphosphate farnesyltransferase 1
chr14_-_93829347 0.098 NM_001100607
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr4_-_175986952 0.096 NM_001042543
NM_006529
GLRA3

glycine receptor, alpha 3

chr11_+_62136788 0.094 NM_000327
ROM1
retinal outer segment membrane protein 1
chr18_+_55718171 0.089 NM_021127
PMAIP1
phorbol-12-myristate-13-acetate-induced protein 1
chr6_+_138767151 0.081 HEBP2
heme binding protein 2
chr6_+_43257883 0.081 NM_015089
CUL9
cullin 9
chr15_-_24570010 0.071 NM_021912
GABRB3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr20_+_13713645 0.069 NM_001039375
NM_024120
C20orf7

chromosome 20 open reading frame 7

chr1_-_149955870 0.068 NM_007185
CELF3
CUGBP, Elav-like family member 3
chr3_-_115380539 0.064 NM_000796
NM_033663
DRD3

dopamine receptor D3

chr11_+_22316242 0.063 NM_020346
SLC17A6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr19_+_51804260 0.060 CALM3
calmodulin 3 (phosphorylase kinase, delta)
chr14_+_20226762 0.059 NM_001097577
NM_194431
ANG
RNASE4
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chr9_+_116131889 0.053 NM_000608
ORM2
orosomucoid 2
chr8_-_145530639 0.053 NM_031309
SCRT1
scratch homolog 1, zinc finger protein (Drosophila)
chr15_+_67009892 0.051 NM_145658
NM_001184780
SPESP1
NOX5
sperm equatorial segment protein 1
NADPH oxidase, EF-hand calcium binding domain 5
chr20_+_35445350 0.049 SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr10_+_26545599 0.048 GAD2
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr1_-_173979292 0.040 NM_003285
TNR
tenascin R (restrictin, janusin)
chr12_+_111713931 0.039 NM_001143854
NM_014954
RPH3A

rabphilin 3A homolog (mouse)

chr9_-_138236775 0.037 NM_178138
LHX3
LIM homeobox 3
chr6_+_153113624 0.028 NM_003381
NM_194435
VIP

vasoactive intestinal peptide

chr1_-_20707196 0.027 NM_024544
MUL1
mitochondrial E3 ubiquitin protein ligase 1
chr12_-_97812633 0.022 ANKS1B
ankyrin repeat and sterile alpha motif domain containing 1B
chr20_+_5839973 0.022 NM_001819
CHGB
chromogranin B (secretogranin 1)
chr1_-_20707103 0.020 MUL1
mitochondrial E3 ubiquitin protein ligase 1
chr17_-_62793129 0.017 NM_002816
NM_174871
PSMD12

proteasome (prosome, macropain) 26S subunit, non-ATPase, 12

chr20_-_61755145 0.013 NM_015894
STMN3
stathmin-like 3
chr10_+_26545241 0.012 NM_000818
NM_001134366
GAD2

glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)

chr20_+_56861430 0.012 NM_001077490
NM_080425
GNAS

GNAS complex locus

chr3_+_52787478 0.011 NM_001166434
ITIH1
inter-alpha (globulin) inhibitor H1
chr8_+_80685859 0.008 STMN2
stathmin-like 2
chr3_-_188870799 0.005 NM_001048
SST
somatostatin
chr2_-_51113040 0.005 NM_001135659
NM_004801
NRXN1

neurexin 1

chr17_-_7095622 0.005 NM_001143775
CTDNEP1
CTD nuclear envelope phosphatase 1
chr1_+_210672817 0.003 NM_013349
NENF
neuron derived neurotrophic factor
chr21_-_34749908 0.003 NM_001127670
KCNE1
potassium voltage-gated channel, Isk-related family, member 1
chr5_+_175231210 0.001 CPLX2
complexin 2
chr5_+_175231144 0.000 CPLX2
complexin 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
5.36 1.27e-08 GO:0050877 neurological system process
7.48 9.77e-08 GO:0019226 transmission of nerve impulse
7.48 9.77e-08 GO:0035637 multicellular organismal signaling
4.27 1.40e-07 GO:0003008 system process
7.87 1.97e-07 GO:0007268 synaptic transmission
4.24 4.88e-05 GO:0007154 cell communication
1.99 2.93e-04 GO:0032501 multicellular organismal process
4.56 2.94e-04 GO:0007267 cell-cell signaling
1.97 2.48e-02 GO:0023052 signaling

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
9.33 2.44e-06 GO:0044456 synapse part
7.35 7.38e-06 GO:0045202 synapse
33.31 4.14e-05 GO:0030672 synaptic vesicle membrane
19.33 7.33e-05 GO:0008021 synaptic vesicle
4.23 1.06e-03 GO:0016023 cytoplasmic membrane-bounded vesicle
4.14 1.34e-03 GO:0031988 membrane-bounded vesicle
3.98 2.02e-03 GO:0031410 cytoplasmic vesicle
4.69 2.19e-03 GO:0030054 cell junction
14.65 2.69e-03 GO:0030665 clathrin coated vesicle membrane
3.84 2.99e-03 GO:0031982 vesicle
9.36 5.06e-03 GO:0030136 clathrin-coated vesicle
5.27 5.67e-03 GO:0043005 neuron projection
36.23 8.64e-03 GO:0032589 neuron projection membrane
11.11 1.02e-02 GO:0019717 synaptosome
10.40 1.41e-02 GO:0030662 coated vesicle membrane
6.19 1.57e-02 GO:0030659 cytoplasmic vesicle membrane
7.44 1.81e-02 GO:0030135 coated vesicle
96.58 1.94e-02 GO:0032590 dendrite membrane
5.94 2.02e-02 GO:0012506 vesicle membrane
2.26 2.11e-02 GO:0044459 plasma membrane part
1.66 2.77e-02 GO:0044425 membrane part
8.13 4.46e-02 GO:0045211 postsynaptic membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
4.86 2.40e-02 GO:0015267 channel activity
4.84 2.46e-02 GO:0022803 passive transmembrane transporter activity
5.60 2.58e-02 GO:0022836 gated channel activity
12.48 3.14e-02 GO:0005230 extracellular ligand-gated ion channel activity
64.39 4.27e-02 GO:0004522 pancreatic ribonuclease activity