Motif ID: REST.p3

Z-value: 0.815


Transcription factors associated with REST.p3:

Gene SymbolEntrez IDGene Name
REST 5978 RE1-silencing transcription factor

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RESTchr4_+_57468847-0.361.7e-01Click!


Activity profile for motif REST.p3.

activity profile for motif REST.p3


Sorted Z-values histogram for motif REST.p3

Sorted Z-values for motif REST.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of REST.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 84 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_207892420 2.980 NM_000228
 LAMB3
laminin, beta 3
chrX_-_152794592 1.980 NM_000425
NM_001143963
NM_024003
 L1CAM


L1 cell adhesion molecule


chr20_+_61798512 1.804 TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr20_+_61798446 1.786 NM_003823
 TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr3_+_62280435 1.552 NM_020685
 C3orf14
chromosome 3 open reading frame 14
chr3_+_62279707 1.322 C3orf14
chromosome 3 open reading frame 14
chr10_+_102780974 1.001 NM_030971
 SFXN3
sideroflexin 3
chr3_+_195336625 0.918 NM_005524
 HES1
hairy and enhancer of split 1, (Drosophila)
chr3_+_195336631 0.852 HES1
hairy and enhancer of split 1, (Drosophila)
chr19_-_50619015 0.748 NM_001166049
NM_001983
 ERCC1

excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)

chr19_-_50618982 0.734 ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr19_-_50618599 0.723 ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr19_-_50618659 0.715 NM_202001
 ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr2_+_46377952 0.695 NM_001430
 EPAS1
endothelial PAS domain protein 1
chr19_-_50618921 0.662 ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr7_+_145444385 0.527 NM_014141
 CNTNAP2
contactin associated protein-like 2
chrX_-_47364173 0.392 NM_006950
NM_133499
 SYN1

synapsin I

chr17_-_37022465 0.339 NM_005557
 KRT16
keratin 16
chr19_+_38867273 0.321 NM_022467
 CHST8
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
chr16_+_24174975 0.310 CACNG3
calcium channel, voltage-dependent, gamma subunit 3

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 9 of 9 entries
enrichment   p-value GO term description
7.87 1.97e-07 GO:0007268 synaptic transmission
7.48 9.77e-08 GO:0019226 transmission of nerve impulse
7.48 9.77e-08 GO:0035637 multicellular organismal signaling
5.36 1.27e-08 GO:0050877 neurological system process
4.56 2.94e-04 GO:0007267 cell-cell signaling
4.27 1.40e-07 GO:0003008 system process
4.24 4.88e-05 GO:0007154 cell communication
1.99 2.93e-04 GO:0032501 multicellular organismal process
1.97 2.48e-02 GO:0023052 signaling

Gene overrepresentation in compartment category:

Showing 1 to 20 of 22 entries
enrichment   p-value GO term description
96.58 1.94e-02 GO:0032590 dendrite membrane
36.23 8.64e-03 GO:0032589 neuron projection membrane
33.31 4.14e-05 GO:0030672 synaptic vesicle membrane
19.33 7.33e-05 GO:0008021 synaptic vesicle
14.65 2.69e-03 GO:0030665 clathrin coated vesicle membrane
11.11 1.02e-02 GO:0019717 synaptosome
10.40 1.41e-02 GO:0030662 coated vesicle membrane
9.36 5.06e-03 GO:0030136 clathrin-coated vesicle
9.33 2.44e-06 GO:0044456 synapse part
8.13 4.46e-02 GO:0045211 postsynaptic membrane
7.44 1.81e-02 GO:0030135 coated vesicle
7.35 7.38e-06 GO:0045202 synapse
6.19 1.57e-02 GO:0030659 cytoplasmic vesicle membrane
5.94 2.02e-02 GO:0012506 vesicle membrane
5.27 5.67e-03 GO:0043005 neuron projection
4.69 2.19e-03 GO:0030054 cell junction
4.23 1.06e-03 GO:0016023 cytoplasmic membrane-bounded vesicle
4.14 1.34e-03 GO:0031988 membrane-bounded vesicle
3.98 2.02e-03 GO:0031410 cytoplasmic vesicle
3.84 2.99e-03 GO:0031982 vesicle

Gene overrepresentation in function category:

Showing 1 to 5 of 5 entries
enrichment   p-value GO term description
64.39 4.27e-02 GO:0004522 pancreatic ribonuclease activity
12.48 3.14e-02 GO:0005230 extracellular ligand-gated ion channel activity
5.60 2.58e-02 GO:0022836 gated channel activity
4.86 2.40e-02 GO:0015267 channel activity
4.84 2.46e-02 GO:0022803 passive transmembrane transporter activity